Details for: GALNT3

Gene ID: 2591

Symbol: GALNT3

Ensembl ID: ENSG00000115339

Description: polypeptide N-acetylgalactosaminyltransferase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.9136
    Cell Significance Index: -15.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.7439
    Cell Significance Index: -14.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.4055
    Cell Significance Index: -14.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.6161
    Cell Significance Index: -17.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.6377
    Cell Significance Index: -14.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.3524
    Cell Significance Index: -15.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2046
    Cell Significance Index: -19.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.3189
    Cell Significance Index: 49.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.1803
    Cell Significance Index: 68.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0637
    Cell Significance Index: 159.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5778
    Cell Significance Index: 74.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4700
    Cell Significance Index: 111.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4113
    Cell Significance Index: 55.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1180
    Cell Significance Index: 30.1500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.1148
    Cell Significance Index: 13.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6143
    Cell Significance Index: 43.9400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5861
    Cell Significance Index: 16.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5649
    Cell Significance Index: -3.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5575
    Cell Significance Index: 72.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4736
    Cell Significance Index: 13.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4700
    Cell Significance Index: 1327.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2579
    Cell Significance Index: 86.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1124
    Cell Significance Index: 200.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0686
    Cell Significance Index: 173.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0170
    Cell Significance Index: 110.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0038
    Cell Significance Index: 548.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0013
    Cell Significance Index: 25.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8793
    Cell Significance Index: 9.1000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.8386
    Cell Significance Index: 5.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8334
    Cell Significance Index: 39.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7837
    Cell Significance Index: 96.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6942
    Cell Significance Index: 19.4000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.6856
    Cell Significance Index: 7.4300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6824
    Cell Significance Index: 7.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6659
    Cell Significance Index: 65.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5155
    Cell Significance Index: 66.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4833
    Cell Significance Index: 36.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4764
    Cell Significance Index: 2.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4416
    Cell Significance Index: 84.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4131
    Cell Significance Index: 13.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3470
    Cell Significance Index: 69.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3372
    Cell Significance Index: 149.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2848
    Cell Significance Index: 20.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2776
    Cell Significance Index: 47.4000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2404
    Cell Significance Index: 2.4800
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.1640
    Cell Significance Index: 1.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1572
    Cell Significance Index: 5.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1444
    Cell Significance Index: 1.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1398
    Cell Significance Index: 3.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1100
    Cell Significance Index: 76.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0788
    Cell Significance Index: 11.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0555
    Cell Significance Index: 11.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0426
    Cell Significance Index: 4.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0367
    Cell Significance Index: 69.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0274
    Cell Significance Index: 20.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0239
    Cell Significance Index: 15.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0236
    Cell Significance Index: 8.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0192
    Cell Significance Index: 35.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0115
    Cell Significance Index: 0.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0101
    Cell Significance Index: 0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0090
    Cell Significance Index: 13.9200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0089
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0048
    Cell Significance Index: 3.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0086
    Cell Significance Index: -5.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0186
    Cell Significance Index: -0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0310
    Cell Significance Index: -14.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0330
    Cell Significance Index: -9.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0357
    Cell Significance Index: -7.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0403
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0523
    Cell Significance Index: -3.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0531
    Cell Significance Index: -6.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0543
    Cell Significance Index: -6.2200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0560
    Cell Significance Index: -0.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0580
    Cell Significance Index: -7.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0629
    Cell Significance Index: -7.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0963
    Cell Significance Index: -11.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1113
    Cell Significance Index: -2.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1137
    Cell Significance Index: -11.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1137
    Cell Significance Index: -7.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1242
    Cell Significance Index: -12.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1793
    Cell Significance Index: -10.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2055
    Cell Significance Index: -4.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2074
    Cell Significance Index: -16.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2184
    Cell Significance Index: -4.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2208
    Cell Significance Index: -16.9500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2328
    Cell Significance Index: -3.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2434
    Cell Significance Index: -13.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2525
    Cell Significance Index: -11.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2527
    Cell Significance Index: -3.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2543
    Cell Significance Index: -13.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2551
    Cell Significance Index: -12.8900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.2780
    Cell Significance Index: -1.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2845
    Cell Significance Index: -17.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2850
    Cell Significance Index: -17.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2950
    Cell Significance Index: -8.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2969
    Cell Significance Index: -10.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2991
    Cell Significance Index: -7.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **O-linked glycosylation**: GALNT3 catalyzes the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine residues on proteins, resulting in the formation of O-glycans. 2. **Glycosylation of mucins**: GALNT3 plays a critical role in the glycosylation of mucins, which are essential components of the epithelial barrier and play a key role in maintaining mucosal homeostasis. 3. **Cell signaling**: O-glycosylation of proteins by GALNT3 can modulate cell signaling pathways, including those mediated by fibroblast growth factor receptors (FGFRs) and receptor tyrosine kinases (RTKs). 4. **Glycosylation of proteins**: GALNT3 is involved in the glycosylation of a wide range of proteins, including those involved in immune response, cell differentiation, and spermatogenesis. **Pathways and Functions:** 1. **Glycosylation pathways**: GALNT3 is involved in the O-glycosylation of proteins, which is a critical step in the glycosylation process. 2. **Cell signaling pathways**: GALNT3 modulates cell signaling pathways, including those mediated by FGFRs and RTKs, which are essential for various cellular processes. 3. **Immune response**: GALNT3 plays a role in the immune response by regulating the glycosylation of proteins involved in immune cell function. 4. **Spermatogenesis**: GALNT3 is involved in the glycosylation of proteins essential for spermatogenesis, highlighting its importance in reproductive health. **Clinical Significance:** 1. **Diseases associated with aberrant glycosylation**: Defects in GALNT3 have been linked to various diseases, including those associated with aberrant glycosylation of proteins, such as HFTC (Heterotaxy-Related Fetal Tissue Congenital). 2. **Cancer**: Alterations in GALNT3 expression have been observed in various types of cancer, including colon, breast, and lung cancer. 3. **Neurological disorders**: GALNT3 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Reproductive health**: Defects in GALNT3 have been linked to reproductive abnormalities, including infertility and miscarriage. In conclusion, GALNT3 is a crucial enzyme involved in the post-translational modification of proteins through O-linked glycosylation. Its widespread expression and involvement in various cellular processes highlight its importance in maintaining cellular homeostasis. Defects in GALNT3 have been linked to various diseases, emphasizing the need for further research into the molecular mechanisms underlying its functions.

