Details for: SDC4

Gene ID: 6385

Symbol: SDC4

Ensembl ID: ENSG00000124145

Description: syndecan 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 246.4878
    Cell Significance Index: -38.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 153.5029
    Cell Significance Index: -38.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.0416
    Cell Significance Index: -33.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.2842
    Cell Significance Index: -39.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.9309
    Cell Significance Index: -33.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.5502
    Cell Significance Index: -38.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5230
    Cell Significance Index: -38.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4869
    Cell Significance Index: -32.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8890
    Cell Significance Index: -39.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.3530
    Cell Significance Index: 57.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 7.7401
    Cell Significance Index: 17.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.3048
    Cell Significance Index: 198.8300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 6.0457
    Cell Significance Index: 17.9800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.3353
    Cell Significance Index: 16.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.2820
    Cell Significance Index: 72.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.1651
    Cell Significance Index: 538.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.9613
    Cell Significance Index: 295.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9569
    Cell Significance Index: -8.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5212
    Cell Significance Index: 130.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3228
    Cell Significance Index: 21.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.8636
    Cell Significance Index: 45.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8188
    Cell Significance Index: 197.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7660
    Cell Significance Index: 318.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7479
    Cell Significance Index: 82.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7378
    Cell Significance Index: 768.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4866
    Cell Significance Index: 69.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4672
    Cell Significance Index: 66.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4113
    Cell Significance Index: 37.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3918
    Cell Significance Index: 171.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3892
    Cell Significance Index: 98.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.2763
    Cell Significance Index: 7.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1631
    Cell Significance Index: 33.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1052
    Cell Significance Index: 31.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0982
    Cell Significance Index: 16.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0978
    Cell Significance Index: 599.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0280
    Cell Significance Index: 195.6300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.9945
    Cell Significance Index: 6.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6269
    Cell Significance Index: 124.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5873
    Cell Significance Index: 8.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5229
    Cell Significance Index: 40.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4940
    Cell Significance Index: 48.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4847
    Cell Significance Index: 10.5000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.4655
    Cell Significance Index: 6.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4620
    Cell Significance Index: 417.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4094
    Cell Significance Index: 309.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3670
    Cell Significance Index: 12.9000
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.3663
    Cell Significance Index: 4.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3533
    Cell Significance Index: 5.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3471
    Cell Significance Index: 44.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3458
    Cell Significance Index: 59.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3299
    Cell Significance Index: 9.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3086
    Cell Significance Index: 8.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2561
    Cell Significance Index: 16.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2417
    Cell Significance Index: 1.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1367
    Cell Significance Index: 15.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1012
    Cell Significance Index: 190.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0950
    Cell Significance Index: 69.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0586
    Cell Significance Index: 37.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0285
    Cell Significance Index: 3.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0163
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0191
    Cell Significance Index: -35.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0197
    Cell Significance Index: -12.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.8600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0290
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0334
    Cell Significance Index: -45.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0393
    Cell Significance Index: -17.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0403
    Cell Significance Index: -4.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0445
    Cell Significance Index: -25.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0485
    Cell Significance Index: -5.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0689
    Cell Significance Index: -0.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0826
    Cell Significance Index: -1.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1049
    Cell Significance Index: -37.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1083
    Cell Significance Index: -15.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1153
    Cell Significance Index: -3.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1165
    Cell Significance Index: -33.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1190
    Cell Significance Index: -25.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1200
    Cell Significance Index: -4.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1686
    Cell Significance Index: -2.0100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1723
    Cell Significance Index: -2.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1841
    Cell Significance Index: -36.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1987
    Cell Significance Index: -23.1600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2363
    Cell Significance Index: -0.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3043
    Cell Significance Index: -31.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3215
    Cell Significance Index: -37.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3480
    Cell Significance Index: -27.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3972
    Cell Significance Index: -12.7200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4092
    Cell Significance Index: -5.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4506
    Cell Significance Index: -27.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4579
    Cell Significance Index: -10.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4944
    Cell Significance Index: -17.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4999
    Cell Significance Index: -26.0400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5040
    Cell Significance Index: -7.0700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.5358
    Cell Significance Index: -5.5500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.5381
    Cell Significance Index: -3.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5448
    Cell Significance Index: -9.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5777
    Cell Significance Index: -37.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5900
    Cell Significance Index: -39.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6053
    Cell Significance Index: -17.8300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.6324
    Cell Significance Index: -3.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Proteoglycan**: SDC4 is a transmembrane glycoprotein composed of a large extracellular domain, a transmembrane domain, and a short intracellular domain. 2. **Glycosaminoglycan (GAG) Chains**: SDC4 contains a tetrasaccharide linker sequence that is required for its proper functioning. The GAG chains are composed of chondroitin sulfate and dermatan sulfate. 3. **Cell Adhesion and Migration**: SDC4 interacts with various ligands, including fibronectin, thrombospondin, and heparan sulfate, to regulate cell adhesion, migration, and signaling. 4. **Signaling Pathways**: SDC4 is involved in various signaling pathways, including the regulation of focal adhesion, stress fiber assembly, and exosomal secretion. **Pathways and Functions:** 1. **Attachment and Entry**: SDC4 plays a crucial role in the attachment and entry of viruses, such as respiratory syncytial virus (RSV) and SARS-CoV-2, into host cells. 2. **Cell Migration**: SDC4 regulates cell migration, particularly in the context of wound healing and tissue repair. 3. **Glycosaminoglycan Metabolism**: SDC4 is involved in the biosynthesis and degradation of heparan sulfate and dermatan sulfate, which are essential for various cellular processes. 4. **Extracellular Matrix Organization**: SDC4 interacts with extracellular matrix components to regulate the organization of the extracellular matrix. **Clinical Significance:** 1. **Cancer**: Alterations in SDC4 expression have been observed in various cancers, including lung, breast, and colon cancer. SDC4 may serve as a biomarker for cancer diagnosis and prognosis. 2. **Respiratory Diseases**: SDC4 is involved in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). SDC4 may be a target for therapeutic intervention. 3. **Neurological Disorders**: SDC4 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. SDC4 may serve as a potential therapeutic target. 4. **Infectious Diseases**: SDC4 plays a crucial role in the attachment and entry of viruses, such as RSV and SARS-CoV-2, into host cells. Understanding the mechanisms of SDC4-mediated viral entry may lead to the development of novel antiviral therapies. In conclusion, Syndecan 4 (SDC4) is a multifunctional transmembrane proteoglycan that plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling. Its dysregulation has been implicated in various diseases, including cancer, respiratory diseases, and neurological disorders. Further research is needed to elucidate the mechanisms of SDC4-mediated cellular processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2576214981

