Details for: SLC2A1

Gene ID: 6513

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SLC2A1

Ensembl ID: ENSG00000117394

Description: solute carrier family 2 member 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • extravillous trophoblast CL0008036
    CSI 30.92
    rCSI 38.26%
    PRS 75.54
  • cerebral cortex endothelial cell CL1001602
    CSI 30.13
    rCSI 52.11%
    PRS 68.95
  • placental villous trophoblast CL2000060
    CSI 28.09
    rCSI 43.41%
    PRS 76.77
  • retinal blood vessel endothelial cell CL0002585
    CSI 21.05
    rCSI 33.61%
    PRS 81.39
  • Mueller cell CL0000636
    CSI 18.31
    rCSI 41.78%
    PRS 69.16
  • retinal pigment epithelial cell CL0002586
    CSI 17.51
    rCSI 34.78%
    PRS 73.66
  • syncytiotrophoblast cell CL0000525
    CSI 17.18
    rCSI 49.49%
    PRS 84.43
  • stem cell CL0000034
    CSI 15.81
    rCSI 15.25%
    PRS 70.66
  • conjunctival epithelial cell CL1000432
    CSI 11.88
    rCSI 18.14%
    PRS 78.02
  • fallopian tube secretory epithelial cell CL4030006
    CSI 11.68
    rCSI 11.24%
    PRS 76.99
  • corneal epithelial cell CL0000575
    CSI 11.23
    rCSI 32.13%
    PRS 85.06
  • endothelial cell of placenta CL0009092
    CSI 9.18
    rCSI 45.24%
    PRS 85.69
  • vascular associated smooth muscle cell CL0000359
    CSI 8.55
    rCSI 27.72%
    PRS 75.65
  • ciliated epithelial cell CL0000067
    CSI 8.41
    rCSI 7.39%
    PRS 66.63
  • nasal mucosa goblet cell CL0002480
    CSI 8.05
    rCSI 9.33%
    PRS 81.71
  • basal cell CL0000646
    CSI 7.88
    rCSI 10.53%
    PRS 76.53
  • myofibroblast cell CL0000186
    CSI 7.54
    rCSI 10.45%
    PRS 75.21
  • intestine goblet cell CL0019031
    CSI 7.26
    rCSI 6.45%
    PRS 75.5
  • astrocyte of the cerebral cortex CL0002605
    CSI 7.15
    rCSI 16.03%
    PRS 60.29
  • perivascular cell CL4033054
    CSI 7.06
    rCSI 9.66%
    PRS 82.12
  • keratinocyte CL0000312
    CSI 6.8
    rCSI 5.7%
    PRS 80.81
  • smooth muscle cell CL0000192
    CSI 5.97
    rCSI 14.23%
    PRS 74.78
  • melanocyte CL0000148
    CSI 5.86
    rCSI 4.34%
    PRS 71.04
  • primitive red blood cell CL0002355
    CSI 5.84
    rCSI 31.52%
    PRS 84.71
  • erythrocyte CL0000232
    CSI 5.82
    rCSI 13.21%
    PRS 78.6
  • secretory cell CL0000151
    CSI 5.67
    rCSI 5.91%
    PRS 77.02
  • interstitial cell of Cajal CL0002088
    CSI 5.52
    rCSI 7.02%
    PRS 82.72
  • colon epithelial cell CL0011108
    CSI 5.35
    rCSI 5.61%
    PRS 75
  • goblet cell CL0000160
    CSI 5.24
    rCSI 4.95%
    PRS 76.58
  • mature B cell CL0000785
    CSI 5.02
    rCSI 4.37%
    PRS 87.22
  • plasmacytoid dendritic cell, human CL0001058
    CSI 5
    rCSI 3.49%
    PRS 81.01
  • mesodermal cell CL0000222
    CSI 4.88
    rCSI 5.86%
    PRS 75.4
  • pro-B cell CL0000826
    CSI 4.78
    rCSI 3.96%
    PRS 80.18
  • endothelial cell of vascular tree CL0002139
    CSI 4.7
    rCSI 25.7%
    PRS 74.36
  • duct epithelial cell CL0000068
    CSI 4.58
    rCSI 6.71%
    PRS 82.51
  • ependymal cell CL0000065
    CSI 4.5
    rCSI 9.13%
    PRS 56.12
  • epithelial cell of lung CL0000082
    CSI 4.47
    rCSI 3.71%
    PRS 78.31
  • ciliated cell CL0000064
    CSI 4.38
    rCSI 7.09%
    PRS 72.84
  • epithelial cell CL0000066
    CSI 4.31
    rCSI 6.63%
    PRS 67.96
  • erythroblast CL0000765
    CSI 4.27
    rCSI 11.33%
    PRS 84.09
  • precursor B cell CL0000817
    CSI 3.88
    rCSI 3.4%
    PRS 85.16
  • radial glial cell CL0000681
    CSI 3.84
    rCSI 5.33%
    PRS 76.44
  • club cell CL0000158
    CSI 3.84
    rCSI 5.62%
    PRS 72.17
  • fibroblast of lung CL0002553
    CSI 3.77
    rCSI 3.51%
    PRS 78.27
  • luminal cell of prostate epithelium CL0002340
    CSI 3.75
    rCSI 20.15%
    PRS 85.77
  • pancreatic D cell CL0000173
    CSI 3.73
    rCSI 3.66%
    PRS 80.63
  • neural crest cell CL0011012
    CSI 3.7
