Details for: EFNA1

Gene ID: 1942

Symbol: EFNA1

Ensembl ID: ENSG00000169242

Description: ephrin A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 188.4339
    Cell Significance Index: -29.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.8356
    Cell Significance Index: -28.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3602
    Cell Significance Index: -30.4300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.4583
    Cell Significance Index: 45.9000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.4163
    Cell Significance Index: 122.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.3643
    Cell Significance Index: -29.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6148
    Cell Significance Index: -10.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.8696
    Cell Significance Index: 52.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.7912
    Cell Significance Index: 196.9400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.6292
    Cell Significance Index: 22.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.5460
    Cell Significance Index: 160.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.2998
    Cell Significance Index: 71.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.0883
    Cell Significance Index: 230.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7131
    Cell Significance Index: 45.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1577
    Cell Significance Index: 350.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0879
    Cell Significance Index: 56.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0426
    Cell Significance Index: 36.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7340
    Cell Significance Index: 49.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6963
    Cell Significance Index: 219.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4467
    Cell Significance Index: 67.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4131
    Cell Significance Index: 84.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1659
    Cell Significance Index: 17.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1546
    Cell Significance Index: 81.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1521
    Cell Significance Index: 509.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0782
    Cell Significance Index: 213.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0723
    Cell Significance Index: 106.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0573
    Cell Significance Index: 49.6900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.0512
    Cell Significance Index: 2.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.9656
    Cell Significance Index: 16.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8489
    Cell Significance Index: 108.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6923
    Cell Significance Index: 7.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6536
    Cell Significance Index: 45.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5910
    Cell Significance Index: 15.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5658
    Cell Significance Index: 5.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4888
    Cell Significance Index: 266.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4851
    Cell Significance Index: 437.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3747
    Cell Significance Index: 67.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3280
    Cell Significance Index: 11.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2920
    Cell Significance Index: 35.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2830
    Cell Significance Index: 1.7100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2253
    Cell Significance Index: 2.0800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.1986
    Cell Significance Index: 1.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1966
    Cell Significance Index: 37.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1449
    Cell Significance Index: 4.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1301
    Cell Significance Index: 1.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1247
    Cell Significance Index: 94.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0719
    Cell Significance Index: 2.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0660
    Cell Significance Index: 11.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0409
    Cell Significance Index: 62.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0253
    Cell Significance Index: 46.7400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0163
    Cell Significance Index: 0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0135
    Cell Significance Index: 9.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0028
    Cell Significance Index: 3.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0182
    Cell Significance Index: -11.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0271
    Cell Significance Index: -9.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0274
    Cell Significance Index: -20.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0333
    Cell Significance Index: -18.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0406
    Cell Significance Index: -18.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0524
    Cell Significance Index: -1.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0548
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0600
    Cell Significance Index: -6.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0692
    Cell Significance Index: -13.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0703
    Cell Significance Index: -9.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0763
    Cell Significance Index: -8.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0830
    Cell Significance Index: -17.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0925
    Cell Significance Index: -26.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1014
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1024
    Cell Significance Index: -11.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1028
    Cell Significance Index: -2.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1059
    Cell Significance Index: -8.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1720
    Cell Significance Index: -25.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1760
    Cell Significance Index: -7.2100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1985
    Cell Significance Index: -4.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2294
    Cell Significance Index: -5.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2635
    Cell Significance Index: -31.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2818
    Cell Significance Index: -29.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3427
    Cell Significance Index: -27.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3808
    Cell Significance Index: -23.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4034
    Cell Significance Index: -21.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4102
    Cell Significance Index: -27.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4433
    Cell Significance Index: -27.9400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4449
    Cell Significance Index: -5.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4454
    Cell Significance Index: -13.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4678
    Cell Significance Index: -12.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4720
    Cell Significance Index: -30.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4835
    Cell Significance Index: -29.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5387
    Cell Significance Index: -30.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5677
    Cell Significance Index: -20.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5699
    Cell Significance Index: -25.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5771
    Cell Significance Index: -8.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6258
    Cell Significance Index: -13.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6447
    Cell Significance Index: -16.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6691
    Cell Significance Index: -23.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6694
    Cell Significance Index: -25.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7139
    Cell Significance Index: -14.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EFNA1 is a transmembrane protein belonging to the ephrin family, which consists of ligands for Eph receptors. The ephrin family is involved in repulsive and attractive cell-cell interactions, influencing the development and organization of tissues. EFNA1 is specifically expressed in various cell types, including type I pneumocytes, thyroid follicular cells, and endothelial cells. Its expression is also observed in progenitor cells of mammary luminal epithelium, bladder urothelial cells, colon epithelial cells, and epithelial cells of lung and prostate. **Pathways and Functions:** EFNA1 is involved in various signaling pathways, including: 1. **Angiogenesis:** EFNA1 regulates the migration and organization of endothelial cells, influencing the formation of blood vessels. 2. **Cell migration:** EFNA1 modulates the movement of cells, including endothelial cells, during tissue development and repair. 3. **Axon guidance:** EFNA1 plays a role in the development and maintenance of the nervous system, influencing the guidance of axons during neural development. 4. **Developmental biology:** EFNA1 is involved in the development of various tissues and organs, including the aortic valve, mitral valve, and notochord. 5. **Cell-cell signaling:** EFNA1 regulates cell-cell interactions, influencing the fate of cells and modulating the development of tissues. **Clinical Significance:** Dysregulation of EFNA1 has been implicated in various diseases, including: 1. **Cardiovascular diseases:** EFNA1 mutations have been associated with aortic valve morphogenesis defects, leading to conditions such as aortic stenosis. 2. **Neurological disorders:** EFNA1 has been implicated in the development of neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer:** EFNA1 has been shown to regulate cell adhesion and migration, influencing the progression of cancer. 4. **Thyroid disorders:** EFNA1 has been associated with thyroid disorders, including goiter and thyroid cancer. In conclusion, EFNA1 is a multifaceted gene involved in various cellular signaling pathways and developmental processes. Its dysregulation has been implicated in various diseases, highlighting the importance of EFNA1 in maintaining tissue homeostasis and organ function. Further research is necessary to fully elucidate the mechanisms by which EFNA1 regulates cellular processes and to explore its potential as a therapeutic target for diseases associated with its dysregulation.

