Details for: RASSF7

Gene ID: 8045

Symbol: RASSF7

Ensembl ID: ENSG00000099849

Description: Ras association domain family member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.1065
    Cell Significance Index: -15.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.4355
    Cell Significance Index: -16.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.1213
    Cell Significance Index: -18.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0475
    Cell Significance Index: -17.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 9.9374
    Cell Significance Index: 247.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5766
    Cell Significance Index: -12.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5666
    Cell Significance Index: -18.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3855
    Cell Significance Index: -13.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.5027
    Cell Significance Index: 47.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.3269
    Cell Significance Index: 49.8500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.9587
    Cell Significance Index: 14.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3540
    Cell Significance Index: 106.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.3183
    Cell Significance Index: 53.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.9561
    Cell Significance Index: 4.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7539
    Cell Significance Index: 91.1100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5844
    Cell Significance Index: 14.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3241
    Cell Significance Index: 38.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2788
    Cell Significance Index: 10.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2197
    Cell Significance Index: 56.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2057
    Cell Significance Index: 658.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1385
    Cell Significance Index: 30.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0304
    Cell Significance Index: 185.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8778
    Cell Significance Index: 107.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8713
    Cell Significance Index: 141.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8453
    Cell Significance Index: -1.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7118
    Cell Significance Index: 77.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5821
    Cell Significance Index: 27.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5552
    Cell Significance Index: 8.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5464
    Cell Significance Index: 54.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5450
    Cell Significance Index: 15.2300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.4721
    Cell Significance Index: 5.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3694
    Cell Significance Index: 10.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3244
    Cell Significance Index: 11.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3094
    Cell Significance Index: 9.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2855
    Cell Significance Index: 6.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2823
    Cell Significance Index: 124.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2776
    Cell Significance Index: 52.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2080
    Cell Significance Index: 5.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2023
    Cell Significance Index: 34.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1981
    Cell Significance Index: 12.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1916
    Cell Significance Index: 10.0600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1915
    Cell Significance Index: 1.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1852
    Cell Significance Index: 13.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1833
    Cell Significance Index: 21.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1338
    Cell Significance Index: 1.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1285
    Cell Significance Index: 9.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1283
    Cell Significance Index: 16.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1144
    Cell Significance Index: 22.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0792
    Cell Significance Index: 0.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0762
    Cell Significance Index: 57.6800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0761
    Cell Significance Index: 1.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0681
    Cell Significance Index: 13.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0558
    Cell Significance Index: 1.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0325
    Cell Significance Index: 59.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0323
    Cell Significance Index: 22.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0309
    Cell Significance Index: 22.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0207
    Cell Significance Index: 31.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0067
    Cell Significance Index: 9.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 4.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0066
    Cell Significance Index: -2.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0119
    Cell Significance Index: -1.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0145
    Cell Significance Index: -9.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0157
    Cell Significance Index: -9.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0284
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0324
    Cell Significance Index: -6.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0396
    Cell Significance Index: -17.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0402
    Cell Significance Index: -1.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0464
    Cell Significance Index: -13.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0464
    Cell Significance Index: -0.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0500
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0590
    Cell Significance Index: -6.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0638
    Cell Significance Index: -8.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0711
    Cell Significance Index: -9.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0738
    Cell Significance Index: -4.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0776
    Cell Significance Index: -2.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0916
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0945
    Cell Significance Index: -10.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1016
    Cell Significance Index: -11.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1017
    Cell Significance Index: -4.5000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1102
    Cell Significance Index: -0.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1149
    Cell Significance Index: -2.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1181
    Cell Significance Index: -1.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1492
    Cell Significance Index: -3.7300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1609
    Cell Significance Index: -1.6600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.1623
    Cell Significance Index: -0.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1701
    Cell Significance Index: -5.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1703
    Cell Significance Index: -17.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1735
    Cell Significance Index: -13.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2020
    Cell Significance Index: -5.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2201
    Cell Significance Index: -16.8900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2283
    Cell Significance Index: -0.8600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2471
    Cell Significance Index: -2.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2536
    Cell Significance Index: -3.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2833
    Cell Significance Index: -15.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2923
    Cell Significance Index: -6.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RASSF7 is a small, non-coding gene that belongs to the RASSF family, which is characterized by the presence of a Ras association domain. The gene is highly conserved across species, suggesting its evolutionary importance. RASSF7 is primarily expressed in cells of the immune system, including immune cells, and in epithelial tissues such as the kidney, colon, and lung. Its expression is also observed in various types of cancer cells, including ovarian, breast, and colon cancer. **Pathways and Functions:** RASSF7 has been implicated in several cellular pathways, including: 1. **Apoptotic Process:** RASSF7 has been shown to regulate apoptosis, a process of programmed cell death, in various cell types. Its expression is often reduced in cancer cells, which may contribute to their survival and proliferation. 2. **Signal Transduction:** RASSF7 has been shown to interact with various signaling proteins, including Ras, MAPK, and PI3K, which are involved in cell growth, differentiation, and survival. 3. **Protein Binding:** RASSF7 has been shown to bind to various proteins, including Ras, MAPK, and PDGF, which are involved in cell signaling and regulation. **Clinical Significance:** RASSF7 has been implicated in various diseases, including: 1. **Cancer:** RASSF7 is often reduced or lost in cancer cells, which may contribute to their survival and proliferation. Its expression has been observed to be reduced in various types of cancer, including ovarian, breast, and colon cancer. 2. **Autoimmune Diseases:** RASSF7 has been shown to regulate immune responses, and its expression has been observed to be altered in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological Disorders:** RASSF7 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, RASSF7 is a complex gene that plays a critical role in regulating various cellular processes, including apoptosis, signal transduction, and protein binding. Its expression is widespread across different tissues and cell types, underscoring its potential role in maintaining tissue homeostasis. Further research is needed to fully elucidate the functions of RASSF7 and its clinical significance in various diseases. **Future Directions:** 1. **Investigating the Role of RASSF7 in Immune Regulation:** Further research is needed to elucidate the role of RASSF7 in immune regulation and its potential therapeutic applications. 2. **Examining the Expression of RASSF7 in Cancer:** The expression of RASSF7 in various types of cancer needs to be further investigated to determine its potential as a biomarker or therapeutic target. 3. **Understanding the Mechanisms of RASSF7 Loss in Cancer:** The mechanisms by which RASSF7 is lost in cancer cells need to be further investigated to determine its potential therapeutic applications. In summary, RASSF7 is a complex gene that plays a critical role in regulating various cellular processes. Its expression is widespread across different tissues and cell types, underscoring its potential role in maintaining tissue homeostasis. Further research is needed to fully elucidate the functions of RASSF7 and its clinical significance in various diseases.