    rCSI 2.92%
    PRS 66.03
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.56
    rCSI 4.29%
    PRS 85.46
  • choroid plexus epithelial cell CL0000706
    CSI 3.53
    rCSI 5.79%
    PRS 67.14
  • bronchus fibroblast of lung CL2000093
    CSI 3.37
    rCSI 2.74%
    PRS 77.11
  • immature B cell CL0000816
    CSI 3.14
    rCSI 2.33%
    PRS 88.36
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.08
    rCSI 3.55%
    PRS 70.02
  • pancreatic A cell CL0000171
    CSI 3.05
    rCSI 3.2%
    PRS 81.23
  • enterocyte CL0000584
    CSI 2.94
    rCSI 4.74%
    PRS 77.27
  • respiratory suprabasal cell CL4033048
    CSI 2.91
    rCSI 3.73%
    PRS 81.14
  • intestinal epithelial cell CL0002563
    CSI 2.83
    rCSI 2.95%
    PRS 75.36
  • early lymphoid progenitor CL0000936
    CSI 2.82
    rCSI 2.48%
    PRS 82.78
  • multi-ciliated epithelial cell CL0005012
    CSI 2.81
    rCSI 2.8%
    PRS 71.43
  • glioblast CL0000030
    CSI 2.79
    rCSI 4.44%
    PRS 69.45
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.76
    rCSI 1.86%
    PRS 90.06
  • pulmonary ionocyte CL0017000
    CSI 2.76
    rCSI 3.36%
    PRS 84.24
  • retinal bipolar neuron CL0000748
    CSI 2.73
    rCSI 5.12%
    PRS 65.86
  • erythroid lineage cell CL0000764
    CSI 2.59
    rCSI 16.69%
    PRS 87.8
  • pancreatic ductal cell CL0002079
    CSI 2.59
    rCSI 5.04%
    PRS 80.95
  • M cell of gut CL0000682
    CSI 2.54
    rCSI 2.7%
    PRS 83.16
  • ionocyte CL0005006
    CSI 2.51
    rCSI 2.69%
    PRS 78.78
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.44
    rCSI 5.57%
    PRS 71.78
  • lung ciliated cell CL1000271
    CSI 2.3
    rCSI 2.65%
    PRS 69.66
  • chondrocyte CL0000138
    CSI 2.25
    rCSI 3.57%
    PRS 70.53
  • enteroendocrine cell CL0000164
    CSI 2.23
    rCSI 3.05%
    PRS 77.93
  • enteric smooth muscle cell CL0002504
    CSI 2.22
    rCSI 3.18%
    PRS 78.61
  • retinal cone cell CL0000573
    CSI 2.17
    rCSI 3.5%
    PRS 67.62
  • deuterosomal cell CL4033044
    CSI 2.15
    rCSI 7.27%
    PRS 76.27
  • respiratory hillock cell CL4030023
    CSI 1.92
    rCSI 3.43%
    PRS 86.64
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.88
    rCSI 1.7%
    PRS 75.9
  • retina horizontal cell CL0000745
    CSI 1.82
    rCSI 2.78%
    PRS 74.61
  • tendon cell CL0000388
    CSI 1.82
    rCSI 4.73%
    PRS 85.41
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.79
    rCSI 3.16%
    PRS 58.75
  • respiratory basal cell CL0002633
    CSI 1.76
    rCSI 1.82%
    PRS 82.05
  • Langerhans cell CL0000453
    CSI 1.74
    rCSI 2.65%
    PRS 88.85
  • dendritic cell, human CL0001056
    CSI 1.73
    rCSI 2.66%
    PRS 86.15
  • kidney epithelial cell CL0002518
    CSI 1.71
    rCSI 3.26%
    PRS 91.38
  • common dendritic progenitor CL0001029
    CSI 1.66
    rCSI 2.08%
    PRS 86.61
  • squamous epithelial cell CL0000076
    CSI 1.65
    rCSI 3.91%
    PRS 78.55
  • renal principal cell CL0005009
    CSI 1.57
    rCSI 4.08%
    PRS 79.11
  • tracheal goblet cell CL1000329
    CSI 1.51
    rCSI 3.29%
    PRS 85.17
  • Hofbauer cell CL3000001
    CSI 1.49
    rCSI 2.82%
    PRS 86.02
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.39
    rCSI 3.53%
    PRS 67.95
  • colon goblet cell CL0009039
    CSI 1.39
    rCSI 3.31%
    PRS 83.62
  • amacrine cell CL0000561
    CSI 1.35
    rCSI 3.91%
    PRS 67.07
  • stratified epithelial cell CL0000079
    CSI 1.26
    rCSI 7.79%
    PRS 87.26
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.21
    rCSI 3.12%
    PRS 73.01
  • stromal cell CL0000499
    CSI 1.16
    rCSI 3.27%
    PRS 72.76
  • pancreatic acinar cell CL0002064
    CSI 1.09
    rCSI 1.45%
    PRS 83.45
  • glial cell CL0000125
    CSI 1
    rCSI 3.79%
    PRS 68.58
  • pancreatic stellate cell CL0002410
    CSI 0.95
    rCSI 5.55%
    PRS 81.96
  • brain vascular cell CL4023072
