Details for: RTL8A

Gene ID: 26071

Symbol: RTL8A

Ensembl ID: ENSG00000203950

Description: retrotransposon Gag like 8A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.15
    Marker Score: 924
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 2.8
    Marker Score: 2,741
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.57
    Marker Score: 2,290
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.25
    Marker Score: 1,508
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.91
    Marker Score: 5,210
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.86
    Marker Score: 898
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.81
    Marker Score: 18,208
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.8
    Marker Score: 1,908
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.71
    Marker Score: 59,299
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7
    Marker Score: 11,055
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.7
    Marker Score: 3,544
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.64
    Marker Score: 1,765
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.62
    Marker Score: 894
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.58
    Marker Score: 20,827
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.56
    Marker Score: 1,653
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.55
    Marker Score: 6,699
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.55
    Marker Score: 1,462
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.55
    Marker Score: 1,036
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.55
    Marker Score: 520
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.55
    Marker Score: 823
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.5
    Marker Score: 12,940
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.42
    Marker Score: 3,351
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.42
    Marker Score: 1,189
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.4
    Marker Score: 8,316
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.39
    Marker Score: 395
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.39
    Marker Score: 2,044
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.38
    Marker Score: 10,769
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.3
    Marker Score: 9,673
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.3
    Marker Score: 484
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.3
    Marker Score: 853
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.29
    Marker Score: 2,725
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.27
    Marker Score: 4,989
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.27
    Marker Score: 2,573
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.26
    Marker Score: 2,369
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.26
    Marker Score: 295
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.26
    Marker Score: 6,600
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.25
    Marker Score: 1,180
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.25
    Marker Score: 2,055
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.25
    Marker Score: 1,332
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.24
    Marker Score: 14,016
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.24
    Marker Score: 585
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.21
    Marker Score: 759
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.18
    Marker Score: 701
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.16
    Marker Score: 1,926
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.13
    Marker Score: 1,736
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.11
    Marker Score: 483
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.11
    Marker Score: 1,785
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.1
    Marker Score: 1,326
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.09
    Marker Score: 1,136
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.09
    Marker Score: 3,430
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.09
    Marker Score: 2,740
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.08
    Marker Score: 612
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.08
    Marker Score: 4,001
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.07
    Marker Score: 345
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.06
    Marker Score: 402
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.05
    Marker Score: 741
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.05
    Marker Score: 1,455
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.03
    Marker Score: 1,048
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.03
    Marker Score: 1,631
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.02
    Marker Score: 200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.01
    Marker Score: 521
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1
    Marker Score: 2,614
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1
    Marker Score: 402
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,695
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1
    Marker Score: 254
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,918
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.99
    Marker Score: 1,985
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.99
    Marker Score: 519
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.98
    Marker Score: 1,351
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.98
    Marker Score: 620
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,391
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.98
    Marker Score: 696
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.98
    Marker Score: 1,181
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.97
    Marker Score: 877
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.97
    Marker Score: 8,407
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.96
    Marker Score: 910
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.95
    Marker Score: 1,350
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.95
    Marker Score: 312
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.95
    Marker Score: 3,650
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.94
    Marker Score: 327
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.94
    Marker Score: 1,000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,393
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.94
    Marker Score: 297
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.94
    Marker Score: 279
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.92
    Marker Score: 1,628
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,175
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9
    Marker Score: 2,043
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.88
    Marker Score: 2,363
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.88
    Marker Score: 438
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.88
    Marker Score: 4,218
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.88
    Marker Score: 217
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.87
    Marker Score: 452
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.87
    Marker Score: 5,689
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.87
    Marker Score: 1,257
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.87
    Marker Score: 931
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.86
    Marker Score: 585

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RTL8A is a member of the retrotransposon family, a class of mobile genetic elements that can replicate and integrate into new genomic locations. The gene encodes a protein with a Gag-like structure, which is characteristic of retroviruses. RTL8A is primarily expressed in cells that are involved in various physiological processes, such as muscle development, hormone regulation, and cellular differentiation. Its expression patterns suggest that RTL8A may play a role in the regulation of cellular proliferation, differentiation, and survival. **Pathways and Functions:** Despite the lack of direct experimental evidence, RTL8A is predicted to be involved in several cellular pathways, including: 1. **Protein binding:** RTL8A is predicted to interact with various proteins, including transcription factors, chaperones, and other proteins involved in cellular processes. 2. **Cellular signaling:** RTL8A may modulate signaling pathways involved in cell growth, differentiation, and survival, such as the PI3K/AKT and MAPK/ERK pathways. 3. **Chromatin remodeling:** RTL8A may influence chromatin structure and function, potentially regulating gene expression and cellular differentiation. **Clinical Significance:** The clinical significance of RTL8A remains largely unknown, but its widespread expression in various tissues and cell types suggests potential implications for human diseases. Some possible areas of research include: 1. **Cancer:** RTL8A expression in cancer cells may be associated with tumorigenesis, tumor progression, or metastasis. 2. **Neurological disorders:** RTL8A expression in neural cells may be linked to neurological diseases, such as Alzheimer's disease or Parkinson's disease. 3. **Muscular dystrophy:** RTL8A expression in skeletal muscle cells may be involved in the pathogenesis of muscular dystrophy. In conclusion, the RTL8A gene is a fascinating and enigmatic gene that warrants further investigation. While its exact function remains unclear, its widespread expression and structural similarities with retroviruses suggest potential roles in cellular processes and disease pathogenesis. Future studies should aim to elucidate the molecular mechanisms underlying RTL8A's functions and explore its clinical significance in various diseases.

Genular Protein ID: 346607358

Symbol: RTL8A_HUMAN

Name: Mammalian retrotransposon derived protein 8A

UniProtKB Accession Codes:

Q9BWD3 A2A2V9 Q8TBU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16093683

Title: A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.

PubMed ID: 16093683

DOI: 10.1159/000084963

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 113
  • Mass: 13188
  • Checksum: 65227B6D28946B9F
  • Sequence:
    • MDGRVQLMKA LLAGPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY MFVDENTFSN 
DALKVTFLIT RLTGPALQWV IPYIRKESPL LNDYRGFLAE MKRVFGWEED EDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.