Details for: DNPH1
Gene ID: 10591
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DNPH1
Ensembl ID: ENSG00000112667
Description: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 63.7rCSI 56.01%PRS 63.34
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CSI 55.04rCSI 57.52%PRS 72.67
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CSI 51.77rCSI 49.91%PRS 67.29
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CSI 46.47rCSI 46.37%PRS 68.51
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CSI 46.18rCSI 54.23%PRS 76.88
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CSI 37.02rCSI 33.43%PRS 72.67
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CSI 36.75rCSI 42.5%PRS 66.52
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CSI 33.01rCSI 29.3%PRS 72.79
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CSI 32.25rCSI 52%PRS 75.13
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CSI 32rCSI 45.87%PRS 76.61
-
CSI 31.06rCSI 29.89%PRS 74.24
-
CSI 28.71rCSI 29.96%PRS 74.58
-
CSI 28.27rCSI 29.62%PRS 72.08
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CSI 27.17rCSI 66.36%PRS 67.67
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CSI 25.13rCSI 38.43%PRS 84.69
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CSI 24.55rCSI 55.97%PRS 69.36
-
CSI 24.14rCSI 22.27%PRS 76.55
-
CSI 22.34rCSI 23.74%PRS 81.4
-
CSI 21.32rCSI 30.73%PRS 83.05
-
CSI 20.68rCSI 16.72%PRS 77.15
-
CSI 19.44rCSI 31.5%PRS 70.31
-
CSI 18.95rCSI 64.06%PRS 74.49
-
CSI 17.41rCSI 12.11%PRS 88.98
-
CSI 17.36rCSI 18.19%PRS 78.19
-
CSI 17.25rCSI 33.55%PRS 78.02
-
CSI 16.73rCSI 12.52%PRS 88.09
-
CSI 15.49rCSI 24.46%PRS 76.71
-
CSI 15.41rCSI 33.93%PRS 79.06
-
CSI 15.39rCSI 14.23%PRS 90.21
-
CSI 14.09rCSI 20.32%PRS 81.95
-
CSI 13.67rCSI 29.11%PRS 82.42
-
CSI 13.54rCSI 23.16%PRS 89.19
-
CSI 13.23rCSI 15.34%PRS 79.85
-
CSI 12.97rCSI 18.38%PRS 71.22
-
CSI 12.06rCSI 18.54%PRS 65.79
-
CSI 11.99rCSI 18.6%PRS 79.94
-
CSI 11.58rCSI 11.85%PRS 84.55
-
CSI 11.56rCSI 31.17%PRS 80.64
-
CSI 11.55rCSI 10.92%PRS 74.1
-
CSI 11.34rCSI 49.8%PRS 84.81
-
CSI 11.06rCSI 10.92%PRS 89.78
-
CSI 10.94rCSI 11.15%PRS 85.65
-
CSI 10.92rCSI 7.63%PRS 78.28
-
CSI 10.64rCSI 9.21%PRS 79.4
-
CSI 10.63rCSI 15.55%PRS 79.86
-
CSI 10.6rCSI 14.68%PRS 73.16
-
CSI 10.24rCSI 8.06%PRS 80.94
-
CSI 10.05rCSI 43.59%PRS 82.22
-
CSI 9.97rCSI 22.61%PRS 76.26
-
CSI 9.85rCSI 14.44%PRS 84.96
-
CSI 9.47rCSI 9.74%PRS 87.94
-
CSI 9.08rCSI 6.31%PRS 86.34
-
CSI 8.64rCSI 11.08%PRS 78.62
-
CSI 8.61rCSI 11.45%PRS 80.83
-
CSI 8.4rCSI 11.23%PRS 73.81
-
CSI 8.11rCSI 19.28%PRS 81.71
-
CSI 8.08rCSI 25.93%PRS 77.86
-
CSI 8rCSI 6.63%PRS 75.41
