Details for: EMCN

Gene ID: 51705

Symbol: EMCN

Ensembl ID: ENSG00000164035

Description: endomucin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.7360
    Cell Significance Index: -17.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.4713
    Cell Significance Index: -16.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.5346
    Cell Significance Index: -17.2800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 33.4884
    Cell Significance Index: 124.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0962
    Cell Significance Index: -17.3800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 11.4666
    Cell Significance Index: 67.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 11.1663
    Cell Significance Index: 160.6000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 9.3450
    Cell Significance Index: 96.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.1207
    Cell Significance Index: 108.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.1274
    Cell Significance Index: 58.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4044
    Cell Significance Index: -17.3800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.0173
    Cell Significance Index: 21.6700
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.2806
    Cell Significance Index: 14.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.0530
    Cell Significance Index: 49.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8025
    Cell Significance Index: 81.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2769
    Cell Significance Index: 243.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2083
    Cell Significance Index: 62.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9206
    Cell Significance Index: 91.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8088
    Cell Significance Index: 730.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5423
    Cell Significance Index: 17.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5276
    Cell Significance Index: 19.9800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4642
    Cell Significance Index: 1.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4524
    Cell Significance Index: 20.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4213
    Cell Significance Index: 68.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3020
    Cell Significance Index: 32.8500
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.2612
    Cell Significance Index: 2.2100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.1625
    Cell Significance Index: 2.2300
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 0.1483
    Cell Significance Index: 0.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1351
    Cell Significance Index: 9.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0929
    Cell Significance Index: 18.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0272
    Cell Significance Index: 4.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0271
    Cell Significance Index: 0.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0196
    Cell Significance Index: 0.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0142
    Cell Significance Index: 0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0129
    Cell Significance Index: 2.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0078
    Cell Significance Index: 3.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0063
    Cell Significance Index: 11.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0015
    Cell Significance Index: -0.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0041
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0045
    Cell Significance Index: -0.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0116
    Cell Significance Index: -0.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0128
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0188
    Cell Significance Index: -3.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0214
    Cell Significance Index: -2.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0257
    Cell Significance Index: -18.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0278
    Cell Significance Index: -15.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0282
    Cell Significance Index: -10.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0397
    Cell Significance Index: -0.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0403
    Cell Significance Index: -0.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0490
    Cell Significance Index: -14.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0606
    Cell Significance Index: -7.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0639
    Cell Significance Index: -4.3000
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0655
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0685
    Cell Significance Index: -5.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0768
    Cell Significance Index: -1.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0850
    Cell Significance Index: -5.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1068
    Cell Significance Index: -14.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1186
    Cell Significance Index: -13.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1253
    Cell Significance Index: -14.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1288
    Cell Significance Index: -16.6400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1416
    Cell Significance Index: -1.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1454
    Cell Significance Index: -15.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1487
    Cell Significance Index: -17.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1548
    Cell Significance Index: -15.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2031
    Cell Significance Index: -12.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2208
    Cell Significance Index: -9.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2311
    Cell Significance Index: -18.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2329
    Cell Significance Index: -17.3600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2523
    Cell Significance Index: -3.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2834
    Cell Significance Index: -4.2700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2923
    Cell Significance Index: -3.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3002
    Cell Significance Index: -19.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3111
    Cell Significance Index: -6.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3143
    Cell Significance Index: -19.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3214
    Cell Significance Index: -18.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3221
    Cell Significance Index: -15.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3251
    Cell Significance Index: -15.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3265
    Cell Significance Index: -16.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3687
    Cell Significance Index: -19.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3788
    Cell Significance Index: -6.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3788
    Cell Significance Index: -19.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3803
    Cell Significance Index: -7.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3921
    Cell Significance Index: -10.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3962
    Cell Significance Index: -11.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4128
    Cell Significance Index: -8.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4365
    Cell Significance Index: -12.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4616
    Cell Significance Index: -16.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4725
    Cell Significance Index: -16.4200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4729
    Cell Significance Index: -6.1100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4749
    Cell Significance Index: -5.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4759
    Cell Significance Index: -17.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** EMCN is predominantly expressed in the extracellular region, where it may interact with various proteins and influence cell-cell interactions. 2. **Cell type specificity:** EMCN is specifically expressed in hematopoietic stem cells, mast cells, and endothelial cells, highlighting its significance in these cell types. 3. **Protein binding:** EMCN interacts with other proteins, which may modulate its function and influence cellular behavior. 4. **Signaling pathways:** EMCN is involved in hematopoietic stem cell homeostasis, suggesting its role in signaling pathways that regulate cell proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Hematopoietic stem cell homeostasis:** EMCN is crucial in maintaining the balance of hematopoietic stem cells in the bone marrow, ensuring proper hematopoiesis and preventing leukemic transformations. 2. **Cell-cell interactions:** EMCN may facilitate cell-cell interactions between hematopoietic stem cells, endothelial cells, and other cell types, influencing cellular communication and signaling. 3. **Immune system regulation:** EMCN's involvement in mast cell function and its expression in endothelial cells suggest its potential role in regulating immune responses and inflammation. 4. **Angiogenesis and vascular development:** EMCN's presence in endothelial cells may contribute to vascular development and angiogenesis, processes essential for tissue growth and repair. **Clinical Significance:** 1. **Hematological disorders:** Alterations in EMCN expression or function may contribute to hematological disorders, such as leukemia or lymphoma, highlighting the need for further research into its role in these diseases. 2. **Immune system dysregulation:** EMCN's involvement in immune system regulation and mast cell function may shed light on the mechanisms underlying immune-related disorders, such as allergy or autoimmune diseases. 3. **Cancer research:** EMCN's expression in endothelial cells and its potential role in angiogenesis may make it a valuable target for cancer research and therapy. 4. **Vascular diseases:** EMCN's presence in endothelial cells and its involvement in vascular development may contribute to the understanding of vascular diseases, such as atherosclerosis or hypertension. In conclusion, EMCN is a gene that plays a critical role in maintaining cellular homeostasis, particularly in the hematopoietic and immune systems. Further research into its functions and clinical significance may uncover new insights into the mechanisms underlying various diseases and provide potential therapeutic targets.

Genular Protein ID: 2007637296

Symbol: MUCEN_HUMAN

Name: Endomucin

UniProtKB Accession Codes:

Q9ULC0 A8K716 B4E347 Q8NEY5 Q8WWE7 Q9NRM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11418125

Title: Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity.

PubMed ID: 11418125

DOI: 10.1016/s0014-5793(01)02520-0

PubMed ID: 12485444

Title: Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin.

PubMed ID: 12485444

DOI: 10.1046/j.1523-1747.2002.19647.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14722670

Title: Identification of tumour antigens by serological analysis of cDNA expression cloning.

PubMed ID: 14722670

DOI: 10.1007/s00262-003-0471-y

Sequence Information:

  • Length: 261
  • Mass: 27452
  • Checksum: 6C88C34F7A81F7D2
  • Sequence:
    • MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK NVVTPTTGTT 
PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS IISNVTVTSV TLPNAVSTLQ 
SSKPKTETQS SIKTTEIPGS VLQPDASPSK TGTLTSIPVT IPENTSQSQV IGTEGGKNAS 
TSATSRSYSS IILPVVIALI VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL 
LTVKTISHES GEHSAQGKTK N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.