Gene ERBB3 - ENSG00000065361 | NCBI Gene ID: 2065

Details for: ERBB3

Gene ID: 2065

Symbol: ERBB3

Ensembl ID: ENSG00000065361

Description: erb-b2 receptor tyrosine kinase 3

Associated with

Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Downregulation of erbb2:erbb3 signaling
(R-HSA-1358803)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Grb7 events in erbb2 signaling
(R-HSA-1306955)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cranial nerve development
(GO:0021545)
Endocardial cushion development
(GO:0003197)
Erbb-3 class receptor binding
(GO:0043125)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Erbb3:erbb2 complex
(GO:0038143)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Growth factor binding
(GO:0019838)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Lateral plasma membrane
(GO:0016328)
Motor neuron apoptotic process
(GO:0097049)
Multicellular organism development
(GO:0007275)
Myelination
(GO:0042552)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of motor neuron apoptotic process
(GO:2000672)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of secretion
(GO:0051048)
Negative regulation of signal transduction
(GO:0009968)
Neuregulin binding
(GO:0038132)
Neuregulin receptor activity
(GO:0038131)
Neurogenesis
(GO:0022008)
Neuron apoptotic process
(GO:0051402)
Peripheral nervous system development
(GO:0007422)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of calcineurin-nfat signaling cascade
(GO:0070886)
Positive regulation of cardiac muscle tissue development
(GO:0055025)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein tyrosine kinase activator activity
(GO:0030296)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Regulation of cell population proliferation
(GO:0042127)
Schwann cell development
(GO:0014044)
Schwann cell differentiation
(GO:0014037)
Signal transduction
(GO:0007165)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)
Wound healing
(GO:0042060)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 2.85
Marker Score: 2170
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.38
Marker Score: 7812
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.22
Marker Score: 2376
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.11
Marker Score: 1984
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.06
Marker Score: 2568
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.04
Marker Score: 8511
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.01
Marker Score: 4802
Cell Name: enterocyte (CL0000584)
Fold Change: 1.94
Marker Score: 9333
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.93
Marker Score: 4402
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.93
Marker Score: 6062
Cell Name: stem cell (CL0000034)
Fold Change: 1.91
Marker Score: 4532
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.89
Marker Score: 883
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.87
Marker Score: 1090
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.87
Marker Score: 1272
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.86
Marker Score: 2746
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.86
Marker Score: 3292
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.73
Marker Score: 3927
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.73
Marker Score: 2083
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.73
Marker Score: 498
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.72
Marker Score: 1147
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.69
Marker Score: 8869.5
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.68
Marker Score: 1606
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.66
Marker Score: 1434
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.66
Marker Score: 10570
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.65
Marker Score: 620
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.64
Marker Score: 3111
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.61
Marker Score: 464
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.57
Marker Score: 866
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.55
Marker Score: 764
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.55
Marker Score: 2384
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.51
Marker Score: 1568
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.49
Marker Score: 1646.5
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.45
Marker Score: 359
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.43
Marker Score: 12318
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.42
Marker Score: 8396.5
Cell Name: secretory cell (CL0000151)
Fold Change: 1.4
Marker Score: 2559
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.37
Marker Score: 2172
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.35
Marker Score: 850
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.31
Marker Score: 1307
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.28
Marker Score: 4926
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.26
Marker Score: 9391
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.25
Marker Score: 562
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.25
Marker Score: 2640
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.25
Marker Score: 1314
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.22
Marker Score: 2880
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.22
Marker Score: 9520
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.22
Marker Score: 10567
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.19
Marker Score: 7771
Cell Name: precursor cell (CL0011115)
Fold Change: 1.18
Marker Score: 286
Cell Name: club cell (CL0000158)
Fold Change: 1.17
Marker Score: 1367
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.15
Marker Score: 365
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.14
Marker Score: 1825
Cell Name: peptic cell (CL0000155)
Fold Change: 1.12
Marker Score: 471
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.12
Marker Score: 3972
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.12
Marker Score: 4386
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.11
Marker Score: 414
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.11
Marker Score: 701
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.09
Marker Score: 4713
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.09
Marker Score: 7000
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.05
Marker Score: 831
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251777
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 789
Cell Name: basal cell (CL0000646)
Fold Change: 1.03
Marker Score: 1329
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.03
Marker Score: 1953.5
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.02
Marker Score: 5506
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.02
Marker Score: 15955
Cell Name: acinar cell (CL0000622)
Fold Change: 1.02
Marker Score: 719
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71796
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48020
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.99
Marker Score: 253
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.99
Marker Score: 1226
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.98
Marker Score: 1991
Cell Name: kidney cell (CL1000497)
Fold Change: 0.98
Marker Score: 651
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.95
Marker Score: 1546
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.94
Marker Score: 842
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5331
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.93
Marker Score: 183
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 0.93
Marker Score: 254
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.92
Marker Score: 31748
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.89
Marker Score: 2249
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.87
Marker Score: 717
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.86
Marker Score: 248
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.86
Marker Score: 1422
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.85
Marker Score: 404
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.83
Marker Score: 287
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.83
Marker Score: 496
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 324
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.79
Marker Score: 2720
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.79
Marker Score: 660
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.78
Marker Score: 278
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.75
Marker Score: 521
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.75
Marker Score: 3125

Hover over a box to see details here...