    CSI 0.92
    rCSI 9.54%
    PRS 71.7
  • bronchial goblet cell CL1000312
    CSI 0.92
    rCSI 3.66%
    PRS 86.16
  • type EC enteroendocrine cell CL0000577
    CSI 0.9
    rCSI 3.21%
    PRS 82.33
  • respiratory epithelial cell CL0002368
    CSI 0.67
    rCSI 4.13%
    PRS 94.24
  • pluripotent stem cell CL0002248
    CSI 0.2
    rCSI 4.8%
    PRS 89.1%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.4
    rCSI 2.2%
    PRS 89.1%
  • erythroid progenitor cell CL0000038
    CSI 0.5
    rCSI 3.0%
    PRS 83.6%
  • respiratory epithelial cell CL0002368
    CSI 0.7
    rCSI 4.1%
    PRS 94.2%
  • type EC enteroendocrine cell CL0000577
    CSI 0.9
    rCSI 3.2%
    PRS 82.3%
  • bronchial goblet cell CL1000312
    CSI 0.9
    rCSI 3.7%
    PRS 86.2%
  • brain vascular cell CL4023072
    CSI 0.9
    rCSI 9.5%
    PRS 71.7%
  • pancreatic stellate cell CL0002410
    CSI 1.0
    rCSI 5.6%
    PRS 82.0%
  • glial cell CL0000125
    CSI 1.0
    rCSI 3.8%
    PRS 68.6%
  • pancreatic acinar cell CL0002064
    CSI 1.1
    rCSI 1.5%
    PRS 83.5%
  • stromal cell CL0000499
    CSI 1.2
    rCSI 3.3%
    PRS 72.8%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.2
    rCSI 3.1%
    PRS 73.0%
  • stratified epithelial cell CL0000079
    CSI 1.3
    rCSI 7.8%
    PRS 87.3%
  • amacrine cell CL0000561
    CSI 1.4
    rCSI 3.9%
    PRS 67.1%
  • colon goblet cell CL0009039
    CSI 1.4
    rCSI 3.3%
    PRS 83.6%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.4
    rCSI 3.5%
    PRS 68.0%
  • Hofbauer cell CL3000001
    CSI 1.5
    rCSI 2.8%
    PRS 86.0%
  • tracheal goblet cell CL1000329
    CSI 1.5
    rCSI 3.3%
    PRS 85.2%
  • renal principal cell CL0005009
    CSI 1.6
    rCSI 4.1%
    PRS 79.1%
  • squamous epithelial cell CL0000076
    CSI 1.7
    rCSI 3.9%
    PRS 78.6%
  • common dendritic progenitor CL0001029
    CSI 1.7
    rCSI 2.1%
    PRS 86.6%
  • kidney epithelial cell CL0002518
    CSI 1.7
    rCSI 3.3%
    PRS 91.4%
  • dendritic cell, human CL0001056
    CSI 1.7
    rCSI 2.7%
    PRS 86.2%
  • Langerhans cell CL0000453
    CSI 1.7
    rCSI 2.7%
    PRS 88.9%
  • respiratory basal cell CL0002633
    CSI 1.8
    rCSI 1.8%
    PRS 82.1%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.8
    rCSI 3.2%
    PRS 58.8%
  • tendon cell CL0000388
    CSI 1.8
    rCSI 4.7%
    PRS 85.4%
  • retina horizontal cell CL0000745
    CSI 1.8
    rCSI 2.8%
    PRS 74.6%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.9
    rCSI 1.7%
    PRS 75.9%
  • respiratory hillock cell CL4030023
    CSI 1.9
    rCSI 3.4%
    PRS 86.6%
  • deuterosomal cell CL4033044
    CSI 2.2
    rCSI 7.3%
    PRS 76.3%
  • retinal cone cell CL0000573
    CSI 2.2
    rCSI 3.5%
    PRS 67.6%
  • enteric smooth muscle cell CL0002504
    CSI 2.2
    rCSI 3.2%
    PRS 78.6%
  • enteroendocrine cell CL0000164
    CSI 2.2
    rCSI 3.1%
    PRS 77.9%
  • chondrocyte CL0000138
    CSI 2.3
    rCSI 3.6%
    PRS 70.5%
  • lung ciliated cell CL1000271
    CSI 2.3
    rCSI 2.7%
    PRS 69.7%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.4
    rCSI 5.6%
    PRS 71.8%
  • ionocyte CL0005006
    CSI 2.5
    rCSI 2.7%
    PRS 78.8%
  • M cell of gut CL0000682
    CSI 2.5
    rCSI 2.7%
    PRS 83.2%
  • pancreatic ductal cell CL0002079
    CSI 2.6
    rCSI 5.0%
    PRS 81.0%
  • erythroid lineage cell CL0000764
    CSI 2.6
    rCSI 16.7%
    PRS 87.8%
  • retinal bipolar neuron CL0000748
    CSI 2.7
    rCSI 5.1%
    PRS 65.9%
  • pulmonary ionocyte CL0017000
    CSI 2.8
    rCSI 3.4%
    PRS 84.2%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 2.8
    rCSI 1.9%
    PRS 90.1%
  • glioblast CL0000030
    CSI 2.8
    rCSI 4.4%
    PRS 69.5%
  • multi-ciliated epithelial cell CL0005012
    CSI 2.8
    rCSI 2.8%
    PRS 71.4%
  • early lymphoid progenitor CL0000936
    CSI 2.8
    rCSI 2.5%
    PRS 82.8%
