Details for: SPINT1

Gene ID: 6692

Symbol: SPINT1

Ensembl ID: ENSG00000166145

Description: serine peptidase inhibitor, Kunitz type 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.6933
    Cell Significance Index: -17.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 61.7205
    Cell Significance Index: -15.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.9684
    Cell Significance Index: -18.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.3541
    Cell Significance Index: -18.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.0468
    Cell Significance Index: -18.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4571
    Cell Significance Index: -17.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 10.0103
    Cell Significance Index: 267.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.7678
    Cell Significance Index: -18.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.2320
    Cell Significance Index: 48.1800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.9945
    Cell Significance Index: 11.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.8761
    Cell Significance Index: 253.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.4742
    Cell Significance Index: 27.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.8469
    Cell Significance Index: 104.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0533
    Cell Significance Index: 66.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.8383
    Cell Significance Index: 128.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7390
    Cell Significance Index: 1495.8500
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.4937
    Cell Significance Index: 13.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9051
    Cell Significance Index: 88.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7009
    Cell Significance Index: 126.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6096
    Cell Significance Index: 207.9500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.6059
    Cell Significance Index: 22.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5017
    Cell Significance Index: 34.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4575
    Cell Significance Index: 262.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3721
    Cell Significance Index: 20.5600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.3456
    Cell Significance Index: 13.8800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.3150
    Cell Significance Index: 7.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2662
    Cell Significance Index: 10.1100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1654
    Cell Significance Index: 7.1900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.0852
    Cell Significance Index: 11.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0824
    Cell Significance Index: 107.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0754
    Cell Significance Index: 50.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0286
    Cell Significance Index: 29.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0018
    Cell Significance Index: 123.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7480
    Cell Significance Index: 330.7300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.6396
    Cell Significance Index: 7.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6081
    Cell Significance Index: 12.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5923
    Cell Significance Index: 12.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5731
    Cell Significance Index: 40.5300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5655
    Cell Significance Index: 2.1300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4253
    Cell Significance Index: 4.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3988
    Cell Significance Index: 14.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3779
    Cell Significance Index: 10.5600
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.3565
    Cell Significance Index: 1.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3537
    Cell Significance Index: 11.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3144
    Cell Significance Index: 59.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2997
    Cell Significance Index: 51.1700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.2508
    Cell Significance Index: 5.2300
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.2251
    Cell Significance Index: 1.5800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2133
    Cell Significance Index: 1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0687
    Cell Significance Index: 52.0100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.0618
    Cell Significance Index: 0.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0274
    Cell Significance Index: 1.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0253
    Cell Significance Index: 18.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0208
    Cell Significance Index: 0.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0163
    Cell Significance Index: 2.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0120
    Cell Significance Index: 2.3800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0006
    Cell Significance Index: 0.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0043
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0048
    Cell Significance Index: -3.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0071
    Cell Significance Index: -4.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0099
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0126
    Cell Significance Index: -23.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0148
    Cell Significance Index: -22.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0172
    Cell Significance Index: -1.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0209
    Cell Significance Index: -6.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0211
    Cell Significance Index: -13.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0309
    Cell Significance Index: -3.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0356
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0360
    Cell Significance Index: -7.5800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0397
    Cell Significance Index: -0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0402
    Cell Significance Index: -14.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0415
    Cell Significance Index: -4.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0431
    Cell Significance Index: -19.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0536
    Cell Significance Index: -10.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0594
    Cell Significance Index: -8.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0604
    Cell Significance Index: -7.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1004
    Cell Significance Index: -14.5900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1114
    Cell Significance Index: -0.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1124
    Cell Significance Index: -2.8900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1188
    Cell Significance Index: -1.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1282
    Cell Significance Index: -5.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1343
    Cell Significance Index: -6.7900
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1415
    Cell Significance Index: -1.1700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1441
    Cell Significance Index: -2.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1700
    Cell Significance Index: -17.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2119
    Cell Significance Index: -16.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2268
    Cell Significance Index: -6.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2331
    Cell Significance Index: -8.1000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2509
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2541
    Cell Significance Index: -2.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2620
    Cell Significance Index: -16.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2655
    Cell Significance Index: -6.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2666
    Cell Significance Index: -20.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2700
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2744
    Cell Significance Index: -18.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPINT1 belongs to the Kunitz-type protease inhibitor family, which is characterized by their ability to inhibit serine proteases. The SPINT1 protein is a small, C-terminal half of the propeptide, which is cleaved off during processing to reveal the active protease inhibitor domain. This domain contains four conserved cysteine residues that form a stable disulfide bond, allowing the protein to bind to serine proteases and inhibit their activity. **Pathways and Functions:** SPINT1 is involved in various signaling pathways that regulate cell growth, differentiation, and survival. Some of the key pathways and functions of SPINT1 include: * **Negative regulation of neural precursor cell proliferation**: SPINT1 has been shown to inhibit the proliferation of neural precursor cells, suggesting a role in regulating the development of the nervous system. * **Signaling by Met**: SPINT1 interacts with the Met receptor tyrosine kinase, modulating its signaling activity and influencing cell growth and differentiation. * **Regulation of glial cell differentiation**: SPINT1 promotes the differentiation of glial cells, suggesting a role in the development and maintenance of the central nervous system. * **Inhibition of serine-type endopeptidase activity**: SPINT1 inhibits the activity of serine proteases, which are involved in various cellular processes, including cell growth, differentiation, and apoptosis. **Signaling Pathways:** SPINT1 is involved in various signaling pathways, including: * **Branching involved in labyrinthine layer morphogenesis**: SPINT1 regulates the development of the labyrinthine layer in the inner ear, a critical structure for hearing and balance. * **Cellular response to BMP stimulus**: SPINT1 modulates the response of cells to bone morphogenetic protein (BMP) signaling, influencing cell growth and differentiation. * **Met receptor activation**: SPINT1 interacts with the Met receptor tyrosine kinase, modulating its signaling activity and influencing cell growth and differentiation. * **Negative regulation of neural precursor cell proliferation**: SPINT1 inhibits the proliferation of neural precursor cells, regulating the development of the nervous system. **Clinical Significance:** Dysregulation of SPINT1 has been implicated in various human diseases, including: * **Cancer**: Altered expression of SPINT1 has been observed in various types of cancer, suggesting a role in tumorigenesis and cancer progression. * **Neurological disorders**: Dysregulation of SPINT1 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. * **Developmental disorders**: Abnormal expression of SPINT1 has been observed in developmental disorders, including congenital heart defects and cleft palate. In conclusion, SPINT1 is a serine peptidase inhibitor that plays a critical role in various developmental and regenerative processes across different tissues. Its dysregulation has been implicated in various human diseases, highlighting the importance of SPINT1 in human health and disease. Further research on SPINT1 is necessary to fully elucidate its mechanisms of action and its role in human disease.

