Details for: PTPRB

Gene ID: 5787

Symbol: PTPRB

Ensembl ID: ENSG00000127329

Description: protein tyrosine phosphatase receptor type B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.7558
    Cell Significance Index: -25.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.2967
    Cell Significance Index: -27.0400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 9.9974
    Cell Significance Index: 37.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 9.3537
    Cell Significance Index: 134.5300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 9.0032
    Cell Significance Index: 93.2500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 6.8095
    Cell Significance Index: 23.6900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 4.3580
    Cell Significance Index: 34.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5713
    Cell Significance Index: 133.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6675
    Cell Significance Index: 334.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5043
    Cell Significance Index: 17.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9741
    Cell Significance Index: 158.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8842
    Cell Significance Index: 39.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7699
    Cell Significance Index: 13.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7426
    Cell Significance Index: 670.5300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7203
    Cell Significance Index: 4.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.7150
    Cell Significance Index: 4.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6860
    Cell Significance Index: 246.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6502
    Cell Significance Index: 24.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5265
    Cell Significance Index: 32.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5008
    Cell Significance Index: 49.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4810
    Cell Significance Index: 52.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3790
    Cell Significance Index: 22.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3789
    Cell Significance Index: 262.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2217
    Cell Significance Index: 15.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2085
    Cell Significance Index: 39.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1935
    Cell Significance Index: 13.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1549
    Cell Significance Index: 4.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1290
    Cell Significance Index: 2.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1178
    Cell Significance Index: 2.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0831
    Cell Significance Index: 9.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0607
    Cell Significance Index: 1.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0564
    Cell Significance Index: 1.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0537
    Cell Significance Index: 2.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0495
    Cell Significance Index: 22.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0434
    Cell Significance Index: 0.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0278
    Cell Significance Index: 17.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0181
    Cell Significance Index: 2.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0105
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0174
    Cell Significance Index: -32.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0186
    Cell Significance Index: -28.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0232
    Cell Significance Index: -31.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0284
    Cell Significance Index: -15.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0362
    Cell Significance Index: -27.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0385
    Cell Significance Index: -28.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0396
    Cell Significance Index: -25.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0455
    Cell Significance Index: -9.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0465
    Cell Significance Index: -20.5400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0482
    Cell Significance Index: -0.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0511
    Cell Significance Index: -10.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0685
    Cell Significance Index: -1.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0791
    Cell Significance Index: -22.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0811
    Cell Significance Index: -13.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0887
    Cell Significance Index: -1.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1244
    Cell Significance Index: -9.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1662
    Cell Significance Index: -10.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1677
    Cell Significance Index: -21.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1807
    Cell Significance Index: -5.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1817
    Cell Significance Index: -26.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1879
    Cell Significance Index: -8.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1955
    Cell Significance Index: -26.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2181
    Cell Significance Index: -28.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2204
    Cell Significance Index: -25.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2336
    Cell Significance Index: -7.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2407
    Cell Significance Index: -4.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2473
    Cell Significance Index: -29.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2481
    Cell Significance Index: -3.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2566
    Cell Significance Index: -26.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2570
    Cell Significance Index: -26.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2656
    Cell Significance Index: -30.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2754
    Cell Significance Index: -6.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2822
    Cell Significance Index: -9.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3282
    Cell Significance Index: -4.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3394
    Cell Significance Index: -5.0900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3528
    Cell Significance Index: -4.8500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3588
    Cell Significance Index: -4.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3628
    Cell Significance Index: -9.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3763
    Cell Significance Index: -5.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3837
    Cell Significance Index: -28.6000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4071
    Cell Significance Index: -5.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4092
    Cell Significance Index: -22.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4443
    Cell Significance Index: -9.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4619
    Cell Significance Index: -16.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4626
    Cell Significance Index: -10.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4641
    Cell Significance Index: -29.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4655
    Cell Significance Index: -24.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4660
    Cell Significance Index: -5.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4981
    Cell Significance Index: -10.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5142
    Cell Significance Index: -27.0000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5428
    Cell Significance Index: -5.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5641
    Cell Significance Index: -26.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5662
    Cell Significance Index: -26.4000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.5689
    Cell Significance Index: -6.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6382
    Cell Significance Index: -13.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6416
    Cell Significance Index: -6.9900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6504
    Cell Significance Index: -8.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane receptor tyrosine phosphatase:** PTPRB is a receptor-type tyrosine phosphatase that spans the cell membrane, possessing an extracellular ligand-binding domain, a transmembrane domain, and an intracellular catalytic domain. 2. **Tyrosine phosphatase activity:** PTPRB is capable of dephosphorylating tyrosine residues on its substrates, thereby regulating signaling pathways and modulating cellular responses. 3. **Endothelial cell specificity:** PTPRB is predominantly expressed in endothelial cells, which line blood vessels and lymphatic vessels, and is involved in the regulation of immune cell migration and vascular development. 4. **Regulation of immune responses:** PTPRB plays a critical role in modulating immune responses, including the regulation of immune cell migration, inflammation, and the activation of immune cells. **Pathways and Functions:** 1. **Angiogenesis:** PTPRB is involved in the regulation of angiogenesis, the process of new blood vessel formation. Its expression in endothelial cells and its role in modulating signaling pathways involved in angiogenesis highlight its importance in vascular development and disease. 2. **Immune system regulation:** PTPRB is involved in the regulation of immune responses, including the regulation of immune cell migration, inflammation, and the activation of immune cells. Its expression in endothelial cells and its role in modulating signaling pathways involved in immune responses highlight its importance in immune regulation. 3. **Cell migration:** PTPRB is involved in the regulation of cell migration, including the migration of immune cells and endothelial cells. Its expression in endothelial cells and its role in modulating signaling pathways involved in cell migration highlight its importance in vascular development and disease. 4. **Dephosphorylation of protein kinases:** PTPRB is capable of dephosphorylating protein kinases, thereby regulating their activity and modulating signaling pathways. **Clinical Significance:** 1. **Vascular diseases:** PTPRB's involvement in angiogenesis and vascular development highlights its potential as a therapeutic target in vascular diseases, including atherosclerosis and hypertension. 2. **Immune-related disorders:** PTPRB's role in modulating immune responses highlights its potential as a therapeutic target in immune-related disorders, including autoimmune diseases and cancer. 3. **Cancer:** PTPRB's expression in endothelial cells and its role in modulating signaling pathways involved in angiogenesis and immune responses highlight its potential as a therapeutic target in cancer. 4. **Neurological disorders:** PTPRB's expression in endothelial cells and its role in modulating signaling pathways involved in angiogenesis and immune responses highlight its potential as a therapeutic target in neurological disorders, including stroke and multiple sclerosis. In conclusion, PTPRB is a complex gene that plays a multifaceted role in modulating various cellular processes, including immune response, angiogenesis, and cell migration. Its significance in disease pathology and its potential as a therapeutic target highlight the need for further research into its mechanisms of action and its role in human disease.

