Details for: LAMB3

Gene ID: 3914

Symbol: LAMB3

Ensembl ID: ENSG00000196878

Description: laminin subunit beta 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.87
    Marker Score: 18282
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.67
    Marker Score: 2105
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.66
    Marker Score: 6494.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.45
    Marker Score: 12053.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.33
    Marker Score: 2811
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.17
    Marker Score: 3201
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.83
    Marker Score: 649
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.76
    Marker Score: 3992
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.69
    Marker Score: 8116
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.66
    Marker Score: 913
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.62
    Marker Score: 3991
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.61
    Marker Score: 5056
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.54
    Marker Score: 1988
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.54
    Marker Score: 1048
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.53
    Marker Score: 1614
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5
    Marker Score: 371
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.44
    Marker Score: 347
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.42
    Marker Score: 10533
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.33
    Marker Score: 45925
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.24
    Marker Score: 5159.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2
    Marker Score: 1194
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.18
    Marker Score: 528
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.17
    Marker Score: 2078
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.17
    Marker Score: 616
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.16
    Marker Score: 392
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17762
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.13
    Marker Score: 1253
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.1
    Marker Score: 2010
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.09
    Marker Score: 729
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2560
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.08
    Marker Score: 341
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.07
    Marker Score: 4138
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.05
    Marker Score: 518
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.04
    Marker Score: 5467
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.99
    Marker Score: 951
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.98
    Marker Score: 198
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.96
    Marker Score: 1524
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1541
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5313
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.91
    Marker Score: 1401
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.89
    Marker Score: 1035
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.87
    Marker Score: 1430
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.86
    Marker Score: 220
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1559
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1656
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 797
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.8
    Marker Score: 252
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.77
    Marker Score: 358
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.75
    Marker Score: 12087
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.73
    Marker Score: 518
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.73
    Marker Score: 6358
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.73
    Marker Score: 827
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.72
    Marker Score: 4678
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.71
    Marker Score: 1684.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.71
    Marker Score: 1138
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.71
    Marker Score: 204
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.71
    Marker Score: 718
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.7
    Marker Score: 331
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2893
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.68
    Marker Score: 603
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.67
    Marker Score: 192
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 435
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.61
    Marker Score: 427
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.59
    Marker Score: 157
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.59
    Marker Score: 522
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.57
    Marker Score: 357
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 174
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.53
    Marker Score: 182
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.53
    Marker Score: 137
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.51
    Marker Score: 1739
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.49
    Marker Score: 225
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.49
    Marker Score: 184
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 470
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.47
    Marker Score: 4033
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.46
    Marker Score: 201
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.46
    Marker Score: 269
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.46
    Marker Score: 1775
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 120
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.45
    Marker Score: 564

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Other Information

**Key characteristics:** * Type: Protein * Ensembl ID: ENSG00000196878 * Protein name: LAMB3_HUMAN * Molecular weight: 450 kDa * Expression: Significantly expressed in cells of the skin, kidney, and lung. * Function: * Anchoring fibril formation * Assembly of collagen fibrils and other multimeric structures * Cell-cell communication * Cell adhesion * Cell junction organization * Collagen formation * Degradation of the extracellular matrix * Extracellular matrix organization * Extracellular matrix structural constituent * Laminin interactions * Met activates ptk2 signaling * Met promotes cell motility * Non-integrin membrane-ecm interactions * Protein-containing complex binding * Protein binding * Signaling by met * Signaling by receptor tyrosine kinases * Signal transduction * Structural molecule activity **Pathways and functions:** * **Anchoring fibril formation:** Laminains are key components of the extracellular matrix (ECM) and play a crucial role in anchoring fibrillary structures, such as collagen fibers. * **Assembly of collagen fibrils and other multimeric structures:** Laminins interact with other ECM proteins, such as collagen type I, to form the structural framework of tissues. * **Cell-cell communication:** Laminains facilitate cell-cell adhesion, allowing cells to interact and form tissues. * **Cell adhesion:** Laminins are crucial for cell adhesion to the ECM and to each other. * **Cell junction organization:** Laminains are involved in the organization and stability of cell junctions, which are important for tissue integrity. * **Collagen formation:** Laminins are essential for the formation of collagen, a major component of the ECM. * **Degradation of the extracellular matrix:** Laminains are involved in the degradation of the ECM, promoting tissue remodeling and wound healing. * **Extracellular matrix organization:** Laminins help to organize the ECM, providing a framework for cell adhesion, migration, and signaling. * **Extracellular matrix structural constituent:** Laminins contribute to the structural integrity of the ECM, providing a stable platform for other extracellular matrix components. * **Laminin interactions:** Laminains interact with various other proteins, including collagen, proteoglycans, and growth factors. * **Met activates ptk2 signaling:** Met, a receptor for epidermal growth factor, binds to laminins and activates ptk2 signaling, which is involved in cell migration and tissue growth. * **Met promotes cell motility:** Met signaling also promotes cell motility through the regulation of cytoskeletal dynamics. **Clinical significance:** * Mutations in the LAMB3 gene have been linked to various skin disorders, including epidermolysis bullosa simplex, a genetic skin disorder characterized by fragile and easily broken skin. * Lamins are also involved in wound healing and tissue regeneration, and mutations in the LAMB3 gene can impair these processes. * Therefore, targeting laminins and their signaling pathways is an emerging therapeutic strategy for skin disorders.

