Details for: MGST1

Gene ID: 4257

Symbol: MGST1

Ensembl ID: ENSG00000008394

Description: microsomal glutathione S-transferase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.69
    Marker Score: 4,552
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.83
    Marker Score: 3,781
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.37
    Marker Score: 1,597
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.96
    Marker Score: 20,838
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.86
    Marker Score: 68,454
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.82
    Marker Score: 2,511
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.81
    Marker Score: 6,963
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.79
    Marker Score: 24,701
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.57
    Marker Score: 12,666
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.23
    Marker Score: 15,854
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.19
    Marker Score: 1,783
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.18
    Marker Score: 5,117
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.14
    Marker Score: 788
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.11
    Marker Score: 2,046
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.07
    Marker Score: 16,519
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.82
    Marker Score: 45,287
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.78
    Marker Score: 761
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.77
    Marker Score: 1,153
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.77
    Marker Score: 3,232
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.76
    Marker Score: 8,657
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.74
    Marker Score: 2,157
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.73
    Marker Score: 20,324
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.7
    Marker Score: 1,168
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.7
    Marker Score: 57,567
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.69
    Marker Score: 10,378
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.66
    Marker Score: 945
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.59
    Marker Score: 8,474
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.57
    Marker Score: 3,790
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.56
    Marker Score: 22,076
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.56
    Marker Score: 1,489
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.52
    Marker Score: 19,663
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.48
    Marker Score: 716
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.47
    Marker Score: 2,103
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.41
    Marker Score: 4,270
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.4
    Marker Score: 598
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.38
    Marker Score: 598
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.38
    Marker Score: 2,502
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.38
    Marker Score: 3,778
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.37
    Marker Score: 5,633
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.33
    Marker Score: 1,950
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.28
    Marker Score: 1,112
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.24
    Marker Score: 10,756
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.23
    Marker Score: 9,637
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.23
    Marker Score: 2,689
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.22
    Marker Score: 714
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.22
    Marker Score: 14,254
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.21
    Marker Score: 5,568
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.19
    Marker Score: 9,453
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.15
    Marker Score: 494
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.11
    Marker Score: 73,213
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.11
    Marker Score: 13,463
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.1
    Marker Score: 673
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1
    Marker Score: 117,225
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.08
    Marker Score: 931
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.07
    Marker Score: 1,020
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.06
    Marker Score: 5,385
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.04
    Marker Score: 1,772
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.04
    Marker Score: 1,126
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.99
    Marker Score: 4,506
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.98
    Marker Score: 1,130
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.97
    Marker Score: 743
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.97
    Marker Score: 476
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.91
    Marker Score: 1,077
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.91
    Marker Score: 11,577
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.89
    Marker Score: 5,059
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.88
    Marker Score: 48,208
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.88
    Marker Score: 967
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.87
    Marker Score: 874
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.82
    Marker Score: 15,848
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.8
    Marker Score: 754
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.8
    Marker Score: 1,204
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.77
    Marker Score: 2,143
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.76
    Marker Score: 448
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.76
    Marker Score: 1,686
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.74
    Marker Score: 1,179
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.73
    Marker Score: 4,232
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.71
    Marker Score: 831
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.71
    Marker Score: 3,603
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.7
    Marker Score: 1,820
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.66
    Marker Score: 606
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.65
    Marker Score: 429
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.65
    Marker Score: 408
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.64
    Marker Score: 1,466
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.64
    Marker Score: 2,114
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.61
    Marker Score: 1,102
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.6
    Marker Score: 2,618
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.59
    Marker Score: 13,670
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.58
    Marker Score: 591
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.56
    Marker Score: 956
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.55
    Marker Score: 446
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.53
    Marker Score: 727
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.51
    Marker Score: 20,306
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.49
    Marker Score: 1,519
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.49
    Marker Score: 394
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.46
    Marker Score: 384
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,326
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.43
    Marker Score: 1,423
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.42
    Marker Score: 449
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.41
    Marker Score: 15,876
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.4
    Marker Score: 887

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MGST1 is a microsomal enzyme, meaning it is primarily located in the endoplasmic reticulum (ER), a crucial organelle involved in lipid metabolism and detoxification. The MGST1 enzyme catalyzes the conjugation of glutathione to a wide range of substrates, including xenobiotics, reactive oxygen species (ROS), and endogenous compounds. This process, known as glutathione conjugation, enhances the solubility and excretion of these compounds, thereby protecting cells from oxidative stress and damage. MGST1 is highly expressed in various cell types, including epithelial cells, immune cells, and cells involved in metabolism and detoxification. The gene is also highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions** MGST1 is involved in several key pathways, including: 1. **Glutathione conjugation**: MGST1 catalyzes the conjugation of glutathione to a wide range of substrates, including xenobiotics, ROS, and endogenous compounds. 2. **Cellular oxidant detoxification**: MGST1 helps to detoxify reactive oxygen species (ROS) and other oxidative stressors, protecting cells from damage. 3. **Immune response**: MGST1 is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Metabolism**: MGST1 plays a role in the metabolism of various endogenous compounds, including steroids and fatty acids. **Clinical Significance** Dysregulation of MGST1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of MGST1 has been observed in certain types of cancer, including lung, breast, and colon cancer. 2. **Neurodegenerative diseases**: MGST1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. **Metabolic disorders**: MGST1 plays a role in the regulation of glucose and lipid metabolism, and dysregulation of the gene has been linked to metabolic disorders, including obesity and insulin resistance. 4. **Toxicity**: MGST1 has been shown to play a role in the detoxification of certain toxins, including pesticides and heavy metals. In conclusion, the MGST1 gene plays a crucial role in detoxification, immune response, and metabolism. Dysregulation of the gene has been implicated in various diseases, highlighting the importance of understanding the functions and clinical significance of MGST1. Further research is needed to elucidate the mechanisms by which MGST1 regulates cellular homeostasis and to explore potential therapeutic strategies for the treatment of diseases associated with MGST1 dysregulation.

Genular Protein ID: 2217552980

Symbol: MGST1_HUMAN

Name: Microsomal glutathione S-transferase 1

UniProtKB Accession Codes:

P10620 A8K533 G5EA53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 1 EMBL 17 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3372534

Title: Gene expression of rat and human microsomal glutathione S-transferases.

PubMed ID: 3372534

DOI: 10.1016/s0021-9258(18)68495-9

PubMed ID: 8812420

Title: Structural organization of the human microsomal glutathione S-transferase gene (GST12).

PubMed ID: 8812420

DOI: 10.1006/geno.1996.0429

PubMed ID: 10524215

Title: Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene.

PubMed ID: 10524215

DOI: 10.1016/s0167-4781(99)00112-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 155
  • Mass: 17599
  • Checksum: 892A529C97E3C853
  • Sequence:
    • MVDLTQVMDD EVFMAFASYA TIILSKMMLM STATAFYRLT RKVFANPEDC VAFGKGENAK 
KYLRTDDRVE RVRRAHLNDL ENIIPFLGIG LLYSLSGPDP STAILHFRLF VGARIYHTIA 
YLTPLPQPNR ALSFFVGYGV TLSMAYRLLK SKLYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.