Details for: LSR

Gene ID: 51599

Symbol: LSR

Ensembl ID: ENSG00000105699

Description: lipolysis stimulated lipoprotein receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.5484
    Cell Significance Index: -21.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.3597
    Cell Significance Index: -20.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.3714
    Cell Significance Index: -20.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.3148
    Cell Significance Index: -22.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9376
    Cell Significance Index: -19.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.3972
    Cell Significance Index: -21.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6562
    Cell Significance Index: -20.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.4713
    Cell Significance Index: -21.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6948
    Cell Significance Index: -14.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6427
    Cell Significance Index: 189.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6265
    Cell Significance Index: 98.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.8762
    Cell Significance Index: 130.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.6938
    Cell Significance Index: 72.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.4016
    Cell Significance Index: 14.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0001
    Cell Significance Index: 29.9700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.9996
    Cell Significance Index: 9.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7505
    Cell Significance Index: 16.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.6689
    Cell Significance Index: 28.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6210
    Cell Significance Index: 37.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5710
    Cell Significance Index: 117.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4147
    Cell Significance Index: 40.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2845
    Cell Significance Index: 59.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2596
    Cell Significance Index: 14.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2506
    Cell Significance Index: 682.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2269
    Cell Significance Index: 209.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8861
    Cell Significance Index: 114.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8730
    Cell Significance Index: 30.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8720
    Cell Significance Index: 157.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8443
    Cell Significance Index: 22.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8353
    Cell Significance Index: 165.7700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8329
    Cell Significance Index: 6.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7430
    Cell Significance Index: 38.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6745
    Cell Significance Index: 82.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6469
    Cell Significance Index: 30.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5734
    Cell Significance Index: 15.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5410
    Cell Significance Index: 19.0100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.5340
    Cell Significance Index: 3.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5174
    Cell Significance Index: 228.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4874
    Cell Significance Index: 10.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4165
    Cell Significance Index: 13.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3791
    Cell Significance Index: 26.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3396
    Cell Significance Index: 55.2400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3351
    Cell Significance Index: 4.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3170
    Cell Significance Index: 8.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2650
    Cell Significance Index: 18.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2196
    Cell Significance Index: 41.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2104
    Cell Significance Index: 13.2600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1804
    Cell Significance Index: 1.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1500
    Cell Significance Index: 2.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1318
    Cell Significance Index: 13.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1028
    Cell Significance Index: 14.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0889
    Cell Significance Index: 11.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0762
    Cell Significance Index: 57.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0504
    Cell Significance Index: 34.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0309
    Cell Significance Index: 58.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0272
    Cell Significance Index: 3.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0166
    Cell Significance Index: 3.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0054
    Cell Significance Index: 8.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0020
    Cell Significance Index: 3.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0112
    Cell Significance Index: -15.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0219
    Cell Significance Index: -7.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0274
    Cell Significance Index: -3.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0304
    Cell Significance Index: -3.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0451
    Cell Significance Index: -20.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0469
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0601
    Cell Significance Index: -12.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0646
    Cell Significance Index: -1.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0662
    Cell Significance Index: -19.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0688
    Cell Significance Index: -0.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0729
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0814
    Cell Significance Index: -9.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0865
    Cell Significance Index: -1.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1073
    Cell Significance Index: -1.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1174
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1236
    Cell Significance Index: -14.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1365
    Cell Significance Index: -2.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1472
    Cell Significance Index: -7.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1660
    Cell Significance Index: -2.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1873
    Cell Significance Index: -19.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1960
    Cell Significance Index: -11.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2278
    Cell Significance Index: -9.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2568
    Cell Significance Index: -3.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2573
    Cell Significance Index: -20.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2659
    Cell Significance Index: -20.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2785
    Cell Significance Index: -3.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2796
    Cell Significance Index: -17.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3144
    Cell Significance Index: -21.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3316
    Cell Significance Index: -21.3900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3451
    Cell Significance Index: -3.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3766
    Cell Significance Index: -23.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3832
    Cell Significance Index: -9.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3989
    Cell Significance Index: -11.7500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4007
    Cell Significance Index: -5.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4051
    Cell Significance Index: -6.7800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4372
    Cell Significance Index: -4.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LSR is a transmembrane receptor that belongs to the scavenger receptor family. It is characterized by its ability to bind to specific ligands, including LDL and VLDL particles, and facilitate their endocytosis. LSR is highly expressed in cells involved in lipid metabolism and immune response, including hematopoietic cells, epithelial cells, and immune cells. The receptor is also involved in the regulation of cell signaling pathways, including the PI3K/Akt pathway, which plays a crucial role in cell survival and differentiation. **Pathways and Functions:** LSR is involved in several key pathways and functions, including: 1. **Lipid Metabolism:** LSR plays a crucial role in the clearance of LDL and VLDL particles from the bloodstream, which is essential for maintaining lipid homeostasis. 2. **Blood-Brain Barrier Establishment:** LSR is involved in the regulation of the blood-brain barrier, which is essential for maintaining the integrity of the central nervous system. 3. **Epithelial Structure Maintenance:** LSR is involved in the maintenance of epithelial structures, including the skin and intestinal epithelium. 4. **Immune Response:** LSR is expressed on immune cells, including T cells and dendritic cells, and plays a crucial role in the regulation of immune responses. 5. **Extracellular Exosome Regulation:** LSR is involved in the regulation of extracellular exosome formation and function. **Clinical Significance:** The LSR gene has significant implications for various diseases, including: 1. **Atherosclerosis:** LSR deficiency has been associated with increased risk of atherosclerosis, a disease characterized by the buildup of LDL particles in the arterial walls. 2. **Type 2 Diabetes:** LSR deficiency has been associated with increased risk of type 2 diabetes, a disease characterized by impaired insulin signaling and lipid metabolism. 3. **Neurological Disorders:** LSR deficiency has been associated with increased risk of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** LSR has been implicated in the regulation of cancer cell growth and metastasis. In conclusion, the LSR gene plays a crucial role in lipid metabolism, immune response, and epithelial structure maintenance. Its dysregulation has significant implications for various diseases, including atherosclerosis, type 2 diabetes, neurological disorders, and cancer. Further research is necessary to fully understand the function of LSR and its implications for human health.