Genular Protein ID: 1798608526

Symbol: SPIT1_HUMAN

Name: Kunitz-type protease inhibitor 1

UniProtKB Accession Codes:

O43278 Q7Z7D2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRIDE 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9045658

Title: Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.

PubMed ID: 9045658

DOI: 10.1074/jbc.272.10.6370

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373425

Title: Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk.

PubMed ID: 10373425

DOI: 10.1074/jbc.274.26.18237

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20977675

Title: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.

PubMed ID: 20977675

DOI: 10.1111/j.1742-4658.2010.07894.x

PubMed ID: 28710277

Title: Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.

PubMed ID: 28710277

DOI: 10.1074/jbc.m117.775999

PubMed ID: 15713485

Title: Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.

PubMed ID: 15713485

DOI: 10.1016/j.jmb.2004.12.048

Sequence Information:

  • Length: 529
  • Mass: 58398
  • Checksum: A87F286C23C73422
  • Sequence:
    • MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC LNSFTAGVPG 
FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA LVELQPDRGE DAIAACFLIN 
CLYEQNFVCK FAPREGFINY LTREVYRSYR QLRTQGFGGS GIPKAWAGID LKVQPQEPLV 
LKDVENTDWR LLRGDTDVRV ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV 
LSTKQTEDYC LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC 
RGVQGGPLRG SSGAQATFPQ GPSMERRHPV CSGTCQPTQF RCSNGCCIDS FLECDDTPNC 
PDASDEAACE KYTSGFDELQ RIHFPSDKGH CVDLPDTGLC KESIPRWYYN PFSEHCARFT 
YGGCYGNKNN FEEEQQCLES CRGISKKDVF GLRREIPIPS TGSVEMAVAV FLVICIVVVV 
AILGYCFFKN QRKDFHGHHH HPPPTPASST VSTTEDTEHL VYNHTTRPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.