Details for: ERBB3

Gene ID: 2065

Symbol: ERBB3

Ensembl ID: ENSG00000065361

Description: erb-b2 receptor tyrosine kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.0376
    Cell Significance Index: -21.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.1482
    Cell Significance Index: -21.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.6661
    Cell Significance Index: -21.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1701
    Cell Significance Index: -21.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0654
    Cell Significance Index: -24.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.5426
    Cell Significance Index: 34.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.2492
    Cell Significance Index: 63.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.5186
    Cell Significance Index: 182.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.4293
    Cell Significance Index: 373.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9179
    Cell Significance Index: 132.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.7545
    Cell Significance Index: 25.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5627
    Cell Significance Index: 73.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6389
    Cell Significance Index: 325.2500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5682
    Cell Significance Index: 15.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4632
    Cell Significance Index: 68.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3692
    Cell Significance Index: 1236.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3148
    Cell Significance Index: 28.4900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.3062
    Cell Significance Index: 1.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1491
    Cell Significance Index: 207.1400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.0823
    Cell Significance Index: 11.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0516
    Cell Significance Index: 14.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.0430
    Cell Significance Index: 14.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9810
    Cell Significance Index: 46.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9756
    Cell Significance Index: 22.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9516
    Cell Significance Index: 70.9300
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.9515
    Cell Significance Index: 0.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7992
    Cell Significance Index: 21.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7826
    Cell Significance Index: 127.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7709
    Cell Significance Index: 46.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7700
    Cell Significance Index: 12.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7297
    Cell Significance Index: 15.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6564
    Cell Significance Index: 18.3500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6534
    Cell Significance Index: 4.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5461
    Cell Significance Index: 4.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5364
    Cell Significance Index: 292.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5076
    Cell Significance Index: 35.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4739
    Cell Significance Index: 80.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4058
    Cell Significance Index: 52.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3489
    Cell Significance Index: 12.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3459
    Cell Significance Index: 65.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3448
    Cell Significance Index: 42.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3391
    Cell Significance Index: 10.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3265
    Cell Significance Index: 144.3600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3136
    Cell Significance Index: 3.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2591
    Cell Significance Index: 29.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2534
    Cell Significance Index: 3.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2372
    Cell Significance Index: 23.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1701
    Cell Significance Index: 4.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0793
    Cell Significance Index: 1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0314
    Cell Significance Index: 23.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0211
    Cell Significance Index: 0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -8.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0105
    Cell Significance Index: -3.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0145
    Cell Significance Index: -26.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0161
    Cell Significance Index: -2.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0162
    Cell Significance Index: -24.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0183
    Cell Significance Index: -11.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0197
    Cell Significance Index: -26.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0226
    Cell Significance Index: -4.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0296
    Cell Significance Index: -16.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0328
    Cell Significance Index: -20.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0360
    Cell Significance Index: -5.2300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0399
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0506
    Cell Significance Index: -22.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0513
    Cell Significance Index: -0.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0534
    Cell Significance Index: -3.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0540
    Cell Significance Index: -5.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0639
    Cell Significance Index: -7.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0656
    Cell Significance Index: -13.8100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0690
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0737
    Cell Significance Index: -21.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0798
    Cell Significance Index: -9.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0912
    Cell Significance Index: -2.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1151
    Cell Significance Index: -15.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1233
    Cell Significance Index: -6.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1642
    Cell Significance Index: -6.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1982
    Cell Significance Index: -20.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2215
    Cell Significance Index: -26.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2307
    Cell Significance Index: -15.5100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2584
    Cell Significance Index: -5.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2726
    Cell Significance Index: -21.5900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2920
    Cell Significance Index: -3.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3003
    Cell Significance Index: -18.4100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3127
    Cell Significance Index: -3.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3158
    Cell Significance Index: -6.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3159
    Cell Significance Index: -24.2400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3162
    Cell Significance Index: -3.3900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3417
    Cell Significance Index: -4.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3425
    Cell Significance Index: -21.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3619
    Cell Significance Index: -22.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3812
    Cell Significance Index: -24.5900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3935
    Cell Significance Index: -2.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4019
    Cell Significance Index: -22.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4025
    Cell Significance Index: -6.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4200
    Cell Significance Index: -12.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4579
    Cell Significance Index: -16.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4632
    Cell Significance Index: -11.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ERBB3 is a transmembrane receptor tyrosine kinase that belongs to the ERBB family, which also includes ERBB2 and ERBB4. It has a characteristic structure, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity. ERBB3 is highly homologous to ERBB2, and the two receptors can form heterodimers, which are thought to be important for the regulation of signaling pathways. **Pathways and Functions** ERBB3 is involved in a wide range of signaling pathways, including: 1. **Neurotrophin signaling**: ERBB3 is a key component of the neurotrophin signaling pathway, which is essential for the development and maintenance of the nervous system. 2. **Cell proliferation and differentiation**: ERBB3 is involved in the regulation of cell proliferation and differentiation in various cell types, including neural crest cells and epithelial cells. 3. **Apoptosis regulation**: ERBB3 can modulate apoptosis through the activation of anti-apoptotic and pro-apoptotic signaling pathways. 4. **Cardiac development and function**: ERBB3 is essential for the development and function of the heart, and its dysregulation has been implicated in cardiac diseases. **Clinical Significance** ERBB3 has been implicated in various diseases, including: 1. **Cancer**: ERBB3 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is thought to contribute to tumorigenesis and metastasis. 2. **Neurological disorders**: ERBB3 is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cardiovascular diseases**: ERBB3 is involved in the regulation of cardiac development and function, and its dysregulation has been implicated in cardiac diseases, such as heart failure and coronary artery disease. In conclusion, ERBB3 is a multifaceted receptor tyrosine kinase that plays a critical role in various cellular processes, from development and signaling to disease and cancer. Its dysregulation has been implicated in various diseases, and understanding the mechanisms of ERBB3 signaling is essential for the development of novel therapeutic strategies. **Proteins and Signaling Pathways** ERBB3 is a transmembrane receptor tyrosine kinase that interacts with various signaling molecules, including: 1. **Neuregulin**: ERBB3 is activated by neuregulin, a ligand that binds to the extracellular domain of the receptor. 2. **Grb7**: ERBB3 can interact with Grb7, a protein that modulates signaling pathways. 3. **PI3K/AKT**: ERBB3 activates the PI3K/AKT signaling pathway, which is involved in cell survival and proliferation. Overall, ERBB3 is a complex receptor tyrosine kinase that plays a critical role in various cellular processes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms of ERBB3 signaling and to develop novel therapeutic strategies for the treatment of diseases associated with this receptor.

