Details for: RCN1

Gene ID: 5954

Symbol: RCN1

Ensembl ID: ENSG00000049449

Description: reticulocalbin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 254.2026
    Cell Significance Index: -39.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.3081
    Cell Significance Index: -34.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 92.8395
    Cell Significance Index: -38.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.7629
    Cell Significance Index: -38.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.8079
    Cell Significance Index: -31.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.9390
    Cell Significance Index: -36.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.1501
    Cell Significance Index: -39.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.1608
    Cell Significance Index: -31.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.8722
    Cell Significance Index: -40.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4875
    Cell Significance Index: -38.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3014
    Cell Significance Index: -40.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8028
    Cell Significance Index: -12.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.6818
    Cell Significance Index: 45.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.4819
    Cell Significance Index: 70.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5405
    Cell Significance Index: 95.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.2159
    Cell Significance Index: 26.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.7432
    Cell Significance Index: 34.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.3933
    Cell Significance Index: 36.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.1468
    Cell Significance Index: 109.3500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.0536
    Cell Significance Index: 17.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7179
    Cell Significance Index: 77.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6927
    Cell Significance Index: 369.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.6792
    Cell Significance Index: 47.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3815
    Cell Significance Index: 123.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1154
    Cell Significance Index: 57.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0305
    Cell Significance Index: 94.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8182
    Cell Significance Index: 95.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7399
    Cell Significance Index: 313.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5396
    Cell Significance Index: 17.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4772
    Cell Significance Index: 82.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3753
    Cell Significance Index: 169.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3682
    Cell Significance Index: 71.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3037
    Cell Significance Index: 711.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2786
    Cell Significance Index: 29.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1727
    Cell Significance Index: 16.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1443
    Cell Significance Index: 146.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0918
    Cell Significance Index: 28.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0227
    Cell Significance Index: 132.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9391
    Cell Significance Index: 69.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7890
    Cell Significance Index: 37.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5865
    Cell Significance Index: 15.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3844
    Cell Significance Index: 169.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3804
    Cell Significance Index: 26.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3663
    Cell Significance Index: 69.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3279
    Cell Significance Index: 5.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3139
    Cell Significance Index: 9.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2905
    Cell Significance Index: 28.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2447
    Cell Significance Index: 39.8000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2433
    Cell Significance Index: 1.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2364
    Cell Significance Index: 213.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1655
    Cell Significance Index: 7.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1618
    Cell Significance Index: 32.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1514
    Cell Significance Index: 43.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1485
    Cell Significance Index: 29.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1198
    Cell Significance Index: 2.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0825
    Cell Significance Index: 1.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0737
    Cell Significance Index: 1.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0466
    Cell Significance Index: 16.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0448
    Cell Significance Index: 33.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0068
    Cell Significance Index: -1.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0069
    Cell Significance Index: -12.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0216
    Cell Significance Index: -39.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0265
    Cell Significance Index: -0.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0265
    Cell Significance Index: -40.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0348
    Cell Significance Index: -47.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0418
    Cell Significance Index: -26.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0428
    Cell Significance Index: -24.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0543
    Cell Significance Index: -0.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0566
    Cell Significance Index: -3.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0647
    Cell Significance Index: -0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0744
    Cell Significance Index: -33.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0775
    Cell Significance Index: -16.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0839
    Cell Significance Index: -9.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1065
    Cell Significance Index: -6.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1164
    Cell Significance Index: -13.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1520
    Cell Significance Index: -17.4100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1561
    Cell Significance Index: -0.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1683
    Cell Significance Index: -1.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1795
    Cell Significance Index: -5.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2183
    Cell Significance Index: -6.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2211
    Cell Significance Index: -32.1400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2229
    Cell Significance Index: -1.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2484
    Cell Significance Index: -6.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2591
    Cell Significance Index: -9.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2644
    Cell Significance Index: -31.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2896
    Cell Significance Index: -7.2400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3768
    Cell Significance Index: -1.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3891
    Cell Significance Index: -17.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3941
    Cell Significance Index: -41.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4253
    Cell Significance Index: -33.6800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4289
    Cell Significance Index: -3.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4583
    Cell Significance Index: -35.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4643
    Cell Significance Index: -10.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4735
    Cell Significance Index: -7.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4749
    Cell Significance Index: -31.9300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.4803
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RCN1 is a gene that codes for a protein involved in protein regulation and cellular development. It is characterized by its ability to bind calcium ions, regulate insulin-like growth factor (IGF) transport and uptake, and participate in post-translational protein modification. RCN1 is also involved in the development of various organs and tissues, including the eye, ovary, mammary gland, kidney, prostate, and salivary gland. Its expression is widespread, with significant levels found in interstitial cells of the ovary, mesodermal cells, and decidual cells. **Pathways and Functions:** RCN1 is involved in several key biological pathways, including: 1. **Calcium ion binding:** RCN1 has been shown to bind calcium ions, which is essential for various cellular processes, including muscle contraction, neurotransmission, and cell signaling. 2. **Endoplasmic reticulum function:** RCN1 is involved in the regulation of endoplasmic reticulum function, including protein folding, transport, and modification. 3. **Post-translational protein modification:** RCN1 participates in post-translational protein modification, including phosphorylation and ubiquitination. 4. **Protein regulation:** RCN1 regulates protein expression and activity, including the transport and uptake of insulin-like growth factor (IGF). 5. **Developmental processes:** RCN1 is involved in the development of various organs and tissues, including the eye, ovary, mammary gland, kidney, prostate, and salivary gland. **Clinical Significance:** While the clinical significance of RCN1 is still emerging, it is clear that this gene plays a crucial role in various cellular processes and developmental pathways. Dysregulation of RCN1 has been implicated in several diseases, including cancer, metabolic disorders, and developmental abnormalities. Further research is needed to fully understand the clinical significance of RCN1 and its potential therapeutic applications. In conclusion, RCN1 is a multifaceted gene that plays a crucial role in protein regulation, development, and metabolism. Its involvement in various biological pathways and cellular processes makes it an important gene that warrants further investigation. As research continues to uncover the clinical significance of RCN1, it is likely that this gene will emerge as a key player in the development of new therapeutic strategies for various diseases.

Genular Protein ID: 1010296425

Symbol: RCN1_HUMAN

Name: Reticulocalbin-1

UniProtKB Accession Codes:

Q15293 B7Z1M1 D3DR00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 28 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8586628

Title: Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs.

PubMed ID: 8586628

DOI: 10.1093/oxfordjournals.jbchem.a124815

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28512129

Title: Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.

PubMed ID: 28512129

DOI: 10.1074/jbc.m117.794487

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 331
  • Mass: 38890
  • Checksum: 608AAD536963F789
  • Sequence:
    • MARGGRGRRL GLALGLLLAL VLAPRVLRAK PTVRKERVVR PDSELGERPP EDNQSFQYDH 
EAFLGKEDSK TFDQLTPDES KERLGKIVDR IDNDGDGFVT TEELKTWIKR VQKRYIFDNV 
AKVWKDYDRD KDDKISWEEY KQATYGYYLG NPAEFHDSSD HHTFKKMLPR DERRFKAADL 
NGDLTATREE FTAFLHPEEF EHMKEIVVLE TLEDIDKNGD GFVDQDEYIA DMFSHEENGP 
EPDWVLSERE QFNEFRDLNK DGKLDKDEIR HWILPQDYDH AQAEARHLVY ESDKNKDEKL 
TKEEILENWN MFVGSQATNY GEDLTKNHDE L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.