Genular Protein ID: 3927690733

Symbol: LSR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86X29 A6NDW3 B4DKL4 E9PHD4 O00112 O00426 Q6ZT80 Q8NBM0 Q9BT33 Q9UQL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21245199

Title: LSR defines cell corners for tricellular tight junction formation in epithelial cells.

PubMed ID: 21245199

DOI: 10.1242/jcs.072058

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23239027

Title: Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis.

PubMed ID: 23239027

DOI: 10.1242/jcs.116442

PubMed ID: 30250217

Title: Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.

PubMed ID: 30250217

DOI: 10.1038/s41436-018-0288-x

Sequence Information:

  • Length: 649
  • Mass: 71439
  • Checksum: 01E8F1CE0197CE9B
  • Sequence:
    • MQQDGLGVGT RNGSGKGRSV HPSWPWCAPR PLRYFGRDAR ARRAQTAAMA LLAGGLSRGL 
GSHPAAAGRD AVVFVWLLLS TWCTAPARAI QVTVSNPYHV VILFQPVTLP CTYQMTSTPT 
QPIVIWKYKS FCRDRIADAF SPASVDNQLN AQLAAGNPGY NPYVECQDSV RTVRVVATKQ 
GNAVTLGDYY QGRRITITGN ADLTFDQTAW GDSGVYYCSV VSAQDLQGNN EAYAELIVLG 
RTSGVAELLP GFQAGPIEDW LFVVVVCLAA FLIFLLLGIC WCQCCPHTCC CYVRCPCCPD 
KCCCPEALYA AGKAATSGVP SIYAPSTYAH LSPAKTPPPP AMIPMGPAYN GYPGGYPGDV 
DRSSSAGGQG SYVPLLRDTD SSVASEVRSG YRIQASQQDD SMRVLYYMEK ELANFDPSRP 
GPPSGRVERA MSEVTSLHED DWRSRPSRGP ALTPIRDEEW GGHSPRSPRG WDQEPAREQA 
GGGWRARRPR ARSVDALDDL TPPSTAESGS RSPTSNGGRS RAYMPPRSRS RDDLYDQDDS 
RDFPRSRDPH YDDFRSRERP PADPRSHHHR TRDPRDNGSR SGDLPYDGRL LEEAVRKKGS 
EERRRPHKEE EEEAYYPPAP PPYSETDSQA SRERRLKKNL ALSRESLVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.