Details for: RCN1
Gene ID: 5954
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RCN1
Ensembl ID: ENSG00000049449
Description: reticulocalbin 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 32.26rCSI 49.85%PRS 77.35
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CSI 24.51rCSI 30.32%PRS 76.19
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CSI 17.92rCSI 17.25%PRS 77.6
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CSI 13.52rCSI 14.16%PRS 81.77
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CSI 13.28rCSI 42.6%PRS 80.47
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CSI 12.89rCSI 63.52%PRS 86.11
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CSI 12.44rCSI 14.93%PRS 75.93
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CSI 11.73rCSI 32.23%PRS 85.37
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CSI 10.41rCSI 22.92%PRS 81.97
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CSI 10.22rCSI 8.3%PRS 77.57
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CSI 10.02rCSI 28.85%PRS 84.81
-
CSI 9.7rCSI 31.47%PRS 76.3
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CSI 9.39rCSI 12.04%PRS 81.68
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CSI 9.27rCSI 8.37%PRS 76.51
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CSI 8.35rCSI 21.46%PRS 75.51
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CSI 7.89rCSI 45.92%PRS 82.26
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CSI 7.64rCSI 32.12%PRS 83.9
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CSI 7.59rCSI 6%PRS 66.77
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CSI 7.41rCSI 16.92%PRS 69.86
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CSI 7.27rCSI 12.81%PRS 83.68
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CSI 6.85rCSI 7.16%PRS 75.91
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CSI 6.77rCSI 6.4%PRS 77.05
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CSI 6.52rCSI 22.88%PRS 86.58
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CSI 6.47rCSI 44.4%PRS 85.19
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CSI 6.41rCSI 7.8%PRS 84.81
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CSI 6.33rCSI 8.77%PRS 75.69
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CSI 6.22rCSI 17.43%PRS 85.91
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CSI 6.05rCSI 4.23%PRS 81.64
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CSI 5.64rCSI 4.68%PRS 78.85
-
CSI 5.46rCSI 5.8%PRS 83.58
-
CSI 5.38rCSI 3.58%PRS 90.41
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CSI 5.35rCSI 5.16%PRS 71.34
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CSI 5.32rCSI 23.41%PRS 66.93
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CSI 5.25rCSI 10.01%PRS 91.75
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CSI 5.02rCSI 9.57%PRS 88.06
-
CSI 5.02rCSI 18.79%PRS 70.64
-
CSI 5.02rCSI 4.63%PRS 79.72
-
CSI 5.01rCSI 12.7%PRS 68.67
-
CSI 4.89rCSI 7.76%PRS 87.13
-
CSI 4.88rCSI 7.45%PRS 82.28
-
CSI 4.85rCSI 6.74%PRS 76.99
-
CSI 4.81rCSI 4.15%PRS 79.41
-
CSI 4.76rCSI 7.25%PRS 75.22
-
CSI 4.71rCSI 5.16%PRS 80.37
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CSI 4.68rCSI 5.96%PRS 83.18
-
CSI 4.67rCSI 3.62%PRS 81.89
-
CSI 4.6rCSI 3.06%PRS 81.21
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CSI 4.37rCSI 11.11%PRS 71.64
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CSI 4.24rCSI 3.95%PRS 78.87
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CSI 4.23rCSI 4.41%PRS 77.54
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CSI 4.11rCSI 8.16%PRS 74.29
