Details for: TCEA2

Gene ID: 6919

Symbol: TCEA2

Ensembl ID: ENSG00000171703

Description: transcription elongation factor A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.9915
    Cell Significance Index: -30.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.0511
    Cell Significance Index: -24.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.2251
    Cell Significance Index: -29.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.8235
    Cell Significance Index: -24.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.7644
    Cell Significance Index: -28.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.0070
    Cell Significance Index: -24.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.5629
    Cell Significance Index: -30.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8699
    Cell Significance Index: -26.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6862
    Cell Significance Index: -30.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8730
    Cell Significance Index: -21.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3133
    Cell Significance Index: -9.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.9346
    Cell Significance Index: 16.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8749
    Cell Significance Index: 98.4400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8084
    Cell Significance Index: 23.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7760
    Cell Significance Index: 14.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4509
    Cell Significance Index: 169.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3067
    Cell Significance Index: 34.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3004
    Cell Significance Index: 178.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1516
    Cell Significance Index: 113.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0850
    Cell Significance Index: 22.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0148
    Cell Significance Index: 916.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9459
    Cell Significance Index: 32.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7938
    Cell Significance Index: 8.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7714
    Cell Significance Index: 154.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7320
    Cell Significance Index: 19.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6172
    Cell Significance Index: 100.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6167
    Cell Significance Index: 336.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6059
    Cell Significance Index: 77.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5794
    Cell Significance Index: 63.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5696
    Cell Significance Index: 35.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5590
    Cell Significance Index: 41.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5436
    Cell Significance Index: 28.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5214
    Cell Significance Index: 24.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5040
    Cell Significance Index: 61.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4881
    Cell Significance Index: 6.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4011
    Cell Significance Index: 24.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3761
    Cell Significance Index: 67.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3155
    Cell Significance Index: 113.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2897
    Cell Significance Index: 57.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2759
    Cell Significance Index: 121.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2750
    Cell Significance Index: 19.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2549
    Cell Significance Index: 32.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2479
    Cell Significance Index: 5.2800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1959
    Cell Significance Index: 1.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1670
    Cell Significance Index: 115.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1610
    Cell Significance Index: 3.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1413
    Cell Significance Index: 9.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0726
    Cell Significance Index: 4.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0701
    Cell Significance Index: 13.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0630
    Cell Significance Index: 2.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0397
    Cell Significance Index: 0.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0385
    Cell Significance Index: 0.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0357
    Cell Significance Index: 1.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0200
    Cell Significance Index: 1.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0180
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0130
    Cell Significance Index: 24.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0110
    Cell Significance Index: 14.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0097
    Cell Significance Index: 7.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0146
    Cell Significance Index: -9.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0228
    Cell Significance Index: -0.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0242
    Cell Significance Index: -18.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0333
    Cell Significance Index: -24.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0348
    Cell Significance Index: -15.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0449
    Cell Significance Index: -25.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0482
    Cell Significance Index: -4.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0539
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0551
    Cell Significance Index: -34.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0773
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0812
    Cell Significance Index: -13.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0817
    Cell Significance Index: -23.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0933
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1001
    Cell Significance Index: -4.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1197
    Cell Significance Index: -8.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1208
    Cell Significance Index: -2.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1228
    Cell Significance Index: -3.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1250
    Cell Significance Index: -18.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1250
    Cell Significance Index: -14.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1289
    Cell Significance Index: -14.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1592
    Cell Significance Index: -33.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1732
    Cell Significance Index: -4.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1844
    Cell Significance Index: -4.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1917
    Cell Significance Index: -5.1200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2010
    Cell Significance Index: -2.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2333
    Cell Significance Index: -18.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2605
    Cell Significance Index: -3.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2658
    Cell Significance Index: -7.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2670
    Cell Significance Index: -7.6200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2706
    Cell Significance Index: -1.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2792
    Cell Significance Index: -29.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2819
    Cell Significance Index: -21.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3001
    Cell Significance Index: -8.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3158
    Cell Significance Index: -6.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3506
    Cell Significance Index: -15.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3708
    Cell Significance Index: -10.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3762
    Cell Significance Index: -21.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3921
    Cell Significance Index: -6.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4034
    Cell Significance Index: -12.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4043
    Cell Significance Index: -24.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCEA2 is a transcription elongation factor that plays a crucial role in the regulation of transcription elongation by RNA polymerase II. This enzyme is responsible for the synthesis of mRNA from DNA templates. TCEA2 has been shown to interact with other proteins, including transcription factors and RNA polymerase II, to facilitate the elongation of transcription. The protein has also been implicated in DNA binding, suggesting its role in regulating gene expression. **Pathways and Functions:** TCEA2 is involved in several cellular pathways, including: 1. **Centrosome formation**: TCEA2 has been shown to interact with centrosomal proteins, suggesting its role in centrosome formation and maintenance. 2. **DNA-templated transcription**: TCEA2 is involved in the regulation of transcription elongation by RNA polymerase II, which is essential for the synthesis of mRNA from DNA templates. 3. **DNA binding**: TCEA2 has been shown to bind to DNA, suggesting its role in regulating gene expression. 4. **Regulation of DNA-templated transcription elongation**: TCEA2 is involved in the regulation of transcription elongation by RNA polymerase II, which is essential for the synthesis of mRNA from DNA templates. **Clinical Significance:** TCEA2 has been implicated in various diseases, including: 1. **Neurodevelopmental disorders**: TCEA2 has been shown to be involved in the development of GABAergic amacrine cells, which are essential for the regulation of visual processing. Mutations in the TCEA2 gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder. 2. **Cancer**: TCEA2 has been shown to be overexpressed in certain types of cancer, including colon cancer. Overexpression of TCEA2 has been associated with poor prognosis and reduced survival rates. 3. **Immunological disorders**: TCEA2 has been implicated in the regulation of immune responses, and its dysregulation has been associated with immunological disorders, such as autoimmune diseases. In conclusion, TCEA2 is a multifunctional protein involved in the regulation of transcription elongation by RNA polymerase II. Its dysregulation has been implicated in various diseases, including neurodevelopmental disorders, cancer, and immunological disorders. Further research is needed to fully understand the functions of TCEA2 and its role in human disease.

Genular Protein ID: 2984116758

Symbol: TCEA2_HUMAN

Name: Transcription elongation factor A protein 2

UniProtKB Accession Codes:

Q15560 B3KNM1 Q8TD37 Q8TD38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8566795

Title: Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II.

PubMed ID: 8566795

DOI: 10.1016/0378-1119(95)00634-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9441762

Title: Genomic characterization of a testis-specific TFIIS (TCEA2) gene.

PubMed ID: 9441762

DOI: 10.1006/geno.1997.5073

PubMed ID: 12034815

Title: RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage.

PubMed ID: 12034815

DOI: 10.1093/nar/30.11.2290

PubMed ID: 12943681

Title: Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.

PubMed ID: 12943681

DOI: 10.1016/s0006-291x(03)01556-0

PubMed ID: 18655026

Title: Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells.

PubMed ID: 18655026

DOI: 10.1002/pmic.200700887

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 299
  • Mass: 33601
  • Checksum: FF0EAE8EDC7BCBE9
  • Sequence:
    • MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG MSVNALRKQS 
SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS RDASEAPDPS RKRPELPRAP 
STPRITTFPP VPVTCDAVRN KCREMLTAAL QTDHDHVAIG ADCERLSAQI EECIFRDVGN 
TDMKYKNRVR SRISNLKDAK NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK 
EAIREHQMAR TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.