Genular Protein ID: 3874706741

Symbol: EFNA1_HUMAN

Name: Ephrin-A1

UniProtKB Accession Codes:

P20827 D3DV86 Q5SR60 Q5SR61 Q6I9T9 Q8N578

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2233719

Title: A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein.

PubMed ID: 2233719

DOI: 10.1128/mcb.10.11.5830-5838.1990

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 7838529

Title: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

PubMed ID: 7838529

PubMed ID: 17332925

Title: Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK.

PubMed ID: 17332925

PubMed ID: 18794797

Title: Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor.

PubMed ID: 18794797

DOI: 10.1038/onc.2008.328

PubMed ID: 23661698

Title: Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase.

PubMed ID: 23661698

DOI: 10.1074/jbc.m113.464008

PubMed ID: 19525919

Title: Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.

PubMed ID: 19525919

DOI: 10.1038/embor.2009.91

PubMed ID: 20505120

Title: Architecture of Eph receptor clusters.

PubMed ID: 20505120

DOI: 10.1073/pnas.1004148107

Sequence Information:

  • Length: 205
  • Mass: 23787
  • Checksum: EFF026BF4C12461F
  • Sequence:
    • MEFLWAPLLG LCCSLAAADR HTVFWNSSNP KFRNEDYTIH VQLNDYVDII CPHYEDHSVA 
DAAMEQYILY LVEHEEYQLC QPQSKDQVRW QCNRPSAKHG PEKLSEKFQR FTPFTLGKEF 
KEGHSYYYIS KPIHQHEDRC LRLKVTVSGK ITHSPQAHDN PQEKRLAADD PEVRVLHSIG 
HSAAPRLFPL AWTVLLLPLL LLQTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.