Details for: DSP

Gene ID: 1832

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DSP

Ensembl ID: ENSG00000096696

Description: desmoplakin

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • keratinocyte CL0000312
    CSI 56.36
    rCSI 47.25%
    PRS 88.78
  • BEST4+ enteroycte CL4030026
    CSI 55.88
    rCSI 69.51%
    PRS 87.43
  • fallopian tube secretory epithelial cell CL4030006
    CSI 49.44
    rCSI 47.6%
    PRS 86.47
  • conjunctival epithelial cell CL1000432
    CSI 46.11
    rCSI 70.42%
    PRS 86.99
  • extravillous trophoblast CL0008036
    CSI 41.24
    rCSI 51.01%
    PRS 85.9
  • ciliated epithelial cell CL0000067
    CSI 39.1
    rCSI 34.38%
    PRS 78.19
  • placental villous trophoblast CL2000060
    CSI 37.92
    rCSI 58.6%
    PRS 86.16
  • blood vessel endothelial cell CL0000071
    CSI 34.63
    rCSI 71.85%
    PRS 85.24
  • pancreatic A cell CL0000171
    CSI 32.53
    rCSI 34.08%
    PRS 89.7
  • M cell of gut CL0000682
    CSI 31.37
    rCSI 33.33%
    PRS 90.14
  • duct epithelial cell CL0000068
    CSI 29.57
    rCSI 43.26%
    PRS 91.36
  • colon epithelial cell CL0011108
    CSI 28.67
    rCSI 30.03%
    PRS 85.03
  • corneal epithelial cell CL0000575
    CSI 28.32
    rCSI 81%
    PRS 90.42
  • pancreatic ductal cell CL0002079
    CSI 27.39
    rCSI 53.27%
    PRS 89.59
  • respiratory suprabasal cell CL4033048
    CSI 26.09
    rCSI 33.46%
    PRS 89.59
  • small intestine goblet cell CL1000495
    CSI 25.22
    rCSI 55.25%
    PRS 90.69
  • enteroendocrine cell of small intestine CL0009006
    CSI 25.14
    rCSI 55.34%
    PRS 91.44
  • IgA plasma cell CL0000987
    CSI 24.61
    rCSI 25.19%
    PRS 90.91
  • type L enteroendocrine cell CL0002279
    CSI 24.26
    rCSI 45.54%
    PRS 90.53
  • intestine goblet cell CL0019031
    CSI 23.67
    rCSI 21.01%
    PRS 84.88
  • pancreatic acinar cell CL0002064
    CSI 23.57
    rCSI 31.32%
    PRS 91.14
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 21.61
    rCSI 58.25%
    PRS 90.23
  • intestinal epithelial cell CL0002563
    CSI 21.42
    rCSI 22.39%
    PRS 85.01
  • stem cell CL0000034
    CSI 21.24
    rCSI 20.48%
    PRS 82.58
  • goblet cell CL0000160
    CSI 21.2
    rCSI 20.03%
    PRS 85.49
  • transit amplifying cell of colon CL0009011
    CSI 21.15
    rCSI 24.84%
    PRS 88.16
  • epithelial cell of lower respiratory tract CL0002632
    CSI 21.11
    rCSI 16.37%
    PRS 90.45
  • cerebral cortex endothelial cell CL1001602
    CSI 21.04
    rCSI 36.39%
    PRS 80.98
  • ionocyte CL0005006
    CSI 21
    rCSI 22.51%
    PRS 89.27
  • lung neuroendocrine cell CL1000223
    CSI 20.22
    rCSI 29.91%
    PRS 89.77
  • intrahepatic cholangiocyte CL0002538
    CSI 20.21
    rCSI 48.51%
    PRS 88.86
  • multi-ciliated epithelial cell CL0005012
    CSI 20.01
    rCSI 19.97%
    PRS 81.7
  • renal alpha-intercalated cell CL0005011
    CSI 18.57
    rCSI 24.82%
    PRS 91.53
  • secretory cell CL0000151
    CSI 18.29
    rCSI 19.08%
    PRS 86.36
  • hepatic stellate cell CL0000632
    CSI 18.04
    rCSI 67.58%
    PRS 81.74
  • kidney connecting tubule epithelial cell CL1000768
    CSI 17.71
    rCSI 44.92%
    PRS 79.91
  • paneth cell of epithelium of small intestine CL1000343
    CSI 17.31
    rCSI 48.52%
    PRS 91.45
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 17.19
    rCSI 44.44%
    PRS 83.95
  • enteroendocrine cell CL0000164
    CSI 16.52
    rCSI 22.57%
    PRS 86.31
  • transit amplifying cell CL0009010
    CSI 16.41
    rCSI 25.1%
    PRS 91.94
  • lung secretory cell CL1000272
    CSI 16.35
    rCSI 40.48%
    PRS 87.73
  • luminal epithelial cell of mammary gland CL0002326
    CSI 16.35
    rCSI 29.7%
    PRS 93.6
  • respiratory hillock cell CL4030023
    CSI 16.12
    rCSI 28.74%
    PRS 92.41
  • myoepithelial cell CL0000185
    CSI 15.83
    rCSI 40.05%
    PRS 90.56
  • epithelial cell of proximal tubule CL0002306
    CSI 15.53
    rCSI 37.94%
    PRS 80.37
  • brush cell of tracheobronchial tree CL0002075
    CSI 15.51
    rCSI 46.02%
    PRS 93.61
  • midzonal region hepatocyte CL0019028
    CSI 15.32
    rCSI 35.95%
    PRS 85.77
  • epithelial cell of lung CL0000082
    CSI 15.31
    rCSI 12.69%
    PRS 88.57
  • foveolar cell of stomach CL0002179
    CSI 15
    rCSI 31.92%
    PRS 90.56
  • epithelial cell CL0000066
    CSI 14.99
    rCSI 23.03%
    PRS 76
  • nasal mucosa goblet cell CL0002480
    CSI 14.83
    rCSI 17.2%
    PRS 88.9
  • pancreatic D cell CL0000173
    CSI 14.77
    rCSI 14.52%
    PRS 89.1
  • lung ciliated cell CL1000271
    CSI 14.74
    rCSI 17.04%
    PRS 81.18
  • colon goblet cell CL0009039
    CSI 14.56
    rCSI 34.61%
    PRS 90.19
  • tracheal goblet cell CL1000329
    CSI 14.48
    rCSI 31.6%
    PRS 91.12
  • renal beta-intercalated cell CL0002201
    CSI 13.8
