Details for: GALNT3

Gene ID: 2591

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: GALNT3

Ensembl ID: ENSG00000115339

Description: polypeptide N-acetylgalactosaminyltransferase 3

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mucous neck cell CL0000651
    CSI 24.64
    rCSI 35.51%
    PRS 83.92
  • small intestine goblet cell CL1000495
    CSI 21.22
    rCSI 46.47%
    PRS 82.14
  • colon goblet cell CL0009039
    CSI 14.06
    rCSI 33.42%
    PRS 82.55
  • corneal epithelial cell CL0000575
    CSI 11.97
    rCSI 34.23%
    PRS 84.03
  • pancreatic acinar cell CL0002064
    CSI 11.92
    rCSI 15.84%
    PRS 81.94
  • plasmablast CL0000980
    CSI 11.73
    rCSI 9.23%
    PRS 81.86
  • transit amplifying cell of colon CL0009011
    CSI 11.66
    rCSI 13.7%
    PRS 77.89
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 11.33
    rCSI 13.68%
    PRS 84.11
  • goblet cell CL0000160
    CSI 9.46
    rCSI 8.94%
    PRS 75.09
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 9.13
    rCSI 24.61%
    PRS 81.56
  • foveolar cell of stomach CL0002179
    CSI 8.59
    rCSI 18.29%
    PRS 83.39
  • ciliated epithelial cell CL0000067
    CSI 8.54
    rCSI 7.51%
    PRS 64.64
  • myoepithelial cell CL0000185
    CSI 7.26
    rCSI 18.36%
    PRS 81.68
  • intestine goblet cell CL0019031
    CSI 6.51
    rCSI 5.78%
    PRS 73.94
  • enteroendocrine cell CL0000164
    CSI 6.05
    rCSI 8.26%
    PRS 76.39
  • ependymal cell CL0000065
    CSI 5.83
    rCSI 11.83%
    PRS 54.12
  • fibroblast CL0000057
    CSI 5.64
    rCSI 16.23%
    PRS 73.44
  • nasal mucosa goblet cell CL0002480
    CSI 5.01
    rCSI 5.8%
    PRS 80.72
  • fallopian tube secretory epithelial cell CL4030006
    CSI 4.77
    rCSI 4.59%
    PRS 75.37
  • naive B cell CL0000788
    CSI 4.72
    rCSI 4.05%
    PRS 83.14
  • extravillous trophoblast CL0008036
    CSI 4.65
    rCSI 5.76%
    PRS 73.71
  • epithelial cell CL0000066
    CSI 4.47
    rCSI 6.87%
    PRS 66.63
  • mucosal invariant T cell CL0000940
    CSI 4.15
    rCSI 3.35%
    PRS 85.26
  • paneth cell CL0000510
    CSI 3.95
    rCSI 5.84%
    PRS 87.47
  • stem cell CL0000034
    CSI 3.77
    rCSI 3.63%
    PRS 68.63
  • enterocyte of epithelium of large intestine CL0002071
    CSI 3.74
    rCSI 19.66%
    PRS 82.77
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.74
    rCSI 11.11%
    PRS 85.05
  • melanocyte CL0000148
    CSI 3.65
    rCSI 2.7%
    PRS 68.99
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.64
    rCSI 2.82%
    PRS 79.56
  • secretory cell CL0000151
    CSI 3.55
    rCSI 3.7%
    PRS 75.58
  • multi-ciliated epithelial cell CL0005012
    CSI 3.43
    rCSI 3.42%
    PRS 69.7
  • BEST4+ enteroycte CL4030026
    CSI 3.43
    rCSI 4.27%
    PRS 77.3
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.39
    rCSI 8.78%
    PRS 71.09
  • basal cell CL0000646
    CSI 3.32
    rCSI 4.45%
    PRS 74.97
  • pulmonary ionocyte CL0017000
    CSI 3.22
    rCSI 3.92%
    PRS 82.86
  • enterocyte CL0000584
    CSI 3.2
    rCSI 5.15%
    PRS 75.92
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 3.18
    rCSI 6.01%
    PRS 88.04
  • pancreatic D cell CL0000173
    CSI 3.12
    rCSI 3.07%
    PRS 78.74
  • squamous epithelial cell CL0000076
    CSI 3.11
    rCSI 7.38%
    PRS 77.19
  • ciliated cell CL0000064
    CSI 3.06
    rCSI 4.95%
    PRS 71.34
  • ionocyte CL0005006
    CSI 2.95
    rCSI 3.17%
    PRS 76.92
  • Mueller cell CL0000636
    CSI 2.92
    rCSI 6.66%
    PRS 67.19
  • type B pancreatic cell CL0000169
    CSI 2.75
    rCSI 6.09%
    PRS 75.04
  • duct epithelial cell CL0000068
    CSI 2.72
    rCSI 3.97%
    PRS 80.98
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.66
    rCSI 4.13%
    PRS 80.81
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.64
    rCSI 6.69%
    PRS 65.99
  • renal alpha-intercalated cell CL0005011