Genular Protein ID: 3034106346

Symbol: RASF7_HUMAN

Name: Ras association domain-containing protein 7

UniProtKB Accession Codes:

Q02833 G5E9N9 Q3KP41 Q3KP42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 5 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339391

Title: The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain.

PubMed ID: 1339391

DOI: 10.1016/s0888-7543(05)80221-6

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20629633

Title: Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis.

PubMed ID: 20629633

DOI: 10.1042/bj20100883

PubMed ID: 21278800

Title: RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7.

PubMed ID: 21278800

DOI: 10.1038/cdd.2010.137

Sequence Information:

  • Length: 373
  • Mass: 39945
  • Checksum: 55DF1DDB1C37CAF3
  • Sequence:
    • MLLGLAAMEL KVWVDGIQRV VCGVSEQTTC QEVVIALAQA IGQTGRFVLV QRLREKERQL 
LPQECPVGAQ ATCGQFASDV QFVLRRTGPS LAGRPSSDSC PPPERCLIRA SLPVKPRAAL 
GCEPRKTLTP EPAPSLSRPG PAAPVTPTPG CCTDLRGLEL RVQRNAEELG HEAFWEQELR 
REQAREREGQ ARLQALSAAT AEHAARLQAL DAQARALEAE LQLAAEAPGP PSPMASATER 
LHQDLAVQER QSAEVQGSLA LVSRALEAAE RALQAQAQEL EELNRELRQC NLQQFIQQTG 
AALPPPPRPD RGPPGTQGPL PPAREESLLG APSESHAGAQ PRPRGGPHDA ELLEVAAAPA 
PEWCPLAAQP QAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.