Gene CXCL3 - ENSG00000163734 | NCBI Gene ID: 2921

Details for: CXCL3

Gene ID: 2921

Symbol: CXCL3

Ensembl ID: ENSG00000163734

Description: C-X-C motif chemokine ligand 3

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cellular response to lipopolysaccharide
(GO:0071222)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Cxcr chemokine receptor binding
(GO:0045236)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Neutrophil chemotaxis
(GO:0030593)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 4.36
Marker Score: 8553
Cell Name: elicited macrophage (CL0000861)
Fold Change: 3.19
Marker Score: 19411
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.91
Marker Score: 6596
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.7
Marker Score: 91832
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.66
Marker Score: 1146
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.27
Marker Score: 2598
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.18
Marker Score: 55716
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.06
Marker Score: 733
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.84
Marker Score: 9023
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.76
Marker Score: 1125
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.62
Marker Score: 10309
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.38
Marker Score: 468
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.36
Marker Score: 850
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 1.25
Marker Score: 449
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.25
Marker Score: 2548
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.25
Marker Score: 585
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.18
Marker Score: 300
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.15
Marker Score: 258
Cell Name: macrophage (CL0000235)
Fold Change: 1.14
Marker Score: 1271
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.13
Marker Score: 39074
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.05
Marker Score: 2710
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71775
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48003.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.99
Marker Score: 2260
Cell Name: club cell (CL0000158)
Fold Change: 0.99
Marker Score: 1154
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.98
Marker Score: 382.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.97
Marker Score: 478
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5337
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.93
Marker Score: 1762
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.93
Marker Score: 924
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2726
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.9
Marker Score: 309
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.87
Marker Score: 748
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.87
Marker Score: 1470.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5266
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.86
Marker Score: 3331
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.86
Marker Score: 5620
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.84
Marker Score: 482
Cell Name: reticular cell (CL0000432)
Fold Change: 0.84
Marker Score: 306
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 635
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.83
Marker Score: 1322
Cell Name: stem cell (CL0000034)
Fold Change: 0.81
Marker Score: 1923
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 323
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1271
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.77
Marker Score: 1893
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.76
Marker Score: 1244
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.75
Marker Score: 1833.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 388
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 676
Cell Name: malignant cell (CL0001064)
Fold Change: 0.73
Marker Score: 9856
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.73
Marker Score: 305
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.72
Marker Score: 2253.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.71
Marker Score: 2625
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.71
Marker Score: 711
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2961
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.7
Marker Score: 361
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.7
Marker Score: 1927
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.66
Marker Score: 966
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.66
Marker Score: 1063
Cell Name: secretory cell (CL0000151)
Fold Change: 0.66
Marker Score: 1201
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.65
Marker Score: 1712
Cell Name: fibroblast (CL0000057)
Fold Change: 0.65
Marker Score: 626
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.65
Marker Score: 297
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.63
Marker Score: 631
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.63
Marker Score: 189
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.63
Marker Score: 1005
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.63
Marker Score: 673
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.61
Marker Score: 585
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.61
Marker Score: 1544
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.6
Marker Score: 513
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.59
Marker Score: 3105
Cell Name: lactocyte (CL0002325)
Fold Change: 0.58
Marker Score: 9293
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.58
Marker Score: 183
Cell Name: stromal cell (CL0000499)
Fold Change: 0.58
Marker Score: 675
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.57
Marker Score: 386
Cell Name: monocyte (CL0000576)
Fold Change: 0.57
Marker Score: 740
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.57
Marker Score: 599
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.57
Marker Score: 557
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.57
Marker Score: 214
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.57
Marker Score: 507
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.56
Marker Score: 231
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.54
Marker Score: 156.5
Cell Name: basal cell (CL0000646)
Fold Change: 0.54
Marker Score: 694
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.53
Marker Score: 133
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.53
Marker Score: 652
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.53
Marker Score: 133
Cell Name: plasmablast (CL0000980)
Fold Change: 0.5
Marker Score: 668
Cell Name: B cell (CL0000236)
Fold Change: 0.5
Marker Score: 476
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.5
Marker Score: 289
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.49
Marker Score: 119
Cell Name: granulocyte (CL0000094)
Fold Change: 0.48
Marker Score: 215
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.48
Marker Score: 694
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.48
Marker Score: 732

Hover over a box to see details here...

**Key characteristics:** - CXCL3 is a chemokine that is primarily produced by epithelial cells and macrophages. - It is a chemotactic factor that binds to its receptor, CXCR2, expressed on immune cells, including neutrophils, macrophages, and dendritic cells. - CXCL3 is a key mediator of the antimicrobial humoral immune response by attracting immune cells to sites of infection. **Pathways and functions:** - CXCL3 is produced in response to infection or injury and acts as a chemoattractant for immune cells. - It binds to CXCR2 on immune cells, which triggers downstream signaling events that lead to the migration and infiltration of immune cells to the site of infection. - CXCL3 also plays a role in the regulation of inflammation by promoting the recruitment of regulatory immune cells. **Clinical significance:** - CXCL3 is a potential therapeutic target for inflammatory diseases, such as sepsis, inflammatory bowel disease, and rheumatoid arthritis. - Blockade of CXCL3 signaling has been shown to inhibit inflammation and improve disease outcomes in animal models of infection. - CXCL3 is a valuable target for the development of novel therapeutic strategies for inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-X-C motif chemokine 3

Genular Protein ID: 2429932623

Symbol: CXCL3_HUMAN

Name: C-X-C motif chemokine 3

UniProtKB Accession Codes:

P19876 Q4W5H9

Database IDs:

Citations:

PubMed ID: 2201751

Title: Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.

PubMed ID: 2201751

DOI: 10.1084/jem.172.3.911

PubMed ID: 2217207

Title: Identification of three related human GRO genes encoding cytokine functions.

PubMed ID: 2217207

DOI: 10.1073/pnas.87.19.7732

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10095777

Title: Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

PubMed ID: 10095777

DOI: 10.1046/j.1432-1327.1999.00166.x

Sequence Information:

Length: 107
Mass: 11342
Checksum: 97A69946B7F1F070
Sequence:

MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ GIHLKNIQSV 
NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI LNKGSTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CXCL3

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. PubMed ID: 2201751

Identification of three related human GRO genes encoding cytokine functions. PubMed ID: 2217207

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161