-
CSI 7.99rCSI 5.73%PRS 88.02
-
CSI 7.94rCSI 4.69%PRS 90.49
-
CSI 7.69rCSI 5.72%PRS 86.66
-
CSI 7.67rCSI 9.27%PRS 83.29
-
CSI 7.66rCSI 9.84%PRS 71.18
-
CSI 7.62rCSI 6.99%PRS 83.49
-
CSI 7.41rCSI 7.29%PRS 77.61
-
CSI 7.38rCSI 4.91%PRS 77.86
-
CSI 7.34rCSI 14.74%PRS 64.39
-
CSI 7.34rCSI 6.12%PRS 78.35
-
CSI 7.32rCSI 8.48%PRS 78.43
-
CSI 7.24rCSI 32.19%PRS 75.29
-
CSI 7.1rCSI 5.95%PRS 78.06
-
CSI 7.06rCSI 24.76%PRS 84.2
-
CSI 6.73rCSI 9.36%PRS 73.42
-
CSI 6.71rCSI 15.74%PRS 76.07
-
CSI 6.69rCSI 17%PRS 68.4
-
CSI 6.66rCSI 6.55%PRS 88.9
-
CSI 6.59rCSI 5.21%PRS 62.61
-
CSI 6.53rCSI 8.92%PRS 75.37
-
CSI 6.35rCSI 6.58%PRS 79.76
-
CSI 6.35rCSI 8.68%PRS 79.78
-
CSI 6.31rCSI 6.2%PRS 89.78
-
CSI 6.04rCSI 4.91%PRS 74.76
-
CSI 5.88rCSI 15.6%PRS 81.99
-
CSI 5.78rCSI 4.98%PRS 77.11
-
CSI 5.66rCSI 4.54%PRS 90.03
-
CSI 5.5rCSI 9.43%PRS 82.21
-
CSI 5.46rCSI 40.99%PRS 86.53
-
CSI 5.45rCSI 8.04%PRS 86.76
-
CSI 5.22rCSI 7.64%PRS 69.56
-
CSI 5.2rCSI 7.92%PRS 71.47
-
CSI 5.15rCSI 13.57%PRS 88.56
-
CSI 5.11rCSI 8.15%PRS 66.46
-
CSI 5.09rCSI 4.47%PRS 80.17
-
CSI 5.06rCSI 21.84%PRS 83.67
-
CSI 5.01rCSI 3.88%PRS 78.25
-
CSI 4.91rCSI 10.96%PRS 82.66
-
CSI 4.9rCSI 7.78%PRS 84.18
-
CSI 4.8rCSI 6.54%PRS 66.2
-
CSI 4.74rCSI 3.6%PRS 87.56
-
CSI 4.72rCSI 5.45%PRS 67
-
CSI 0.1rCSI 2.7%PRS 88.8%
-
CSI 0.2rCSI 2.3%PRS 84.9%
-
CSI 0.3rCSI 1.6%PRS 84.7%
-
CSI 0.3rCSI 5.8%PRS 93.5%
-
CSI 0.3rCSI 2.7%PRS 81.9%
-
CSI 0.4rCSI 12.3%PRS 87.9%
-
CSI 0.6rCSI 9.1%PRS 85.6%
-
CSI 0.7rCSI 2.2%PRS 58.0%
-
CSI 0.7rCSI 8.0%PRS 82.5%
-
CSI 0.8rCSI 3.4%PRS 93.0%
-
CSI 0.8rCSI 2.0%PRS 64.8%
-
CSI 0.8rCSI 2.3%PRS 70.2%
-
CSI 0.9rCSI 4.6%PRS 94.4%
-
CSI 0.9rCSI 5.7%PRS 86.2%
-
CSI 0.9rCSI 2.0%PRS 73.9%
-
CSI 0.9rCSI 2.4%PRS 83.4%
-
CSI 1.0rCSI 2.1%PRS 88.2%
-
CSI 1.2rCSI 7.5%PRS 92.8%
-
CSI 1.2rCSI 2.5%PRS 84.3%
-
CSI 1.2rCSI 2.5%PRS 81.1%
-
CSI 1.2rCSI 8.3%PRS 82.6%
-
CSI 1.2rCSI 3.0%PRS 70.0%
-
CSI 1.2rCSI 3.3%PRS 93.9%
-
CSI 1.3rCSI 5.0%PRS 83.8%
-
CSI 1.3rCSI 2.8%PRS 83.5%
-
CSI 1.3rCSI 2.1%PRS 64.4%
-
CSI 1.3rCSI 7.2%PRS 94.0%
-
CSI 1.4rCSI 13.5%PRS 83.4%
-
CSI 1.4rCSI 18.7%PRS 93.2%
-
CSI 1.5rCSI 9.0%PRS 93.5%
-
CSI 1.5rCSI 2.3%PRS 79.1%
-
CSI 1.5rCSI 2.7%PRS 86.4%
-
CSI 1.6rCSI 25.0%PRS 87.1%
-
CSI 1.6rCSI 2.1%PRS 90.7%
-
CSI 1.6rCSI 2.5%PRS 78.7%
-
CSI 1.6rCSI 4.2%PRS 65.9%
-
CSI 1.6rCSI 2.8%PRS 55.4%
-
CSI 1.6rCSI 1.4%PRS 84.8%
-
CSI 1.6rCSI 2.5%PRS 87.5%
-
CSI 1.6rCSI 5.8%PRS 80.6%
-
CSI 1.6rCSI 1.5%PRS 87.6%
-
CSI 1.7rCSI 7.9%PRS 85.9%
-
CSI 1.7rCSI 3.0%PRS 81.2%
-
CSI 1.7rCSI 6.2%PRS 90.9%
-
CSI 1.8rCSI 1.3%PRS 88.2%
-
CSI 1.8rCSI 2.1%PRS 90.6%
-
CSI 1.8rCSI 10.3%PRS 81.4%
-
CSI 1.9rCSI 10.0%PRS 82.7%
