Details for: LAMB3

Gene ID: 3914

Symbol: LAMB3

Ensembl ID: ENSG00000196878

Description: laminin subunit beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.0142
    Cell Significance Index: -16.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.8824
    Cell Significance Index: -15.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9938
    Cell Significance Index: -15.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3906
    Cell Significance Index: -16.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 8.7842
    Cell Significance Index: 239.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 7.3169
    Cell Significance Index: 99.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.1817
    Cell Significance Index: 321.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.1065
    Cell Significance Index: 91.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.6729
    Cell Significance Index: 166.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.4088
    Cell Significance Index: 73.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.2207
    Cell Significance Index: 92.8000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.8366
    Cell Significance Index: 17.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0911
    Cell Significance Index: 257.1200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.0133
    Cell Significance Index: 17.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6403
    Cell Significance Index: -3.5900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.6101
    Cell Significance Index: 3.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1235
    Cell Significance Index: 202.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0706
    Cell Significance Index: 138.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0219
    Cell Significance Index: 28.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9550
    Cell Significance Index: 521.5500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.9516
    Cell Significance Index: 2.8300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.8878
    Cell Significance Index: 5.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8835
    Cell Significance Index: 31.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8254
    Cell Significance Index: 11.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8071
    Cell Significance Index: 558.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6596
    Cell Significance Index: 65.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6246
    Cell Significance Index: 276.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5498
    Cell Significance Index: 11.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3170
    Cell Significance Index: 22.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2863
    Cell Significance Index: 4.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2761
    Cell Significance Index: 6.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2539
    Cell Significance Index: 229.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2528
    Cell Significance Index: 6.3200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2399
    Cell Significance Index: 2.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2058
    Cell Significance Index: 4.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1600
    Cell Significance Index: 7.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1564
    Cell Significance Index: 11.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1231
    Cell Significance Index: 14.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1092
    Cell Significance Index: 20.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0733
    Cell Significance Index: 14.7000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0497
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0283
    Cell Significance Index: 3.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0141
    Cell Significance Index: 10.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0027
    Cell Significance Index: 0.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0082
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0126
    Cell Significance Index: -23.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0153
    Cell Significance Index: -23.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0172
    Cell Significance Index: -23.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0231
    Cell Significance Index: -4.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0273
    Cell Significance Index: -17.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0277
    Cell Significance Index: -3.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0358
    Cell Significance Index: -4.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0439
    Cell Significance Index: -19.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0489
    Cell Significance Index: -10.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0515
    Cell Significance Index: -14.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0522
    Cell Significance Index: -8.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0574
    Cell Significance Index: -1.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0590
    Cell Significance Index: -8.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0592
    Cell Significance Index: -0.5500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0716
    Cell Significance Index: -1.2300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0861
    Cell Significance Index: -0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0970
    Cell Significance Index: -9.9100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0980