  • intestinal epithelial cell CL0002563
    CSI 2.8
    rCSI 3.0%
    PRS 75.4%
  • respiratory suprabasal cell CL4033048
    CSI 2.9
    rCSI 3.7%
    PRS 81.1%
  • enterocyte CL0000584
    CSI 2.9
    rCSI 4.7%
    PRS 77.3%
  • pancreatic A cell CL0000171
    CSI 3.1
    rCSI 3.2%
    PRS 81.2%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.1
    rCSI 3.6%
    PRS 70.0%
  • immature B cell CL0000816
    CSI 3.1
    rCSI 2.3%
    PRS 88.4%
  • bronchus fibroblast of lung CL2000093
    CSI 3.4
    rCSI 2.7%
    PRS 77.1%
  • choroid plexus epithelial cell CL0000706
    CSI 3.5
    rCSI 5.8%
    PRS 67.1%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.6
    rCSI 4.3%
    PRS 85.5%
  • neural crest cell CL0011012
    CSI 3.7
    rCSI 2.9%
    PRS 66.0%
  • pancreatic D cell CL0000173
    CSI 3.7
    rCSI 3.7%
    PRS 80.6%
  • luminal cell of prostate epithelium CL0002340
    CSI 3.8
    rCSI 20.2%
    PRS 85.8%
  • fibroblast of lung CL0002553
    CSI 3.8
    rCSI 3.5%
    PRS 78.3%
  • club cell CL0000158
    CSI 3.8
    rCSI 5.6%
    PRS 72.2%
  • radial glial cell CL0000681
    CSI 3.8
    rCSI 5.3%
    PRS 76.4%
  • precursor B cell CL0000817
    CSI 3.9
    rCSI 3.4%
    PRS 85.2%
  • erythroblast CL0000765
    CSI 4.3
    rCSI 11.3%
    PRS 84.1%
  • epithelial cell CL0000066
    CSI 4.3
    rCSI 6.6%
    PRS 68.0%
  • ciliated cell CL0000064
    CSI 4.4
    rCSI 7.1%
    PRS 72.8%
  • epithelial cell of lung CL0000082
    CSI 4.5
    rCSI 3.7%
    PRS 78.3%
  • ependymal cell CL0000065
    CSI 4.5
    rCSI 9.1%
    PRS 56.1%
  • duct epithelial cell CL0000068
    CSI 4.6
    rCSI 6.7%
    PRS 82.5%
  • endothelial cell of vascular tree CL0002139
    CSI 4.7
    rCSI 25.7%
    PRS 74.4%
  • pro-B cell CL0000826
    CSI 4.8
    rCSI 4.0%
    PRS 80.2%
  • mesodermal cell CL0000222
    CSI 4.9
    rCSI 5.9%
    PRS 75.4%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 5.0
    rCSI 3.5%
    PRS 81.0%
  • mature B cell CL0000785
    CSI 5.0
    rCSI 4.4%
    PRS 87.2%
  • goblet cell CL0000160
    CSI 5.2
    rCSI 5.0%
    PRS 76.6%
  • colon epithelial cell CL0011108
    CSI 5.4
    rCSI 5.6%
    PRS 75.0%
  • interstitial cell of Cajal CL0002088
    CSI 5.5
    rCSI 7.0%
    PRS 82.7%
  • secretory cell CL0000151
    CSI 5.7
    rCSI 5.9%
    PRS 77.0%
  • erythrocyte CL0000232
    CSI 5.8
    rCSI 13.2%
    PRS 78.6%
  • primitive red blood cell CL0002355
    CSI 5.8
    rCSI 31.5%
    PRS 84.7%
  • melanocyte CL0000148
    CSI 5.9
    rCSI 4.3%
    PRS 71.0%
  • smooth muscle cell CL0000192
    CSI 6.0
    rCSI 14.2%
    PRS 74.8%
  • keratinocyte CL0000312
    CSI 6.8
    rCSI 5.7%
    PRS 80.8%
  • perivascular cell CL4033054
    CSI 7.1
    rCSI 9.7%
    PRS 82.1%
  • astrocyte of the cerebral cortex CL0002605
    CSI 7.2
    rCSI 16.0%
    PRS 60.3%
  • intestine goblet cell CL0019031
    CSI 7.3
    rCSI 6.5%
    PRS 75.5%
  • myofibroblast cell CL0000186
    CSI 7.5
    rCSI 10.5%
    PRS 75.2%
  • basal cell CL0000646
    CSI 7.9
    rCSI 10.5%
    PRS 76.5%
  • nasal mucosa goblet cell CL0002480
    CSI 8.1
    rCSI 9.3%
    PRS 81.7%
  • ciliated epithelial cell CL0000067
    CSI 8.4
    rCSI 7.4%
    PRS 66.6%
  • vascular associated smooth muscle cell CL0000359
    CSI 8.6
    rCSI 27.7%
    PRS 75.7%
  • endothelial cell of placenta CL0009092
    CSI 9.2
    rCSI 45.2%
    PRS 85.7%
  • corneal epithelial cell CL0000575
    CSI 11.2
    rCSI 32.1%
    PRS 85.1%
  • fallopian tube secretory epithelial cell CL4030006
    CSI 11.7
    rCSI 11.2%
    PRS 77.0%
  • conjunctival epithelial cell CL1000432
    CSI 11.9
    rCSI 18.1%
    PRS 78.0%
  • stem cell CL0000034
    CSI 15.8
    rCSI 15.3%
    PRS 70.7%
  • syncytiotrophoblast cell CL0000525
    CSI 17.2
    rCSI 49.5%
    PRS 84.4%
  • retinal pigment epithelial cell CL0002586
    CSI 17.5
    rCSI 34.8%
