Details for: ZNF581

Gene ID: 51545

Symbol: ZNF581

Ensembl ID: ENSG00000171425

Description: zinc finger protein 581

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 92.6097
    Cell Significance Index: -14.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.1286
    Cell Significance Index: -15.4900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.8474
    Cell Significance Index: -17.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.4402
    Cell Significance Index: -16.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4150
    Cell Significance Index: -6.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.3211
    Cell Significance Index: -16.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.4861
    Cell Significance Index: -15.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.8634
    Cell Significance Index: -15.8600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 5.5978
    Cell Significance Index: 13.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2485
    Cell Significance Index: -14.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2219
    Cell Significance Index: -16.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5420
    Cell Significance Index: 181.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.4421
    Cell Significance Index: 24.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4353
    Cell Significance Index: 86.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3051
    Cell Significance Index: 10.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1781
    Cell Significance Index: 128.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0215
    Cell Significance Index: 557.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8624
    Cell Significance Index: 140.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7058
    Cell Significance Index: 96.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6894
    Cell Significance Index: 68.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6528
    Cell Significance Index: 8.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6296
    Cell Significance Index: 43.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6249
    Cell Significance Index: 18.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5598
    Cell Significance Index: 36.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5510
    Cell Significance Index: 5.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5388
    Cell Significance Index: 69.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5079
    Cell Significance Index: 6.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4827
    Cell Significance Index: 34.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4443
    Cell Significance Index: 9.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4310
    Cell Significance Index: 22.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4223
    Cell Significance Index: 186.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3832
    Cell Significance Index: 18.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3750
    Cell Significance Index: 4.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3299
    Cell Significance Index: 40.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3289
    Cell Significance Index: 11.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3274
    Cell Significance Index: 8.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3163
    Cell Significance Index: 60.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3085
    Cell Significance Index: 16.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3027
    Cell Significance Index: 13.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2945
    Cell Significance Index: 265.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2778
    Cell Significance Index: 47.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2717
    Cell Significance Index: 12.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2688
    Cell Significance Index: 48.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2541
    Cell Significance Index: 18.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2384
    Cell Significance Index: 6.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2248
    Cell Significance Index: 4.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1870
    Cell Significance Index: 5.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1668
    Cell Significance Index: 4.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0954
    Cell Significance Index: 12.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0852
    Cell Significance Index: 1.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0824
    Cell Significance Index: 2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0233
    Cell Significance Index: 0.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0168
    Cell Significance Index: 0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0021
    Cell Significance Index: 0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0058
    Cell Significance Index: -0.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0065
    Cell Significance Index: -1.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0102
    Cell Significance Index: -0.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0116
    Cell Significance Index: -4.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0128
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0164
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0205
    Cell Significance Index: -15.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0243
    Cell Significance Index: -13.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0344
    Cell Significance Index: -0.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0352
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0414
    Cell Significance Index: -25.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0519
    Cell Significance Index: -14.9300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0549
    Cell Significance Index: -0.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0571
    Cell Significance Index: -1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0584
    Cell Significance Index: -1.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0587
    Cell Significance Index: -1.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0736
    Cell Significance Index: -1.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0758
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0844
    Cell Significance Index: -9.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0857
    Cell Significance Index: -9.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0867
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0981
    Cell Significance Index: -20.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1438
    Cell Significance Index: -7.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1474
    Cell Significance Index: -21.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1700
    Cell Significance Index: -2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1708
    Cell Significance Index: -10.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1835
    Cell Significance Index: -2.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1986
    Cell Significance Index: -15.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2097
    Cell Significance Index: -3.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2103
    Cell Significance Index: -16.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2186
    Cell Significance Index: -13.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2329
    Cell Significance Index: -13.0700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2364
    Cell Significance Index: -1.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2372
    Cell Significance Index: -6.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2961
    Cell Significance Index: -1.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3242
    Cell Significance Index: -9.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3693
    Cell Significance Index: -7.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3863
    Cell Significance Index: -14.1800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4710
    Cell Significance Index: -6.7500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4812
    Cell Significance Index: -3.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4975
    Cell Significance Index: -7.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5009
    Cell Significance Index: -12.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5035
    Cell Significance Index: -7.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5073
    Cell Significance Index: -17.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF581 is a member of the zinc finger protein family, characterized by its ability to bind to specific DNA sequences and regulate transcription. This protein has a unique structure, consisting of a C-terminal zinc finger domain that facilitates DNA binding, and a N-terminal proline-rich region that mediates protein-protein interactions. ZNF581 is predominantly expressed in cells of the immune system, including hematopoietic cells, epithelial cells, and dendritic cells. **Pathways and Functions:** ZNF581 is involved in several signaling pathways, including: 1. **DNA-binding transcription factor activity**: ZNF581 regulates gene expression by binding to specific DNA sequences, thereby modulating the transcription of target genes. 2. **Metal ion binding**: The zinc finger domain of ZNF581 facilitates metal ion binding, which is essential for its DNA-binding activity. 3. **Regulation of transcription by RNA polymerase II**: ZNF581 interacts with RNA polymerase II to regulate the transcription of genes involved in immune responses. 4. **RNA polymerase II cis-regulatory region sequence-specific DNA binding**: ZNF581 binds to specific DNA sequences in the promoter region of target genes, regulating their expression. **Functions:** ZNF581 plays a critical role in maintaining immune homeostasis by regulating the expression of genes involved in immune responses, including: 1. **Immune cell development**: ZNF581 regulates the expression of genes involved in the development and differentiation of immune cells, such as T cells and dendritic cells. 2. **Cytokine production**: ZNF581 modulates the expression of cytokines, which are essential for immune responses, including inflammation and cell-mediated immunity. 3. **Antigen presentation**: ZNF581 regulates the expression of genes involved in antigen presentation, including major histocompatibility complex (MHC) molecules. **Clinical Significance:** Dysregulation of ZNF581 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: Aberrant expression of ZNF581 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: ZNF581 has been identified as a tumor suppressor gene in certain types of cancer, including leukemia and lymphoma. 3. **Inflammatory disorders**: ZNF581 has been implicated in inflammatory disorders, such as asthma and chronic obstructive pulmonary disease (COPD). In conclusion, ZNF581 is a transcription factor that plays a critical role in regulating gene expression in immune cells and maintaining immune homeostasis. Its dysregulation has been implicated in a range of immune-related disorders, highlighting the importance of further research into the mechanisms of ZNF581 and its potential therapeutic applications.

Genular Protein ID: 2754495322

Symbol: ZN581_HUMAN

Name: Zinc finger protein 581

UniProtKB Accession Codes:

Q9P0T4 B2RDM6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 197
  • Mass: 22010
  • Checksum: B62F1FAFD4829EE5
  • Sequence:
    • MLVLPSPCPQ PLAFSSVETM EGPPRRTCRS PEPGPSSSIG SPQASSPPRP NHYLLIDTQG 
VPYTVLVDEE SQREPGASGA PGQKKCYSCP VCSRVFEYMS YLQRHSITHS EVKPFECDIC 
GKAFKRASHL ARHHSIHLAG GGRPHGCPLC PRRFRDAGEL AQHSRVHSGE RPFQCPHCPR 
RFMEQNTLQK HTRWKHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.