    Cell Significance Index: -0.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1090
    Cell Significance Index: -5.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1165
    Cell Significance Index: -16.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1343
    Cell Significance Index: -1.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1401
    Cell Significance Index: -5.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1467
    Cell Significance Index: -3.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1572
    Cell Significance Index: -8.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1611
    Cell Significance Index: -16.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1637
    Cell Significance Index: -10.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1854
    Cell Significance Index: -21.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1875
    Cell Significance Index: -14.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2046
    Cell Significance Index: -2.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2231
    Cell Significance Index: -17.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2687
    Cell Significance Index: -18.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2802
    Cell Significance Index: -17.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2931
    Cell Significance Index: -10.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2967
    Cell Significance Index: -13.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3129
    Cell Significance Index: -8.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3195
    Cell Significance Index: -20.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3407
    Cell Significance Index: -19.1200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.3441
    Cell Significance Index: -3.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3520
    Cell Significance Index: -9.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3575
    Cell Significance Index: -18.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3577
    Cell Significance Index: -15.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3788
    Cell Significance Index: -13.2700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.4034
    Cell Significance Index: -3.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4034
    Cell Significance Index: -10.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4146
    Cell Significance Index: -4.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4242
    Cell Significance Index: -4.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4268
    Cell Significance Index: -16.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4869
    Cell Significance Index: -12.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4908
    Cell Significance Index: -15.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4916
    Cell Significance Index: -13.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Laminin subunit beta 3 exhibits several key characteristics that make it an essential component of the ECM. These include: 1. **Structural role**: LAMB3 forms part of the laminin-5 complex, which provides structural support and stability to tissues. 2. **Cell adhesion**: Laminin subunit beta 3 interacts with integrins and other cell surface receptors to facilitate cell adhesion and migration. 3. **Signal transduction**: LAMB3 can interact with various signaling molecules, including the Met receptor tyrosine kinase, to regulate cellular processes such as proliferation, differentiation, and survival. 4. **Cell junction organization**: Laminin subunit beta 3 is involved in the formation and organization of cell junctions, which are critical for maintaining tissue integrity and function. **Pathways and Functions** Laminin subunit beta 3 is involved in several key pathways and functions, including: 1. **Anchoring fibril formation**: LAMB3 is required for the formation of anchoring fibrils, which are critical for maintaining tissue integrity and function. 2. **Collagen formation**: Laminin subunit beta 3 interacts with collagen to regulate collagen fibril formation and organization. 3. **Cell-cell communication**: LAMB3 plays a role in cell-cell communication, facilitating the exchange of signals between cells. 4. **Cell adhesion**: Laminin subunit beta 3 interacts with integrins and other cell surface receptors to facilitate cell adhesion and migration. 5. **Signal transduction**: LAMB3 can interact with various signaling molecules, including the Met receptor tyrosine kinase, to regulate cellular processes such as proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of laminin subunit beta 3 has been implicated in various diseases and disorders, including: 1. **Alport syndrome**: A genetic disorder characterized by renal failure and hearing loss, caused by mutations in the COL4A3, COL4A4, and COL4A5 genes, which encode for laminin subunits. 2. **Ehlers-Danlos syndrome**: A group of genetic disorders characterized by skin hyperextensibility, joint hypermobility, and tissue fragility, caused by mutations in the COL5A1, COL5A2, and COL5A3 genes, which encode for collagen and laminin subunits. 3. **Cancer**: Laminin subunit beta 3 has been implicated in cancer progression and metastasis, as it can regulate cell adhesion, migration, and signaling. In conclusion, laminin subunit beta 3 is a critical component of the extracellular matrix, playing a vital role in maintaining tissue structure, facilitating cell adhesion, migration, and signaling, and regulating various biological processes. Dysregulation of LAMB3 has been implicated in various diseases and disorders, highlighting the importance of further research in this area.

