Details for: PTPRB

Gene ID: 5787

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PTPRB

Ensembl ID: ENSG00000127329

Description: protein tyrosine phosphatase receptor type B

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 31.01
    rCSI 52.04%
    PRS 84.46
  • cerebral cortex endothelial cell CL1001602
    CSI 30.88
    rCSI 53.42%
    PRS 90.06
  • pulmonary artery endothelial cell CL1001568
    CSI 23.66
    rCSI 32.2%
    PRS 96.68
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 20.74
    rCSI 63.9%
    PRS 94.85
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 18.5
    rCSI 23.01%
    PRS 82.25
  • cardiac endothelial cell CL0010008
    CSI 17.75
    rCSI 71.62%
    PRS 94.36
  • VIP GABAergic cortical interneuron CL4023016
    CSI 17.02
    rCSI 20.33%
    PRS 84.36
  • endothelial cell of artery CL1000413
    CSI 16.69
    rCSI 24.45%
    PRS 95.29
  • L6b glutamatergic cortical neuron CL4023038
    CSI 14.67
    rCSI 45.83%
    PRS 85.33
  • retinal blood vessel endothelial cell CL0002585
    CSI 14.53
    rCSI 23.2%
    PRS 95.45
  • inhibitory interneuron CL0000498
    CSI 13.41
    rCSI 30.96%
    PRS 87
  • sst GABAergic cortical interneuron CL4023017
    CSI 13.33
    rCSI 17.19%
    PRS 85.3
  • retinal bipolar neuron CL0000748
    CSI 12.86
    rCSI 24.09%
    PRS 87.53
  • capillary endothelial cell CL0002144
    CSI 12.49
    rCSI 22.9%
    PRS 93.03
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 11.16
    rCSI 42.19%
    PRS 84.54
  • hepatic stellate cell CL0000632
    CSI 11.01
    rCSI 41.26%
    PRS 90.96
  • amacrine cell CL0000561
    CSI 11.01
    rCSI 31.9%
    PRS 87.37
  • pulmonary capillary endothelial cell CL4028001
    CSI 10.14
    rCSI 19.33%
    PRS 97.11
  • lung endothelial cell CL1001567
    CSI 9.84
    rCSI 22.94%
    PRS 97.58
  • vasa recta ascending limb cell CL1001131
    CSI 9.12
    rCSI 41.27%
    PRS 96.46
  • cardiac blood vessel endothelial cell CL0010006
    CSI 8.98
    rCSI 63.51%
    PRS 88.93
  • melanocyte CL0000148
    CSI 8.74
    rCSI 6.47%
    PRS 91.52
  • neuron CL0000540
    CSI 8.68
    rCSI 23.11%
    PRS 83.7
  • blood vessel endothelial cell CL0000071
    CSI 8.51
    rCSI 17.67%
    PRS 92.47
  • adipocyte CL0000136
    CSI 7.96
    rCSI 10.22%
    PRS 87.23
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 7.94
    rCSI 19.31%
    PRS 82.29
  • pericyte CL0000669
    CSI 7.76
    rCSI 20.67%
    PRS 72.87
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 7.7
    rCSI 35.32%
    PRS 95.5
  • endothelial cell of arteriole CL1000412
    CSI 7.6
    rCSI 42.17%
    PRS 97.31
  • endocardial cell CL0002350
    CSI 7.42
    rCSI 35.53%
    PRS 91.11
  • vein endothelial cell CL0002543
    CSI 7.35
    rCSI 20.06%
    PRS 95.49
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 6.98
    rCSI 18.19%
    PRS 95.24
  • endothelial cell of placenta CL0009092
    CSI 6.9
    rCSI 34.03%
    PRS 95.83
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 6.79
    rCSI 11.99%