    rCSI 32.9%
    PRS 87.35
  • Kupffer cell CL0000091
    CSI 13.58
    rCSI 31.05%
    PRS 88.36
  • ciliated cell CL0000064
    CSI 13.28
    rCSI 21.51%
    PRS 81.91
  • retinal blood vessel endothelial cell CL0002585
    CSI 12.98
    rCSI 20.73%
    PRS 90.36
  • enterocyte of epithelium of large intestine CL0002071
    CSI 12.92
    rCSI 67.87%
    PRS 90.13
  • pancreatic epsilon cell CL0005019
    CSI 12.81
    rCSI 59.71%
    PRS 91.82
  • transit amplifying cell of small intestine CL0009012
    CSI 12.79
    rCSI 56.17%
    PRS 92.03
  • respiratory basal cell CL0002633
    CSI 12.71
    rCSI 13.16%
    PRS 89.74
  • enterocyte CL0000584
    CSI 12.67
    rCSI 20.42%
    PRS 84.9
  • syncytiotrophoblast cell CL0000525
    CSI 12.52
    rCSI 36.07%
    PRS 90.07
  • endothelial cell of lymphatic vessel CL0002138
    CSI 12.28
    rCSI 24.34%
    PRS 89.99
  • periportal region hepatocyte CL0019026
    CSI 12.09
    rCSI 47%
    PRS 85.19
  • intestinal tuft cell CL0019032
    CSI 11.76
    rCSI 17.97%
    PRS 89.86
  • neuroendocrine cell CL0000165
    CSI 11.66
    rCSI 45.07%
    PRS 92.02
  • pulmonary ionocyte CL0017000
    CSI 11.47
    rCSI 13.97%
    PRS 91.96
  • mucous neck cell CL0000651
    CSI 11.21
    rCSI 16.16%
    PRS 91.2
  • squamous epithelial cell CL0000076
    CSI 11.19
    rCSI 26.56%
    PRS 85.67
  • basal cell CL0000646
    CSI 11.15
    rCSI 14.91%
    PRS 85.02
  • parietal epithelial cell CL1000452
    CSI 10.97
    rCSI 29.32%
    PRS 80.91
  • pancreatic PP cell CL0002275
    CSI 10.83
    rCSI 43.11%
    PRS 91.68
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 10.76
    rCSI 20.34%
    PRS 93.81
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 10.7
    rCSI 49.09%
    PRS 89.82
  • ependymal cell CL0000065
    CSI 10.67
    rCSI 21.66%
    PRS 68.42
  • P/D1 enteroendocrine cell CL0002268
    CSI 10.66
    rCSI 58.02%
    PRS 91.02
  • renal principal cell CL0005009
    CSI 10.47
    rCSI 27.2%
    PRS 87.01
  • type B pancreatic cell CL0000169
    CSI 10.43
    rCSI 23.1%
    PRS 87.39
  • colonocyte CL1000347
    CSI 10.43
    rCSI 14.95%
    PRS 86.45
  • myofibroblast cell CL0000186
    CSI 10.3
    rCSI 14.27%
    PRS 84.12
  • innate lymphoid cell CL0001065
    CSI 10.18
    rCSI 21.01%
    PRS 82.46
  • mammary gland epithelial cell CL0002327
    CSI 10.05
    rCSI 35.26%
    PRS 92.46
  • brush cell CL0002204
    CSI 9.91
    rCSI 19.62%
    PRS 91.8
  • cardiac muscle cell CL0000746
    CSI 9.5
    rCSI 13.64%
    PRS 78.78
  • endocardial cell CL0002350
    CSI 9.46
    rCSI 45.31%
    PRS 83.5
  • centrilobular region hepatocyte CL0019029
    CSI 9.25
    rCSI 24.15%
    PRS 84.2
  • paneth cell CL0000510
    CSI 9.04
    rCSI 13.35%
    PRS 93.73
  • club cell CL0000158
    CSI 9.03
    rCSI 13.23%
    PRS 82.7
  • mucus secreting cell CL0000319
    CSI 9
    rCSI 14.29%
    PRS 92.88
  • endocrine cell CL0000163
    CSI 8.52
    rCSI 43.71%
    PRS 95.21
  • retinal pigment epithelial cell CL0002586
    CSI 8.49
    rCSI 16.86%
    PRS 83.58
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 8.28
    rCSI 21.59%
    PRS 88.64
  • acinar cell CL0000622
    CSI 7.77
    rCSI 11.39%
    PRS 93.81
  • pulmonary alveolar type 1 cell CL0002062
    CSI 7.74
    rCSI 44.6%
    PRS 84.05
  • intestinal crypt stem cell of colon CL0009043
    CSI 7.54
    rCSI 56.61%
    PRS 93.33
  • hepatocyte CL0000182
    CSI 7.43
    rCSI 13.3%
    PRS 86.53
  • renal interstitial pericyte CL1001318
    CSI 7.09
    rCSI 19.54%
    PRS 83.86
  • peptic cell CL0000155
    CSI 0.3
    rCSI 2.8%
    PRS 93.0%
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 0.5
    rCSI 2.6%
    PRS 91.2%
  • lung goblet cell CL1000143
    CSI 0.6
    rCSI 6.9%
    PRS 92.3%
  • pluripotent stem cell CL0002248
    CSI 0.9
    rCSI 26.2%
    PRS 93.3%
  • follicular dendritic cell CL0000442
    CSI 1.5
    rCSI 24.8%
    PRS 92.7%
  • epithelial cell of urethra CL1000296
    CSI 1.6
    rCSI 39.2%
    PRS 91.4%
  • mesodermal cell CL0000222
    CSI 1.6
    rCSI 2.0%
    PRS 86.1%
  • cholangiocyte CL1000488
    CSI 1.7
    rCSI 10.0%
    PRS 87.6%
  • ventricular cardiac muscle cell CL2000046
    CSI 1.8
    rCSI 6.1%
    PRS 91.4%
  • pancreatic stellate cell CL0002410
    CSI 1.9
    rCSI 10.8%
    PRS 89.7%
  • acinar cell of salivary gland CL0002623
    CSI 2.4
    rCSI 56.0%
    PRS 94.2%
  • helper T cell CL0000912
    CSI 2.6
    rCSI 3.7%
    PRS 84.1%
  • parietal cell CL0000162
    CSI 2.6
    rCSI 22.3%
    PRS 93.7%
  • tracheobronchial serous cell CL0019001
    CSI 2.6
    rCSI 11.2%
    PRS 91.0%
  • Merkel cell CL0000242
    CSI 2.6
    rCSI 60.9%
    PRS 96.9%
  • kidney epithelial cell CL0002518
    CSI 2.7
    rCSI 5.2%
    PRS 95.6%
  • luminal cell of prostate epithelium CL0002340
