Details for: FXYD3

Gene ID: 5349

Symbol: FXYD3

Ensembl ID: ENSG00000089356

Description: FXYD domain containing ion transport regulator 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 293.5481
    Cell Significance Index: -45.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 183.4465
    Cell Significance Index: -46.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.5770
    Cell Significance Index: -34.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.7921
    Cell Significance Index: -45.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.6818
    Cell Significance Index: -46.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.8421
    Cell Significance Index: -34.2200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 13.3157
    Cell Significance Index: 30.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 12.4903
    Cell Significance Index: 76.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 10.6911
    Cell Significance Index: 484.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 10.1558
    Cell Significance Index: 473.5100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 9.8871
    Cell Significance Index: 84.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.6154
    Cell Significance Index: 88.5500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 8.6079
    Cell Significance Index: 25.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2013
    Cell Significance Index: -25.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1229
    Cell Significance Index: -21.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.1415
    Cell Significance Index: 370.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.5232
    Cell Significance Index: 1175.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.0846
    Cell Significance Index: 748.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 5.6249
    Cell Significance Index: 58.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.4651
    Cell Significance Index: 81.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.5326
    Cell Significance Index: 337.8100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 3.7602
    Cell Significance Index: 57.1100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.7462
    Cell Significance Index: 78.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.6834
    Cell Significance Index: 364.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.5713
    Cell Significance Index: 252.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4302
    Cell Significance Index: 443.1600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.2645
    Cell Significance Index: 24.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1588
    Cell Significance Index: 85.9800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.9917
    Cell Significance Index: 18.5200
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 2.9524
    Cell Significance Index: 2.1100
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.9338
    Cell Significance Index: 16.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7449
    Cell Significance Index: 76.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.7329
    Cell Significance Index: 1208.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6254
    Cell Significance Index: 123.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2936
    Cell Significance Index: 158.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2206
    Cell Significance Index: -4.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3308
    Cell Significance Index: 216.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2773
    Cell Significance Index: 29.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1756
    Cell Significance Index: 31.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1671
    Cell Significance Index: 37.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8491
    Cell Significance Index: 8.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7837
    Cell Significance Index: 428.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7784
    Cell Significance Index: 148.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3589
    Cell Significance Index: 271.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3250
    Cell Significance Index: 9.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2904
    Cell Significance Index: 49.5900
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.2381
    Cell Significance Index: 1.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1898
    Cell Significance Index: 4.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0688
    Cell Significance Index: 62.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0026
    Cell Significance Index: 1.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0002
    Cell Significance Index: 0.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0176
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0247
    Cell Significance Index: -46.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0409
    Cell Significance Index: -4.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0455
    Cell Significance Index: -0.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0498
    Cell Significance Index: -6.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0534
    Cell Significance Index: -39.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0550
    Cell Significance Index: -0.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0567
    Cell Significance Index: -31.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0652
    Cell Significance Index: -41.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0682
    Cell Significance Index: -2.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0735
    Cell Significance Index: -3.7100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0796
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1125
    Cell Significance Index: -51.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1143
    Cell Significance Index: -13.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1169
    Cell Significance Index: -24.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1221
    Cell Significance Index: -2.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1255
    Cell Significance Index: -45.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1332
    Cell Significance Index: -18.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1662
    Cell Significance Index: -47.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1826
    Cell Significance Index: -20.9300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1864