    CSI 2.54
    rCSI 3.4%
    PRS 82.81
  • lung secretory cell CL1000272
    CSI 2.46
    rCSI 6.1%
    PRS 75.38
  • respiratory goblet cell CL0002370
    CSI 2.45
    rCSI 26.67%
    PRS 85.53
  • conjunctival epithelial cell CL1000432
    CSI 2.43
    rCSI 3.71%
    PRS 76.39
  • IgA plasma cell CL0000987
    CSI 2.43
    rCSI 2.48%
    PRS 85.2
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.35
    rCSI 3.34%
    PRS 72.5
  • acinar cell of salivary gland CL0002623
    CSI 2.35
    rCSI 54.73%
    PRS 89.34
  • epithelial cell of lung CL0000082
    CSI 2.33
    rCSI 1.94%
    PRS 76.56
  • granulocyte CL0000094
    CSI 2.31
    rCSI 3.53%
    PRS 84.08
  • peptic cell CL0000155
    CSI 2.29
    rCSI 22.49%
    PRS 88
  • colon epithelial cell CL0011108
    CSI 2.19
    rCSI 2.3%
    PRS 73.22
  • pancreatic A cell CL0000171
    CSI 2.08
    rCSI 2.18%
    PRS 79.23
  • lung ciliated cell CL1000271
    CSI 2.05
    rCSI 2.37%
    PRS 67.66
  • basophil CL0000767
    CSI 1.97
    rCSI 4.18%
    PRS 88.46
  • glandular epithelial cell CL0000150
    CSI 1.97
    rCSI 5.18%
    PRS 89.05
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.89
    rCSI 3.43%
    PRS 87.23
  • intestinal epithelial cell CL0002563
    CSI 1.84
    rCSI 1.93%
    PRS 73.75
  • tracheal goblet cell CL1000329
    CSI 1.82
    rCSI 3.98%
    PRS 84.29
  • mucus secreting cell CL0000319
    CSI 1.8
    rCSI 2.86%
    PRS 85.31
  • club cell CL0000158
    CSI 1.79
    rCSI 2.63%
    PRS 70.71
  • lung neuroendocrine cell CL1000223
    CSI 1.77
    rCSI 2.62%
    PRS 80.6
  • M cell of gut CL0000682
    CSI 1.73
    rCSI 1.84%
    PRS 82.04
  • intrahepatic cholangiocyte CL0002538
    CSI 1.65
    rCSI 3.96%
    PRS 81.35
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.63
    rCSI 1.94%
    PRS 91.09
  • keratinocyte CL0000312
    CSI 1.62
    rCSI 1.36%
    PRS 79.26
  • colonocyte CL1000347
    CSI 1.52
    rCSI 2.19%
    PRS 77.49
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.48
    rCSI 3.38%
    PRS 70.25
  • acinar cell CL0000622
    CSI 1.42
    rCSI 2.09%
    PRS 86.03
  • pancreatic ductal cell CL0002079
    CSI 1.4
    rCSI 2.73%
    PRS 79.27
  • mammary gland epithelial cell CL0002327
    CSI 1.4
    rCSI 4.9%
    PRS 85.11
  • epithelial cell of urethra CL1000296
    CSI 1.36
    rCSI 34.3%
    PRS 85.07
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.33
    rCSI 1.02%
    PRS 78.22
  • respiratory basal cell CL0002633
    CSI 1.29
    rCSI 1.34%
    PRS 80.77
  • transit amplifying cell CL0009010
    CSI 1.28
    rCSI 1.95%
    PRS 85.51
  • intestinal crypt stem cell of colon CL0009043
    CSI 1.25
    rCSI 9.41%
    PRS 87.31
  • intestinal tuft cell CL0019032
    CSI 1.17
    rCSI 1.78%
    PRS 80.12
  • basal cell of prostate epithelium CL0002341
    CSI 1.11
    rCSI 3.2%
    PRS 83.48
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.06
    rCSI 2.97%
    PRS 84.09
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 0.96
    rCSI 5.47%
    PRS 87.04
  • glial cell CL0000125
    CSI 0.89
    rCSI 3.38%
    PRS 66.55
  • luminal cell of prostate epithelium CL0002340
    CSI 0.88
    rCSI 4.76%
    PRS 84.36
  • deuterosomal cell CL4033044
    CSI 0.84
    rCSI 2.84%
    PRS 75.18
  • enteroendocrine cell of colon CL0009042
    CSI 0.67
    rCSI 3.12%
    PRS 86.42
  • respiratory epithelial cell CL0002368
    CSI 0.65
    rCSI 4.01%
    PRS 93.94
  • transit amplifying cell of small intestine CL0009012
    CSI 0.65
    rCSI 2.84%
    PRS 85.43
  • bronchial goblet cell CL1000312
    CSI 0.62
    rCSI 2.47%
    PRS 85.44
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.47
    rCSI 7.29%
    PRS 85.78
  • tracheobronchial serous cell CL0019001
    CSI 0.36
    rCSI 1.58%
    PRS 84.25
  • eosinophil CL0000771
    CSI 0.35
    rCSI 2.28%
    PRS 93.03

