Details for: TNFRSF12A

Gene ID: 51330

Symbol: TNFRSF12A

Ensembl ID: ENSG00000006327

Description: TNF receptor superfamily member 12A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 192.4842
    Cell Significance Index: -29.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.2619
    Cell Significance Index: -30.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.6839
    Cell Significance Index: -29.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.2309
    Cell Significance Index: -27.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0575
    Cell Significance Index: -21.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.5799
    Cell Significance Index: -27.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.3561
    Cell Significance Index: -30.0300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 22.7941
    Cell Significance Index: 67.7900
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 11.1152
    Cell Significance Index: 42.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9702
    Cell Significance Index: -24.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.5899
    Cell Significance Index: -29.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.7466
    Cell Significance Index: 41.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.5502
    Cell Significance Index: 488.1800
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 6.2965
    Cell Significance Index: 21.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8844
    Cell Significance Index: 160.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.5812
    Cell Significance Index: 721.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9488
    Cell Significance Index: -15.2000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 4.3369
    Cell Significance Index: 26.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.5408
    Cell Significance Index: 101.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.3311
    Cell Significance Index: 58.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2852
    Cell Significance Index: 118.7100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.2733
    Cell Significance Index: 36.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2624
    Cell Significance Index: 430.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2009
    Cell Significance Index: 1201.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0943
    Cell Significance Index: 51.1000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.9842
    Cell Significance Index: 17.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9099
    Cell Significance Index: -4.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8613
    Cell Significance Index: 27.8900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7614
    Cell Significance Index: 12.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3981
    Cell Significance Index: 63.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2944
    Cell Significance Index: 11.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2638
    Cell Significance Index: 27.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1581
    Cell Significance Index: 512.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1461
    Cell Significance Index: 33.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0618
    Cell Significance Index: 172.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8902
    Cell Significance Index: 41.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8529
    Cell Significance Index: 60.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7946
    Cell Significance Index: 97.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7898
    Cell Significance Index: 85.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7557
    Cell Significance Index: 10.3100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.7169
    Cell Significance Index: 2.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5378
    Cell Significance Index: 61.3900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5070
    Cell Significance Index: 3.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5019
    Cell Significance Index: 10.6900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4591
    Cell Significance Index: 2.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4328
    Cell Significance Index: 29.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3895
    Cell Significance Index: 10.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3722
    Cell Significance Index: 13.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3412
    Cell Significance Index: 46.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2656
    Cell Significance Index: 47.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2477
    Cell Significance Index: 49.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2006
    Cell Significance Index: 34.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1528
    Cell Significance Index: 15.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1499
    Cell Significance Index: 135.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1137
    Cell Significance Index: 5.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0886
    Cell Significance Index: 67.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0844
    Cell Significance Index: 0.5100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0833
    Cell Significance Index: 0.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0812
    Cell Significance Index: 2.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0334
    Cell Significance Index: 2.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0175
    Cell Significance Index: 12.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0124
    Cell Significance Index: 16.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0112
    Cell Significance Index: -7.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0169
    Cell Significance Index: -31.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0188
    Cell Significance Index: -1.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0211
    Cell Significance Index: -11.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0238
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0298
    Cell Significance Index: -18.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0303
    Cell Significance Index: -6.3800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0317
    Cell Significance Index: -0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0408
    Cell Significance Index: -5.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0421
    Cell Significance Index: -2.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0425
    Cell Significance Index: -1.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0519
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0552
    Cell Significance Index: -25.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0592
    Cell Significance Index: -17.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0593
    Cell Significance Index: -6.8000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0637
    Cell Significance Index: -0.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0725
    Cell Significance Index: -26.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0897
    Cell Significance Index: -13.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1066
    Cell Significance Index: -12.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1181
    Cell Significance Index: -3.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1471
    Cell Significance Index: -29.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1570
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1704
    Cell Significance Index: -1.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1764
    Cell Significance Index: -5.6500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2120
    Cell Significance Index: -2.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2327
    Cell Significance Index: -27.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2473
    Cell Significance Index: -4.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2593
    Cell Significance Index: -2.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2691
    Cell Significance Index: -2.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2740
    Cell Significance Index: -16.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2872
    Cell Significance Index: -22.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2896
    Cell Significance Index: -30.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3048
    Cell Significance Index: -7.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3445
    Cell Significance Index: -21.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3543
    Cell Significance Index: -5.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFRSF12A shares structural and functional similarities with other members of the tumor necrosis factor receptor superfamily. It consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain binds to its ligand, TNF-alpha, while the intracellular domain regulates downstream signaling pathways. TNFRSF12A has been shown to activate various signaling pathways, including the non-canonical NF-κB pathway, which is involved in cell survival, proliferation, and differentiation. **Pathways and Functions** TNFRSF12A is involved in multiple cellular processes, including: 1. **Angiogenesis**: TNFRSF12A promotes angiogenesis by regulating the expression of pro-angiogenic factors, such as vascular endothelial growth factor (VEGF). 2. **Apoptosis**: TNFRSF12A can induce apoptosis by activating the extrinsic apoptotic signaling pathway, which involves the activation of caspases and the release of cytochrome C. 3. **Cell Adhesion**: TNFRSF12A regulates cell adhesion by interacting with other adhesion molecules, such as integrins and selectins. 4. **Cell Differentiation**: TNFRSF12A regulates cell differentiation by activating signaling pathways involved in the development and maintenance of various cell types, including hematopoietic cells and epithelial cells. 5. **Immune System Regulation**: TNFRSF12A is involved in immune system regulation by modulating the activity of immune cells, such as T cells and macrophages. **Clinical Significance** Dysregulation of TNFRSF12A has been implicated in various diseases, including: 1. **Cancer**: TNFRSF12A overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. TNFRSF12A can promote tumor growth, angiogenesis, and metastasis. 2. **Inflammatory Disorders**: TNFRSF12A is involved in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and psoriasis. TNFRSF12A can regulate the expression of pro-inflammatory cytokines and promote inflammation. 3. **Neurological Disorders**: TNFRSF12A has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. TNFRSF12A can regulate the expression of neurotrophic factors and promote neuroinflammation. In conclusion, TNFRSF12A is a multifunctional gene that plays a critical role in various cellular processes, including angiogenesis, apoptosis, cell adhesion, cell differentiation, and immune system regulation. Dysregulation of TNFRSF12A has been implicated in various diseases, highlighting the potential for therapeutic targeting of this gene in the treatment of cancer, inflammatory disorders, and neurological disorders.

Genular Protein ID: 3862658520

Symbol: TNR12_HUMAN

Name: Tumor necrosis factor receptor superfamily member 12A

UniProtKB Accession Codes:

Q9NP84 D3DUA6 Q9HCS0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10751351

Title: The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas.

PubMed ID: 10751351

DOI: 10.1016/s0002-9440(10)64996-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11728344

Title: A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.

PubMed ID: 11728344

DOI: 10.1016/s1074-7613(01)00232-1

PubMed ID: 19241374

Title: Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily.

PubMed ID: 19241374

DOI: 10.1002/pro.49

Sequence Information:

  • Length: 129
  • Mass: 13911
  • Checksum: BF3FDFB9C1E1C448
  • Sequence:
    • MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH 
SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE 
GCPAVALIQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.