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CSI 4.09rCSI 6.29%PRS 68.35
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CSI 4.05rCSI 5.54%PRS 82.67
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CSI 4.03rCSI 7.32%PRS 69.82
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CSI 4.02rCSI 4.65%PRS 70.66
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CSI 4rCSI 7.77%PRS 81.4
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CSI 3.99rCSI 15.89%PRS 86.16
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CSI 3.95rCSI 6.29%PRS 70.03
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CSI 3.85rCSI 11.14%PRS 67.83
-
CSI 3.8rCSI 6.97%PRS 83.39
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CSI 3.74rCSI 7.41%PRS 83.8
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CSI 3.69rCSI 7.66%PRS 74.98
-
CSI 3.64rCSI 3.58%PRS 81.13
-
CSI 3.59rCSI 5.74%PRS 82.01
-
CSI 3.4rCSI 4.98%PRS 85.26
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CSI 3.38rCSI 32.07%PRS 94.73
-
CSI 3.26rCSI 4.44%PRS 86.88
-
CSI 3.23rCSI 4.42%PRS 70.3
-
CSI 3.23rCSI 6.49%PRS 68.34
-
CSI 3.23rCSI 8.5%PRS 90.13
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CSI 3.08rCSI 8.91%PRS 77.91
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CSI 3.07rCSI 33.58%PRS 83.95
-
CSI 3.04rCSI 4.15%PRS 78.37
-
CSI 3rCSI 7.91%PRS 85.04
-
CSI 3rCSI 5.66%PRS 89.4
-
CSI 3rCSI 5.25%PRS 71.81
-
CSI 2.98rCSI 8.58%PRS 73.98
-
CSI 2.96rCSI 4.7%PRS 71.19
-
CSI 2.83rCSI 2.49%PRS 67.33
-
CSI 2.82rCSI 8.33%PRS 79.23
-
CSI 2.81rCSI 12.88%PRS 83.03
-
CSI 2.79rCSI 4.41%PRS 79.94
-
CSI 2.79rCSI 2.85%PRS 86.49
-
CSI 2.76rCSI 3.77%PRS 69.83
-
CSI 2.74rCSI 7.78%PRS 74.57
-
CSI 2.71rCSI 6.31%PRS 89.1
-
CSI 2.59rCSI 2.3%PRS 76
-
CSI 2.58rCSI 3.96%PRS 86.67
-
CSI 2.58rCSI 6.13%PRS 84.02
-
CSI 2.57rCSI 3.82%PRS 78.47
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CSI 2.46rCSI 3.99%PRS 73.39
-
CSI 2.41rCSI 3.56%PRS 82.49
-
CSI 2.4rCSI 5.78%PRS 91.15
-
CSI 2.38rCSI 3.19%PRS 77.24
-
CSI 2.33rCSI 6.07%PRS 85.63
-
CSI 2.31rCSI 3.78%PRS 67.8
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CSI 2.25rCSI 4.22%PRS 66.63
-
CSI 2.24rCSI 5.66%PRS 83.72
-
CSI 2.23rCSI 8.99%PRS 77.82
-
CSI 2.23rCSI 6.27%PRS 73.45
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CSI 0.2rCSI 4.2%PRS 89.3%
-
CSI 0.3rCSI 3.3%PRS 86.8%
-
CSI 0.4rCSI 9.8%PRS 58.7%
-
CSI 0.5rCSI 3.9%PRS 87.2%
-
CSI 0.5rCSI 12.0%PRS 59.2%
-
CSI 0.5rCSI 2.1%PRS 86.4%
-
CSI 0.6rCSI 2.8%PRS 87.2%
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CSI 0.7rCSI 3.1%PRS 78.9%
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CSI 0.8rCSI 3.2%PRS 85.7%
-
CSI 0.8rCSI 4.7%PRS 94.6%
-
CSI 0.8rCSI 2.8%PRS 82.7%
-
CSI 0.8rCSI 6.7%PRS 72.2%
-
CSI 0.8rCSI 1.9%PRS 72.3%
-
CSI 0.8rCSI 4.5%PRS 86.4%
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CSI 0.9rCSI 5.3%PRS 84.8%
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CSI 1.0rCSI 2.4%PRS 58.2%
-
CSI 1.0rCSI 16.0%PRS 88.5%
-
CSI 1.0rCSI 2.3%PRS 84.8%
-
CSI 1.0rCSI 2.6%PRS 73.7%
-
CSI 1.0rCSI 19.6%PRS 86.7%
-
CSI 1.1rCSI 2.8%PRS 83.6%
-
CSI 1.1rCSI 1.6%PRS 87.0%
-
CSI 1.1rCSI 27.8%PRS 87.1%
-
CSI 1.1rCSI 4.7%PRS 86.9%
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CSI 1.1rCSI 7.2%PRS 85.7%
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CSI 1.2rCSI 27.1%PRS 90.6%
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CSI 1.2rCSI 2.6%PRS 77.7%
-
CSI 1.2rCSI 1.4%PRS 79.9%
-
CSI 1.2rCSI 2.7%PRS 85.5%
-
CSI 1.3rCSI 2.8%PRS 86.7%
-
CSI 1.3rCSI 1.3%PRS 82.6%
-
CSI 1.4rCSI 3.0%PRS 84.2%
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CSI 1.4rCSI 1.9%PRS 84.0%