    CSI 3.0
    rCSI 16.1%
    PRS 92.4%
  • cytotoxic T cell CL0000910
    CSI 3.2
    rCSI 18.5%
    PRS 87.8%
  • blood vessel smooth muscle cell CL0019018
    CSI 3.3
    rCSI 26.9%
    PRS 83.5%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.3
    rCSI 4.7%
    PRS 84.8%
  • paneth cell of colon CL0009009
    CSI 3.3
    rCSI 32.8%
    PRS 92.2%
  • stratified epithelial cell CL0000079
    CSI 3.6
    rCSI 22.0%
    PRS 92.0%
  • vascular leptomeningeal cell CL4023051
    CSI 3.6
    rCSI 6.4%
    PRS 82.9%
  • bronchial goblet cell CL1000312
    CSI 3.8
    rCSI 15.1%
    PRS 91.7%
  • respiratory goblet cell CL0002370
    CSI 3.8
    rCSI 41.2%
    PRS 91.6%
  • enteroendocrine cell of colon CL0009042
    CSI 4.0
    rCSI 18.8%
    PRS 91.1%
  • hair follicular keratinocyte CL2000092
    CSI 4.1
    rCSI 71.9%
    PRS 92.3%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 4.2
    rCSI 64.7%
    PRS 91.5%
  • respiratory epithelial cell CL0002368
    CSI 4.3
    rCSI 26.5%
    PRS 96.9%
  • regular ventricular cardiac myocyte CL0002131
    CSI 4.6
    rCSI 28.9%
    PRS 80.5%
  • deuterosomal cell CL4033044
    CSI 4.7
    rCSI 16.0%
    PRS 83.0%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 5.0
    rCSI 6.0%
    PRS 67.8%
  • basal cell of epidermis CL0002187
    CSI 5.0
    rCSI 8.9%
    PRS 57.6%
  • regular atrial cardiac myocyte CL0002129
    CSI 5.2
    rCSI 16.8%
    PRS 84.2%
  • choroid plexus epithelial cell CL0000706
    CSI 5.3
    rCSI 8.6%
    PRS 79.1%
  • Langerhans cell CL0000453
    CSI 5.3
    rCSI 8.1%
    PRS 94.7%
  • basal cell of prostate epithelium CL0002341
    CSI 5.3
    rCSI 15.4%
    PRS 91.4%
  • type EC enteroendocrine cell CL0000577
    CSI 5.4
    rCSI 19.2%
    PRS 89.4%
  • tuft cell of colon CL0009041
    CSI 5.5
    rCSI 12.7%
    PRS 90.5%
  • vascular associated smooth muscle cell CL0000359
    CSI 5.7
    rCSI 18.4%
    PRS 85.6%
  • epithelial cell of esophagus CL0002252
    CSI 5.9
    rCSI 58.6%
    PRS 88.5%
  • suprabasal keratinocyte CL4033013
    CSI 6.0
    rCSI 9.8%
    PRS 56.5%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 6.2
    rCSI 14.1%
    PRS 80.5%
  • basal cell of epithelium of trachea CL1000348
    CSI 6.5
    rCSI 46.1%
    PRS 89.6%
  • glandular epithelial cell CL0000150
    CSI 6.8
    rCSI 17.9%
    PRS 94.8%
  • dendritic cell CL0000451
    CSI 7.0
    rCSI 8.6%
    PRS 87.8%
  • renal interstitial pericyte CL1001318
    CSI 7.1
    rCSI 19.5%
    PRS 83.9%
  • hepatocyte CL0000182
    CSI 7.4
    rCSI 13.3%
    PRS 86.5%
  • intestinal crypt stem cell of colon CL0009043
    CSI 7.5
    rCSI 56.6%
    PRS 93.3%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 7.7
    rCSI 44.6%
    PRS 84.1%
  • acinar cell CL0000622
    CSI 7.8
    rCSI 11.4%
    PRS 93.8%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 8.3
    rCSI 21.6%
    PRS 88.6%
  • retinal pigment epithelial cell CL0002586
    CSI 8.5
    rCSI 16.9%
    PRS 83.6%
  • endocrine cell CL0000163
    CSI 8.5
    rCSI 43.7%
    PRS 95.2%
  • mucus secreting cell CL0000319
    CSI 9.0
    rCSI 14.3%
    PRS 92.9%
  • club cell CL0000158
    CSI 9.0
    rCSI 13.2%
    PRS 82.7%
  • paneth cell CL0000510
    CSI 9.0
    rCSI 13.4%
    PRS 93.7%
  • centrilobular region hepatocyte CL0019029
    CSI 9.3
    rCSI 24.2%
    PRS 84.2%
  • endocardial cell CL0002350
    CSI 9.5
    rCSI 45.3%
    PRS 83.5%
  • cardiac muscle cell CL0000746
    CSI 9.5
    rCSI 13.6%
    PRS 78.8%
  • brush cell CL0002204
    CSI 9.9
    rCSI 19.6%
    PRS 91.8%
  • mammary gland epithelial cell CL0002327
    CSI 10.1
    rCSI 35.3%
    PRS 92.5%
  • innate lymphoid cell CL0001065
    CSI 10.2
    rCSI 21.0%
    PRS 82.5%
  • myofibroblast cell CL0000186
    CSI 10.3
    rCSI 14.3%
    PRS 84.1%
  • colonocyte CL1000347
    CSI 10.4
    rCSI 15.0%
    PRS 86.5%
  • type B pancreatic cell CL0000169
    CSI 10.4
    rCSI 23.1%
    PRS 87.4%
  • renal principal cell CL0005009
    CSI 10.5
    rCSI 27.2%
    PRS 87.0%
  • P/D1 enteroendocrine cell CL0002268
    CSI 10.7
    rCSI 58.0%
    PRS 91.0%
  • ependymal cell CL0000065
    CSI 10.7
    rCSI 21.7%
    PRS 68.4%
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 10.7
    rCSI 49.1%
    PRS 89.8%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 10.8
    rCSI 20.3%
    PRS 93.8%
  • pancreatic PP cell CL0002275
    CSI 10.8
    rCSI 43.1%
    PRS 91.7%
  • parietal epithelial cell CL1000452
    CSI 11.0
    rCSI 29.3%
    PRS 80.9%
  • basal cell CL0000646
    CSI 11.2
    rCSI 14.9%
    PRS 85.0%
  • squamous epithelial cell CL0000076
    CSI 11.2
    rCSI 26.6%
    PRS 85.7%
  • mucous neck cell CL0000651
    CSI 11.2
    rCSI 16.2%
    PRS 91.2%
  • pulmonary ionocyte CL0017000
    CSI 11.5
    rCSI 14.0%
    PRS 92.0%
  • neuroendocrine cell CL0000165
