Details for: S100P

Gene ID: 6286

Symbol: S100P

Ensembl ID: ENSG00000163993

Description: S100 calcium binding protein P

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.6097
    Cell Significance Index: -14.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.5217
    Cell Significance Index: -14.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.1102
    Cell Significance Index: -13.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 27.7183
    Cell Significance Index: 740.1200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.1438
    Cell Significance Index: -15.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 15.4213
    Cell Significance Index: 142.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.5848
    Cell Significance Index: -12.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 12.9464
    Cell Significance Index: 672.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.6833
    Cell Significance Index: -14.4100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 7.7532
    Cell Significance Index: 90.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.1105
    Cell Significance Index: 1281.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.3318
    Cell Significance Index: 655.6000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.6061
    Cell Significance Index: 28.6200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 4.2270
    Cell Significance Index: 26.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 4.1073
    Cell Significance Index: 468.8500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.2707
    Cell Significance Index: 5.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2117
    Cell Significance Index: 33.1400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.9719
    Cell Significance Index: 16.3000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.1226
    Cell Significance Index: 11.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0652
    Cell Significance Index: 48.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8881
    Cell Significance Index: 53.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7817
    Cell Significance Index: 127.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7585
    Cell Significance Index: 684.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7561
    Cell Significance Index: 16.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7311
    Cell Significance Index: 72.3200
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.6889
    Cell Significance Index: 4.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6766
    Cell Significance Index: 73.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5650
    Cell Significance Index: 308.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5342
    Cell Significance Index: 15.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3843
    Cell Significance Index: 26.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2709
    Cell Significance Index: 9.5200
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.2438
    Cell Significance Index: 2.2400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1442
    Cell Significance Index: 1.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1196
    Cell Significance Index: 3.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1092
    Cell Significance Index: 1.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0965
    Cell Significance Index: 18.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0540
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0502
    Cell Significance Index: 31.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0453
    Cell Significance Index: 8.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0376
    Cell Significance Index: 28.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0226
    Cell Significance Index: 0.6500
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0210
    Cell Significance Index: 0.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0158
    Cell Significance Index: 1.1800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0113
    Cell Significance Index: 0.0700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0083
    Cell Significance Index: 0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0032
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0071
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0074
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0111
    Cell Significance Index: -20.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0120
    Cell Significance Index: -2.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0141
    Cell Significance Index: -21.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0149
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0162
    Cell Significance Index: -22.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0224
    Cell Significance Index: -14.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0240
    Cell Significance Index: -1.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0286
    Cell Significance Index: -3.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0336
    Cell Significance Index: -14.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0359
    Cell Significance Index: -16.3100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0377
    Cell Significance Index: -0.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0406
    Cell Significance Index: -14.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0417
    Cell Significance Index: -5.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0441
    Cell Significance Index: -7.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0470
    Cell Significance Index: -1.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0490
    Cell Significance Index: -1.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0510
    Cell Significance Index: -3.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0511
    Cell Significance Index: -14.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0526
    Cell Significance Index: -6.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0684
    Cell Significance Index: -13.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0796
    Cell Significance Index: -9.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0817
    Cell Significance Index: -10.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0972
    Cell Significance Index: -14.1400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0973
    Cell Significance Index: -1.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1377
    Cell Significance Index: -14.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1414
    Cell Significance Index: -16.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1472
    Cell Significance Index: -15.0400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1511
    Cell Significance Index: -2.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1544
    Cell Significance Index: -1.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1636
    Cell Significance Index: -4.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1642
    Cell Significance Index: -3.0400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1887
    Cell Significance Index: -1.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2192
    Cell Significance Index: -14.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2205
    Cell Significance Index: -16.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2262
    Cell Significance Index: -6.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2292
    Cell Significance Index: -6.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2432
    Cell Significance Index: -15.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2569
    Cell Significance Index: -18.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2612
    Cell Significance Index: -9.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2776
    Cell Significance Index: -17.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2859
    Cell Significance Index: -13.4400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3026
    Cell Significance Index: -3.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3124
    Cell Significance Index: -3.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3131
    Cell Significance Index: -5.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3270
    Cell Significance Index: -18.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3297
    Cell Significance Index: -6.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3297
    Cell Significance Index: -17.3100
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.3389
    Cell Significance Index: -2.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3493
    Cell Significance Index: -15.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein**: S100P exhibits high affinity for calcium ions, which is essential for its biological functions. 2. **Cellular localization**: S100P is predominantly expressed in epithelial cells, including those of the stomach, urethra, and bladder, as well as in immune cells such as neutrophils and myelocytes. 3. **Multi-functional**: S100P participates in various cellular processes, including cell adhesion, migration, and regulation of calcium homeostasis. 4. **Homodimerization**: S100P can form homodimers, which may influence its biological activity and interactions with other proteins. **Pathways and Functions:** 1. **Immune response**: S100P plays a crucial role in the regulation of immune responses, particularly in the context of innate immunity. It modulates the expression of adhesion molecules and chemokines, influencing the migration and activation of immune cells. 2. **Cell migration**: S100P is involved in the regulation of cell migration, which is essential for immune cell trafficking and the establishment of tissue homeostasis. 3. **Calcium homeostasis**: S100P regulates calcium ion homeostasis, which is critical for various cellular processes, including muscle contraction, neurotransmission, and cell signaling. 4. **Protein interactions**: S100P interacts with numerous proteins, including cadherins, calcium-binding proteins, and transcription factors, influencing its biological activity and cellular localization. **Clinical Significance:** 1. **Inflammatory disorders**: Dysregulation of S100P has been implicated in various inflammatory disorders, including atherosclerosis, arthritis, and inflammatory bowel disease. 2. **Cancer**: S100P expression is often upregulated in cancer cells, contributing to tumor progression, metastasis, and immune evasion. 3. **Regenerative medicine**: S100P may play a role in tissue regeneration and repair, particularly in the context of epithelial and immune system disorders. 4. **Therapeutic potential**: Targeting S100P or its interactions with other proteins may provide novel therapeutic strategies for the treatment of inflammatory and cancerous diseases. In conclusion, S100P is a multifaceted protein that plays a crucial role in various cellular processes, including immune response, cell migration, and regulation of calcium homeostasis. Its dysregulation has been implicated in various diseases, including inflammatory disorders and cancer. Further research is necessary to fully elucidate the biological functions of S100P and to explore its therapeutic potential.