Genular Protein ID: 2277047232

Symbol: PTPRB_HUMAN

Name: Receptor-type tyrosine-protein phosphatase beta

UniProtKB Accession Codes:

P23467 B7ZKS8 B7ZKT0 C9JX87 F5H3G6 Q14D85 Q3MIV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2170109

Title: Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

PubMed ID: 2170109

DOI: 10.1002/j.1460-2075.1990.tb07523.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19116766

Title: Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.

PubMed ID: 19116766

DOI: 10.1007/s10456-008-9126-0

PubMed ID: 19136612

Title: Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.

PubMed ID: 19136612

DOI: 10.1096/fj.08-123810

PubMed ID: 19451274

Title: VE-PTP controls blood vessel development by balancing Tie-2 activity.

PubMed ID: 19451274

DOI: 10.1083/jcb.200811159

PubMed ID: 17139078

Title: Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.

PubMed ID: 17139078

DOI: 10.1107/s0907444906037784

PubMed ID: 16759857

Title: Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.

PubMed ID: 16759857

DOI: 10.1016/j.bmcl.2006.05.074

PubMed ID: 19167335

Title: Large-scale structural analysis of the classical human protein tyrosine phosphatome.

PubMed ID: 19167335

DOI: 10.1016/j.cell.2008.11.038

Sequence Information:

  • Length: 1997
  • Mass: 224301
  • Checksum: 76E67B4A6109AA0F
  • Sequence:
    • MLSHGAGLAL WITLSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS PCNFSLIYSS 
DTLGAALCPT FRIDNTTYGC NLQDLQAGTI YNFRIISLDE ERTVVLQTDP LPPARFGVSK 
EKTTSTSLHV WWTPSSGKVT SYEVQLFDEN NQKIQGVQIQ ESTSWNEYTF FNLTAGSKYN 
IAITAVSGGK RSFSVYTNGS TVPSPVKDIG ISTKANSLLI SWSHGSGNVE RYRLMLMDKG 
ILVHGGVVDK HATSYAFHGL TPGYLYNLTV MTEAAGLQNY RWKLVRTAPM EVSNLKVTND 
GSLTSLKVKW QRPPGNVDSY NITLSHKGTI KESRVLAPWI TETHFKELVP GRLYQVTVSC 
VSGELSAQKM AVGRTFPDKV ANLEANNNGR MRSLVVSWSP PAGDWEQYRI LLFNDSVVLL 
NITVGKEETQ YVMDDTGLVP GRQYEVEVIV ESGNLKNSER CQGRTVPLAV LQLRVKHANE 
TSLSIMWQTP VAEWEKYIIS LADRDLLLIH KSLSKDAKEF TFTDLVPGRK YMATVTSISG 
DLKNSSSVKG RTVPAQVTDL HVANQGMTSS LFTNWTQAQG DVEFYQVLLI HENVVIKNES 
ISSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT VNNSGRNDYL 
SVSWLLAPGD VDNYEVTLSH DGKVVQSLVI AKSVRECSFS SLTPGRLYTV TITTRSGKYE 
NHSFSQERTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN NFIQTKSIPK 
SENECVFVQL VPGRLYSVTV TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR STEDLHVTWS 
GANGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF 
IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD SQTIPKHVFE 
HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG VIADNAYSSY SLIVSWQKAA 
GVAERYDILL LTENGILLRN TSEPATTKQH KFEDLTPGKK YKIQILTVSG GLFSKEAQTE 
GRTVPAAVTD LRITENSTRH LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPLVQSFS 
FQNLLQGRMY KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL WFNWSPASGD 
FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS NKVTAESRTA 
PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR DALTVFNPYN NRKSEGRIVY 
GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS VRTKPDKIQN LHCRPQNSTA IACSWIPPDS 
DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS 
TITMIDRPPP PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE 
LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA EMESLGGKCD 
PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT TESEPLFGAI 
EGVSAGLFLI GMLVAVVALL ICRQKVSHGR ERPSARLSIR RDRPLSVHLN LGQKGNRKTS 
CPIKINQFEG HFMKLQADSN YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD 
ATRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM 
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG EEQLDAHRLI 
RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT VVHCSAGVGR TGTFIALDRI 
LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR SEQENPLFPI 
YENVNPEYHR DPVYSRH

