Details for: IFI27

Gene ID: 3429

Symbol: IFI27

Ensembl ID: ENSG00000165949

Description: interferon alpha inducible protein 27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 285.0618
    Cell Significance Index: -44.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 213.3113
    Cell Significance Index: -54.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 125.0159
    Cell Significance Index: -51.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 122.1394
    Cell Significance Index: -49.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 112.8097
    Cell Significance Index: -53.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 80.8021
    Cell Significance Index: -54.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.2549
    Cell Significance Index: -49.8900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 41.2115
    Cell Significance Index: 354.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.7743
    Cell Significance Index: -49.0400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 22.4459
    Cell Significance Index: 83.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.3133
    Cell Significance Index: -46.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 16.7602
    Cell Significance Index: 120.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.5133
    Cell Significance Index: -50.7200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.5855
    Cell Significance Index: 257.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5661
    Cell Significance Index: -53.5300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 12.3863
    Cell Significance Index: 72.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.3614
    Cell Significance Index: 106.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 7.0498
    Cell Significance Index: 367.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.6812
    Cell Significance Index: 131.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.7416
    Cell Significance Index: 98.3900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.0217
    Cell Significance Index: 46.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5619
    Cell Significance Index: 253.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0515
    Cell Significance Index: 30.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5623
    Cell Significance Index: 44.7900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.5060
    Cell Significance Index: 9.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1998
    Cell Significance Index: 164.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9887
    Cell Significance Index: 160.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9680
    Cell Significance Index: 528.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8750
    Cell Significance Index: 60.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8133
    Cell Significance Index: 104.2600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.5890
    Cell Significance Index: 5.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5379
    Cell Significance Index: 24.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5105
    Cell Significance Index: 97.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5055
    Cell Significance Index: 223.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3027
    Cell Significance Index: 37.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1038
    Cell Significance Index: 2.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0684
    Cell Significance Index: 51.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0259
    Cell Significance Index: 0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0244
    Cell Significance Index: -18.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0261
    Cell Significance Index: -49.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0380
    Cell Significance Index: -70.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0407
    Cell Significance Index: -22.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0443
    Cell Significance Index: -68.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0499
    Cell Significance Index: -9.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0517
    Cell Significance Index: -70.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0633
    Cell Significance Index: -11.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0684
    Cell Significance Index: -50.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0755
    Cell Significance Index: -47.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0835
    Cell Significance Index: -8.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0871
    Cell Significance Index: -0.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1161
    Cell Significance Index: -41.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1167
    Cell Significance Index: -33.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1263
    Cell Significance Index: -57.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1327
    Cell Significance Index: -4.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1339
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1648
    Cell Significance Index: -34.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1748
    Cell Significance Index: -4.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1845
    Cell Significance Index: -3.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2089
    Cell Significance Index: -24.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2141
    Cell Significance Index: -36.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2174
    Cell Significance Index: -24.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2356
    Cell Significance Index: -47.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2641
    Cell Significance Index: -28.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2877
    Cell Significance Index: -37.1700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.3406
    Cell Significance Index: -1.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3539
    Cell Significance Index: -51.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3563
    Cell Significance Index: -6.5900
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.4241
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4263
    Cell Significance Index: -48.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4537
    Cell Significance Index: -18.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4718
    Cell Significance Index: -55.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4912
    Cell Significance Index: -7.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4959
    Cell Significance Index: -25.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5175
    Cell Significance Index: -53.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5300
    Cell Significance Index: -39.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5338
    Cell Significance Index: -25.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6028
    Cell Significance Index: -37.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6058
    Cell Significance Index: -3.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6162
    Cell Significance Index: -47.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6251
    Cell Significance Index: -44.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6343
    Cell Significance Index: -50.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6498
    Cell Significance Index: -18.1600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.6777
    Cell Significance Index: -9.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7037
    Cell Significance Index: -15.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7700
    Cell Significance Index: -47.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8244
    Cell Significance Index: -16.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8357
    Cell Significance Index: -53.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9961
    Cell Significance Index: -13.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0300
    Cell Significance Index: -54.0800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.0348
    Cell Significance Index: -6.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0455
    Cell Significance Index: -58.6700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -1.1378
    Cell Significance Index: -7.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.1464
    Cell Significance Index: -30.6100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.1818
    Cell Significance Index: -7.7100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.2301
    Cell Significance Index: -25.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2534
    Cell Significance Index: -46.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3826
    Cell Significance Index: -48.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3857
    Cell Significance Index: -64.6100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.3875
    Cell Significance Index: -11.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFI27 is a small protein (11.5 kDa) that is induced by interferon alpha (IFN-α) signaling. It is highly expressed in various types of endothelial cells, including alveolar capillary type 1 and 2 endothelial cells, pulmonary artery endothelial cells, and intestinal goblet cells. IFI27 is also found in other cell types, such as foveolar cells of the stomach, endothelial cells of the uterus, and enterocytes. **Pathways and Functions:** IFI27 is involved in several key pathways, including: 1. **Apoptotic signaling pathway:** IFI27 regulates apoptosis by interacting with lamin B, a component of the nuclear envelope. 2. **Cytokine signaling in immune system:** IFI27 modulates cytokine signaling by interacting with various proteins, including interferons and cytokine receptors. 3. **Innate immune response:** IFI27 is involved in the regulation of innate immune responses, including the defense against viral infections. 4. **Extrinsic apoptotic signaling pathway:** IFI27 interacts with caspases, which are key regulators of apoptosis. 5. **Type I interferon-mediated signaling pathway:** IFI27 is induced by IFN-α and modulates its signaling pathway. IFI27 functions as a molecular adaptor protein, interacting with various proteins and influencing their activity. It regulates protein export from the nucleus, interacts with RNA polymerase II, and modulates transcriptional regulation. **Significant Expression in Different Cell Types:** IFI27 is highly expressed in endothelial cells, which are critical for maintaining vascular integrity and regulating immune responses. Its expression is also observed in other cell types, including foveolar cells of the stomach, endothelial cells of the uterus, and enterocytes. **Clinical Significance:** IFI27 plays a crucial role in regulating immune responses and maintaining tissue homeostasis. Its dysregulation has been implicated in various diseases, including: 1. **Viral infections:** IFI27 is induced by IFN-α and plays a key role in regulating the innate immune response against viral infections. 2. **Cancer:** IFI27 has been shown to inhibit cancer cell growth and promote apoptosis. 3. **Inflammatory diseases:** IFI27 regulates inflammation by modulating cytokine signaling and immune response. 4. **Cardiovascular diseases:** IFI27 is involved in regulating vascular integrity and maintaining endothelial function. In conclusion, IFI27 is a multifaceted protein that plays a crucial role in regulating immune responses and maintaining tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of IFI27 and its clinical significance.