Genular Protein ID: 360980544

Symbol: S100P_HUMAN

Name: Protein S100-P

UniProtKB Accession Codes:

P25815 Q5J7W2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1633809

Title: S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties.

PubMed ID: 1633809

DOI: 10.1111/j.1432-1033.1992.tb17080.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1540168

Title: Purification and characterization of a new member of the S-100 protein family from human placenta.

PubMed ID: 1540168

DOI: 10.1016/0006-291x(92)91865-n

PubMed ID: 12808036

Title: Ca2+-dependent binding and activation of dormant ezrin by dimeric S100P.

PubMed ID: 12808036

DOI: 10.1091/mbc.e02-09-0553

PubMed ID: 14672411

Title: Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein.

PubMed ID: 14672411

DOI: 10.1023/a:1026311423326

PubMed ID: 15171681

Title: Heterodimeric interaction and interfaces of S100A1 and S100P.

PubMed ID: 15171681

DOI: 10.1042/bj20040142

PubMed ID: 14617629

Title: S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE).

PubMed ID: 14617629

DOI: 10.1074/jbc.m310124200

PubMed ID: 15632002

Title: Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.

PubMed ID: 15632002

DOI: 10.1016/s0002-9440(10)62234-1

PubMed ID: 19111582

Title: Generation and characterization of a novel, permanently active S100P mutant.

PubMed ID: 19111582

DOI: 10.1016/j.bbamcr.2008.11.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22399290

Title: S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.

PubMed ID: 22399290

DOI: 10.1074/jbc.m111.329771

PubMed ID: 22431641

Title: Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P.

PubMed ID: 22431641

DOI: 10.1073/pnas.1202689109

PubMed ID: 12507480

Title: The crystal structure at 2A resolution of the Ca2+ -binding protein S100P.

PubMed ID: 12507480

DOI: 10.1016/s0022-2836(02)01278-0

PubMed ID: 15213440

Title: NMR structure of the Apo-S100P protein.

PubMed ID: 15213440

DOI: 10.1023/b:jnmr.0000032617.88899.4b

Sequence Information:

  • Length: 95
  • Mass: 10400
  • Checksum: 786E6E3F3EACC6C1
  • Sequence:
    • MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD 
LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.