    PRS 73.7%
  • Mueller cell CL0000636
    CSI 18.3
    rCSI 41.8%
    PRS 69.2%
  • retinal blood vessel endothelial cell CL0002585
    CSI 21.1
    rCSI 33.6%
    PRS 81.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SLC2A1](/details-gene/6513), or Solute Carrier Family 2 Member 1, encodes the well-characterized glucose transporter 1 (GLUT1). This integral membrane protein is a primary facilitator of glucose transport across the plasma membrane of many cell types. Expression data indicates that **Overall**, [SLC2A1](/details-gene/6513) is a gene of paramount significance in tissues that form critical biological barriers or have high energy demands. Its most prominent expression is observed in placental cells, such as [extravillous trophoblast](/details-cell/CL0008036) and [placental villous trophoblast](/details-cell/CL2000060), as well as in endothelial cells of the blood-brain barrier ([cerebral cortex endothelial cell](/details-cell/CL1001602)) and blood-retina barrier ([retinal blood vessel endothelial cell](/details-cell/CL0002585)). Clinically, mutations in [SLC2A1](/details-gene/6513) are associated with GLUT1 deficiency syndrome, a metabolic encephalopathy ([138140](https://omim.org/entry/138140), [601042](https://omim.org/entry/601042)). ## Cellular Roles and Expression Landscape The expression profile of [SLC2A1](/details-gene/6513) underscores its fundamental role in glucose homeostasis and energy supply to specialized tissues. The highest significance scores for this gene are found in cells that constitute major transport interfaces. * **Placental Tissues:** [SLC2A1](/details-gene/6513) shows exceptional significance in various trophoblast populations, including [extravillous trophoblast](/details-cell/CL0008036), [placental villous trophoblast](/details-cell/CL2000060), and [syncytiotrophoblast cell](/details-cell/CL0000525). This pattern is consistent with the high metabolic activity of the placenta and its critical function in transporting glucose from maternal to fetal circulation. * **Neurovascular and Retinal Barriers:** The gene is a defining marker for [cerebral cortex endothelial cell](/details-cell/CL1001602) and [retinal blood vessel endothelial cell](/details-cell/CL0002585), highlighting its essential role in maintaining the blood-brain and blood-retina barriers, respectively. These barriers strictly regulate the passage of nutrients to the central nervous system and the eye. Furthermore, its high significance in specialized retinal cells like [Mueller cell](/details-cell/CL0000636) and [retinal pigment epithelial cell](/details-cell/CL0002586) suggests a crucial role in supporting the immense energetic demands of photoreceptor function. * **Epithelial and Other Tissues:** High significance is also noted in various epithelial cells, such as [conjunctival epithelial cell](/details-cell/CL1000432), [fallopian tube secretory epithelial cell](/details-cell/CL4030006), and [corneal epithelial cell](/details-cell/CL0000575), indicating its importance in glucose uptake in these tissues. Its presence in [stem cell](/details-cell/CL0000034) populations points to a role in maintaining metabolic activity required for self-renewal and differentiation. ## Pathways and Molecular Function Functional annotations for [SLC2A1](/details-gene/6513) confirm its primary identity as a glucose transporter. Its molecular function is dominated by D-glucose transmembrane transporter activity ([GO:0055056](https://www.ebi.ac.uk/QuickGO/term/GO:0055056)), participating in biological processes like D-glucose import ([GO:0046323](https://www.ebi.ac.uk/QuickGO/term/GO:0046323)) and transport across the blood-brain barrier ([GO:0150104](https://www.ebi.ac.uk/QuickGO/term/GO:0150104)). This aligns perfectly with its high expression in cerebral endothelial cells. The gene's involvement in the