Symbol: SDC4_HUMAN

Name: Amphiglycan

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1500433

Title: Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells.

PubMed ID: 1500433

DOI: 10.1083/jcb.118.4.961

PubMed ID: 7916598

Title: Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene.

PubMed ID: 7916598

DOI: 10.1006/bbrc.1993.1122

PubMed ID: 8797100

Title: Structural organization and promoter activity of the human ryudocan gene.

PubMed ID: 8797100

DOI: 10.1093/oxfordjournals.jbchem.a021338

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8889549

Title: Generation and analysis of 280,000 human expressed sequence tags.

PubMed ID: 8889549

DOI: 10.1101/gr.6.9.807

PubMed ID: 9169435

Title: Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation.

PubMed ID: 9169435

DOI: 10.1074/jbc.272.23.14713

PubMed ID: 14675776

Title: Widespread production of novel soluble protein isoforms by alternative splicing removal of transmembrane anchoring domains.

PubMed ID: 14675776

DOI: 10.1016/s0014-5793(03)01354-1

PubMed ID: 16007225

Title: Adhesion signaling by a novel mitotic substrate of src kinases.

PubMed ID: 16007225

DOI: 10.1038/sj.onc.1208582

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 11456484

Title: Solution structure of the dimeric cytoplasmic domain of syndecan-4.

PubMed ID: 11456484

DOI: 10.1021/bi002750r

PubMed ID: 12842047

Title: Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.

PubMed ID: 12842047

DOI: 10.1016/s0969-2126(03)00125-4

PubMed ID: 16533050

Title: The binding of the PDZ tandem of syntenin to target proteins.

PubMed ID: 16533050

DOI: 10.1021/bi052225y

Sequence Information:

  • Length: 198
  • Mass: 21642
  • Checksum: 8229AA2733F77A10
  • Sequence:
  • MAPARLFALL LFFVGGVAES IRETEVIDPQ DLLEGRYFSG ALPDDEDVVG PGQESDDFEL 
    SGSGDLDDLE DSMIGPEVVH PLVPLDNHIP ERAGSGSQVP TEPKKLEENE VIPKRISPVE 
    ESEDVSNKVS MSSTVQGSNI FERTEVLAAL IVGGIVGILF AVFLILLLMY RMKKKDEGSY 
    DLGKKPIYKK APTNEFYA

Genular Protein ID: 540529032

Symbol: B4E1S6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 126
  • Mass: 13910
  • Checksum: FFFFA5D3D4B914A4
  • Sequence:
  • MIGPEVVHPL VPLDNHIPER AGSGSQVPTE PKKLEENEVI PKRISPVEES EDVSNKVSMS 
    STVQGSNIFE RTEVLAALIV GGIVGILFAV FLILLLMYRM KKKDEGSYDL GKKPIYKKAP 
    TNEFYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.