    CSI 11.7
    rCSI 45.1%
    PRS 92.0%
  • intestinal tuft cell CL0019032
    CSI 11.8
    rCSI 18.0%
    PRS 89.9%
  • periportal region hepatocyte CL0019026
    CSI 12.1
    rCSI 47.0%
    PRS 85.2%
  • endothelial cell of lymphatic vessel CL0002138
    CSI 12.3
    rCSI 24.3%
    PRS 90.0%
  • syncytiotrophoblast cell CL0000525
    CSI 12.5
    rCSI 36.1%
    PRS 90.1%
  • enterocyte CL0000584
    CSI 12.7
    rCSI 20.4%
    PRS 84.9%
  • respiratory basal cell CL0002633
    CSI 12.7
    rCSI 13.2%
    PRS 89.7%
  • transit amplifying cell of small intestine CL0009012
    CSI 12.8
    rCSI 56.2%
    PRS 92.0%
  • pancreatic epsilon cell CL0005019
    CSI 12.8
    rCSI 59.7%
    PRS 91.8%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 12.9
    rCSI 67.9%
    PRS 90.1%
  • retinal blood vessel endothelial cell CL0002585
    CSI 13.0
    rCSI 20.7%
    PRS 90.4%
  • ciliated cell CL0000064
    CSI 13.3
    rCSI 21.5%
    PRS 81.9%
  • Kupffer cell CL0000091
    CSI 13.6
    rCSI 31.1%
    PRS 88.4%
  • renal beta-intercalated cell CL0002201
    CSI 13.8
    rCSI 32.9%
    PRS 87.4%
  • tracheal goblet cell CL1000329
    CSI 14.5
    rCSI 31.6%
    PRS 91.1%
  • colon goblet cell CL0009039
    CSI 14.6
    rCSI 34.6%
    PRS 90.2%
  • lung ciliated cell CL1000271
    CSI 14.7
    rCSI 17.0%
    PRS 81.2%
  • pancreatic D cell CL0000173
    CSI 14.8
    rCSI 14.5%
    PRS 89.1%
  • nasal mucosa goblet cell CL0002480
    CSI 14.8
    rCSI 17.2%
    PRS 88.9%
  • epithelial cell CL0000066
    CSI 15.0
    rCSI 23.0%
    PRS 76.0%
  • foveolar cell of stomach CL0002179
    CSI 15.0
    rCSI 31.9%
    PRS 90.6%
  • epithelial cell of lung CL0000082
    CSI 15.3
    rCSI 12.7%
    PRS 88.6%
  • midzonal region hepatocyte CL0019028
    CSI 15.3
    rCSI 36.0%
    PRS 85.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DSP](/details-gene/1832), or desmoplakin, is a protein-coding gene located on chromosome 6p24.3. It encodes a critical cytoskeletal linker protein that forms an essential component of desmosomes. As an obligate component of the desmosomal plaque, [DSP](/details-gene/1832) functions to anchor intermediate filaments, such as keratin and desmin, to the plasma membrane at sites of cell-cell contact. This function is fundamental to maintaining the mechanical integrity of tissues, particularly those subject to high mechanical stress. Expression data reveals its highest significance in various epithelial cells, most notably [keratinocytes](/details-cell/CL0000312), enterocytes, and trophoblasts, underscoring its role in epidermal, intestinal, and placental barriers. Clinically, mutations in [DSP](/details-gene/1832) are associated with a range of inherited disorders affecting the skin and heart, such as arrhythmogenic cardiomyopathy and various keratodermas ([125647](https://omim.org/entry/125647)). ## Cellular Roles and Expression Landscape The expression profile of [DSP](/details-gene/1832) strongly supports its canonical role as a cornerstone of epithelial and endothelial tissue integrity. **Overall**, the gene shows the highest significance in cells forming biological barriers. It is a defining marker for [keratinocytes](/details-cell/CL0000312) (CSI: 56.36), which is consistent with its essential function in maintaining the structural integrity of the epidermis. High significance is also observed in a broad spectrum of other epithelial cell types, including [fallopian tube secretory epithelial cells](/details-cell/CL4030006) (CSI: 49.44), [conjunctival epithelial cells](/details-cell/CL1000432) (CSI: 46.11), and [ciliated epithelial cells](/details-cell/CL0000067) (CSI: 39.10), indicating its widespread importance in mucosal and glandular tissues. Beyond the skin, [DSP](/details-gene/1832) is highly significant in specialized intestinal epithelial cells, such as [BEST4+ enteroyctes](/details-cell/CL4030026) (CSI: 55.88) and [M cells of the gut](/details-cell/CL0000682) (CSI: 31.37), suggesting a role in maintaining the gut barrier and potentially contributing to mucosal immune functions. Furthermore, its prominent expression in placental cells, including [extravillous trophoblasts](/details-cell/CL0008036) (CSI: 41.24) and [placental villous trophoblasts](/details-cell/CL2000060) (CSI: 37.92), highlights its necessity for feto-maternal interface integrity. The gene is also significantly expressed in [blood vessel endothelial cells](/details-cell/CL0000071) (CSI: 34.63), which aligns with its role in maintaining vascular stability. This broad but specific expression pattern solidifies the role of [DSP](/details-gene/1832) as a fundamental scaffold protein essential for the architecture of multiple tissues. ## Pathways and Molecular Function The functions of [DSP](/details-gene/1832) are centered on