Details for: GOLM1

Gene ID: 51280

Symbol: GOLM1

Ensembl ID: ENSG00000135052

Description: golgi membrane protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.8192
    Cell Significance Index: -45.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.8194
    Cell Significance Index: -45.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 112.0045
    Cell Significance Index: -46.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.3614
    Cell Significance Index: -39.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.7599
    Cell Significance Index: -39.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.8789
    Cell Significance Index: -45.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.2316
    Cell Significance Index: -48.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6040
    Cell Significance Index: -45.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6351
    Cell Significance Index: -16.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.0240
    Cell Significance Index: 273.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 5.2920
    Cell Significance Index: 114.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1335
    Cell Significance Index: 61.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8150
    Cell Significance Index: 364.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7892
    Cell Significance Index: 1615.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6103
    Cell Significance Index: 83.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4985
    Cell Significance Index: 84.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4800
    Cell Significance Index: 808.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4090
    Cell Significance Index: 86.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3988
    Cell Significance Index: 34.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.1716
    Cell Significance Index: 170.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0660
    Cell Significance Index: 115.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0611
    Cell Significance Index: 15.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0328
    Cell Significance Index: 35.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.9219
    Cell Significance Index: 22.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8839
    Cell Significance Index: 611.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8227
    Cell Significance Index: 93.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8209
    Cell Significance Index: 61.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7857
    Cell Significance Index: 281.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5801
    Cell Significance Index: 79.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5490
    Cell Significance Index: 98.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5048
    Cell Significance Index: 49.9400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.4436
    Cell Significance Index: 2.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4025
    Cell Significance Index: 12.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3094
    Cell Significance Index: 50.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3093
    Cell Significance Index: 58.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2868
    Cell Significance Index: 35.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2232
    Cell Significance Index: 38.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2051
    Cell Significance Index: 40.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2043
    Cell Significance Index: 5.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1125
    Cell Significance Index: 5.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0979
    Cell Significance Index: 62.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0956
    Cell Significance Index: 70.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0922
    Cell Significance Index: 1.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0872
    Cell Significance Index: 164.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0851
    Cell Significance Index: 5.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0410
    Cell Significance Index: 1.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0212
    Cell Significance Index: 32.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0182
    Cell Significance Index: 8.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0087
    Cell Significance Index: 11.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0154
    Cell Significance Index: -9.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0162
    Cell Significance Index: -2.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0241
    Cell Significance Index: -10.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0277
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0390
    Cell Significance Index: -29.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0476
    Cell Significance Index: -6.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0489
    Cell Significance Index: -27.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0719
    Cell Significance Index: -1.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0840
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1117
    Cell Significance Index: -23.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1221
    Cell Significance Index: -6.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1285
    Cell Significance Index: -36.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1403
    Cell Significance Index: -14.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1754
    Cell Significance Index: -20.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2073
    Cell Significance Index: -2.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2389
    Cell Significance Index: -3.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2626
    Cell Significance Index: -7.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2639
    Cell Significance Index: -30.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3147
    Cell Significance Index: -8.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3260
    Cell Significance Index: -15.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3538
    Cell Significance Index: -15.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3842
    Cell Significance Index: -29.4800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3972
    Cell Significance Index: -4.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4030
    Cell Significance Index: -41.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4243
    Cell Significance Index: -50.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4389
    Cell Significance Index: -16.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4443
    Cell Significance Index: -20.8800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4595
    Cell Significance Index: -3.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4805
    Cell Significance Index: -33.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5095
    Cell Significance Index: -40.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5320
    Cell Significance Index: -32.6200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5351
    Cell Significance Index: -3.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5381
    Cell Significance Index: -5.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5839
    Cell Significance Index: -15.5900
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.5885
    Cell Significance Index: -3.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6168
    Cell Significance Index: -13.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6545
    Cell Significance Index: -41.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7373
    Cell Significance Index: -24.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7443
    Cell Significance Index: -23.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7510
    Cell Significance Index: -48.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7646
    Cell Significance Index: -22.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8033
    Cell Significance Index: -18.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8618
    Cell Significance Index: -16.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8795
    Cell Significance Index: -30.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8961
    Cell Significance Index: -10.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9092
    Cell Significance Index: -23.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.9246
    Cell Significance Index: -13.2500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9581
    Cell Significance Index: -9.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9857
    Cell Significance Index: -19.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GOLM1 is a transmembrane protein that is primarily localized to the Golgi apparatus, a complex organelle responsible for protein modification, sorting, and packaging. The protein's structure consists of two subunits, each containing an N-terminal transmembrane domain, a cytoplasmic domain, and a C-terminal domain that interacts with other proteins. GOLM1's expression is widespread, with significant levels found in hematopoietic cells, stem cells, and epithelial cells. **Pathways and Functions:** GOLM1's involvement in various cellular processes is multifaceted. It is primarily implicated in the regulation of protein transport and modification, particularly in the context of insulin-like growth factor (IGF) signaling. GOLM1 interacts with IGF binding proteins (IGFBPs) to regulate the transport and uptake of IGFs, which play a crucial role in cell growth, differentiation, and survival. Additionally, GOLM1 is involved in lipid metabolic processes, influencing the transport and storage of lipids within the cell. Furthermore, GOLM1 has been implicated in the regulation of post-translational protein phosphorylation, which is essential for various cellular signaling pathways. The protein's interaction with other signaling molecules, such as kinases and phosphatases, suggests a role in modulating cellular responses to external stimuli. **Clinical Significance:** The clinical significance of GOLM1 is an area of ongoing research. Dysregulation of GOLM1 has been linked to various diseases, including cancer, where it may contribute to the development of tumor cells. Additionally, GOLM1's involvement in IGF signaling pathways suggests a potential role in the pathogenesis of insulin resistance and related metabolic disorders. Furthermore, GOLM1's expression in hematopoietic cells and stem cells raises questions about its potential role in hematological disorders, such as leukemia and lymphoma. The protein's interaction with other signaling molecules, such as receptors and transcription factors, suggests a complex regulatory network that may be exploited in the development of novel therapeutic strategies. In conclusion, GOLM1 is a multifunctional protein with a wide range of cellular processes, including regulation of protein transport, modification, and signaling. Further research is necessary to fully elucidate the protein's role in various diseases and to explore its potential as a therapeutic target. **Future Directions:** Future studies should focus on the following areas: 1. Elucidating the molecular mechanisms underlying GOLM1's regulation of IGF signaling and lipid metabolic processes. 2. Investigating the protein's role in the development and progression of cancer. 3. Examining the potential of GOLM1 as a therapeutic target for various diseases, including metabolic disorders and hematological disorders. 4. Characterizing the protein's interactions with other signaling molecules and elucidating its regulatory network. By further exploring the multifaceted role of GOLM1, we may uncover novel therapeutic strategies and gain a deeper understanding of the complex cellular processes that govern human health and disease.