Genular Protein ID: 2693094369

Symbol: GALT3_HUMAN

Name: Polypeptide N-acetylgalactosaminyltransferase 3

UniProtKB Accession Codes:

Q14435 Q53TG9 Q7Z476

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 2 CCDS 1 CDD 2 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663203

Title: cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase, GalNAc-T3.

PubMed ID: 8663203

DOI: 10.1074/jbc.271.29.17006

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9295285

Title: Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

PubMed ID: 9295285

DOI: 10.1074/jbc.272.38.23503

PubMed ID: 9394011

Title: Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

PubMed ID: 9394011

DOI: 10.1242/jcs.111.1.45

PubMed ID: 12708471

Title: Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma.

PubMed ID: 12708471

DOI: 10.1111/j.1349-7006.2003.tb01348.x

PubMed ID: 15133511

Title: Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis.

PubMed ID: 15133511

DOI: 10.1038/ng1358

PubMed ID: 15599692

Title: Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders.

PubMed ID: 15599692

DOI: 10.1007/s00109-004-0610-8

PubMed ID: 16638743

Title: Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.

PubMed ID: 16638743

DOI: 10.1074/jbc.m602469200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 31932717

Title: Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.

PubMed ID: 31932717

DOI: 10.1038/s41589-019-0444-x

Sequence Information:

  • Length: 633
  • Mass: 72610
  • Checksum: 3019B2DCCC19A584
  • Sequence:
    • MAHLKRLVKL HIKRHYHKKF WKLGAVIFFF IIVLVLMQRE VSVQYSKEES RMERNMKNKN 
KMLDLMLEAV NNIKDAMPKM QIGAPVRQNI DAGERPCLQG YYTAAELKPV LDRPPQDSNA 
PGASGKAFKT TNLSVEEQKE KERGEAKHCF NAFASDRISL HRDLGPDTRP PECIEQKFKR 
CPPLPTTSVI IVFHNEAWST LLRTVHSVLY SSPAILLKEI ILVDDASVDE YLHDKLDEYV 
KQFSIVKIVR QRERKGLITA RLLGATVATA ETLTFLDAHC ECFYGWLEPL LARIAENYTA 
VVSPDIASID LNTFEFNKPS PYGSNHNRGN FDWSLSFGWE SLPDHEKQRR KDETYPIKTP 
TFAGGLFSIS KEYFEYIGSY DEEMEIWGGE NIEMSFRVWQ CGGQLEIMPC SVVGHVFRSK 
SPHSFPKGTQ VIARNQVRLA EVWMDEYKEI FYRRNTDAAK IVKQKAFGDL SKRFEIKHRL 
QCKNFTWYLN NIYPEVYVPD LNPVISGYIK SVGQPLCLDV GENNQGGKPL IMYTCHGLGG 
NQYFEYSAQH EIRHNIQKEL CLHAAQGLVQ LKACTYKGHK TVVTGEQIWE IQKDQLLYNP 
FLKMCLSANG EHPSLVSCNP SDPLQKWILS QND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.