Details for: MGST1

Gene ID: 4257

Symbol: MGST1

Ensembl ID: ENSG00000008394

Description: microsomal glutathione S-transferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 384.0684
    Cell Significance Index: -59.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.3863
    Cell Significance Index: -39.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 152.6650
    Cell Significance Index: -62.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.9479
    Cell Significance Index: -59.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 123.0401
    Cell Significance Index: -63.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.3562
    Cell Significance Index: -59.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.5013
    Cell Significance Index: -59.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7560
    Cell Significance Index: -60.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3369
    Cell Significance Index: -60.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 12.6109
    Cell Significance Index: 77.6100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 11.7792
    Cell Significance Index: 79.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.4256
    Cell Significance Index: 105.2200
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 10.3415
    Cell Significance Index: 13.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 9.6744
    Cell Significance Index: 162.9700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 7.8723
    Cell Significance Index: 99.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.5916
    Cell Significance Index: 128.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.3662
    Cell Significance Index: 170.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 5.5782
    Cell Significance Index: 394.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.4414
    Cell Significance Index: 980.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.3549
    Cell Significance Index: 143.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.1851
    Cell Significance Index: 96.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.8643
    Cell Significance Index: 200.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.7913
    Cell Significance Index: 466.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.6043
    Cell Significance Index: 169.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.5121
    Cell Significance Index: 261.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.3543
    Cell Significance Index: 45.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1311
    Cell Significance Index: 621.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.0812
    Cell Significance Index: 398.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9432
    Cell Significance Index: 1061.2200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 1.8228
    Cell Significance Index: 7.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.6674
    Cell Significance Index: 1262.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5891
    Cell Significance Index: 95.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4094
    Cell Significance Index: 35.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.1721
    Cell Significance Index: 12.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1384
    Cell Significance Index: 503.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9538
    Cell Significance Index: 26.6600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.8696
    Cell Significance Index: 12.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7934
    Cell Significance Index: 129.0400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7859
    Cell Significance Index: 11.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7204
    Cell Significance Index: 20.6500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6373
    Cell Significance Index: 3.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6039
    Cell Significance Index: 26.7100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5836
    Cell Significance Index: 8.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5414
    Cell Significance Index: 92.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5265
    Cell Significance Index: 35.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5258
    Cell Significance Index: 19.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4777
    Cell Significance Index: 10.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4722
    Cell Significance Index: 426.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4628
    Cell Significance Index: 13.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4447
    Cell Significance Index: 8.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2927
    Cell Significance Index: 55.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2320
    Cell Significance Index: 7.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2006
    Cell Significance Index: 308.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1481
    Cell Significance Index: 18.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0798
    Cell Significance Index: 7.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0750
    Cell Significance Index: 26.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0581
    Cell Significance Index: 6.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0465
    Cell Significance Index: 34.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0426
    Cell Significance Index: 8.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0254
    Cell Significance Index: 46.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0179
    Cell Significance Index: 0.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0121
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0191
    Cell Significance Index: -11.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0237
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0275
    Cell Significance Index: -20.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0291
    Cell Significance Index: -54.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0360
    Cell Significance Index: -48.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0463
    Cell Significance Index: -29.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0592
    Cell Significance Index: -6.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0806
    Cell Significance Index: -45.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0847
    Cell Significance Index: -24.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1055
    Cell Significance Index: -12.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1406
    Cell Significance Index: -63.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2245
    Cell Significance Index: -47.2800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3179
    Cell Significance Index: -2.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3338
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3362
    Cell Significance Index: -38.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3807
    Cell Significance Index: -55.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4398
    Cell Significance Index: -6.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4621
    Cell Significance Index: -28.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5368
    Cell Significance Index: -63.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5712
    Cell Significance Index: -45.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5991
    Cell Significance Index: -62.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6522
    Cell Significance Index: -13.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7108
    Cell Significance Index: -43.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7127
    Cell Significance Index: -54.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7776
    Cell Significance Index: -25.4600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7823
    Cell Significance Index: -10.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8446
    Cell Significance Index: -29.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8816
    Cell Significance Index: -23.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9410
    Cell Significance Index: -16.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9556
    Cell Significance Index: -25.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0033
    Cell Significance Index: -64.7300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -1.0216
    Cell Significance Index: -8.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0233
    Cell Significance Index: -30.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1241
    Cell Significance Index: -63.0800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -1.1378
    Cell Significance Index: -7.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1972
    Cell Significance Index: -43.9500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.2091
    Cell Significance Index: -9.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MGST1 is a microsomal enzyme, meaning it is primarily located in the endoplasmic reticulum (ER), a crucial organelle involved in lipid metabolism and detoxification. The MGST1 enzyme catalyzes the conjugation of glutathione to a wide range of substrates, including xenobiotics, reactive oxygen species (ROS), and endogenous compounds. This process, known as glutathione conjugation, enhances the solubility and excretion of these compounds, thereby protecting cells from oxidative stress and damage. MGST1 is highly expressed in various cell types, including epithelial cells, immune cells, and cells involved in metabolism and detoxification. The gene is also highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions** MGST1 is involved in several key pathways, including: 1. **Glutathione conjugation**: MGST1 catalyzes the conjugation of glutathione to a wide range of substrates, including xenobiotics, ROS, and endogenous compounds. 2. **Cellular oxidant detoxification**: MGST1 helps to detoxify reactive oxygen species (ROS) and other oxidative stressors, protecting cells from damage. 3. **Immune response**: MGST1 is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Metabolism**: MGST1 plays a role in the metabolism of various endogenous compounds, including steroids and fatty acids. **Clinical Significance** Dysregulation of MGST1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of MGST1 has been observed in certain types of cancer, including lung, breast, and colon cancer. 2. **Neurodegenerative diseases**: MGST1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. **Metabolic disorders**: MGST1 plays a role in the regulation of glucose and lipid metabolism, and dysregulation of the gene has been linked to metabolic disorders, including obesity and insulin resistance. 4. **Toxicity**: MGST1 has been shown to play a role in the detoxification of certain toxins, including pesticides and heavy metals. In conclusion, the MGST1 gene plays a crucial role in detoxification, immune response, and metabolism. Dysregulation of the gene has been implicated in various diseases, highlighting the importance of understanding the functions and clinical significance of MGST1. Further research is needed to elucidate the mechanisms by which MGST1 regulates cellular homeostasis and to explore potential therapeutic strategies for the treatment of diseases associated with MGST1 dysregulation.

Genular Protein ID: 2217552980

Symbol: MGST1_HUMAN

Name: Microsomal glutathione S-transferase 1

UniProtKB Accession Codes:

P10620 A8K533 G5EA53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 17 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3372534

Title: Gene expression of rat and human microsomal glutathione S-transferases.

PubMed ID: 3372534

DOI: 10.1016/s0021-9258(18)68495-9

PubMed ID: 8812420

Title: Structural organization of the human microsomal glutathione S-transferase gene (GST12).

PubMed ID: 8812420

DOI: 10.1006/geno.1996.0429

PubMed ID: 10524215

Title: Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene.

PubMed ID: 10524215

DOI: 10.1016/s0167-4781(99)00112-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 155
  • Mass: 17599
  • Checksum: 892A529C97E3C853
  • Sequence:
    • MVDLTQVMDD EVFMAFASYA TIILSKMMLM STATAFYRLT RKVFANPEDC VAFGKGENAK 
KYLRTDDRVE RVRRAHLNDL ENIIPFLGIG LLYSLSGPDP STAILHFRLF VGARIYHTIA 
YLTPLPQPNR ALSFFVGYGV TLSMAYRLLK SKLYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.