response to hypoxia ([GO:0001666](https://www.ebi.ac.uk/QuickGO/term/GO:0001666)) and glucose starvation ([GO:0042149](https://www.ebi.ac.uk/QuickGO/term/GO:0042149)) suggests that its expression is dynamically regulated by cellular metabolic stress, a critical adaptation for tissues like the placenta and rapidly proliferating cells. Reactome pathway analysis further reinforces its central role in `Metabolism of carbohydrates` ([R-HSA-71387](https://reactome.org/content/detail/R-HSA-71387)) and `Cellular hexose transport` ([R-HSA-189200](https://reactome.org/content/detail/R-HSA-189200)). Notably, Reactome explicitly links defects in the gene to `GLUT1 deficiency syndrome 1 (GLUT1DS1)` ([R-HSA-5619043](https://reactome.org/content/detail/R-HSA-5619043)), directly connecting its molecular function to a defined clinical disorder. ## Research Directions The well-established role of [SLC2A1](/details-gene/6513) as a primary glucose transporter, combined with its specific expression profile, opens several avenues for further investigation, particularly concerning its role in pathology beyond monogenic deficiency syndromes. **Proposed Hypotheses:** 1. Given the high significance of [SLC2A1](/details-gene/6513) in [extravillous trophoblast](/details-cell/CL0008036) and its known upregulation in response to hypoxia ([GO:0001666](https://www.ebi.ac.uk/QuickGO/term/GO:0001666)), it is hypothesized that dysregulation of [SLC2A1](/details-gene/6513) expression or function in trophoblasts contributes to the pathogenesis of pregnancy disorders associated with placental insufficiency and hypoxia, such as pre-eclampsia and fetal growth restriction. 2. The high expression of [SLC2A1](/details-gene/6513) in endothelial cells forming the blood-brain and blood-retina barriers suggests that subtle, genetically- or environmentally-induced reductions in its transport efficiency could be a contributing factor to the progression of neurodegenerative and retinal diseases with metabolic components, such as Alzheimer's disease or diabetic retinopathy, by creating a state of chronic, low-grade energy deficit in the CNS and retina. **Experimental Approach:** To test the first hypothesis regarding the role of [SLC2A1](/details-gene/6513) in placental pathology, a multi-faceted approach could be employed. Primary human trophoblasts or an immortalized cell line (e.g., HTR-8/SVneo) could be cultured under normoxic and hypoxic conditions. CRISPR-Cas9-mediated knockout or siRNA-mediated knockdown of [SLC2A1](/details-gene/6513) would be performed. The impact of its loss on cellular metabolism could be quantified using radiolabeled glucose uptake assays and Seahorse metabolic flux analysis. Functional consequences on trophoblast biology, such as proliferation, migration, and invasion, could be assessed using Matrigel invasion assays. Comparing these results between normoxic and hypoxic conditions would elucidate the specific role of [SLC2A1](/details-gene/6513) in the cellular adaptation to placental stress. **Therapeutic Potential:** The therapeutic potential of targeting [SLC2A1](/details-gene/6513) is highly context-dependent. For loss-of-function diseases like GLUT1 deficiency syndrome ([138140](https://omim.org/entry/138140)), therapeutic strategies would focus on **activation** or compensation, such as gene therapy or the use of ketogenic diets to provide an alternative fuel source for the brain. In stark contrast, many cancers exhibit a profound reliance on glucose and highly overexpress [SLC2A1](/details-gene/6513) to fuel their growth (the Warburg effect). In this oncologic context, [SLC2A1](/details-gene/6513) is a prime target for **inhibition**. Its localization on the plasma membrane makes it accessible to small molecule inhibitors or antibody-based therapies designed to block glucose uptake and starve cancer cells.

