Details for: PRSS8

Gene ID: 5652

Symbol: PRSS8

Ensembl ID: ENSG00000052344

Description: serine protease 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5729
    Cell Significance Index: -36.3600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 8.0647
    Cell Significance Index: 61.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.4328
    Cell Significance Index: 206.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.5582
    Cell Significance Index: 161.2800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.6475
    Cell Significance Index: 16.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4424
    Cell Significance Index: 315.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.3383
    Cell Significance Index: 67.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1966
    Cell Significance Index: 238.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9618
    Cell Significance Index: 29.4000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.7950
    Cell Significance Index: 4.0500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.3175
    Cell Significance Index: 7.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1469
    Cell Significance Index: 626.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9928
    Cell Significance Index: 26.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8300
    Cell Significance Index: 61.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7902
    Cell Significance Index: 16.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7473
    Cell Significance Index: 20.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7217
    Cell Significance Index: 117.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7086
    Cell Significance Index: 33.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6311
    Cell Significance Index: 569.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5237
    Cell Significance Index: 51.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4331
    Cell Significance Index: 13.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4300
    Cell Significance Index: 10.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4149
    Cell Significance Index: 4.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3792
    Cell Significance Index: 13.3300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3201
    Cell Significance Index: 1.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2765
    Cell Significance Index: 7.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2697
    Cell Significance Index: 119.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2682
    Cell Significance Index: 13.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2575
    Cell Significance Index: 18.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1605
    Cell Significance Index: 4.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1099
    Cell Significance Index: 20.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1077
    Cell Significance Index: 18.3900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0699
    Cell Significance Index: 0.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0672
    Cell Significance Index: 50.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0441
    Cell Significance Index: 32.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0395
    Cell Significance Index: 4.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0196
    Cell Significance Index: 3.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0051
    Cell Significance Index: -0.2600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.0097
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0165
    Cell Significance Index: -30.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0243
    Cell Significance Index: -44.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0260
    Cell Significance Index: -2.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0291
    Cell Significance Index: -44.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0329
    Cell Significance Index: -44.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0422
    Cell Significance Index: -26.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0425
    Cell Significance Index: -26.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0426
    Cell Significance Index: -31.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0592
    Cell Significance Index: -33.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0649
    Cell Significance Index: -29.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0675
    Cell Significance Index: -6.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0706
    Cell Significance Index: -1.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0709
    Cell Significance Index: -25.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0748
    Cell Significance Index: -1.0200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0935
    Cell Significance Index: -0.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1075
    Cell Significance Index: -21.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1138
    Cell Significance Index: -13.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1154
    Cell Significance Index: -33.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1357
    Cell Significance Index: -18.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1635
    Cell Significance Index: -3.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1699
    Cell Significance Index: -34.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1806
    Cell Significance Index: -38.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1848
    Cell Significance Index: -26.8600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1952
    Cell Significance Index: -2.0200
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.2100
    Cell Significance Index: -1.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2623
    Cell Significance Index: -16.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2787
    Cell Significance Index: -2.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2894
    Cell Significance Index: -7.4400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2932
    Cell Significance Index: -2.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2933
    Cell Significance Index: -8.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3009
    Cell Significance Index: -23.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3422
    Cell Significance Index: -43.8700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3514
    Cell Significance Index: -2.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4112
    Cell Significance Index: -27.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4160
    Cell Significance Index: -26.2200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4188
    Cell Significance Index: -4.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4867
    Cell Significance Index: -31.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5177
    Cell Significance Index: -39.7300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.5311
    Cell Significance Index: -3.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5475
    Cell Significance Index: -33.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5627
    Cell Significance Index: -20.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5788
    Cell Significance Index: -8.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6019
    Cell Significance Index: -20.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6238
    Cell Significance Index: -12.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6258
    Cell Significance Index: -15.6300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6788
    Cell Significance Index: -5.4200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6930
    Cell Significance Index: -5.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6944
    Cell Significance Index: -10.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7233
    Cell Significance Index: -40.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7535
    Cell Significance Index: -33.3300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.7676
    Cell Significance Index: -10.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7853
    Cell Significance Index: -41.2300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.8018
    Cell Significance Index: -8.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8172
    Cell Significance Index: -18.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8490
    Cell Significance Index: -13.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8802
    Cell Significance Index: -33.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8841
    Cell Significance Index: -23.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8908
    Cell Significance Index: -12.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9156
    Cell Significance Index: -23.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9361
    Cell Significance Index: -8.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9366
    Cell Significance Index: -32.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRSS8 is a serine protease enzyme that exhibits a unique structure, consisting of a proline-rich domain and a catalytic domain. Its expression is tissue-specific, with high levels observed in epithelial cells, which are involved in the formation of the cornified envelope and keratinization. PRSS8 has been shown to interact with various proteins, including sodium channels and ion transporters, suggesting its role in regulating sodium ion transport. Its proteolytic activity is also noteworthy, as it can cleave and activate various proteins, influencing cellular signaling pathways. **Pathways and Functions:** PRSS8 is involved in several cellular pathways, including: 1. **Sodium ion transport:** PRSS8 has been shown to regulate sodium ion transport by interacting with sodium channels and ion transporters. This function is crucial for maintaining proper ion balance and cellular homeostasis. 2. **Proteolysis:** PRSS8's proteolytic activity can cleave and activate various proteins, influencing cellular signaling pathways and gene expression. 3. **Protein binding:** PRSS8 interacts with various proteins, including those involved in cell adhesion, migration, and differentiation. 4. **Extracellular matrix remodeling:** PRSS8's proteolytic activity can also contribute to the remodeling of the extracellular matrix, influencing tissue development and remodeling. **Clinical Significance:** PRSS8's role in various cellular processes has significant implications for human disease. Dysregulation of PRSS8 has been implicated in several conditions, including: 1. **Epidermolysis bullosa:** A genetic disorder characterized by skin blistering and fragility. Mutations in the PRSS8 gene have been associated with this condition. 2. **Pulmonary fibrosis:** A disease characterized by scarring of lung tissue. PRSS8's role in extracellular matrix remodeling may contribute to the pathogenesis of this condition. 3. **Cancer:** PRSS8's proteolytic activity and protein binding capabilities may influence cancer cell migration, invasion, and metastasis. In conclusion, PRSS8 is a multifunctional enzyme that plays a critical role in various cellular processes. Its dysregulation has significant implications for human disease, highlighting the need for further research into the molecular mechanisms underlying PRSS8's functions.

