Details for: ID1

Gene ID: 3397

Symbol: ID1

Ensembl ID: ENSG00000125968

Description: inhibitor of DNA binding 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.58
    Marker Score: 11642
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.43
    Marker Score: 2953
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.22
    Marker Score: 4656
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.16
    Marker Score: 6305
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.14
    Marker Score: 24508.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.95
    Marker Score: 3552.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.89
    Marker Score: 2265
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.84
    Marker Score: 4961
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.7
    Marker Score: 3930
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.69
    Marker Score: 5615
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.68
    Marker Score: 6089
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.66
    Marker Score: 12746
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.53
    Marker Score: 4066
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.51
    Marker Score: 3694
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.5
    Marker Score: 3981
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.49
    Marker Score: 1663
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.47
    Marker Score: 575
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.44
    Marker Score: 3146.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.43
    Marker Score: 1376
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.43
    Marker Score: 779
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.41
    Marker Score: 6089
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.39
    Marker Score: 4355.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.37
    Marker Score: 2763
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.36
    Marker Score: 15071
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.34
    Marker Score: 2076
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.33
    Marker Score: 7319
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.32
    Marker Score: 26157
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.3
    Marker Score: 2209
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2
    Marker Score: 19321.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.2
    Marker Score: 3739
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.14
    Marker Score: 18440
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.13
    Marker Score: 2245
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.11
    Marker Score: 13736
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.1
    Marker Score: 1818
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.08
    Marker Score: 1478
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.08
    Marker Score: 1636
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.07
    Marker Score: 7648
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.06
    Marker Score: 3170
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.05
    Marker Score: 1931.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.03
    Marker Score: 3128
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.03
    Marker Score: 15097
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.03
    Marker Score: 1210
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.01
    Marker Score: 441
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2
    Marker Score: 1166
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2
    Marker Score: 485
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.97
    Marker Score: 387
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.97
    Marker Score: 1764
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.97
    Marker Score: 4806.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.97
    Marker Score: 2563
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.97
    Marker Score: 1960
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.95
    Marker Score: 2361
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.94
    Marker Score: 4567
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.94
    Marker Score: 481
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.94
    Marker Score: 1617
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.92
    Marker Score: 543.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.92
    Marker Score: 2062
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.9
    Marker Score: 854
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.89
    Marker Score: 521
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.89
    Marker Score: 402
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.84
    Marker Score: 4370
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.83
    Marker Score: 904
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.83
    Marker Score: 1269
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.82
    Marker Score: 1735
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.8
    Marker Score: 1624
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.78
    Marker Score: 513
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.76
    Marker Score: 905
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.74
    Marker Score: 1857
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.72
    Marker Score: 404
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.71
    Marker Score: 495
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.71
    Marker Score: 2892
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.69
    Marker Score: 57643
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.68
    Marker Score: 564
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.67
    Marker Score: 1844
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.66
    Marker Score: 1478.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.65
    Marker Score: 26558
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.63
    Marker Score: 899
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.63
    Marker Score: 953
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.62
    Marker Score: 1631
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.6
    Marker Score: 603
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.6
    Marker Score: 406
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.59
    Marker Score: 714
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.57
    Marker Score: 1759
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.55
    Marker Score: 449
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.55
    Marker Score: 373
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.54
    Marker Score: 1087
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.51
    Marker Score: 712
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.5
    Marker Score: 1162.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.5
    Marker Score: 6235
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166704
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.44
    Marker Score: 2362.5
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.42
    Marker Score: 389
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.4
    Marker Score: 880
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.39
    Marker Score: 826
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.38
    Marker Score: 352
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.38
    Marker Score: 351
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.37
    Marker Score: 388
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.37
    Marker Score: 393
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.36
    Marker Score: 18003
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.36
    Marker Score: 911
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.36
    Marker Score: 275

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - ID1 is a protein of the immunoglobulin superfamily. - It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and germ cells. - ID1 is a negative regulator of transcription by RNA polymerase II. - It regulates the expression of genes involved in cell differentiation, angiogenesis, and cellular responses to stress. - ID1 is a key regulator of tumor growth and survival. **Pathways and functions:** - ID1 inhibits the binding of DBP1 to its target DNA sequences, thereby blocking its transcriptional activity. - This prevents the expression of genes that are regulated by DBP1, including those involved in cell cycle regulation, cell growth, and differentiation. - ID1 also regulates the expression of genes involved in stress response and cellular senescence. - In cancer, ID1 overexpression leads to the activation of oncogenes and the development of tumors. **Clinical significance:** - ID1 is a potential therapeutic target for cancer and other diseases characterized by abnormal cell growth and proliferation. - Agents that inhibit ID1 have been shown to be effective in preclinical models of cancer. - Further research is needed to develop safe and effective ID1 inhibitors for clinical use.

Genular Protein ID: 1702071202

Symbol: ID1_HUMAN

Name: DNA-binding protein inhibitor ID-1

UniProtKB Accession Codes:

P41134 A8K537 E1P5L4 O00651 O00652 Q16371 Q16377 Q5TE66 Q5TE67 Q969Z7 Q9H0Z5 Q9H109

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 2 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8086456

Title: Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins.

PubMed ID: 8086456

DOI: 10.1016/0167-4781(94)90261-5

PubMed ID: 8294468

Title: Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.

PubMed ID: 8294468

DOI: 10.1016/s0021-9258(17)42146-6

PubMed ID: 7637581

Title: Id gene expression during development and molecular cloning of the human Id-1 gene.

PubMed ID: 7637581

DOI: 10.1016/0169-328x(95)00017-m

PubMed ID: 9070860

Title: Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene.

PubMed ID: 9070860

DOI: 10.1006/bbrc.1997.6152

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20861012

Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.

PubMed ID: 20861012

DOI: 10.1074/jbc.m110.175182

Sequence Information:

  • Length: 155
  • Mass: 16133
  • Checksum: 480287384B667161
  • Sequence:
    • MKVASGSTAT AAAGPSCALK AGKTASGAGE VVRCLSEQSV AISRCAGGAG ARLPALLDEQ 
QVNVLLYDMN GCYSRLKELV PTLPQNRKVS KVEILQHVID YIRDLQLELN SESEVGTPGG 
RGLPVRAPLS TLNGEISALT AEAACVPADD RILCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.