Genular Protein ID: 2329031875

Symbol: LAMB3_HUMAN

Name: Laminin subunit beta-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7512558

Title: The complete primary structure for a novel laminin chain, the laminin B1k chain.

PubMed ID: 7512558

DOI: 10.1016/s0021-9258(19)78093-4

PubMed ID: 7774918

Title: Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa.

PubMed ID: 7774918

DOI: 10.1016/0888-7543(95)80125-6

PubMed ID: 8530036

Title: Chromosomal loci of 50 human keratinocyte cDNAs assigned by fluorescence in situ hybridization.

PubMed ID: 8530036

DOI: 10.1006/geno.1995.1141

PubMed ID: 11296269

Title: In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa.

PubMed ID: 11296269

DOI: 10.1073/pnas.091484998

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19275936

Title: ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.

PubMed ID: 19275936

DOI: 10.1016/j.matbio.2009.02.003

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23958762

Title: LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta.

PubMed ID: 23958762

DOI: 10.1177/0022034513502054

PubMed ID: 23632796

Title: Whole-exome sequencing, without prior linkage, identifies a mutation in LAMB3 as a cause of dominant hypoplastic amelogenesis imperfecta.

PubMed ID: 23632796

DOI: 10.1038/ejhg.2013.76

PubMed ID: 7550237

Title: Detection of sequence variants in the gene encoding the beta 3 chain of laminin 5 (LAMB3).

PubMed ID: 7550237

DOI: 10.1002/humu.1380060115

PubMed ID: 9767254

Title: E210K mutation in the gene encoding the beta3 chain of laminin-5 (LAMB3) is predictive of a phenotype of generalized atrophic benign epidermolysis bullosa.

PubMed ID: 9767254

DOI: 10.1046/j.1365-2133.1998.02377.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17476356

Title: Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3.

PubMed ID: 17476356

DOI: 10.1172/jci30465

Sequence Information:

  • Length: 1172
  • Mass: 129572
  • Checksum: 61BC1A60BBD4FA05
  • Sequence:
  • MRPFFLLCFA LPGLLHAQQA CSRGACYPPV GDLLVGRTRF LRASSTCGLT KPETYCTQYG 
    EWQMKCCKCD SRQPHNYYSH RVENVASSSG PMRWWQSQND VNPVSLQLDL DRRFQLQEVM 
    MEFQGPMPAG MLIERSSDFG KTWRVYQYLA ADCTSTFPRV RQGRPQSWQD VRCQSLPQRP 
    NARLNGGKVQ LNLMDLVSGI PATQSQKIQE VGEITNLRVN FTRLAPVPQR GYHPPSAYYA 
    VSQLRLQGSC FCHGHADRCA PKPGASAGPS TAVQVHDVCV CQHNTAGPNC ERCAPFYNNR 
    PWRPAEGQDA HECQRCDCNG HSETCHFDPA VFAASQGAYG GVCDNCRDHT EGKNCERCQL 
    HYFRNRRPGA SIQETCISCE CDPDGAVPGA PCDPVTGQCV CKEHVQGERC DLCKPGFTGL 
    TYANPQGCHR CDCNILGSRR DMPCDEESGR CLCLPNVVGP KCDQCAPYHW KLASGQGCEP 
    CACDPHNSLS PQCNQFTGQC PCREGFGGLM CSAAAIRQCP DRTYGDVATG CRACDCDFRG 
    TEGPGCDKAS GRCLCRPGLT GPRCDQCQRG YCNRYPVCVA CHPCFQTYDA DLREQALRFG 
    RLRNATASLW SGPGLEDRGL ASRILDAKSK IEQIRAVLSS PAVTEQEVAQ VASAILSLRR 
    TLQGLQLDLP LEEETLSLPR DLESLDRSFN GLLTMYQRKR EQFEKISSAD PSGAFRMLST 
    AYEQSAQAAQ QVSDSSRLLD QLRDSRREAE RLVRQAGGGG GTGSPKLVAL RLEMSSLPDL 
    TPTFNKLCGN SRQMACTPIS CPGELCPQDN GTACGSRCRG VLPRAGGAFL MAGQVAEQLR 
    GFNAQLQRTR QMIRAAEESA SQIQSSAQRL ETQVSASRSQ MEEDVRRTRL LIQQVRDFLT 
    DPDTDAATIQ EVSEAVLALW LPTDSATVLQ KMNEIQAIAA RLPNVDLVLS QTKQDIARAR 
    RLQAEAEEAR SRAHAVEGQV EDVVGNLRQG TVALQEAQDT MQGTSRSLRL IQDRVAEVQQ 
    VLRPAEKLVT SMTKQLGDFW TRMEELRHQA RQQGAEAVQA QQLAEGASEQ ALSAQEGFER 
    IKQKYAELKD RLGQSSMLGE QGARIQSVKT EAEELFGETM EMMDRMKDME LELLRGSQAI 
    MLRSADLTGL EKRVEQIRDH INGRVLYYAT CK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.