Details for: LAMB3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 106.0142
Cell Significance Index: -16.4900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 37.8824
Cell Significance Index: -15.3900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.9938
Cell Significance Index: -15.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.3906
Cell Significance Index: -16.5100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 8.7842
Cell Significance Index: 239.1000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 7.3169
Cell Significance Index: 99.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 6.1817
Cell Significance Index: 321.1200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 6.1065
Cell Significance Index: 91.5000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.6729
Cell Significance Index: 166.4800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 3.4088
Cell Significance Index: 73.8500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 3.2207
Cell Significance Index: 92.8000 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.8366
Cell Significance Index: 17.5600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.0911
Cell Significance Index: 257.1200 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 2.0133
Cell Significance Index: 17.3000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.6403
Cell Significance Index: -3.5900 - Cell Name: epidermal cell (CL0000362)
Fold Change: 1.6101
Cell Significance Index: 3.6300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1235
Cell Significance Index: 202.5400 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.0706
Cell Significance Index: 138.3100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0219
Cell Significance Index: 28.5600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9550
Cell Significance Index: 521.5500 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.9516
Cell Significance Index: 2.8300 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.8878
Cell Significance Index: 5.3200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8835
Cell Significance Index: 31.0500 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.8254
Cell Significance Index: 11.7500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8071
Cell Significance Index: 558.2300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6596
Cell Significance Index: 65.2500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6246
Cell Significance Index: 276.1400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.5498
Cell Significance Index: 11.7100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3170
Cell Significance Index: 22.4200 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2863
Cell Significance Index: 4.4300 - Cell Name: peg cell (CL4033014)
Fold Change: 0.2761
Cell Significance Index: 6.3800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2539
Cell Significance Index: 229.2300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2528
Cell Significance Index: 6.3200 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.2399
Cell Significance Index: 2.6000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2058
Cell Significance Index: 4.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1600
Cell Significance Index: 7.5200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1564
Cell Significance Index: 11.6600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1231
Cell Significance Index: 14.1000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1092
Cell Significance Index: 20.7800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0733
Cell Significance Index: 14.7000 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.0497
Cell Significance Index: 0.6900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0283
Cell Significance Index: 3.2300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0141
Cell Significance Index: 10.6800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0027
Cell Significance Index: 0.4600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0057
Cell Significance Index: -4.2400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0065
Cell Significance Index: -12.2500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0082
Cell Significance Index: -2.9400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0095
Cell Significance Index: -5.9300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0126
Cell Significance Index: -23.2700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0153
Cell Significance Index: -23.5200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0155
Cell Significance Index: -8.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0172
Cell Significance Index: -23.3800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0190
Cell Significance Index: -13.9200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0231
Cell Significance Index: -4.5900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0273
Cell Significance Index: -17.3100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0277
Cell Significance Index: -3.2300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0358
Cell Significance Index: -4.5900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0439
Cell Significance Index: -19.9200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0489
Cell Significance Index: -10.2900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0515
Cell Significance Index: -14.8200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0522
Cell Significance Index: -8.4900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0574
Cell Significance Index: -1.8400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0590
Cell Significance Index: -8.1000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0592
Cell Significance Index: -0.5500 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.0716
Cell Significance Index: -1.2300 - Cell Name: mucous neck cell (CL0000651)
Fold Change: -0.0861
Cell Significance Index: -0.4100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0970
Cell Significance Index: -9.9100 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.0980
Cell Significance Index: -0.8700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1090
Cell Significance Index: -5.5100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1165
Cell Significance Index: -16.9300 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1343
Cell Significance Index: -1.3900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1401
Cell Significance Index: -5.7400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1467
Cell Significance Index: -3.9300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1572
Cell Significance Index: -8.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1611
Cell Significance Index: -16.7700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1637
Cell Significance Index: -10.0400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1854
Cell Significance Index: -21.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1875
Cell Significance Index: -14.3900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2046
Cell Significance Index: -2.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2231
Cell Significance Index: -17.6700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2687
Cell Significance Index: -18.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2802
Cell Significance Index: -17.2300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2931
Cell Significance Index: -10.7600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2967
Cell Significance Index: -13.8400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3129
Cell Significance Index: -8.9700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3195
Cell Significance Index: -20.6100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3407
Cell Significance Index: -19.1200 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: -0.3441
Cell Significance Index: -3.5500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3520
Cell Significance Index: -9.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3575
Cell Significance Index: -18.7700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3577
Cell Significance Index: -15.8200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3788
Cell Significance Index: -13.2700 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.4034
Cell Significance Index: -3.2100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4034
Cell Significance Index: -10.3700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4146
Cell Significance Index: -4.7100 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.4242
Cell Significance Index: -4.4800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4268
Cell Significance Index: -16.1600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4869
Cell Significance Index: -12.1600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4908
Cell Significance Index: -15.6300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4916
Cell Significance Index: -13.1500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2329031875
Symbol: LAMB3_HUMAN
Name: Laminin subunit beta-3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7512558
Title: The complete primary structure for a novel laminin chain, the laminin B1k chain.
PubMed ID: 7512558
PubMed ID: 7774918
Title: Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa.
PubMed ID: 7774918
PubMed ID: 8530036
Title: Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization.
PubMed ID: 8530036
PubMed ID: 11296269
Title: In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa.
PubMed ID: 11296269
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19275936
Title: ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.
PubMed ID: 19275936
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23958762
Title: LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta.
PubMed ID: 23958762
PubMed ID: 23632796
Title: Whole-exome sequencing, without prior linkage, identifies a mutation in LAMB3 as a cause of dominant hypoplastic amelogenesis imperfecta.
PubMed ID: 23632796
DOI: 10.1038/ejhg.2013.76
PubMed ID: 7550237
Title: Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3).
PubMed ID: 7550237
PubMed ID: 9767254
Title: E210K mutation in the gene encoding the beta3 chain of laminin-5 (LAMB3) is predictive of a phenotype of generalized atrophic benign epidermolysis bullosa.
PubMed ID: 9767254
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17476356
Title: Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3.
PubMed ID: 17476356
DOI: 10.1172/jci30465
Sequence Information:
- Length: 1172
- Mass: 129572
- Checksum: 61BC1A60BBD4FA05
- Sequence:
MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT KPETYCTQYG EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRWWQSQND VNPVSLQLDL DRRFQLQEVM MEFQGPMPAG MLIERSSDFG KTWRVYQYLA ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP NARLNGGKVQ LNLMDLVSGI PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA VSQLRLQGSC FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT EGKNCERCQL HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV CKEHVQGERC DLCKPGFTGL TYANPQGCHR CDCNILGSRR DMPCDEESGR CLCLPNVVGP KCDQCAPYHW KLASGQGCEP CACDPHNSLS PQCNQFTGQC PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG RLRNATASLW SGPGLEDRGL ASRILDAKSK IEQIRAVLSS PAVTEQEVAQ VASAILSLRR TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR EQFEKISSAD PSGAFRMLST AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL TPTFNKLCGN SRQMACTPIS CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR GFNAQLQRTR QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS QTKQDIARAR RLQAEAEEAR SRAHAVEGQV EDVVGNLRQG TVALQEAQDT MQGTSRSLRL IQDRVAEVQQ VLRPAEKLVT SMTKQLGDFW TRMEELRHQA RQQGAEAVQA QQLAEGASEQ ALSAQEGFER IKQKYAELKD RLGQSSMLGE QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI MLRSADLTGL EKRVEQIRDH INGRVLYYAT CK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.