Genular Protein ID: 2329031875

Symbol: LAMB3_HUMAN

Name: Laminin subunit beta-3

UniProtKB Accession Codes:

Q13751 D3DT88 O14947 Q14733 Q9UJK4 Q9UJL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7512558

Title: The complete primary structure for a novel laminin chain, the laminin B1k chain.

PubMed ID: 7512558

DOI: 10.1016/s0021-9258(19)78093-4

PubMed ID: 7774918

Title: Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa.

PubMed ID: 7774918

DOI: 10.1016/0888-7543(95)80125-6

PubMed ID: 8530036

Title: Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization.

PubMed ID: 8530036

DOI: 10.1006/geno.1995.1141

PubMed ID: 11296269

Title: In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa.

PubMed ID: 11296269

DOI: 10.1073/pnas.091484998

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19275936

Title: ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.

PubMed ID: 19275936

DOI: 10.1016/j.matbio.2009.02.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23958762

Title: LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta.

PubMed ID: 23958762

DOI: 10.1177/0022034513502054

PubMed ID: 23632796

Title: Whole-exome sequencing, without prior linkage, identifies a mutation in LAMB3 as a cause of dominant hypoplastic amelogenesis imperfecta.

PubMed ID: 23632796

DOI: 10.1038/ejhg.2013.76

PubMed ID: 7550237

Title: Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3).

PubMed ID: 7550237

DOI: 10.1002/humu.1380060115

PubMed ID: 9767254

Title: E210K mutation in the gene encoding the beta3 chain of laminin-5 (LAMB3) is predictive of a phenotype of generalized atrophic benign epidermolysis bullosa.

PubMed ID: 9767254

DOI: 10.1046/j.1365-2133.1998.02377.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17476356

Title: Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3.

PubMed ID: 17476356

DOI: 10.1172/jci30465

Sequence Information:

  • Length: 1172
  • Mass: 129572
  • Checksum: 61BC1A60BBD4FA05
  • Sequence:
    • MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT KPETYCTQYG 
EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRWWQSQND VNPVSLQLDL DRRFQLQEVM 
MEFQGPMPAG MLIERSSDFG KTWRVYQYLA ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP 
NARLNGGKVQ LNLMDLVSGI PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA 
VSQLRLQGSC FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR 
PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT EGKNCERCQL 
HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV CKEHVQGERC DLCKPGFTGL 
TYANPQGCHR CDCNILGSRR DMPCDEESGR CLCLPNVVGP KCDQCAPYHW KLASGQGCEP 
CACDPHNSLS PQCNQFTGQC PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG 
TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG 
RLRNATASLW SGPGLEDRGL ASRILDAKSK IEQIRAVLSS PAVTEQEVAQ VASAILSLRR 
TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR EQFEKISSAD PSGAFRMLST 
AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL 
TPTFNKLCGN SRQMACTPIS CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR 
GFNAQLQRTR QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT 
DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS QTKQDIARAR 
RLQAEAEEAR SRAHAVEGQV EDVVGNLRQG TVALQEAQDT MQGTSRSLRL IQDRVAEVQQ 
VLRPAEKLVT SMTKQLGDFW TRMEELRHQA RQQGAEAVQA QQLAEGASEQ ALSAQEGFER 
IKQKYAELKD RLGQSSMLGE QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI 
MLRSADLTGL EKRVEQIRDH INGRVLYYAT CK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.