Details for: NIBAN2
Gene ID: 64855
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NIBAN2
Ensembl ID: ENSG00000136830
Description: niban apoptosis regulator 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 34.31rCSI 81.43%PRS 79.69
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CSI 10.38rCSI 8.05%PRS 82.86
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CSI 10.16rCSI 15.52%PRS 79.49
-
CSI 8.31rCSI 10.11%PRS 85.75
-
CSI 7.72rCSI 19.59%PRS 69.58
-
CSI 7.5rCSI 19.4%PRS 74.64
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CSI 7.36rCSI 7.68%PRS 78.56
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CSI 6.3rCSI 16.58%PRS 90.69
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CSI 6.25rCSI 9.16%PRS 88.16
-
CSI 5.9rCSI 11.48%PRS 82.18
-
CSI 5.54rCSI 20.75%PRS 71.64
-
CSI 5.16rCSI 4.08%PRS 67.87
-
CSI 5.01rCSI 9.1%PRS 89.3
-
CSI 4.86rCSI 7.51%PRS 78.29
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CSI 4.79rCSI 4.02%PRS 82.25
-
CSI 4.76rCSI 6.33%PRS 84.78
-
CSI 4.68rCSI 3.6%PRS 82.03
-
CSI 4.66rCSI 24.47%PRS 84.86
-
CSI 4.42rCSI 6.04%PRS 79.03
-
CSI 4.36rCSI 3.87%PRS 76.89
-
CSI 4.33rCSI 5.02%PRS 83.12
-
CSI 3.75rCSI 11.12%PRS 87.82
-
CSI 3.26rCSI 5.05%PRS 83.43
-
CSI 3.06rCSI 3.7%PRS 86.66
-
CSI 3.04rCSI 3.18%PRS 76.62
-
CSI 3rCSI 3.28%PRS 81.24
-
CSI 2.97rCSI 5.14%PRS 70.79
-
CSI 2.75rCSI 10.97%PRS 87.26
-
CSI 2.72rCSI 2.53%PRS 79.97
-
CSI 2.7rCSI 5.89%PRS 86.33
-
CSI 2.66rCSI 6.33%PRS 84.73
-
CSI 2.59rCSI 7.26%PRS 86.33
-
CSI 2.48rCSI 3.63%PRS 83.91
-
CSI 2.47rCSI 3.62%PRS 73.72
-
CSI 2.44rCSI 3.76%PRS 68.95
-
CSI 2.41rCSI 4.59%PRS 88.65
-
CSI 2.38rCSI 5.56%PRS 89.61
-
CSI 2.38rCSI 1.97%PRS 79.85
-
CSI 2.33rCSI 3.56%PRS 87.6
-
CSI 2.29rCSI 6.18%PRS 84.15
-
CSI 2.27rCSI 3.98%PRS 72.93
-
CSI 2.24rCSI 2.4%PRS 80.46
-
CSI 2.23rCSI 4.62%PRS 75.97
-
CSI 2.22rCSI 3.02%PRS 87.54
-
CSI 2.21rCSI 6.37%PRS 85.57
-
CSI 2.21rCSI 3.14%PRS 75.93
-
CSI 2.15rCSI 3.49%PRS 74.25
-
CSI 2.07rCSI 3.38%PRS 68.74
-
CSI 2.07rCSI 5.87%PRS 75.36
-
CSI 1.99rCSI 4.54%PRS 73.13
-
CSI 1.94rCSI 2.49%PRS 82.58
-
CSI 1.93rCSI 19.06%PRS 85.12
-
CSI 1.91rCSI 1.84%PRS 72.38
-
CSI 1.88rCSI 2.37%PRS 88.16
-
CSI 1.85rCSI 3.3%PRS 87.7
-
CSI 1.85rCSI 1.62%PRS 68.37
-
CSI 1.83rCSI 1.68%PRS 86.81
-
CSI 1.79rCSI 1.87%PRS 76.79
-
CSI 1.76rCSI 4.37%PRS 78.84
-
CSI 1.76rCSI 1.76%PRS 73.08
-
CSI 1.76rCSI 3.87%PRS 82.89
-
CSI 1.75rCSI 1.81%PRS 83.46
-
CSI 1.73rCSI 1.66%PRS 78.51
-
CSI 1.72rCSI 3.67%PRS 85.58
-
CSI 1.71rCSI 4.71%PRS 74.27
-
CSI 1.7rCSI 3.79%PRS 86.16
-
CSI 1.67rCSI 9.53%PRS 88.09
-
CSI 1.63rCSI 2.59%PRS 72.18
-
CSI 1.56rCSI 6.29%PRS 78.87