cell adhesion and cytoskeletal organization, as reflected in its functional annotations. Its primary molecular function is as a [structural constituent of the cytoskeleton](/details-cell/GO:0005200) that physically resides within the [desmosome](/details-cell/GO:0030057), a specialized cell-cell junction. This is critical for the biological processes of [desmosome organization](/details-cell/GO:0002934) and [cell-cell adhesion](/details-cell/GO:0098609), particularly [epithelial cell-cell adhesion](/details-cell/GO:0090136). The protein acts as a bridge by engaging in [protein binding](/details-cell/GO:0005515) with both desmosomal cadherins (via plakoglobin) and [intermediate filaments](/details-cell/GO:0005882), thereby facilitating [intermediate filament cytoskeleton organization](/details-cell/GO:0045104) ([Link](https://doi.org/10.1083/jcb.139.3.773)). This structural role is crucial for tissue development and homeostasis, including [epidermis development](/details-cell/GO:0008544), [skin development](/details-cell/GO:0043588), and [keratinocyte differentiation](/details-cell/GO:0030216). Indeed, Reactome pathway analysis highlights its involvement in [Keratinization](/details-cell/R-HSA-6805567) and the [Formation of the cornified envelope](/details-cell/R-HSA-6809371). Beyond the skin, its presence in the [intercalated disc](/details-cell/GO:0014704) of cardiomyocytes is essential for cardiac function, including the [regulation of heart rate by cardiac conduction](/details-cell/GO:0086091). Mutations disrupting this function are known to cause severe cardiac pathologies ([Link](https://doi.org/10.1093/hmg/9.18.2761)). Interestingly, [DSP](/details-gene/1832) is also implicated in pathways beyond structural support, such as [Neutrophil degranulation](/details-cell/R-HSA-6798695) and [Apoptosis](/details-cell/R-HSA-109581), suggesting that its role may extend to immune processes and programmed cell death. ## Research Directions While the structural role of [DSP](/details-gene/1832) in skin and heart is well-established, its high significance in other specialized barrier tissues, such as the gut and placenta, warrants further investigation. The current data prompts several testable hypotheses regarding its context-specific functions. 1. **Hypothesis 1:** Given its high significance in both [extravillous](/details-cell/CL0008036) and [villous trophoblasts](/details-cell/CL2000060), [DSP](/details-gene/1832)-mediated desmosomal adhesion is likely critical for proper placental invasion and the maintenance of the maternal-fetal barrier. Dysregulation or reduced expression of [DSP](/details-gene/1832) may contribute to pathologies of placentation, such as pre-eclampsia or intrauterine growth restriction, by compromising the structural integrity of the trophoblast layers. 2. **Hypothesis 2:** The high expression of [DSP](/details-gene/1832) in [M cells of the gut](/details-cell/CL0000682), which are specialized for mucosal antigen sampling, suggests that beyond general barrier function, [DSP](/details-gene/1832) is required to maintain the unique morphology and stability of these cells within the follicle-associated epithelium. Loss of [DSP](/details-gene/1832) function could impair M cell integrity, leading to defective mucosal immune surveillance and altered host-pathogen interactions. A key experiment to test the second hypothesis would involve the use of a conditional knockout mouse model. Specifically, generating an intestinal epithelial cell-specific knockout of [DSP](/details-gene/1832) (e.g., using a *Villin-Cre;Dspfl/fl* system) would allow for targeted investigation. The structural integrity and number of M cells in the Peyer's patches of these mice could be quantified using electron microscopy and immunofluorescence for M cell markers like GP2. Functional consequences could be assessed by measuring transepithelial antigen uptake and the subsequent immune response following oral administration of fluorescent microbeads or a model antigen. From a therapeutic perspective, [DSP](/details-gene/1832) is a challenging target. The associated diseases are primarily loss-of-function disorders resulting from haploinsufficiency or recessive mutations ([Link](https://doi.org/10.1046/j.1523-1747.1999.00783.x)). Therefore, therapeutic strategies would need to focus on restoring protein function or expression, such as through gene therapy or small molecules that enhance the stability of the mutant protein, rather than inhibition. The widespread expression of [DSP](/details-gene/1832) in multiple essential tissues means that systemic treatments would carry a high risk of off-target effects, suggesting that tissue-specific delivery systems (e.g., topical formulations for skin disorders) would be required for any potential intervention.