Genular Protein ID: 1112091813

Symbol: GOLM1_HUMAN

Name: Golgi membrane protein 1

UniProtKB Accession Codes:

Q8NBJ4 Q6IAF4 Q9NRB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10831838

Title: GP73, a novel Golgi-localized protein upregulated by viral infection.

PubMed ID: 10831838

DOI: 10.1016/s0378-1119(00)00136-0

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12191016

Title: Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption.

PubMed ID: 12191016

DOI: 10.1034/j.1600-0854.2002.30906.x

PubMed ID: 12029628

Title: Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease.

PubMed ID: 12029628

DOI: 10.1053/jhep.2002.32525

PubMed ID: 12359426

Title: Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain.

PubMed ID: 12359426

DOI: 10.1006/viro.2002.1523

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21280149

Title: Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development.

PubMed ID: 21280149

DOI: 10.1002/humu.21413

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 401
  • Mass: 45333
  • Checksum: 24C1DC31E47B5B77
  • Sequence:
    • MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE GRVRRAAAER 
GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ DEKAVLVNNI TTGERLIRVL 
QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER KFSYDLSQCI NQMKEVKEQC EERIEEVTKK 
GNEAVASRDL SENNDQRQQL QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS 
EVVLDSKRQV EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP 
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD YNMDENEAES 
ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.