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CSI 1.4rCSI 7.3%PRS 92.7%
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CSI 1.5rCSI 5.5%PRS 69.2%
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CSI 1.5rCSI 3.3%PRS 61.1%
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CSI 1.5rCSI 4.2%PRS 85.2%
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CSI 1.5rCSI 4.6%PRS 82.9%
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CSI 1.6rCSI 2.7%PRS 69.7%
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CSI 1.6rCSI 1.7%PRS 79.5%
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CSI 1.6rCSI 1.3%PRS 80.6%
-
CSI 1.6rCSI 8.2%PRS 93.3%
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CSI 1.7rCSI 3.4%PRS 88.3%
-
CSI 1.7rCSI 2.5%PRS 88.8%
-
CSI 1.7rCSI 3.9%PRS 66.4%
-
CSI 1.7rCSI 12.3%PRS 86.7%
-
CSI 1.7rCSI 1.5%PRS 82.4%
-
CSI 1.7rCSI 2.5%PRS 87.6%
-
CSI 1.7rCSI 2.2%PRS 61.3%
-
CSI 1.8rCSI 10.3%PRS 75.3%
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CSI 1.8rCSI 3.2%PRS 59.5%
-
CSI 1.8rCSI 2.1%PRS 70.5%
-
CSI 1.8rCSI 44.8%PRS 92.0%
-
CSI 1.8rCSI 3.2%PRS 77.5%
-
CSI 1.8rCSI 2.7%PRS 72.9%
-
CSI 1.8rCSI 4.0%PRS 64.2%
-
CSI 1.9rCSI 3.4%PRS 88.8%
-
CSI 1.9rCSI 57.3%PRS 89.4%
-
CSI 1.9rCSI 3.4%PRS 71.8%
-
CSI 2.0rCSI 4.7%PRS 82.6%
-
CSI 2.0rCSI 5.4%PRS 86.5%
-
CSI 2.0rCSI 2.5%PRS 79.7%
-
CSI 2.0rCSI 3.0%PRS 83.1%
-
CSI 2.0rCSI 2.0%PRS 72.1%
-
CSI 2.1rCSI 3.0%PRS 85.4%
-
CSI 2.1rCSI 3.0%PRS 71.3%
-
CSI 2.1rCSI 1.8%PRS 81.4%
-
CSI 2.1rCSI 2.2%PRS 75.7%
-
CSI 2.1rCSI 3.1%PRS 79.2%
-
CSI 2.2rCSI 2.8%PRS 74.5%
-
CSI 2.2rCSI 2.5%PRS 82.3%
-
CSI 2.2rCSI 5.4%PRS 77.8%
-
CSI 2.2rCSI 6.3%PRS 73.5%
-
CSI 2.2rCSI 9.0%PRS 77.8%
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CSI 2.2rCSI 5.7%PRS 83.7%
-
CSI 2.3rCSI 4.2%PRS 66.6%
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CSI 2.3rCSI 3.8%PRS 67.8%
-
CSI 2.3rCSI 6.1%PRS 85.6%
-
CSI 2.4rCSI 3.2%PRS 77.2%
-
CSI 2.4rCSI 5.8%PRS 91.2%
-
CSI 2.4rCSI 3.6%PRS 82.5%
-
CSI 2.5rCSI 4.0%PRS 73.4%
-
CSI 2.6rCSI 3.8%PRS 78.5%
-
CSI 2.6rCSI 6.1%PRS 84.0%
-
CSI 2.6rCSI 4.0%PRS 86.7%
-
CSI 2.6rCSI 2.3%PRS 76.0%
-
CSI 2.7rCSI 6.3%PRS 89.1%
-
CSI 2.7rCSI 7.8%PRS 74.6%
-
CSI 2.8rCSI 3.8%PRS 69.8%
-
CSI 2.8rCSI 2.9%PRS 86.5%
-
CSI 2.8rCSI 4.4%PRS 79.9%
-
CSI 2.8rCSI 12.9%PRS 83.0%
-
CSI 2.8rCSI 8.3%PRS 79.2%
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CSI 2.8rCSI 2.5%PRS 67.3%
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CSI 3.0rCSI 4.7%PRS 71.2%
-
CSI 3.0rCSI 8.6%PRS 74.0%
-
CSI 3.0rCSI 5.3%PRS 71.8%
-
CSI 3.0rCSI 5.7%PRS 89.4%
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CSI 3.0rCSI 7.9%PRS 85.0%
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CSI 3.0rCSI 4.2%PRS 78.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1010296425
Symbol: RCN1_HUMAN
Name: Reticulocalbin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8586628
Title: Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs.
PubMed ID: 8586628
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28512129
Title: Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.
PubMed ID: 28512129
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 331
- Mass: 38890
- Checksum: 608AAD536963F789
- Sequence:
MARGGRGRRL GLALGLLLAL VLAPRVLRAK PTVRKERVVR PDSELGERPP EDNQSFQYDH EAFLGKEDSK TFDQLTPDES KERLGKIVDR IDNDGDGFVT TEELKTWIKR VQKRYIFDNV AKVWKDYDRD KDDKISWEEY KQATYGYYLG NPAEFHDSSD HHTFKKMLPR DERRFKAADL NGDLTATREE FTAFLHPEEF EHMKEIVVLE TLEDIDKNGD GFVDQDEYIA DMFSHEENGP EPDWVLSERE QFNEFRDLNK DGKLDKDEIR HWILPQDYDH AQAEARHLVY ESDKNKDEKL TKEEILENWN MFVGSQATNY GEDLTKNHDE L