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [GALNT3](/details-gene/2591) (Polypeptide N-acetylgalactosaminyltransferase 3) is a protein-coding gene located on chromosome 2q24.3. It encodes a crucial glycosyltransferase enzyme that resides primarily in the Golgi apparatus. This enzyme, GalNAc-T3, initiates the process of O-linked glycosylation by catalyzing the transfer of N-acetyl-D-galactosamine (GalNAc) to serine and threonine residues on target polypeptides. Expression data indicates that [GALNT3](/details-gene/2591) is a highly significant marker for various secretory epithelial cells, particularly `mucous neck cell` ([CL0000651](/details-cell/CL0000651)) and `goblet cell` ([CL0000160](/details-cell/CL0000160)) lineages in the gastrointestinal tract, suggesting a primary role in mucin biosynthesis and the modification of other secreted proteins. Clinically, loss-of-function mutations in [GALNT3](/details-gene/2591) are causally linked to familial tumoral calcinosis ([211900](https://omim.org/entry/211900)) and hyperostosis-hyperphosphatemia syndrome ([601756](https://omim.org/entry/601756)), conditions caused by impaired O-glycosylation and subsequent dysregulation of Fibroblast Growth Factor 23 (FGF23) ([Link](https://doi.org/10.1038/ng1358); [Link](https://doi.org/10.1074/jbc.m602469200)). ## Cellular Roles and Expression Landscape The expression profile of [GALNT3](/details-gene/2591) strongly points to a specialized function in professional secretory cells. **Overall**, the gene exhibits its highest significance in cell types responsible for producing and secreting glycoproteins, particularly mucins. It is the top marker in `mucous neck cell` ([CL0000651](/details-cell/CL0000651)) (CSI: 24.64), `small intestine goblet cell` ([CL1000495](/details-cell/CL1000495)) (CSI: 21.22), and `colon goblet cell` ([CL0009039](/details-cell/CL0009039)) (CSI: 14.06). This enrichment extends to other glandular and mucosal cells, including `pancreatic acinar cell` ([CL0002064](/details-cell/CL0002064)), `corneal epithelial cell` ([CL0000575](/details-cell/CL0000575)), and `foveolar cell of stomach` ([CL0002179](/details-cell/CL0002179)). This pattern suggests [GALNT3](/details-gene/2591) is a key enzymatic component of the protein modification machinery that establishes the protective mucosal barriers in the digestive and respiratory tracts, as well as in other secretory tissues. Interestingly, [GALNT3](/details-gene/2591) also shows significant expression in immune cells involved in antibody production, such as the `plasmablast` ([CL0000980](/details-cell/CL0000980)), and in antigen-presenting cells like the `CD1c-positive myeloid dendritic cell` ([CL0002399](/details-cell/CL0002399)). This suggests a secondary, but potentially important, role in modulating immune functions through the glycosylation of secreted immunoglobulins, cytokines, or cell surface receptors. The high specificity of its expression in these distinct secretory lineages underscores its specialized role in post-translational protein modification. ## Pathways and Molecular Function [GALNT3](/details-gene/2591) encodes an enzyme with well-defined `polypeptide n-acetylgalactosaminyltransferase activity` ([GO:0004653](https://www.ebi.ac.uk/QuickGO/term/GO:0004653)), which requires `manganese ion binding` ([GO:0030145](https://www.ebi.ac.uk/QuickGO/term/GO:0030145)) for its catalytic function. Its activity is a foundational step in `protein o-linked glycosylation` ([GO:0006493](https://www.ebi.ac.uk/QuickGO/term/GO:0006493)), a process that occurs within the `Golgi apparatus` ([GO:0005794](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)). The functional consequences of this activity are broad, impacting processes from `carbohydrate metabolic process` ([GO:0005975](https://www.ebi.ac.uk/QuickGO/term/GO:0005975)) to the regulation of key signaling pathways. Reactome pathway analysis reinforces its central role in glycosylation, with explicit involvement in `O-linked