Genular Protein ID: 1418441008

Symbol: DESP_HUMAN

Name: Desmoplakin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1731325

Title: Molecular structure of the human desmoplakin I and II amino terminus.

PubMed ID: 1731325

DOI: 10.1073/pnas.89.2.544

PubMed ID: 20524011

Title: Identification and characterization of DSPIa, a novel isoform of human desmoplakin.

PubMed ID: 20524011

DOI: 10.1007/s00441-010-0989-1

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1689290

Title: Structure of the human desmoplakins. Implications for function in the desmosomal plaque.

PubMed ID: 1689290

DOI: 10.1016/s0021-9258(19)39844-8

PubMed ID: 2391353

Title:

PubMed ID: 2391353

DOI: 10.1016/s0021-9258(19)38608-9

PubMed ID: 10594734

Title: Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency.

PubMed ID: 10594734

DOI: 10.1046/j.1523-1747.1999.00783.x

PubMed ID: 9348293

Title: The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.

PubMed ID: 9348293

DOI: 10.1083/jcb.139.3.773

PubMed ID: 9887343

Title: Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma.

PubMed ID: 9887343

DOI: 10.1093/hmg/8.1.143

PubMed ID: 11063735

Title: Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.

PubMed ID: 11063735

DOI: 10.1093/hmg/9.18.2761

PubMed ID: 10852826

Title: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

PubMed ID: 10852826

DOI: 10.1242/jcs.113.13.2471

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 12482924

Title: Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

PubMed ID: 12482924

DOI: 10.1242/jcs.00241

PubMed ID: 16628197

Title: Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin.

PubMed ID: 16628197

DOI: 10.1038/sj.jid.5700291

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21062920

Title: Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.

PubMed ID: 21062920

DOI: 10.1093/cvr/cvq353

PubMed ID: 20859650

Title: E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.

PubMed ID: 20859650

DOI: 10.1007/s00018-010-0531-3

PubMed ID: 20940358

Title: A new hypo/oligodontia syndrome: Carvajal/Naxos syndrome secondary to desmoplakin-dominant mutations.

PubMed ID: 20940358

DOI: 10.1177/0022034510383984

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22781308

Title: Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.

PubMed ID: 22781308

DOI: 10.1161/circgenetics.111.961854

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25208567

Title: Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.

PubMed ID: 25208567

DOI: 10.1091/mbc.e14-05-0968

PubMed ID: 29034528

Title: Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF.

PubMed ID: 29034528

DOI: 10.1111/ced.13214

PubMed ID: 30479852

Title: Subclinical oral involvement in patients with endemic pemphigus foliaceus.

PubMed ID: 30479852

DOI: 10.5826/dpc.0804a02

PubMed ID: 12101406

Title: Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.

PubMed ID: 12101406

DOI: 10.1038/nsb818

PubMed ID: 21536047

Title: Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.

PubMed ID: 21536047

DOI: 10.1016/j.jmb.2011.04.046

PubMed ID: 26808545

Title: Structure of the Intermediate Filament-Binding Region of Desmoplakin.

PubMed ID: 26808545

DOI: 10.1371/journal.pone.0147641

PubMed ID: 12373648

Title: Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy.

PubMed ID: 12373648

DOI: 10.1086/344208

PubMed ID: 11841538

Title: Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome.

PubMed ID: 11841538

DOI: 10.1046/j.0022-202x.2001.01664.x

PubMed ID: 12875771

Title: A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair.

PubMed ID: 12875771

DOI: 10.1016/s0735-1097(03)00628-4

PubMed ID: 16175511

Title: Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa.

PubMed ID: 16175511

DOI: 10.1086/496901

PubMed ID: 15941723

Title: Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations.

PubMed ID: 15941723

DOI: 10.1093/eurheartj/ehi341

PubMed ID: 20031617

Title: Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

PubMed ID: 20031617

DOI: 10.1161/circgenetics.109.858217

PubMed ID: 19863551

Title: Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia.

PubMed ID: 19863551

DOI: 10.1111/j.1399-0004.2009.01282.x

PubMed ID: 22795705

Title: Expanding the phenotype associated with a desmoplakin dominant mutation: Carvajal/Naxos syndrome associated with leukonychia and oligodontia.

PubMed ID: 22795705

DOI: 10.1016/j.ijcard.2012.06.068

Sequence Information:

  • Length: 2871
  • Mass: 331774
  • Checksum: 5770CC6B4F9F9F7B
  • Sequence:
  • MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD QNSDGYCQTG 
    TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ LTRSRELDEC FAQANDQMEI 
    LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR ALYKAISVPR VRRASSKGGG GYTCQSGSGW 
    DEFTKHVTSE CLGWMRQQRA EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA 
    DLREKSAIYQ LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD 
    KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY MDTLQTQWSW 
    ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR KKYPCDKNMP LQHLLEQIKE 
    LEKEREKILE YKRQVQNLVN KSKKIVQLKP RNPDYRSNKP IILRALCDYK QDQKIVHKGD 
    ECILKDNNER SKWYVTGPGG VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL 
    YINMKSLVSW HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF 
    GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN HNKVIETNRE 
    NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH HITVKINELK SVQNDSQAIA 
    EVLNQLKDML ANFRGSEKYC YLQNEVFGLF QKLENINGVT DGYLNSLCTV RALLQAILQT 
    EDMLKVYEAR LTEEETVCLD LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS 
    QTSQQYPLYD LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK 
    WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI AELCANSIKD 
    YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH ARYIELLTRS GDYYRFLSEM 
    LKSLEDLKLK NTKIEVLEEE LRLARDANSE NCNKNKFLDQ NLQKYQAECS QFKAKLASLE 
    ELKRQAELDG KSAKQNLDKC YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD 
    QLQKARQCEK ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKVRNHYN 
    EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD RLSRENRDLK DEIVRLNDSI 
    LQATEQRRRA EENALQQKAC GSEIMQKKQH LEIELKQVMQ QRSEDNARHK QSLEEAAKTI 
    QDKNKEIERL KAEFQEEAKR RWEYENELSK VRNNYDEEII SLKNQFETEI NITKTTIHQL 
    TMQKEEDTSG YRAQIDNLTR ENRSLSEEIK RLKNTLTQTT ENLRRVEEDI QQQKATGSEV 
    SQRKQQLEVE LRQVTQMRTE ESVRYKQSLD DAAKTIQDKN KEIERLKQLI DKETNDRKCL 
    EDENARLQRV QYDLQKANSS ATETINKLKV QEQELTRLRI DYERVSQERT VKDQDITRFQ 
    NSLKELQLQK QKVEEELNRL KRTASEDSCK RKKLEEELEG MRRSLKEQAI KITNLTQQLE 
    QASIVKKRSE DDLRQQRDVL DGHLREKQRT QEELRRLSSE VEALRRQLLQ EQESVKQAHL 
    RNEHFQKAIE DKSRSLNESK IEIERLQSLT ENLTKEHLML EEELRNLRLE YDDLRRGRSE 
    ADSDKNATIL ELRSQLQISN NRTLELQGLI NDLQRERENL RQEIEKFQKQ ALEASNRIQE 
    SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEDELNRAK STLEAETRVK QRLECEKQQI 
    QNDLNQWKTQ YSRKEEAIRK IESEREKSER EKNSLRSEIE RLQAEIKRIE ERCRRKLEDS 
    TRETQSQLET ERSRYQREID KLRQRPYGSH RETQTECEWT VDTSKLVFDG LRKKVTAMQL 
    YECQLIDKTT LDKLLKGKKS VEEVASEIQP FLRGAGSIAG ASASPKEKYS LVEAKRKKLI 
    SPESTVMLLE AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYAAE KAITGFDDPF 
    SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS VFLPKDVALA RGLIDRDLYR 
    SLNDPRDSQK NFVDPVTKKK VSYVQLKERC RIEPHTGLLL LSVQKRSMSF QGIRQPVTVT 
    ELVDSGILRP STVNELESGQ ISYDEVGERI KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI 
    GLVRPGTALE LLEAQAATGF IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN 
    DPETGNIISL FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI AYKRGYFNEE 
    LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG LCLLPLKEKK KQVQTSQKNT 
    LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY ETFKELCEQE CEWEEITITG SDGSTRVVLV 
    DRKTGSQYDI QDAIDKGLVD RKFFDQYRSG SLSLTQFADM ISLKNGVGTS SSMGSGVSDD 
    VFSSSRHESV SKISTISSVR NLTIRSSSFS DTLEESSPIA AIFDTENLEK ISITEGIERG 
    IVDSITGQRL LEAQACTGGI IHPTTGQKLS LQDAVSQGVI DQDMATRLKP AQKAFIGFEG 
    VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE VHGRISTEEA IRKGFIDGRA 
    AQRLQDTSSY AKILTCPKTK LKISYKDAIN RSMVEDITGL RLLEAASVSS KGLPSPYNMS 
    SAPGSRSGSR SGSRSGSRSG SRSGSRRGSF DATGNSSYSY SYSFSSSSIG H

Genular Protein ID: 176758002

Symbol: B4DKX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 954
  • Mass: 112269
  • Checksum: 2462F79A57364219
  • Sequence:
  • MRQQRAEMDM VAWGVDLASV EQHINSHRGI HNSIGDYRWQ LDKIKADLRE KSAIYQLEEE 
    YENLLKASFE RMDHLRQLQN IIQATSREIM WINDCEEEEL LYDWSDKNTN IAQKQEAFSI 
    RMSQLEVKEK ELNKLKQESD QLVLNQHPAS DKIEAYMDTL QTQWSWILQI TKCIDVHLKE 
    NAAYFQFFEE AQSTEAYLKG LQDSIRKKYP CDKNMPLQHL LEQIKELEKE REKILEYKRQ 
    VQNLVNKSKK IVQLKPRNPD YRSNKPIILR ALCDYKQDQK IVHKGDECIL KDNNERSKWY 
    VTGPGGVDML VPSVGLIIPP PNPLAVDLSC KIEQYYEAIL ALWNQLYINM KSLVSWHYCM 
    IDIEKIRAMT IAKLKTMRQE DYMKTIADLE LHYQEFIRNS QGSEMFGDDD KRKIQSQFTD 
    AQKHYQTLVI QLPGYPQHQT VTTTEITHHG TCQDVNHNKV IETNRENDKQ ETWMLMELQK 
    IRRQIEHCEG RMTLKNLPLA DQGSSHHITV KINELKSVQN DSQAIAEVLN QLKDMLANFR 
    GSEKYCYLQN EVFGLFQKLE NINGVTDGYL NSLCTVRALL QAILQTEDML KVYEARLTEE 
    ETVCLDLDKV EAYRCGLKKI KNDLNLKKSL LATMKTELQK AQQIHSQTSQ QYPLYDLDLG 
    KFGEKVTQLT DRWQRIDKQI DFRLWDLEKQ IKQLRNYRDN YQAFCKWLYD AKRRQDSLES 
    MKFGDSNTVM RFLNEQKNLH SEISGKRDKS EEVQKIAELC ANSIKDYELQ LASYTSGLET 
    LLNIPIKRTM IQSPSGVILQ EAADVHARYI ELLTRSGDYY RFLSEMLKSL EDLKLKNTKI 
    EVLEEELRLA RDANSENCNK NKFLDQNLQK YQAECSQFKA KLASLEELKR QAELDGKSAK 
    QNLDKCYGQI KELNEKITRL TYEIEDEKRR RKSVEDRFDQ QKNDYDQLQK ARQC