Genular Protein ID: 308488164

Symbol: ERBB3_HUMAN

Name: Receptor tyrosine-protein kinase erbB-3

UniProtKB Accession Codes:

P21860 A8K6L6 B4DIK7 B4DV32 E9PDT8 Q9BUD7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 10 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 ELM 1 EMBL 10 EMDB 3 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 15 RefSeq 2 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2687875

Title: Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

PubMed ID: 2687875

DOI: 10.1073/pnas.86.23.9193

PubMed ID: 2164210

Title: Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

PubMed ID: 2164210

DOI: 10.1073/pnas.87.13.4905

PubMed ID: 7685162

Title: c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.

PubMed ID: 7685162

DOI: 10.1006/bbrc.1993.1542

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9516479

Title: Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

PubMed ID: 9516479

DOI: 10.1074/jbc.273.13.7717

PubMed ID: 11325528

Title: Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.

PubMed ID: 11325528

DOI: 10.1016/s0303-7207(01)00387-2

PubMed ID: 12939402

Title: Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

PubMed ID: 12939402

PubMed ID: 15358134

Title: Neuroglycan C, a novel member of the neuregulin family.

PubMed ID: 15358134

DOI: 10.1016/j.bbrc.2004.07.066

PubMed ID: 16832058

Title: Ebp1 isoforms distinctively regulate cell survival and differentiation.

PubMed ID: 16832058

DOI: 10.1073/pnas.0602923103

PubMed ID: 17701904

Title: Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway.

PubMed ID: 17701904

DOI: 10.1086/520770

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12154198

Title: Structure of the extracellular region of HER3 reveals an interdomain tether.

PubMed ID: 12154198

DOI: 10.1126/science.1074611

PubMed ID: 20007378

Title: Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.

PubMed ID: 20007378

DOI: 10.1073/pnas.0912101106

PubMed ID: 20351256

Title: ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.

PubMed ID: 20351256

DOI: 10.1073/pnas.1002753107

PubMed ID: 21575594

Title: Spatial structure and dimer-monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles.

PubMed ID: 21575594

DOI: 10.1016/j.bbamem.2011.04.017

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 27416908

Title: A germline ERBB3 variant is a candidate for predisposition to erythroid MDS/erythroleukemia.

PubMed ID: 27416908

DOI: 10.1038/leu.2016.173

PubMed ID: 33497358

Title: Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.

PubMed ID: 33497358

DOI: 10.1172/jci145837

Sequence Information:

  • Length: 1342
  • Mass: 148098
  • Checksum: 7201E7F66CA374BD
  • Sequence:
    • MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM 
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 
LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 
RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 
TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 
CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TKVLRGPTEE 
RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 
REFAHEAECF SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI 
YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA GLVVIFMMLG 
GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 
GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG 
SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 
LLKSPSQVQV ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 
VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 
LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL EEVELEPELD LDLDLEAEED 
NLATTTLGSA LSLPVGTLNR PRGSQSLLSP SSGYMPMNQG NLGESCQESA VSGSSERCPR 
PVSLHPMPRG CLASESSEGH VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL 
TPVTPLSPPG LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM 
NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP TAGTTPDEDY 
EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH QAPHVHYARL KTLRSLEATD 
SAFDNPDYWH SRLFPKANAQ RT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.