Genular Protein ID: 4196089677

Symbol: GTR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3839598

Title: Sequence and structure of a human glucose transporter.

PubMed ID: 3839598

DOI: 10.1126/science.3839598

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2834252

Title: Characterization and expression of human HepG2/erythrocyte glucose-transporter gene.

PubMed ID: 2834252

DOI: 10.2337/diab.37.5.657

PubMed ID: 10954735

Title: Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes.

PubMed ID: 10954735

DOI: 10.1073/pnas.170153097

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18245775

Title: Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activity.

PubMed ID: 18245775

DOI: 10.1074/jbc.m708896200

PubMed ID: 18347014

Title: Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1.

PubMed ID: 18347014

DOI: 10.1074/jbc.m707818200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19449892

Title: Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis.

PubMed ID: 19449892

DOI: 10.1021/bi900521n

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23219802

Title: Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains.

PubMed ID: 23219802

DOI: 10.1016/j.bbamem.2012.11.030

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23563491

Title: A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.

PubMed ID: 23563491

DOI: 10.1038/ncb2721

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25957687

Title: Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

PubMed ID: 25957687

DOI: 10.1016/j.cell.2015.03.023

PubMed ID: 25982116

Title: A protein kinase C phosphorylation motif in GLUT1 affects glucose transport and is mutated in GLUT1 deficiency syndrome.

PubMed ID: 25982116

DOI: 10.1016/j.molcel.2015.04.015

PubMed ID: 32860739

Title: Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.

PubMed ID: 32860739

DOI: 10.1016/j.cell.2020.08.015

PubMed ID: 35810171

Title: A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells.

PubMed ID: 35810171

DOI: 10.1038/s41467-022-31762-x

PubMed ID: 24847886

Title: Crystal structure of the human glucose transporter GLUT1.

PubMed ID: 24847886

DOI: 10.1038/nature13306

PubMed ID: 27078104

Title: Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.

PubMed ID: 27078104

DOI: 10.1073/pnas.1603735113

PubMed ID: 10227690

Title: Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome.

PubMed ID: 10227690

DOI: 10.1023/a:1022544131826

PubMed ID: 10980529

Title: Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome.

PubMed ID: 10980529

DOI: 10.1002/1098-1004(200009)16:3<224::aid-humu5>3.0.co;2-p

PubMed ID: 11603379

Title: Autosomal dominant Glut-1 deficiency syndrome and familial epilepsy.

PubMed ID: 11603379

DOI: 10.1002/ana.1222

PubMed ID: 11136715

Title: Autosomal dominant transmission of GLUT1 deficiency.

PubMed ID: 11136715

DOI: 10.1093/hmg/10.1.63

PubMed ID: 12325075

Title: Imaging the metabolic footprint of Glut1 deficiency on the brain.

PubMed ID: 12325075

DOI: 10.1002/ana.10311

PubMed ID: 14605501

Title: GLUT-1 deficiency without epilepsy -- an exceptional case.

PubMed ID: 14605501

DOI: 10.1023/a:1025999914822

PubMed ID: 15622525

Title: Glut-1 deficiency syndrome: clinical, genetic, and therapeutic aspects.

PubMed ID: 15622525

DOI: 10.1002/ana.20331

PubMed ID: 18451999

Title: GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak.

PubMed ID: 18451999

DOI: 10.1172/jci34438

PubMed ID: 19798636

Title: Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1.

PubMed ID: 19798636

DOI: 10.1002/ana.21724

PubMed ID: 19901175

Title: Childhood chorea with cerebral hypotrophy: a treatable GLUT1 energy failure syndrome.

PubMed ID: 19901175

DOI: 10.1001/archneurol.2009.236

PubMed ID: 19630075

Title: GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias.

