Details for: IFI27

Gene ID: 3429

Symbol: IFI27

Ensembl ID: ENSG00000165949

Description: interferon alpha inducible protein 27

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.91
    Marker Score: 15027
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.74
    Marker Score: 6861
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.52
    Marker Score: 28837
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.22
    Marker Score: 3634
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.68
    Marker Score: 3527.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.65
    Marker Score: 7298
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.49
    Marker Score: 5071
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.37
    Marker Score: 16184
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.32
    Marker Score: 4004
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.21
    Marker Score: 747
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.12
    Marker Score: 27342
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.04
    Marker Score: 1049
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.96
    Marker Score: 9290
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.95
    Marker Score: 6696
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.85
    Marker Score: 4673
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.84
    Marker Score: 6984
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.77
    Marker Score: 4696
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.76
    Marker Score: 5040
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.74
    Marker Score: 1830
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.68
    Marker Score: 4123
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.66
    Marker Score: 1032
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.64
    Marker Score: 22921
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.54
    Marker Score: 1819.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.53
    Marker Score: 13315
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.51
    Marker Score: 1711
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 2.48
    Marker Score: 1029
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.46
    Marker Score: 8472
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.42
    Marker Score: 1245.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.39
    Marker Score: 2406
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.32
    Marker Score: 10004
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.31
    Marker Score: 2075
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.29
    Marker Score: 4359
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.27
    Marker Score: 946
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.18
    Marker Score: 554
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.13
    Marker Score: 15880
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.12
    Marker Score: 1268.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.11
    Marker Score: 16481
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.1
    Marker Score: 446
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.1
    Marker Score: 2881
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.05
    Marker Score: 462
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.04
    Marker Score: 589
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.95
    Marker Score: 66289
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.94
    Marker Score: 1754
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.8
    Marker Score: 671.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.79
    Marker Score: 1244
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.78
    Marker Score: 922
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.77
    Marker Score: 826
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.76
    Marker Score: 485
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.73
    Marker Score: 2756
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.73
    Marker Score: 19453
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.71
    Marker Score: 374
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.67
    Marker Score: 951
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.63
    Marker Score: 391
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.6
    Marker Score: 5917
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.54
    Marker Score: 646
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.53
    Marker Score: 1529
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.53
    Marker Score: 417
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.53
    Marker Score: 957
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.52
    Marker Score: 1779
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.51
    Marker Score: 570
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.49
    Marker Score: 1600
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166468
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.41
    Marker Score: 3662
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.39
    Marker Score: 3292
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.38
    Marker Score: 366
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.38
    Marker Score: 3438.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.38
    Marker Score: 846
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.37
    Marker Score: 676
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.37
    Marker Score: 348
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.37
    Marker Score: 613
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.33
    Marker Score: 11450
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.31
    Marker Score: 592
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.28
    Marker Score: 20588
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.26
    Marker Score: 330
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.25
    Marker Score: 14564
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.25
    Marker Score: 361
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.25
    Marker Score: 2002
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.21
    Marker Score: 67648
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.2
    Marker Score: 514
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.18
    Marker Score: 494
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.17
    Marker Score: 337
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.17
    Marker Score: 40510
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1227
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.15
    Marker Score: 4088
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.15
    Marker Score: 544
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.15
    Marker Score: 976
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.11
    Marker Score: 1075
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.1
    Marker Score: 621
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.09
    Marker Score: 7104
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.09
    Marker Score: 436
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.07
    Marker Score: 294
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.06
    Marker Score: 359
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.03
    Marker Score: 272
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.02
    Marker Score: 1350.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1
    Marker Score: 2617
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71694
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47918
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.99
    Marker Score: 723
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.99
    Marker Score: 25367
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390

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Other Information

## Summary The IFI27 gene encodes a protein called IFI27, which is a key regulator of the innate immune response. It is highly expressed in various cell types, including endothelial cells, immune cells, and cancer cells. IFI27 plays a crucial role in the regulation of apoptosis, inflammation, and cell migration. ## Key characteristics * IFI27 is a member of the IFN alpha/beta receptor family. * It is a protein of the immunoglobulin superfamily. * IFI27 is a key regulator of the innate immune response. * It is involved in the regulation of apoptosis, inflammation, and cell migration. * It is a target for cancer immunotherapy. ## Pathways and functions * IFI27 is involved in the regulation of apoptosis. * It is a key regulator of inflammation. * It is involved in the regulation of cell migration. * It is a target for cancer immunotherapy. ## Clinical significance * IFI27 is a potential therapeutic target for cancer. * Mutations in the IFI27 gene have been linked to the development of cancer. * IFI27 inhibitors are being investigated as cancer treatments. ## Additional notes * IFI27 is a highly conserved protein. * It is expressed in high levels in many cancer cells. * It is a key regulator of the tumor microenvironment.

Genular Protein ID: 1573242795

Symbol: IFI27_HUMAN

Name: Interferon alpha-induced 11.5 kDa protein

UniProtKB Accession Codes:

P40305 A0A087WZF8 A8K0H0 Q53YA6 Q6IEC1 Q7Z5R0 Q7Z5R1 Q7Z5R2 Q96BK3 Q9H4B1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 8 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 10 STRING 1 SignaLink 1 TreeFam 1 UCSC 3 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8358738

Title: Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma.

PubMed ID: 8358738

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11722583

Title: The interferon alpha induced protein ISG12 is localized to the nuclear membrane.

PubMed ID: 11722583

DOI: 10.1046/j.0014-2956.2001.02545.x

PubMed ID: 12878323

Title: A nine-nucleotide deletion and splice variation in the coding region of the interferon induced ISG12 gene.

PubMed ID: 12878323

DOI: 10.1016/s0925-4439(03)00087-5

PubMed ID: 14728724

Title: Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12.

PubMed ID: 14728724

DOI: 10.1186/1471-2164-5-8

PubMed ID: 18330707

Title: Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a.

PubMed ID: 18330707

DOI: 10.1007/s10495-008-0190-0

PubMed ID: 22427340

Title: The interferon stimulated gene 12 inactivates vasculoprotective functions of NR4A nuclear receptors.

PubMed ID: 22427340

DOI: 10.1161/circresaha.111.258814

PubMed ID: 24970806

Title: miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT.

PubMed ID: 24970806

DOI: 10.18632/oncotarget.2067

PubMed ID: 27194766

Title: ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway.

PubMed ID: 27194766

DOI: 10.1128/jvi.00352-16

PubMed ID: 27673746

Title: Apoptotic properties of the type 1 interferon induced family of human mitochondrial membrane ISG12 proteins.

PubMed ID: 27673746

DOI: 10.1111/boc.201600034

PubMed ID: 27777077

Title: ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-alpha through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis.

PubMed ID: 27777077

DOI: 10.1016/j.virusres.2016.10.013

PubMed ID: 36426955

Title: TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a.

PubMed ID: 36426955

DOI: 10.4049/jimmunol.2200163

Sequence Information:

  • Length: 122
  • Mass: 11542
  • Checksum: A424B2EDEAA678A3
  • Sequence:
    • MEASALTSSA VTSVAKVVRV ASGSAVVLPL ARIATVVIGG VVAMAAVPMV LSAMGFTAAG 
IASSSIAAKM MSAAAIANGG GVASGSLVAT LQSLGATGLS GLTKFILGSI GSAIAAVIAR 
FY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.