glycosylation` ([R-HSA-5173105](https://reactome.org/content/detail/R-HSA-5173105)) and, more specifically, `O-linked glycosylation of mucins` ([R-HSA-913709](https://reactome.org/content/detail/R-HSA-913709)). This aligns perfectly with its high expression in mucin-producing cells. Critically, the annotations also highlight its role in human disease, as seen in pathways like `Defective galnt3 causes hftc` ([R-HSA-5083625](https://reactome.org/content/detail/R-HSA-5083625)). This is directly related to its role in the `Fibroblast growth factor receptor signaling pathway` ([GO:0008543](https://www.ebi.ac.uk/QuickGO/term/GO:0008543)), where it is responsible for the specific O-glycosylation of FGF23. This post-translational modification is essential for preventing FGF23 cleavage and allowing its secretion, a critical step in phosphate homeostasis ([Link](https://doi.org/10.1074/jbc.m602469200); [Link](https://doi.org/10.1038/s41589-019-0444-x)). ## Research Directions The well-defined enzymatic function and specific expression pattern of [GALNT3](/details-gene/2591) open several avenues for future research, particularly concerning its role in pathology beyond familial tumoral calcinosis. ### Testable Hypotheses 1. **Role in Gastric Cancer:** Given its high expression in gastric mucosal cells like `foveolar cell of stomach` ([CL0002179](/details-cell/CL0002179)) and a reported association with gastric carcinoma prognosis ([Link](https://doi.org/10.1111/j.1349-7006.2003.tb01348.x)), it is hypothesized that dysregulation of [GALNT3](/details-gene/2591) expression during malignant transformation leads to aberrant mucin glycosylation (glycoforms), which disrupts the protective mucosal barrier, alters cell signaling, and promotes tumor progression and invasion. 2. **Function in Humoral Immunity:** The significant expression of [GALNT3](/details-gene/2591) in `plasmablast` ([CL0000980](/details-cell/CL0000980)) suggests a role in modifying secreted antibodies. It is hypothesized that [GALNT3](/details-gene/2591) specifically glycosylates the hinge region of IgA subclasses at mucosal sites, and that this modification is critical for conferring resistance to microbial proteases and mediating proper effector functions within the gut lumen. ### Proposed Experiment To test the hypothesis regarding the role of [GALNT3](/details-gene/2591) in gastric cancer (Hypothesis 1), a multi-faceted approach using gastric organoids would be highly informative. CRISPR-Cas9 could be used to knock out [GALNT3](/details-gene/2591) in organoids derived from normal human gastric tissue. These knockout organoids, along with isogenic controls, could then be cultured under conditions that promote tumorigenesis (e.g., exposure to *Helicobacter pylori* extracts or oncogenic mutations). The impact of [GALNT3](/details-gene/2591) loss would be assessed by monitoring changes in organoid morphology, proliferation, and invasive potential using 3D Matrigel invasion assays. Furthermore, secreted proteins and cell lysates would be subjected to lectin blotting and mass spectrometry-based glycoproteomics to identify specific changes in mucin and other glycoprotein structures. ### Therapeutic Potential The therapeutic potential of targeting [GALNT3](/details-gene/2591) is context-dependent. For monogenic diseases like familial tumoral calcinosis, which result from loss-of-function mutations, a therapeutic strategy would involve enzyme activation or gene replacement therapy, though this remains challenging. Conversely, in pathologies potentially driven by its overexpression, such as certain cancers, [GALNT3](/details-gene/2591) could be a target for **inhibition**. As an intracellular Golgi-resident enzyme, it is best suited for targeting with specific small molecule inhibitors. The highly restricted expression pattern of [GALNT3](/details-gene/2591) may limit systemic off-target effects, but potential toxicity in the gastrointestinal tract and other secretory tissues would be a primary concern to evaluate.

