Gene EFNA1 - ENSG00000169242 | NCBI Gene ID: 1942

Details for: EFNA1

Gene ID: 1942

Symbol: EFNA1

Ensembl ID: ENSG00000169242

Description: ephrin A1

Associated with

Developmental biology
(R-HSA-1266738)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Epha-mediated growth cone collapse
(R-HSA-3928663)
Nervous system development
(R-HSA-9675108)
Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Axon guidance
(GO:0007411)
Cell-cell signaling
(GO:0007267)
Cell migration
(GO:0016477)
Endocardial cushion to mesenchymal transition involved in heart valve formation
(GO:0003199)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Extracellular region
(GO:0005576)
Mitral valve morphogenesis
(GO:0003183)
Negative regulation of dendritic spine morphogenesis
(GO:0061002)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of mapk cascade
(GO:0043409)
Negative regulation of proteolysis involved in protein catabolic process
(GO:1903051)
Negative regulation of thymocyte apoptotic process
(GO:0070244)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notochord formation
(GO:0014028)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of angiogenesis
(GO:0045765)
Regulation of axonogenesis
(GO:0050770)
Regulation of blood vessel endothelial cell migration
(GO:0043535)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Side of membrane
(GO:0098552)
Signaling receptor binding
(GO:0005102)
Substrate adhesion-dependent cell spreading
(GO:0034446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.82
Marker Score: 3397
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.45
Marker Score: 1920
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.31
Marker Score: 2172
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.25
Marker Score: 8666.5
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.09
Marker Score: 3079
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.06
Marker Score: 6458
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.04
Marker Score: 10717
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.02
Marker Score: 1179
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.02
Marker Score: 3246
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.97
Marker Score: 3930
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.91
Marker Score: 858
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.87
Marker Score: 1030
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.85
Marker Score: 4207.5
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.83
Marker Score: 445
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.79
Marker Score: 7032
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.76
Marker Score: 3118
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.73
Marker Score: 1082
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.71
Marker Score: 11125
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.69
Marker Score: 418
Cell Name: lactocyte (CL0002325)
Fold Change: 1.65
Marker Score: 26447
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.6
Marker Score: 3642
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.52
Marker Score: 2349
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.52
Marker Score: 1519
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.5
Marker Score: 2178
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.47
Marker Score: 1548
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167864
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.45
Marker Score: 2308
Cell Name: enterocyte (CL0000584)
Fold Change: 1.44
Marker Score: 6901
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.38
Marker Score: 8794
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.36
Marker Score: 10643
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.35
Marker Score: 4992
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.29
Marker Score: 5585
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.29
Marker Score: 2183
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.29
Marker Score: 6933
Cell Name: malignant cell (CL0001064)
Fold Change: 1.28
Marker Score: 17140
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.27
Marker Score: 1094
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.27
Marker Score: 1319
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.27
Marker Score: 359
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.26
Marker Score: 2971
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.25
Marker Score: 291
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.23
Marker Score: 7903
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.23
Marker Score: 3115
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.17
Marker Score: 925
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.15
Marker Score: 1885
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 1.14
Marker Score: 276
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.14
Marker Score: 362
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.13
Marker Score: 530
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.13
Marker Score: 676
Cell Name: club cell (CL0000158)
Fold Change: 1.13
Marker Score: 1321
Cell Name: stem cell (CL0000034)
Fold Change: 1.13
Marker Score: 2673
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.12
Marker Score: 779
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.11
Marker Score: 930
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.1
Marker Score: 374
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.09
Marker Score: 1174
Cell Name: kidney cell (CL1000497)
Fold Change: 1.08
Marker Score: 720
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.08
Marker Score: 446
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16662.5
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.06
Marker Score: 522
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.04
Marker Score: 935
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251744
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.04
Marker Score: 333
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.04
Marker Score: 937
Cell Name: germ cell (CL0000586)
Fold Change: 1.04
Marker Score: 1810
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.03
Marker Score: 366
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.01
Marker Score: 7513.5
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.01
Marker Score: 967
Cell Name: secretory cell (CL0000151)
Fold Change: 1
Marker Score: 1829
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1
Marker Score: 515
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1
Marker Score: 232
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71764
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47987.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.98
Marker Score: 2404
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.98
Marker Score: 989
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.98
Marker Score: 1985
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.97
Marker Score: 280
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.97
Marker Score: 8362.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.94
Marker Score: 833
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.94
Marker Score: 271
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.93
Marker Score: 182
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5296
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.92
Marker Score: 492
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.89
Marker Score: 227
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.89
Marker Score: 208
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.88
Marker Score: 947
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.88
Marker Score: 254
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.87
Marker Score: 338
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.87
Marker Score: 208
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.86
Marker Score: 321
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.86
Marker Score: 1251
Cell Name: basal cell (CL0000646)
Fold Change: 0.86
Marker Score: 1110
Cell Name: peptic cell (CL0000155)
Fold Change: 0.86
Marker Score: 360
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.85
Marker Score: 579
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.84
Marker Score: 315.5

