Details for: TNFRSF12A
Gene ID: 51330
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TNFRSF12A
Ensembl ID: ENSG00000006327
Description: TNF receptor superfamily member 12A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 26.85rCSI 35.68%PRS 85.29
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CSI 26.7rCSI 51.93%PRS 82.79
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CSI 22.22rCSI 21.39%PRS 79.2
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CSI 21.08rCSI 50.58%PRS 83.75
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CSI 20.26rCSI 36.8%PRS 89.7
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CSI 17.82rCSI 14.77%PRS 80.53
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CSI 16.01rCSI 46.33%PRS 86.5
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CSI 15.62rCSI 15.37%PRS 82.46
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CSI 14.37rCSI 18.44%PRS 83.14
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CSI 13.48rCSI 31.99%PRS 80.27
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CSI 13.24rCSI 46.46%PRS 87.74
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CSI 12.87rCSI 18.47%PRS 69.75
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CSI 12.53rCSI 13.12%PRS 83.12
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CSI 12.15rCSI 15.03%PRS 77.74
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CSI 11.49rCSI 9.63%PRS 82.81
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CSI 10.18rCSI 19.42%PRS 89.18
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CSI 9.88rCSI 10.24%PRS 83.97
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CSI 9.63rCSI 18.22%PRS 90.31
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CSI 9.32rCSI 14.4%PRS 78.94
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CSI 9.23rCSI 16.27%PRS 84.97
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CSI 9.2rCSI 49.46%PRS 87.48
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CSI 9.11rCSI 7.06%PRS 83.49
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CSI 8.54rCSI 49.67%PRS 83.79
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CSI 7.88rCSI 15.62%PRS 85.34
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CSI 7.7rCSI 9.3%PRS 87.26
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CSI 7.67rCSI 22.1%PRS 86.01
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CSI 7.55rCSI 7.03%PRS 80.72
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CSI 6.95rCSI 29.22%PRS 85.41
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CSI 6.61rCSI 5.37%PRS 79.23
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CSI 6.4rCSI 14.09%PRS 83.57
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CSI 6.39rCSI 5.51%PRS 80.88
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CSI 6.2rCSI 9.52%PRS 69.43
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CSI 5.81rCSI 8.24%PRS 76.61
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CSI 5.72rCSI 18.54%PRS 78.01
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CSI 5.63rCSI 7.8%PRS 77.19
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CSI 5.61rCSI 16.13%PRS 75.2
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CSI 5.49rCSI 5.73%PRS 79.25
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CSI 5.49rCSI 7.5%PRS 84.21
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CSI 5.35rCSI 4.92%PRS 87.29
-
CSI 5.35rCSI 5.86%PRS 81.73
-
CSI 5.3rCSI 5.55%PRS 77.3
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CSI 5.22rCSI 6.49%PRS 80.84
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CSI 5.06rCSI 21.84%PRS 86.76
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CSI 5.02rCSI 5.38%PRS 81.16
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CSI 4.9rCSI 7.19%PRS 88.8
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CSI 4.77rCSI 7.54%PRS 81.43