Genular Protein ID: 1573242795

Symbol: IFI27_HUMAN

Name: Interferon alpha-induced 11.5 kDa protein

UniProtKB Accession Codes:

P40305 A0A087WZF8 A8K0H0 Q53YA6 Q6IEC1 Q7Z5R0 Q7Z5R1 Q7Z5R2 Q96BK3 Q9H4B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 8 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 10 STRING 1 SignaLink 1 TreeFam 1 UCSC 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8358738

Title: Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma.

PubMed ID: 8358738

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11722583

Title: The interferon alpha induced protein ISG12 is localized to the nuclear membrane.

PubMed ID: 11722583

DOI: 10.1046/j.0014-2956.2001.02545.x

PubMed ID: 12878323

Title: A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene.

PubMed ID: 12878323

DOI: 10.1016/s0925-4439(03)00087-5

PubMed ID: 14728724

Title: Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.

PubMed ID: 14728724

DOI: 10.1186/1471-2164-5-8

PubMed ID: 18330707

Title: Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a.

PubMed ID: 18330707

DOI: 10.1007/s10495-008-0190-0

PubMed ID: 22427340

Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.

PubMed ID: 22427340

DOI: 10.1161/circresaha.111.258814

PubMed ID: 24970806

Title: miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT.

PubMed ID: 24970806

DOI: 10.18632/oncotarget.2067

PubMed ID: 27194766

Title: ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway.

PubMed ID: 27194766

DOI: 10.1128/jvi.00352-16

PubMed ID: 27673746

Title: Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

PubMed ID: 27673746

DOI: 10.1111/boc.201600034

PubMed ID: 27777077

Title: ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-alpha through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis.

PubMed ID: 27777077

DOI: 10.1016/j.virusres.2016.10.013

PubMed ID: 36426955

Title: TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a.

PubMed ID: 36426955

DOI: 10.4049/jimmunol.2200163

Sequence Information:

  • Length: 122
  • Mass: 11542
  • Checksum: A424B2EDEAA678A3
  • Sequence:
    • MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAMAAVPMV LSAMGFTAAG 
IASSSIAAKM MSAAAIANGG GVASGSLVAT LQSLGATGLS GLTKFILGSI GSAIAAVIAR 
FY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.