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**Key characteristics:** * EFNA1 is a secreted protein that is expressed in a variety of cell types. * It is a glycoprotein with a molecular weight of approximately 180 kDa. * It is a transmembrane protein that is expressed on endothelial cells, smooth muscle cells, and other cell types. * It is a key regulator of cell migration and adhesion. **Pathways and functions:** * EFNA1 signaling is involved in the regulation of angiogenesis. It is expressed in the developing blood-brain barrier and is essential for the migration and survival of endothelial cells. * It is also involved in the development and maintenance of the aortic valve. * It plays a role in the regulation of cell migration and adhesion in the heart. * It is involved in the regulation of epithelial to mesenchymal transition, which is essential for the formation of new tissues and organs. * It is also involved in the regulation of the immune system. **Clinical significance:** * Mutations in the EFNA1 gene have been linked to a number of human diseases, including heart valve disease, stroke, and cancer. * The development of drugs that target EFNA1 has shown promise in treating these diseases. **Additional information:** * EFNA1 is a highly conserved protein, with similar sequences found in organisms from humans to flies. * It is a member of the Eph family of cell adhesion molecules, which are characterized by their ability to bind to Eph receptors on adjacent cells. * It is a key regulator of cell migration and adhesion, and its dysfunction can lead to a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ephrin-A1

Genular Protein ID: 3874706741

Symbol: EFNA1_HUMAN

Name: Ephrin-A1

UniProtKB Accession Codes:

P20827 D3DV86 Q5SR60 Q5SR61 Q6I9T9 Q8N578

Database IDs:

Citations:

PubMed ID: 2233719

Title: A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.

PubMed ID: 2233719

DOI: 10.1128/mcb.10.11.5830-5838.1990

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 7838529

Title: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

PubMed ID: 7838529

PubMed ID: 17332925

Title: Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.

PubMed ID: 17332925

PubMed ID: 18794797

Title: Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor.

PubMed ID: 18794797

DOI: 10.1038/onc.2008.328

PubMed ID: 23661698

Title: Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase.

PubMed ID: 23661698

DOI: 10.1074/jbc.m113.464008

PubMed ID: 19525919

Title: Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

PubMed ID: 19525919

DOI: 10.1038/embor.2009.91

PubMed ID: 20505120

Title: Architecture of Eph receptor clusters.

PubMed ID: 20505120

DOI: 10.1073/pnas.1004148107

Sequence Information:

Length: 205
Mass: 23787
Checksum: EFF026BF4C12461F
Sequence:

MEFLWAPLLG LCCSLAAADR HTVFWNSSNP KFRNEDYTIH VQLNDYVDII CPHYEDHSVA 
DAAMEQYILY LVEHEEYQLC QPQSKDQVRW QCNRPSAKHG PEKLSEKFQR FTPFTLGKEF 
KEGHSYYYIS KPIHQHEDRC LRLKVTVSGK ITHSPQAHDN PQEKRLAADD PEVRVLHSIG 
HSAAPRLFPL AWTVLLLPLL LLQTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EFNA1

Associated with

Cells (max top 100)

Other Information

A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. PubMed ID: 2233719

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. PubMed ID: 7838529

Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. PubMed ID: 17332925

Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. PubMed ID: 18794797

Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase. PubMed ID: 23661698

Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. PubMed ID: 19525919

Architecture of Eph receptor clusters. PubMed ID: 20505120