-
CSI 1.55rCSI 2.03%PRS 89.47
-
CSI 1.52rCSI 2.19%PRS 86.08
-
CSI 1.52rCSI 4.34%PRS 86.09
-
CSI 1.49rCSI 2.38%PRS 82.91
-
CSI 1.48rCSI 1.71%PRS 71.47
-
CSI 1.47rCSI 2.33%PRS 87.81
-
CSI 1.43rCSI 3.42%PRS 83.42
-
CSI 1.41rCSI 3.72%PRS 85.78
-
CSI 1.4rCSI 1.73%PRS 77.12
-
CSI 1.31rCSI 2.47%PRS 87.14
-
CSI 1.31rCSI 2.76%PRS 90.22
-
CSI 1.3rCSI 4.4%PRS 77.09
-
CSI 1.29rCSI 1.86%PRS 80.05
-
CSI 1.26rCSI 1.9%PRS 84.4
-
CSI 1.25rCSI 2.21%PRS 84.33
-
CSI 1.22rCSI 13.28%PRS 87.39
-
CSI 1.19rCSI 7.01%PRS 85.28
-
CSI 1.17rCSI 3.75%PRS 76.47
-
CSI 1.11rCSI 8.15%PRS 87.37
-
CSI 1.1rCSI 5.09%PRS 90.93
-
CSI 0.97rCSI 5.97%PRS 94.91
-
CSI 0.95rCSI 5.46%PRS 76.09
-
CSI 0.94rCSI 2.74%PRS 78.72
-
CSI 0.88rCSI 4.35%PRS 86.98
-
CSI 0.83rCSI 2.21%PRS 71
-
CSI 0.81rCSI 3.51%PRS 86.28
-
CSI 0.78rCSI 5.82%PRS 89
-
CSI 0.7rCSI 3.78%PRS 86.96
-
CSI 0.62rCSI 14.46%PRS 91.02
-
CSI 0.57rCSI 2.02%PRS 83.28
-
CSI 0.44rCSI 2.54%PRS 83.16
-
CSI 0.2rCSI 4.5%PRS 86.7%
-
CSI 0.3rCSI 5.5%PRS 87.3%
-
CSI 0.3rCSI 2.5%PRS 73.3%
-
CSI 0.3rCSI 2.3%PRS 86.1%
-
CSI 0.4rCSI 2.5%PRS 83.2%
-
CSI 0.6rCSI 2.0%PRS 83.3%
-
CSI 0.6rCSI 14.5%PRS 91.0%
-
CSI 0.7rCSI 3.8%PRS 87.0%
-
CSI 0.8rCSI 5.8%PRS 89.0%
-
CSI 0.8rCSI 3.5%PRS 86.3%
-
CSI 0.8rCSI 2.2%PRS 71.0%
-
CSI 0.9rCSI 4.4%PRS 87.0%
-
CSI 0.9rCSI 2.7%PRS 78.7%
-
CSI 1.0rCSI 5.5%PRS 76.1%
-
CSI 1.0rCSI 6.0%PRS 94.9%
-
CSI 1.1rCSI 5.1%PRS 90.9%
-
CSI 1.1rCSI 8.2%PRS 87.4%
-
CSI 1.2rCSI 3.8%PRS 76.5%
-
CSI 1.2rCSI 7.0%PRS 85.3%
-
CSI 1.2rCSI 13.3%PRS 87.4%
-
CSI 1.3rCSI 2.2%PRS 84.3%
-
CSI 1.3rCSI 1.9%PRS 84.4%
-
CSI 1.3rCSI 1.9%PRS 80.1%
-
CSI 1.3rCSI 4.4%PRS 77.1%
-
CSI 1.3rCSI 2.8%PRS 90.2%
-
CSI 1.3rCSI 2.5%PRS 87.1%
-
CSI 1.4rCSI 1.7%PRS 77.1%
-
CSI 1.4rCSI 3.7%PRS 85.8%
-
CSI 1.4rCSI 3.4%PRS 83.4%
-
CSI 1.5rCSI 2.3%PRS 87.8%
-
CSI 1.5rCSI 1.7%PRS 71.5%
-
CSI 1.5rCSI 2.4%PRS 82.9%
-
CSI 1.5rCSI 4.3%PRS 86.1%
-
CSI 1.5rCSI 2.2%PRS 86.1%
-
CSI 1.6rCSI 2.0%PRS 89.5%
-
CSI 1.6rCSI 6.3%PRS 78.9%
-
CSI 1.6rCSI 2.6%PRS 72.2%
-
CSI 1.7rCSI 9.5%PRS 88.1%
-
CSI 1.7rCSI 3.8%PRS 86.2%
-
CSI 1.7rCSI 4.7%PRS 74.3%
-
CSI 1.7rCSI 3.7%PRS 85.6%
-
CSI 1.7rCSI 1.7%PRS 78.5%
-
CSI 1.8rCSI 1.8%PRS 83.5%
-
CSI 1.8rCSI 3.9%PRS 82.9%
-
CSI 1.8rCSI 1.8%PRS 73.1%
-
CSI 1.8rCSI 4.4%PRS 78.8%
-
CSI 1.8rCSI 1.9%PRS 76.8%
-
CSI 1.8rCSI 1.7%PRS 86.8%
-
CSI 1.9rCSI 1.6%PRS 68.4%
-
CSI 1.9rCSI 3.3%PRS 87.7%
-
CSI 1.9rCSI 2.4%PRS 88.2%
-
CSI 1.9rCSI 1.8%PRS 72.4%
-
CSI 1.9rCSI 19.1%PRS 85.1%
-
CSI 1.9rCSI 2.5%PRS 82.6%
-
CSI 2.0rCSI 4.5%PRS 73.1%
-
CSI 2.1rCSI 5.9%PRS 75.4%
-
CSI 2.1rCSI 3.4%PRS 68.7%
-
CSI 2.2rCSI 3.5%PRS 74.3%
-
CSI 2.2rCSI 3.1%PRS 75.9%