-
CSI 1.9rCSI 1.5%PRS 92.3%
-
CSI 1.9rCSI 2.5%PRS 57.5%
-
CSI 2.0rCSI 5.6%PRS 71.2%
-
CSI 2.0rCSI 6.3%PRS 73.4%
-
CSI 2.0rCSI 5.7%PRS 75.1%
-
CSI 2.0rCSI 2.4%PRS 76.3%
-
CSI 2.1rCSI 2.9%PRS 93.0%
-
CSI 2.3rCSI 3.6%PRS 75.2%
-
CSI 2.4rCSI 5.6%PRS 80.7%
-
CSI 2.4rCSI 3.6%PRS 75.3%
-
CSI 2.4rCSI 6.0%PRS 74.1%
-
CSI 2.4rCSI 19.2%PRS 75.1%
-
CSI 2.4rCSI 3.0%PRS 81.9%
-
CSI 2.5rCSI 9.8%PRS 84.9%
-
CSI 2.5rCSI 13.0%PRS 81.9%
-
CSI 2.5rCSI 4.7%PRS 84.4%
-
CSI 2.5rCSI 7.5%PRS 86.6%
-
CSI 2.6rCSI 3.1%PRS 73.0%
-
CSI 2.7rCSI 2.9%PRS 75.6%
-
CSI 2.8rCSI 5.5%PRS 71.0%
-
CSI 2.8rCSI 4.3%PRS 84.0%
-
CSI 2.8rCSI 12.3%PRS 63.4%
-
CSI 2.9rCSI 5.4%PRS 95.0%
-
CSI 2.9rCSI 15.1%PRS 91.1%
-
CSI 3.0rCSI 7.1%PRS 89.0%
-
CSI 3.0rCSI 5.6%PRS 84.0%
-
CSI 3.0rCSI 10.7%PRS 94.6%
-
CSI 3.1rCSI 4.7%PRS 80.3%
-
CSI 3.1rCSI 7.2%PRS 75.6%
-
CSI 3.2rCSI 6.0%PRS 89.7%
-
CSI 3.4rCSI 4.9%PRS 88.3%
-
CSI 3.5rCSI 34.6%PRS 86.2%
-
CSI 3.6rCSI 8.4%PRS 76.3%
-
CSI 3.6rCSI 54.9%PRS 85.3%
-
CSI 3.7rCSI 4.4%PRS 87.1%
-
CSI 3.7rCSI 6.1%PRS 64.0%
-
CSI 3.7rCSI 17.5%PRS 86.0%
-
CSI 3.7rCSI 39.6%PRS 71.5%
-
CSI 3.8rCSI 10.5%PRS 83.2%
-
CSI 3.8rCSI 9.8%PRS 74.7%
-
CSI 3.8rCSI 37.2%PRS 87.2%
-
CSI 3.8rCSI 4.7%PRS 84.3%
-
CSI 3.8rCSI 3.2%PRS 88.7%
-
CSI 3.8rCSI 5.1%PRS 82.2%
-
CSI 3.9rCSI 7.0%PRS 74.2%
-
CSI 4.2rCSI 5.4%PRS 86.7%
-
CSI 4.2rCSI 24.6%PRS 80.4%
-
CSI 4.2rCSI 21.4%PRS 91.1%
-
CSI 4.3rCSI 7.7%PRS 68.0%
-
CSI 4.3rCSI 5.5%PRS 80.4%
-
CSI 4.4rCSI 6.2%PRS 76.3%
-
CSI 4.5rCSI 17.5%PRS 75.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1670526254
Symbol: DNPH1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9271375
Title: Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene.
PubMed ID: 9271375
PubMed ID: 18726892
Title: Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors.
PubMed ID: 18726892
DOI: 10.1002/jcb.21884
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24260472
Title: N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
PubMed ID: 24260472
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33833118
Title: Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.
PubMed ID: 33833118
PubMed ID: 37142196
Title: An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1.
PubMed ID: 37142196
PubMed ID: 25108359
Title: 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities.
PubMed ID: 25108359
Sequence Information:
- Length: 174
- Mass: 19108
- Checksum: C148641A60F383A3
- Sequence:
MAAAMVPGRS ESWERGEPGR PALYFCGSIR GGREDRTLYE RIVSRLRRFG TVLTEHVAAA ELGARGEEAA GGDRLIHEQD LEWLQQADVV VAEVTQPSLG VGYELGRAVA FNKRILCLFR PQSGRVLSAM IRGAADGSRF QVWDYEEGEV EALLDRYFEA DPPGQVAASP DPTT