Details for: BCAM

Gene ID: 4059

Symbol: BCAM

Ensembl ID: ENSG00000187244

Description: basal cell adhesion molecule (Lutheran blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.53
    Marker Score: 8891
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.24
    Marker Score: 4689
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3
    Marker Score: 2858
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.91
    Marker Score: 2070
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.91
    Marker Score: 7795
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.87
    Marker Score: 11070
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.81
    Marker Score: 7150
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.8
    Marker Score: 20852
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.73
    Marker Score: 3868
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.72
    Marker Score: 7401
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.66
    Marker Score: 3207
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.65
    Marker Score: 5296
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.61
    Marker Score: 22949.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.59
    Marker Score: 2439.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.55
    Marker Score: 5327
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.53
    Marker Score: 1689
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.52
    Marker Score: 87256
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.5
    Marker Score: 2004
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.48
    Marker Score: 4204
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.46
    Marker Score: 790
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.45
    Marker Score: 1269
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.38
    Marker Score: 3947
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.37
    Marker Score: 4454
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.32
    Marker Score: 9113
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.3
    Marker Score: 12105
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.23
    Marker Score: 1226
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.22
    Marker Score: 2254
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.2
    Marker Score: 2332
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.17
    Marker Score: 3691
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.13
    Marker Score: 1842
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.06
    Marker Score: 8589
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.06
    Marker Score: 3373
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.05
    Marker Score: 1764
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.94
    Marker Score: 456
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.92
    Marker Score: 19311
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.91
    Marker Score: 1112
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.85
    Marker Score: 2695
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.85
    Marker Score: 4511
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.84
    Marker Score: 6036
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.82
    Marker Score: 679
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.74
    Marker Score: 779
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.7
    Marker Score: 383
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.69
    Marker Score: 430.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.67
    Marker Score: 328
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.65
    Marker Score: 352
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.64
    Marker Score: 1158
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.63
    Marker Score: 391
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.62
    Marker Score: 1463
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.61
    Marker Score: 912
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.6
    Marker Score: 1658
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.56
    Marker Score: 2019
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.55
    Marker Score: 604
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.53
    Marker Score: 2060
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.53
    Marker Score: 5423
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.51
    Marker Score: 1353
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.5
    Marker Score: 439
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.48
    Marker Score: 23727
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.47
    Marker Score: 534
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.46
    Marker Score: 340
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.46
    Marker Score: 9527.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.44
    Marker Score: 579
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.44
    Marker Score: 1544
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.34
    Marker Score: 2158
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.33
    Marker Score: 1338
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.29
    Marker Score: 478.5
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.29
    Marker Score: 300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.28
    Marker Score: 975
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.28
    Marker Score: 326
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.25
    Marker Score: 520
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.23
    Marker Score: 534
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.22
    Marker Score: 660
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.22
    Marker Score: 2153
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.19
    Marker Score: 7085
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.17
    Marker Score: 2558
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.16
    Marker Score: 952
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.15
    Marker Score: 294
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.15
    Marker Score: 325
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.15
    Marker Score: 15408.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.13
    Marker Score: 273
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.12
    Marker Score: 399
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.12
    Marker Score: 423
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.09
    Marker Score: 4035
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.07
    Marker Score: 945
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.05
    Marker Score: 1135.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251733
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.02
    Marker Score: 470
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.02
    Marker Score: 205
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1
    Marker Score: 1067
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1
    Marker Score: 329
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1
    Marker Score: 401
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47976
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.99
    Marker Score: 1160
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.99
    Marker Score: 1567
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.98
    Marker Score: 648
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Marker Score: 2232.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.98
    Marker Score: 957.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458

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Other Information

**Key characteristics** - BCAM is a glycoprotein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in epithelial cells, where it is involved in cell-cell adhesion and cell migration. - BCAM is also expressed in endothelial cells, where it is involved in cell adhesion to the extracellular matrix. - It is also expressed in immune cells, where it is involved in cell adhesion and activation. **Pathways and functions** - BCAM is involved in cell-matrix adhesion by binding to the extracellular matrix protein laminin. - It is also involved in cell adhesion to the extracellular matrix by binding to other cell adhesion molecules, such as cadherins. - BCAM is involved in signaling by binding to the transmembrane signaling receptor laminin receptor. - It is involved in the regulation of cell migration by binding to the extracellular matrix and signaling through the integrin-linked signaling pathway. **Clinical significance** - Mutations in the BCAM gene have been linked to a number of human diseases, including cancer, cardiovascular disease, and kidney disease. - BCAM is a potential target for cancer therapy, as it is often overexpressed in cancer cells. - Targeting BCAM with antibodies or small molecules could be a promising new treatment for cancer.