-
CSI 2.2rCSI 6.4%PRS 85.6%
-
CSI 2.2rCSI 3.0%PRS 87.5%
-
CSI 2.2rCSI 4.6%PRS 76.0%
-
CSI 2.2rCSI 2.4%PRS 80.5%
-
CSI 2.3rCSI 4.0%PRS 72.9%
-
CSI 2.3rCSI 6.2%PRS 84.2%
-
CSI 2.3rCSI 3.6%PRS 87.6%
-
CSI 2.4rCSI 2.0%PRS 79.9%
-
CSI 2.4rCSI 5.6%PRS 89.6%
-
CSI 2.4rCSI 4.6%PRS 88.7%
-
CSI 2.4rCSI 3.8%PRS 69.0%
-
CSI 2.5rCSI 3.6%PRS 73.7%
-
CSI 2.5rCSI 3.6%PRS 83.9%
-
CSI 2.6rCSI 7.3%PRS 86.3%
-
CSI 2.7rCSI 6.3%PRS 84.7%
-
CSI 2.7rCSI 5.9%PRS 86.3%
-
CSI 2.7rCSI 2.5%PRS 80.0%
-
CSI 2.8rCSI 11.0%PRS 87.3%
-
CSI 3.0rCSI 5.1%PRS 70.8%
-
CSI 3.0rCSI 3.3%PRS 81.2%
-
CSI 3.0rCSI 3.2%PRS 76.6%
-
CSI 3.1rCSI 3.7%PRS 86.7%
-
CSI 3.3rCSI 5.1%PRS 83.4%
-
CSI 3.8rCSI 11.1%PRS 87.8%
-
CSI 4.3rCSI 5.0%PRS 83.1%
-
CSI 4.4rCSI 3.9%PRS 76.9%
-
CSI 4.4rCSI 6.0%PRS 79.0%
-
CSI 4.7rCSI 24.5%PRS 84.9%
-
CSI 4.7rCSI 3.6%PRS 82.0%
-
CSI 4.8rCSI 6.3%PRS 84.8%
-
CSI 4.8rCSI 4.0%PRS 82.3%
-
CSI 4.9rCSI 7.5%PRS 78.3%
-
CSI 5.0rCSI 9.1%PRS 89.3%
-
CSI 5.2rCSI 4.1%PRS 67.9%
-
CSI 5.5rCSI 20.8%PRS 71.6%
-
CSI 5.9rCSI 11.5%PRS 82.2%
-
CSI 6.3rCSI 9.2%PRS 88.2%
-
CSI 6.3rCSI 16.6%PRS 90.7%
-
CSI 7.4rCSI 7.7%PRS 78.6%
-
CSI 7.5rCSI 19.4%PRS 74.6%
-
CSI 7.7rCSI 19.6%PRS 69.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 626730425
Symbol: NIBA2_HUMAN
Name: Meg-3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19362540
Title: Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.
PubMed ID: 19362540
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21148485
Title: FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells.
PubMed ID: 21148485
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 25807930
Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.
PubMed ID: 25807930
Sequence Information:
- Length: 746
- Mass: 84138
- Checksum: 2049835F08356944
- Sequence:
MGDVLSTHLD DARRQHIAEK TGKILTEFLQ FYEDQYGVAL FNSMRHEIEG TGLPQAQLLW RKVPLDERIV FSGNLFQHQE DSKKWRNRFS LVPHNYGLVL YENKAAYERQ VPPRAVINSA GYKILTSVDQ YLELIGNSLP GTTAKSGSAP ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC IRHCNNGIPE DSKVEGPAFT DAIRMYRQSK ELYGTWEMLC GNEVQILSNL VMEELGPELK AELGPRLKGK PQERQRQWIQ ISDAVYHMVY EQAKARFEEV LSKVQQVQPA MQAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSRLAYHPL KMQSCYEKME SLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET LLHQELGKGP TKEELCKSIQ RVLERVLKKY DYDSSSVRKR FFREALLQIS IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL QAVKEAAVQR KHNLYRDSMV MHNSDPNLHL LAEGAPIDWG EEYSNSGGGG SPSPSTPESA TLSEKRRRAK QVVSVVQDEE VGLPFEASPE SPPPASPDGV TEIRGLLAQG LRPESPPPAG PLLNGAPAGE SPQPKAAPEA SSPPASPLQH LLPGKAVDLG PPKPSDQETG EQVSSPSSHP ALHTTTEDSA GVQTEF