Genular Protein ID: 3453633946

Symbol: F8VU56_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VU56

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 12 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 2127
  • Mass: 239565
  • Checksum: 54FDF7C61DBE92B0
  • Sequence:
    • MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTEDEKL 
LHVKSALCLA ISNSSRGPSR SAILDRCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV 
KKARKYLHSW MKIDVNKEGK LVNESLCLQK AGLGAEVSVR STRNTAPPQI LTTFNAVPDG 
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SSTTEETGLA 
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPTFR IDNTTYGCNL 
QDLQAGTIYN FRIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY 
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS FSVYTNGSTV 
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP 
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI 
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN 
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI TVGKEETQYV MDDTGLVPGR 
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQTPVA EWEKYIISLA 
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT VPAQVTDLHV 
ANQGMTSSLF TNWTQAQGDV EFYQVLLIHE NVVIKNESIS SETSRYSFHS LKSGSLYSVV 
VTTVSGGISS RQVVVEGRTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN 
NFIQTKSIPK SENECVFVQL VPGRLYSVTV TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR 
STEDLHVTWS GANGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT 
ISGDVQQSAF IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD 
SQTIPKHVFE HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG VIADNAYSSY 
SLIVSWQKAA GVAERYDILL LTENGILLRN TSEPATTKQH KFEDLTPGKK YKIQILTVSG 
GLFSKEAQTE GRTVPAAVTD LRITENSTRH LSFRWTASEG ELSWYNIFLY NPDGNLQERA 
QVDPLVQSFS FQNLLQGRMY KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL 
WFNWSPASGD FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS 
NKVTAESRTA PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR DALTVFNPYN 
NRKSEGRIVY GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS VRTKPDKIQN LHCRPQNSTA 
IACSWIPPDS DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA 
GMTSEVVEDS TITMIDRPPP PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV 
VVREADGSDE LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA 
EMESLGGKCD PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT 
TESEPLFGAI EGVSAGLFLI GMLVAVVALL ICRQKVSHGR ERPSARLSIR RDRPLSVHLN 
LGQKGNRKTS CPIKINQFEG HFMKLQADSN YLLSKEYEEL KDVGRNQSCD IALLPENRGK 
NRYNNILPYD ATRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV 
WEQNVHNIVM VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG 
EEQLDAHRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT VVHCSAGVGR 
TGTFIALDRI LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR 
SEQENPLFPI YENVNPEYHR DPVYSRH

Genular Protein ID: 251245051

Symbol: Q68D73_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D73

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 919
  • Mass: 102459
  • Checksum: 7723EFDBC03CEED0
  • Sequence:
    • MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTENEKL 
LHVKSALCLA ISNSSRGPSR SAILDRCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV 
KKARKYLHSW MKIDVNKEGK LVNESLCLQK AGLGAEVSVR STRNTAPPQI LTTFNAVPDG 
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SSTTEETGLA 
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPTFR IDNTTYGCNL 
QDLQAGTIYN FKIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY 
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS FSVYTNGSTV 
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP 
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI 
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN 
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI TVGKEETQYV MDDTGLVPGR 
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQTPVA EWEKYIISLA 
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT VPAQVTDLHV 
ANQGMTSSLF TNWTQAQGDV EFYQVLLIHE NVVIKNESIS SETSRYSFHS LKSGSLYSVV 
VTTVSGGISS RQVVVEGRTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN 
NFIQTKAFPS QKTNVYLFS

Genular Protein ID: 831200787

Symbol: Q86VA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VA4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 771
  • Mass: 86056
  • Checksum: B6E388D6E3F573BF
  • Sequence:
    • MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTEDEKL 
LHVKSALCLA ISNSSRGPSR SAILDRCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV 
KKARKYLHSW MKIDVNKEGK LVNESLCLQK AGLGAEVSVR STRNTAPPQI LTTFNAVPDG 
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SSTTEETGLA 
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPTFR IDNTTYGCNL 
QDLQAGTIYN FKIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY 
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS FSVYTNGSTV 
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP 
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI 
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN 
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI TVGKEETQYV MDDTGLVPGR 
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQTPVA EWEKYIISLA 
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.