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CSI 4.71rCSI 23.21%PRS 87.37
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CSI 4.66rCSI 5.41%PRS 83.72
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CSI 4.5rCSI 4.34%PRS 73.13
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CSI 4.4rCSI 10.74%PRS 72.33
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CSI 4.4rCSI 12.72%PRS 79.36
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CSI 4.22rCSI 5.64%PRS 78.45
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CSI 4.21rCSI 9.33%PRS 79.26
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CSI 4.19rCSI 8.7%PRS 76.66
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CSI 4.13rCSI 5.89%PRS 80.68
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CSI 4.07rCSI 6.57%PRS 79.05
-
CSI 3.86rCSI 3.85%PRS 73.73
-
CSI 3.85rCSI 5.7%PRS 83.69
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CSI 3.76rCSI 9.31%PRS 79.56
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CSI 3.73rCSI 8.91%PRS 83.99
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CSI 3.7rCSI 14.75%PRS 86.93
-
CSI 3.66rCSI 6.53%PRS 88.17
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CSI 3.62rCSI 26.46%PRS 88.03
-
CSI 3.59rCSI 39.05%PRS 87.99
-
CSI 3.33rCSI 3.85%PRS 72.26
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CSI 3.32rCSI 4.86%PRS 74.5
-
CSI 3.26rCSI 2.86%PRS 84.67
-
CSI 3.22rCSI 7.67%PRS 76.67
-
CSI 3.12rCSI 2.47%PRS 68.66
-
CSI 3.08rCSI 8.12%PRS 86.34
-
CSI 2.89rCSI 3.87%PRS 85.95
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CSI 2.85rCSI 3.42%PRS 77.59
-
CSI 2.85rCSI 4.35%PRS 87.02
-
CSI 2.71rCSI 2.83%PRS 77.48
-
CSI 2.64rCSI 3.21%PRS 86.26
-
CSI 2.61rCSI 2.47%PRS 78.46
-
CSI 2.59rCSI 16.15%PRS 71.52
-
CSI 2.56rCSI 15.36%PRS 82.41
-
CSI 2.5rCSI 3.82%PRS 88.03
-
CSI 2.5rCSI 6.57%PRS 91.21
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CSI 2.47rCSI 6.38%PRS 75.32
-
CSI 2.47rCSI 2.19%PRS 77.49
-
CSI 2.45rCSI 3.89%PRS 88.28
-
CSI 2.41rCSI 4.13%PRS 91.78
-
CSI 2.39rCSI 11.14%PRS 88.15
-
CSI 2.38rCSI 3.41%PRS 80.56
-
CSI 2.38rCSI 3.43%PRS 86.59
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CSI 2.29rCSI 14.62%PRS 85.3
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CSI 2.24rCSI 4.28%PRS 92.69
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CSI 2.21rCSI 2.59%PRS 81.45
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CSI 2.2rCSI 12.7%PRS 76.73
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CSI 2.18rCSI 54.98%PRS 87.48
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CSI 2.09rCSI 4.29%PRS 89.04
-
CSI 2.02rCSI 1.78%PRS 69.13
-
CSI 2.02rCSI 2.14%PRS 84.94
-
CSI 2rCSI 8.93%PRS 89.24
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CSI 1.96rCSI 7.85%PRS 87.87
-
CSI 1.95rCSI 2.98%PRS 80.13
-
CSI 1.95rCSI 6.27%PRS 76.75
-
CSI 1.94rCSI 11.41%PRS 86.17
-
CSI 0.4rCSI 4.1%PRS 85.5%
-
CSI 0.5rCSI 3.5%PRS 89.2%
-
CSI 0.5rCSI 5.5%PRS 76.4%
-
CSI 0.7rCSI 4.4%PRS 95.4%
-
CSI 0.8rCSI 13.6%PRS 89.9%
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CSI 0.8rCSI 6.4%PRS 74.0%
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CSI 0.9rCSI 7.9%PRS 74.9%
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CSI 0.9rCSI 1.4%PRS 89.6%
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CSI 0.9rCSI 2.6%PRS 86.8%
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CSI 1.1rCSI 16.7%PRS 88.4%
-
CSI 1.2rCSI 8.1%PRS 86.6%
-
CSI 1.4rCSI 3.6%PRS 87.0%
-
CSI 1.4rCSI 3.8%PRS 80.8%
-
CSI 1.5rCSI 3.2%PRS 87.0%
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CSI 1.6rCSI 4.0%PRS 70.3%
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CSI 1.6rCSI 2.5%PRS 72.9%
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CSI 1.6rCSI 5.1%PRS 81.9%
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CSI 1.7rCSI 5.8%PRS 77.6%
-
CSI 1.7rCSI 2.4%PRS 79.6%
-
CSI 1.7rCSI 4.7%PRS 84.6%
-
CSI 1.7rCSI 5.9%PRS 88.6%
-