Genular Protein ID: 2803160571

Symbol: Q4LE79_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 2319
  • Mass: 265195
  • Checksum: A226A8D19C52AF27
  • Sequence:
  • RAATSRAFRT PARFPGRPPI LGPLRFLRAG PPRLCLGAEP LSRLPADMSC NGGSHPRINT 
    LGRMIRAESG PDLRYEVTSG GGGTSRMYYS RRGVITDQNS DGYCQTGTMS RHQNQNTIQE 
    LLQNCSDCLM RAELIVQPEL KYGDGIQLTR SRELDECFAQ ANDQMEILDS LIREMRQMGQ 
    PCDAYQKRLL QLQEQMRALY KAISVPRVRR ASSKGGGGYT CQSGSGWDEF TKHVTSECLG 
    WMRQQRAEMD MVAWGVDLAS VEQHINSHRG IHNSIGDYRW QLDKIKADLR EKSAIYQLEE 
    EYENLLKASF ERMDHLRQLQ NIIQATSREI MWINDCEEEE LLYDWSDKNT NIAQKQEAFS 
    IRMSQLEVKE KELNKLKQES DQLVLNQHPA SDKIEAYMDT LQTQWSWILQ ITKCIDVHLK 
    ENAAYFQFFE EAQSTEAYLK GLQDSIRKKY PCDKNMPLQH LLEQIKELEK EREKILEYKR 
    QVQNLVNKSK KIVQLKPRNP DYRSNKPIIL RALCDYKQDQ KIVHKGDECI LKDNNERSKW 
    YVTGPGGVDM LVPSVGLIIP PPNPLAVDLS CKIEQYYEAI LALWNQLYIN MKSLVSWHYC 
    MIDIEKIRAM TIAKLKTMRQ EDYMKTIADL ELHYQEFIRN SQGSEMFGDD DKRKIQSQFT 
    DAQKHYQTLV IQLPGYPQHQ TVTTTEITHH GTCQDVNHNK VIETNRENDK QETWMLMELQ 
    KIRRQIEHCE GRMTLKNLPL ADQGSSHHIT VKINELKSVQ NDSQAIAEVL NQLKDMLANF 
    RGSEKYCYLQ NEVFGLFQKL ENINGVTDGY LNSLCTVRAL LQAILQTEDM LKVYEARLTE 
    EETVCLDLDK VEAYRCGLKK IKNDLNLKKS LLATMKTELQ KAQQIHSQTS QQYPLYDLDL 
    GKFGEKVTQL TDRWQRIDKQ IDFRLWDLEK QIKQLRNYRD NYQAFCKWLY DAKRRQDSLE 
    SMKFGDSNTV MRFLNEQKNL HSEISGKRDK SEEVQKIAEL CANSIKDYEL QLASYTSGLE 
    TLLNIPIKRT MIQSPSGVIL QEAADVHARY IELLTRSGDY YRFLSEMLKS LEDLKLKNTK 
    IEVLEEELRL ARDANSENCN KNKFLDQNLQ KYQAECSQFK AKLASLEELK RQAELDGKSA 
    KQNLDKCYGQ IKELNEKITR LTYEIEDEKR RRKSVEDRFD QQKNDYDQLQ KARQCEKENL 
    GWQKLESEKA IKEKEYEIER LRVLLQEEGT RKREYENELA KASNRIQESK NQCTQVVQER 
    ESLLVKIKVL EQDKARLQRL EDELNRAKST LEAETRVKQR LECEKQQIQN DLNQWKTQYS 
    RKEEAIRKIE SEREKSEREK NSLRSEIERL QAEIKRIEER CRRKLEDSTR ETQSQLETER 
    SRYQREIDKL RQRPYGSHRE TQTECEWTVD TSKLVFDGLR KKVTAMQLYE CQLIDKTTLD 
    KLLKGKKSVE EVASEIQPFL RGAGSIAGAS ASPKEKYSLV EAKRKKLISP ESTVMLLEAQ 
    AATGGIIDPH RNEKLTVDSA IARDLIDFDD RQQIYAAEKA ITGFDDPFSG KTVSVSEAIK 
    KNLIDRETGM RLLEAQIASG GVVDPVNSVF LPKDVALARG LIDRDLYRSL NDPRDSQKNF 
    VDPVTKKKVS YVQLKERCRI EPHTGLLLLS VQKRSMSFQG IRQPVTVTEL VDSGILRPST 
    VNELESGQIS YDEVGERIKD FLQGSSCIAG IYNETTKQKL GIYEAMKIGL VRPGTALELL 
    EAQAATGFIV DPVSNLRLPV EEAYKRGLVG IEFKEKLLSA ERAVTGYNDP ETGNIISLFQ 
    AMNKELIEKG HGIRLLEAQI ATGGIIDPKE SHRLPVDIAY KRGYFNEELS EILSDPSDDT 
    KGFFDPNTEE NLTYLQLKER CIKDEETGLC LLPLKEKKKQ VQTSQKNTLR KRRVVIVDPE 
    TNKEMSVQEA YKKGLIDYET FKELCEQECE WEEITITGSD GSTRVVLVDR KTGSQYDIQD 
    AIDKGLVDRK FFDQYRSGSL SLTQFADMIS LKNGVGTSSS MGSGVSDDVF SSSRHESVSK 
    ISTISSVRNL TIRSSSFSDT LEESSPIAAI FDTENLEKIS ITEGIERGIV DSITGQRLLE 
    AQACTGGIIH PTTGQKLSLQ DAVSQGVIDQ DMATRLKPAQ KAFIGFEGVK GKKKMSAAEA 
    VKEKWLPYEA GQRFLEFQYL TGGLVDPEVH GRISTEEAIR KGFIDGRAAQ RLQDTSSYAK 
    ILTCPKTKLK ISYKDAINRS MVEDITGLRL LEAASVSSKG LPSPYNMSSA PGSRSGSRSG 
    SRSGSRSGSR SGSRRGSFDA TGNSSYSYSY SFSSSSIGH