Genular Protein ID: 3769318367

Symbol: BCAM_HUMAN

Name: Basal cell adhesion molecule

UniProtKB Accession Codes:

P50895 A8MYF9 A9YWT5 A9YWT6 Q86VC7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7777537

Title: The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver.

PubMed ID: 7777537

DOI: 10.1073/pnas.92.12.5496

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7954395

Title: Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily.

PubMed ID: 7954395

PubMed ID: 9166867

Title: Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms.

PubMed ID: 9166867

PubMed ID: 9192786

Title: Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism.

PubMed ID: 9192786

PubMed ID: 9616226

Title: Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin.

PubMed ID: 9616226

DOI: 10.1172/jci1204

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15975931

Title: Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5.

PubMed ID: 15975931

DOI: 10.1074/jbc.m503293200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17319831

Title: Different inactivating mutations in the LU genes of three individuals with the Lutheran-null phenotype.

PubMed ID: 17319831

DOI: 10.1111/j.1537-2995.2006.01141.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17638854

Title: The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3.

PubMed ID: 17638854

DOI: 10.1182/blood-2007-06-094748

Sequence Information:

  • Length: 628
  • Mass: 67405
  • Checksum: C88F4F5C640C3F5B
  • Sequence:
    • MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI LDCTPTGTHD 
HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP PYQLDSQGRL VLAEAQVGDE 
RDYVCVVRAG AAGTAEATAR LNVFAKPEAT EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA 
PKITWYRNGQ RLEVPVEMNP EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH 
YSLPEGRHGR LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE 
YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL SKTLELRVAY 
LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS TPLGDGPMLS LSSITFDSNG 
TYVCEASLPT VPVLSRTQNF TLLVQGSPEL KTAEIEPKAD GSWREGDEVT LICSARGHPD 
PKLSWSQLGG SPAEPIPGRQ GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV 
SPQTSQAGVA VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAPPP GEPGLSHSGS 
EQPEQTGLLM GGASGGARGG SGGFGDEC

Genular Protein ID: 4233784196

Symbol: A0A087WXM8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WXM8

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 7 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 4 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 588
  • Mass: 63694
  • Checksum: 5E61DACC360FB1FF
  • Sequence:
    • MEPPDAPAQA RGAPRLLLLA VLLAAHPDAQ AEVRLSVPPL VEVMRGKSVI LDCTPTGTHD 
HYMLEWFLTD RSGARPRLAS AEMQGSELQV TMHDTRGRSP PYQLDSQGRL VLAEAQVGDE 
RDYVCVVRAG AAGTAEATAR LNVFAKPEAT EVSPNKGTLS VMEDSAQEIA TCNSRNGNPA 
PKITWYRNGQ RLEVPVEMNP EGYMTSRTVR EASGLLSLTS TLYLRLRKDD RDASFHCAAH 
YSLPEGRHGR LDSPTFHLTL HYPTEHVQFW VGSPSTPAGW VREGDTVQLL CRGDGSPSPE 
YTLFRLQDEQ EEVLNVNLEG NLTLEGVTRG QSGTYGCRVE DYDAADDVQL SKTLELRVAY 
LDPLELSEGK VLSLPLNSSA VVNCSVHGLP TPALRWTKDS TPLGDGPMLS LSSITFDSNG 
TYVCEASLPT VPVLSRTQNF TLLVQGSPEL KTAEIEPKAD GSWREGDEVT LICSARGHPD 
PKLSWSQLGG SPAEPIPGRQ GWVSSSLTLK VTSALSRDGI SCEASNPHGN KRHVFHFGTV 
SPQTSQAGVA VMAVAVSVGL LLLVVAVFYC VRRKGGPCCR QRREKGAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.