CSI 1.8rCSI 4.8%PRS 71.7%
-
CSI 1.9rCSI 44.4%PRS 88.4%
-
CSI 1.9rCSI 2.8%PRS 84.5%
-
CSI 1.9rCSI 11.4%PRS 86.2%
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CSI 2.0rCSI 6.3%PRS 76.8%
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CSI 2.0rCSI 3.0%PRS 80.1%
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CSI 2.0rCSI 7.9%PRS 87.9%
-
CSI 2.0rCSI 8.9%PRS 89.2%
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CSI 2.0rCSI 2.1%PRS 84.9%
-
CSI 2.0rCSI 1.8%PRS 69.1%
-
CSI 2.1rCSI 4.3%PRS 89.0%
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CSI 2.2rCSI 55.0%PRS 87.5%
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CSI 2.2rCSI 12.7%PRS 76.7%
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CSI 2.2rCSI 2.6%PRS 81.5%
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CSI 2.2rCSI 4.3%PRS 92.7%
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CSI 2.3rCSI 14.6%PRS 85.3%
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CSI 2.4rCSI 3.4%PRS 86.6%
-
CSI 2.4rCSI 3.4%PRS 80.6%
-
CSI 2.4rCSI 11.1%PRS 88.2%
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CSI 2.4rCSI 4.1%PRS 91.8%
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CSI 2.5rCSI 3.9%PRS 88.3%
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CSI 2.5rCSI 2.2%PRS 77.5%
-
CSI 2.5rCSI 6.4%PRS 75.3%
-
CSI 2.5rCSI 6.6%PRS 91.2%
-
CSI 2.5rCSI 3.8%PRS 88.0%
-
CSI 2.6rCSI 15.4%PRS 82.4%
-
CSI 2.6rCSI 16.2%PRS 71.5%
-
CSI 2.6rCSI 2.5%PRS 78.5%
-
CSI 2.6rCSI 3.2%PRS 86.3%
-
CSI 2.7rCSI 2.8%PRS 77.5%
-
CSI 2.9rCSI 4.4%PRS 87.0%
-
CSI 2.9rCSI 3.4%PRS 77.6%
-
CSI 2.9rCSI 3.9%PRS 86.0%
-
CSI 3.1rCSI 8.1%PRS 86.3%
-
CSI 3.1rCSI 2.5%PRS 68.7%
-
CSI 3.2rCSI 7.7%PRS 76.7%
-
CSI 3.3rCSI 2.9%PRS 84.7%
-
CSI 3.3rCSI 4.9%PRS 74.5%
-
CSI 3.3rCSI 3.9%PRS 72.3%
-
CSI 3.6rCSI 39.1%PRS 88.0%
-
CSI 3.6rCSI 26.5%PRS 88.0%
-
CSI 3.7rCSI 6.5%PRS 88.2%
-
CSI 3.7rCSI 14.8%PRS 86.9%
-
CSI 3.7rCSI 8.9%PRS 84.0%
-
CSI 3.8rCSI 9.3%PRS 79.6%
-
CSI 3.9rCSI 5.7%PRS 83.7%
-
CSI 3.9rCSI 3.9%PRS 73.7%
-
CSI 4.1rCSI 6.6%PRS 79.1%
-
CSI 4.1rCSI 5.9%PRS 80.7%
-
CSI 4.2rCSI 8.7%PRS 76.7%
-
CSI 4.2rCSI 9.3%PRS 79.3%
-
CSI 4.2rCSI 5.6%PRS 78.5%
-
CSI 4.4rCSI 12.7%PRS 79.4%
-
CSI 4.4rCSI 10.7%PRS 72.3%
-
CSI 4.5rCSI 4.3%PRS 73.1%
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CSI 4.7rCSI 5.4%PRS 83.7%
-
CSI 4.7rCSI 23.2%PRS 87.4%
-
CSI 4.8rCSI 7.5%PRS 81.4%
-
CSI 4.9rCSI 7.2%PRS 88.8%
-
CSI 5.0rCSI 5.4%PRS 81.2%
-
CSI 5.1rCSI 21.8%PRS 86.8%
-
CSI 5.2rCSI 6.5%PRS 80.8%
-
CSI 5.3rCSI 5.6%PRS 77.3%
-
CSI 5.4rCSI 5.9%PRS 81.7%
-
CSI 5.4rCSI 4.9%PRS 87.3%
-
CSI 5.5rCSI 7.5%PRS 84.2%
-
CSI 5.5rCSI 5.7%PRS 79.3%
-
CSI 5.6rCSI 16.1%PRS 75.2%
-
CSI 5.6rCSI 7.8%PRS 77.2%
-
CSI 5.7rCSI 18.5%PRS 78.0%
-
CSI 5.8rCSI 8.2%PRS 76.6%
-
CSI 6.2rCSI 9.5%PRS 69.4%
-
CSI 6.4rCSI 5.5%PRS 80.9%
-
CSI 6.4rCSI 14.1%PRS 83.6%
-
CSI 6.6rCSI 5.4%PRS 79.2%
-
CSI 7.0rCSI 29.2%PRS 85.4%
-
CSI 7.6rCSI 7.0%PRS 80.7%
-
CSI 7.7rCSI 22.1%PRS 86.0%
-
CSI 7.7rCSI 9.3%PRS 87.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
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Comma-separated if multiple.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3862658520
Symbol: TNR12_HUMAN
Name: Tumor necrosis factor receptor superfamily member 12A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10751351
Title: The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas.
PubMed ID: 10751351
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11728344
Title: A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.
PubMed ID: 11728344
PubMed ID: 19241374
Title: Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily.
PubMed ID: 19241374
DOI: 10.1002/pro.49
Sequence Information:
- Length: 129
- Mass: 13911
- Checksum: BF3FDFB9C1E1C448
- Sequence:
MARGSLRRLL RLLVLGLWLA LLRSVAGEQA PGTAPCSRGS SWSADLDKCM DCASCRARPH SDFCLGCAAA PPAPFRLLWP ILGGALSLTF VLGLLSGFLV WRRCRRREKF TTPIEETGGE GCPAVALIQ