Genular Protein ID: 648185350

Symbol: PRSS8_HUMAN

Name: Prostasin

UniProtKB Accession Codes:

Q16651 B4DWP2 Q9UCA3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7768952

Title: Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA.

PubMed ID: 7768952

DOI: 10.1074/jbc.270.22.13483

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8034638

Title: Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland.

PubMed ID: 8034638

DOI: 10.1016/s0021-9258(17)32244-5

PubMed ID: 15246975

Title: Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.

PubMed ID: 15246975

DOI: 10.1152/ajplung.00160.2004

PubMed ID: 15474520

Title: Biochemical characterization of prostasin, a channel activating protease.

PubMed ID: 15474520

DOI: 10.1016/j.bbrc.2004.09.123

PubMed ID: 19388054

Title: Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.

PubMed ID: 19388054

DOI: 10.1002/pro.118

Sequence Information:

  • Length: 343
  • Mass: 36431
  • Checksum: 98DD6447F5A8C1B2
  • Sequence:
    • MAQKGVLGPG QLGAVAILLY LGLLRSGTGA EGAEAPCGVA PQARITGGSS AVAGQWPWQV 
SITYEGVHVC GGSLVSEQWV LSAAHCFPSE HHKEAYEVKL GAHQLDSYSE DAKVSTLKDI 
IPHPSYLQEG SQGDIALLQL SRPITFSRYI RPICLPAANA SFPNGLHCTV TGWGHVAPSV 
SLLTPKPLQQ LEVPLISRET CNCLYNIDAK PEEPHFVQED MVCAGYVEGG KDACQGDSGG 
PLSCPVEGLW YLTGIVSWGD ACGARNRPGV YTLASSYASW IQSKVTELQP RVVPQTQESQ 
PDSNLCGSHL AFSSAPAQGL LRPILFLPLG LALGLLSPWL SEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.