**Key characteristics** * ERBB3 is a member of the ERBB family of tyrosine kinases. * It is a transmembrane protein with a cytoplasmic domain and an extracellular domain. * The cytoplasmic domain is responsible for binding to its substrate proteins. * The extracellular domain is responsible for binding to growth factor receptors. * ERBB3 is activated by the binding of growth factor receptors to its extracellular domain. * Activation of ERBB3 leads to the phosphorylation of its cytoplasmic domain, which in turn activates downstream signaling pathways. **Pathways and functions** * ERBB3 is a key regulator of cell growth, proliferation, and survival. * It is involved in the regulation of cell cycle progression, apoptosis, and migration. * ERBB3 is also involved in the regulation of angiogenesis and cell migration. * Mutations in ERBB3 have been linked to a number of human cancers. **Clinical significance** * ERBB3 is a promising target for cancer therapy. * Inhibition of ERBB3 has been shown to inhibit cancer growth and metastasis. * Clinical trials of ERBB3 inhibitors are currently underway. **Additional information** * ERBB3 is a highly conserved protein. * It is expressed in all tissues of the body. * It is a substrate for a number of downstream signaling proteins, including PI3K, MAPK, and STAT. * It is a key regulator of cell growth, proliferation, and survival.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Receptor tyrosine-protein kinase erbB-3

Genular Protein ID: 308488164

Symbol: ERBB3_HUMAN

Name: Receptor tyrosine-protein kinase erbB-3

UniProtKB Accession Codes:

P21860 A8K6L6 B4DIK7 B4DV32 E9PDT8 Q9BUD7

Database IDs:

Citations:

PubMed ID: 2687875

Title: Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

PubMed ID: 2687875

DOI: 10.1073/pnas.86.23.9193

PubMed ID: 2164210

Title: Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

PubMed ID: 2164210

DOI: 10.1073/pnas.87.13.4905

PubMed ID: 7685162

Title: c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.

PubMed ID: 7685162

DOI: 10.1006/bbrc.1993.1542

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9516479

Title: Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

PubMed ID: 9516479

DOI: 10.1074/jbc.273.13.7717

PubMed ID: 11325528

Title: Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.

PubMed ID: 11325528

DOI: 10.1016/s0303-7207(01)00387-2

PubMed ID: 12939402

Title: Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

PubMed ID: 12939402

PubMed ID: 15358134

Title: Neuroglycan C, a novel member of the neuregulin family.

PubMed ID: 15358134

DOI: 10.1016/j.bbrc.2004.07.066

PubMed ID: 16832058

Title: Ebp1 isoforms distinctively regulate cell survival and differentiation.

PubMed ID: 16832058

DOI: 10.1073/pnas.0602923103

PubMed ID: 17701904

Title: Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway.

PubMed ID: 17701904

DOI: 10.1086/520770

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12154198

Title: Structure of the extracellular region of HER3 reveals an interdomain tether.

PubMed ID: 12154198

DOI: 10.1126/science.1074611

PubMed ID: 20007378

Title: Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.

PubMed ID: 20007378

DOI: 10.1073/pnas.0912101106

PubMed ID: 20351256

Title: ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.

PubMed ID: 20351256

DOI: 10.1073/pnas.1002753107

PubMed ID: 21575594

Title: Spatial structure and dimer-monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles.

PubMed ID: 21575594

DOI: 10.1016/j.bbamem.2011.04.017

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 27416908

Title: A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia.

PubMed ID: 27416908

DOI: 10.1038/leu.2016.173

PubMed ID: 33497358

Title: Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.

PubMed ID: 33497358

DOI: 10.1172/jci145837

Sequence Information:

Length: 1342
Mass: 148098
Checksum: 7201E7F66CA374BD
Sequence:

MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM 
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 
LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 
RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 
TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 
CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TKVLRGPTEE 
RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 
REFAHEAECF SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI 
YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA GLVVIFMMLG 
GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 
GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG 
SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 
LLKSPSQVQV ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 
VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 
LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL EEVELEPELD LDLDLEAEED 
NLATTTLGSA LSLPVGTLNR PRGSQSLLSP SSGYMPMNQG NLGESCQESA VSGSSERCPR 
PVSLHPMPRG CLASESSEGH VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL 
TPVTPLSPPG LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM 
NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP TAGTTPDEDY 
EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH QAPHVHYARL KTLRSLEATD 
SAFDNPDYWH SRLFPKANAQ RT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ERBB3

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. PubMed ID: 2687875

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. PubMed ID: 2164210

c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. PubMed ID: 7685162

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. PubMed ID: 9516479

Regulation of the ErbB3 binding protein Ebp1 by protein kinase C. PubMed ID: 11325528

Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. PubMed ID: 12939402

Neuroglycan C, a novel member of the neuregulin family. PubMed ID: 15358134

Ebp1 isoforms distinctively regulate cell survival and differentiation. PubMed ID: 16832058

Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway. PubMed ID: 17701904

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling. PubMed ID: 20682778

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of the extracellular region of HER3 reveals an interdomain tether. PubMed ID: 12154198

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. PubMed ID: 20007378

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. PubMed ID: 20351256

Spatial structure and dimer-monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles. PubMed ID: 21575594

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia. PubMed ID: 27416908

Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans. PubMed ID: 33497358