Genular Protein ID: 2693094369

Symbol: GALT3_HUMAN

Name: Polypeptide N-acetylgalactosaminyltransferase 3

UniProtKB Accession Codes:

Q14435 Q53TG9 Q7Z476

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 2 CCDS 1 CDD 2 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663203

Title: cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase, GalNAc-T3.

PubMed ID: 8663203

DOI: 10.1074/jbc.271.29.17006

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9295285

Title: Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

PubMed ID: 9295285

DOI: 10.1074/jbc.272.38.23503

PubMed ID: 9394011

Title: Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

PubMed ID: 9394011

DOI: 10.1242/jcs.111.1.45

PubMed ID: 12708471

Title: Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma.

PubMed ID: 12708471

DOI: 10.1111/j.1349-7006.2003.tb01348.x

PubMed ID: 15133511

Title: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis.

PubMed ID: 15133511

DOI: 10.1038/ng1358

PubMed ID: 15599692

Title: Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders.

PubMed ID: 15599692

DOI: 10.1007/s00109-004-0610-8

PubMed ID: 16638743

Title: Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.

PubMed ID: 16638743

DOI: 10.1074/jbc.m602469200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31932717

Title: Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.

PubMed ID: 31932717

DOI: 10.1038/s41589-019-0444-x

Sequence Information:

  • Length: 633
  • Mass: 72610
  • Checksum: 3019B2DCCC19A584
  • Sequence:
    • MAHLKRLVKL HIKRHYHKKF WKLGAVIFFF IIVLVLMQRE VSVQYSKEES RMERNMKNKN 
KMLDLMLEAV NNIKDAMPKM QIGAPVRQNI DAGERPCLQG YYTAAELKPV LDRPPQDSNA 
PGASGKAFKT TNLSVEEQKE KERGEAKHCF NAFASDRISL HRDLGPDTRP PECIEQKFKR 
CPPLPTTSVI IVFHNEAWST LLRTVHSVLY SSPAILLKEI ILVDDASVDE YLHDKLDEYV 
KQFSIVKIVR QRERKGLITA RLLGATVATA ETLTFLDAHC ECFYGWLEPL LARIAENYTA 
VVSPDIASID LNTFEFNKPS PYGSNHNRGN FDWSLSFGWE SLPDHEKQRR KDETYPIKTP 
TFAGGLFSIS KEYFEYIGSY DEEMEIWGGE NIEMSFRVWQ CGGQLEIMPC SVVGHVFRSK 
SPHSFPKGTQ VIARNQVRLA EVWMDEYKEI FYRRNTDAAK IVKQKAFGDL SKRFEIKHRL 
QCKNFTWYLN NIYPEVYVPD LNPVISGYIK SVGQPLCLDV GENNQGGKPL IMYTCHGLGG 
NQYFEYSAQH EIRHNIQKEL CLHAAQGLVQ LKACTYKGHK TVVTGEQIWE IQKDQLLYNP 
FLKMCLSANG EHPSLVSCNP SDPLQKWILS QND