    Cell Significance Index: -2.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2017
    Cell Significance Index: -40.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2324
    Cell Significance Index: -46.6200
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.2734
    Cell Significance Index: -2.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2841
    Cell Significance Index: -41.2900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2901
    Cell Significance Index: -2.6600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3079
    Cell Significance Index: -1.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3233
    Cell Significance Index: -3.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3528
    Cell Significance Index: -36.0400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3648
    Cell Significance Index: -2.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3892
    Cell Significance Index: -5.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4061
    Cell Significance Index: -47.8900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.4401
    Cell Significance Index: -4.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4579
    Cell Significance Index: -47.6800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4640
    Cell Significance Index: -3.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4931
    Cell Significance Index: -27.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5213
    Cell Significance Index: -31.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5311
    Cell Significance Index: -42.0600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.5875
    Cell Significance Index: -6.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5931
    Cell Significance Index: -37.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6021
    Cell Significance Index: -12.4900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.6217
    Cell Significance Index: -5.9100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6228
    Cell Significance Index: -4.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6262
    Cell Significance Index: -15.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6416
    Cell Significance Index: -33.4200
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.6456
    Cell Significance Index: -3.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6490
    Cell Significance Index: -14.0600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.6523
    Cell Significance Index: -5.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6718
    Cell Significance Index: -24.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **FXYD Domain:** The FXYD domain of FXYD3 is a conserved region that is essential for regulating ion transport and cellular signaling. This domain is characterized by a unique structure that allows it to interact with other proteins and regulate the activity of ion channels and transporters. 2. **Ion Transport Regulation:** FXYD3 regulates various ion transport processes, including chloride, sodium, potassium, and calcium transport. This regulation is crucial for maintaining cellular homeostasis and responding to environmental stimuli. 3. **Cellular Expression:** FXYD3 is significantly expressed in various cell types, including epithelial cells, muscle cells, and immune cells. This widespread expression highlights the importance of FXYD3 in maintaining tissue homeostasis and responding to environmental stimuli. 4. **Pathway Involvement:** FXYD3 is involved in various signaling pathways, including the regulation of cardiac conduction, muscle contraction, and immune responses. **Pathways and Functions:** 1. **Cardiac Conduction:** FXYD3 regulates cardiac conduction by modulating the activity of ion channels and transporters involved in the transmission of electrical signals in the heart. 2. **Muscle Contraction:** FXYD3 regulates muscle contraction by modulating the activity of ion channels and transporters involved in the regulation of muscle excitability. 3. **Immune Responses:** FXYD3 regulates immune responses by modulating the activity of ion channels and transporters involved in the regulation of immune cell function and cytokine production. 4. **Ion Homeostasis:** FXYD3 regulates ion homeostasis by modulating the activity of ion channels and transporters involved in the regulation of ion balance across cell membranes. **Clinical Significance:** 1. **Dysregulation in Disease:** Dysregulation of FXYD3 has been implicated in various diseases, including heart failure, muscle disorders, and immune-related disorders. 2. **Therapeutic Potential:** FXYD3 has been identified as a potential therapeutic target for various diseases, including heart failure and muscle disorders. 3. **Viral Infections:** FXYD3 has been implicated in the regulation of viral infections, including SARS-CoV, highlighting its potential role in modulating immune responses to viral pathogens. 4. **Cancer:** FXYD3 has been implicated in the regulation of cancer cell growth and metastasis, highlighting its potential role in cancer development and progression. In conclusion, FXYD3 is a crucial regulator of ion transport and cellular homeostasis, playing a vital role in maintaining tissue homeostasis and responding to environmental stimuli. Its dysregulation has been implicated in various diseases, and it has been identified as a potential therapeutic target for various conditions. Further research is needed to fully elucidate the role of FXYD3 in human health and disease.

Genular Protein ID: 1619497486

Symbol: FXYD3_HUMAN

Name: FXYD domain-containing ion transport regulator 3

UniProtKB Accession Codes:

Q14802 A6NDE0 C9JDU2 F5H174 F8WB34 Q13211 Q6IB59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 10 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 11 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7836447

Title: Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes.

PubMed ID: 7836447

DOI: 10.1074/jbc.270.5.2176

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17077088

Title: Structural and functional properties of two human FXYD3 (Mat-8) isoforms.

PubMed ID: 17077088

DOI: 10.1074/jbc.m605221200

PubMed ID: 21454534

Title: FXYD proteins reverse inhibition of the Na+-K+ pump mediated by glutathionylation of its beta1 subunit.

PubMed ID: 21454534

DOI: 10.1074/jbc.m110.184101

Sequence Information:

  • Length: 87
  • Mass: 9263
  • Checksum: 6D674D668EB32493
  • Sequence:
    • MQKVTLGLLV FLAGFPVLDA NDLEDKNSPF YYDWHSLQVG GLICAGVLCA MGIIIVMSAK 
CKCKFGQKSG HHPGETPPLI TPGSAQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.