PubMed ID: 19630075

DOI: 10.1002/mds.22507

PubMed ID: 20221955

Title: Autosomal recessive inheritance of GLUT1 deficiency syndrome.

PubMed ID: 20221955

DOI: 10.1055/s-0030-1248264

PubMed ID: 20129935

Title: Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder.

PubMed ID: 20129935

DOI: 10.1093/brain/awp336

PubMed ID: 21204808

Title: Mild adolescent/adult onset epilepsy and paroxysmal exercise-induced dyskinesia due to GLUT1 deficiency.

PubMed ID: 21204808

DOI: 10.1111/j.1528-1167.2010.02726.x

PubMed ID: 20621801

Title: Paroxysmal exercise-induced dyskinesia, writer's cramp, migraine with aura and absence epilepsy in twin brothers with a novel SLC2A1 missense mutation.

PubMed ID: 20621801

DOI: 10.1016/j.jns.2010.05.017

PubMed ID: 20574033

Title: Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency.

PubMed ID: 20574033

DOI: 10.1212/wnl.0b013e3181eb58b4

PubMed ID: 21791420

Title: Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome.

PubMed ID: 21791420

DOI: 10.1182/blood-2010-12-326645

PubMed ID: 20830593

Title: Excellent response to acetazolamide in a case of paroxysmal dyskinesias due to GLUT1-deficiency.

PubMed ID: 20830593

DOI: 10.1007/s00415-010-5702-5

PubMed ID: 21832227

Title: Paroxysmal choreoathetosis/spasticity (DYT9) is caused by a GLUT1 defect.

PubMed ID: 21832227

DOI: 10.1212/wnl.0b013e31822e0479

PubMed ID: 23280796

Title: Glucose transporter 1 deficiency in the idiopathic generalized epilepsies.

PubMed ID: 23280796

DOI: 10.1002/ana.23702

PubMed ID: 22492876

Title: An infant with pseudohyperkalemia, hemolysis, and seizures: cation-leaky GLUT1-deficiency syndrome due to a SLC2A1 mutation.

PubMed ID: 22492876

DOI: 10.1210/jc.2012-1399

PubMed ID: 22282645

Title: GLUT1 mutations are a rare cause of familial idiopathic generalized epilepsy.

PubMed ID: 22282645

DOI: 10.1212/wnl.0b013e318247ff54

PubMed ID: 30197081

Title: Mutations in disordered regions can cause disease by creating dileucine motifs.

PubMed ID: 30197081

DOI: 10.1016/j.cell.2018.08.019

Sequence Information:

  • Length: 492
  • Mass: 54084
  • Checksum: E71E1C6BD1B00B1E
  • Sequence:
  • MEPSSKKLTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWVH RYGESILPTT 
    LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN LLAFVSAVLM GFSKLGKSFE 
    MLILGRFIIG VYCGLTTGFV PMYVGEVSPT ALRGALGTLH QLGIVVGILI AQVFGLDSIM 
    GNKDLWPLLL SIIFIPALLQ CIVLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTHD 
    LQEMKEESRQ MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK 
    AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAIL MTIALALLEQ 
    LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR PAAIAVAGFS NWTSNFIVGM 
    CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF KVPETKGRTF DEIASGFRQG GASQSDKTPE 
    ELFHPLGADS QV

Genular Protein ID: 3480551254

Symbol: Q59GX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 517
  • Mass: 57018
  • Checksum: 0A15C476A80ABF02
  • Sequence:
  • AGERRSHARR HPRTRRSQSH QRSAAMEPSS KKLTGRLMLA VGGAVLGSLQ FGYNTGVINA 
    PQKVIEEFYN QTWVHRYGES ILPTTLTTLW SLSVAIFSVG GMIGSFSVGL FVNRFGRRNS 
    MLMMNLLAFV SAVLMGFSKL GKSFEMLILG RFIIGVYCGL TTGFVPMYVG EVSPTALRGA 
    LGTLHQLGIV VGILIAQVFG LDSIMGNKDL WPLLLSIIFI PALLQCIVLP FCPESPRFLL 
    INRNEENRAK SVLKKLRGTA DVTHDLQEMK EESRQMMREK KVTILELFRS PAYRQPILIA 
    VVLQLSQQLS GINAVFYYST SIFEKAGVQQ PVYATIGSGI VNTAFTVVSL FVVERAGRRT 
    LHLIGLAGMA GCAILMTIAL ALLEQLPWMS YLSIVAIFGF VAFFEVGPGP IPWFIVAELF 
    SQGPRPAAIA VAGFSNWTSN FIVGMCFQYV EQLCGPYVFI IFTVLLVLFF IFTYFKVPET 
    KGRTFDEIAS GFRQGGASQS DKTPEELFHP LGADSQV