    PRS 83.77
  • GABAergic amacrine cell CL4030027
    CSI 6.33
    rCSI 21.67%
    PRS 83.59
  • vein endothelial cell of respiratory system CL4033008
    CSI 6.2
    rCSI 42.58%
    PRS 96.09
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 6.04
    rCSI 13.1%
    PRS 84.6
  • endothelial cell of lymphatic vessel CL0002138
    CSI 5.89
    rCSI 11.68%
    PRS 94.18
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 5.88
    rCSI 21.14%
    PRS 82.56
  • epithelial cell of proximal tubule CL0002306
    CSI 5.65
    rCSI 13.79%
    PRS 88.92
  • dopaminergic neuron CL0000700
    CSI 5.61
    rCSI 31.71%
    PRS 85.44
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 5.55
    rCSI 18.25%
    PRS 84.62
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 5.51
    rCSI 17.23%
    PRS 87.09
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 5.42
    rCSI 31.94%
    PRS 84.71
  • Kupffer cell CL0000091
    CSI 5.4
    rCSI 12.35%
    PRS 94.69
  • stem cell CL0000034
    CSI 5.4
    rCSI 5.2%
    PRS 91.14
  • type EC enteroendocrine cell CL0000577
    CSI 5.25
    rCSI 18.65%
    PRS 94.47
  • sncg GABAergic cortical interneuron CL4023015
    CSI 5.12
    rCSI 8.24%
    PRS 85.36
  • collagen secreting cell CL0000667
    CSI 4.76
    rCSI 27.33%
    PRS 96.18
  • renal interstitial pericyte CL1001318
    CSI 4.65
    rCSI 12.82%
    PRS 92.32
  • endothelial cell of uterus CL0009095
    CSI 4.64
    rCSI 33.95%
    PRS 96.89
  • interneuron CL0000099
    CSI 4.37
    rCSI 8.78%
    PRS 89.45
  • endothelial cell of vascular tree CL0002139
    CSI 4.09
    rCSI 22.38%
    PRS 90.37
  • brain vascular cell CL4023072
    CSI 3.5
    rCSI 36.18%
    PRS 88.45
  • H2 horizontal cell CL0004218
    CSI 3.36
    rCSI 16.7%
    PRS 89.37
  • diffuse bipolar 6 cell CL4033032
    CSI 3.36
    rCSI 17.66%
    PRS 85.31
  • basket cell CL0000118
    CSI 2.81
    rCSI 17.61%
    PRS 77.16
  • lung microvascular endothelial cell CL2000016
    CSI 2.55
    rCSI 49.31%
    PRS 96.29
  • cerebellar granule cell CL0001031
    CSI 2.45
    rCSI 3.6%
    PRS 90.06
  • central nervous system neuron CL2000029
    CSI 2.37
    rCSI 17.43%
    PRS 87.97
  • glutamatergic neuron CL0000679
    CSI 2.33
    rCSI 4.78%
    PRS 84.27
  • diffuse bipolar 3a cell CL4033029
    CSI 2.31
    rCSI 15.72%
    PRS 86.87
  • vasa recta descending limb cell CL1001285
    CSI 2.31
    rCSI 18.43%
    PRS 96.58
  • BEST4+ enteroycte CL4030026
    CSI 2.21
    rCSI 2.75%
    PRS 93.25
  • OFFx cell CL4033036
    CSI 2.1
    rCSI 9.86%
    PRS 85.2
  • serotonergic neuron CL0000850
    CSI 2.04
    rCSI 9.1%
    PRS 81.69
  • indirect pathway medium spiny neuron CL4023029
    CSI 2
    rCSI 48.18%
    PRS 82.11
  • diffuse bipolar 3b cell CL4033030
    CSI 1.93
    rCSI 12.84%
    PRS 88.61
  • starburst amacrine cell CL0004232
    CSI 1.88
    rCSI 15.85%
    PRS 82.09
  • direct pathway medium spiny neuron CL4023026
    CSI 1.68
    rCSI 40.24%
    PRS 82.18
  • diffuse bipolar 1 cell CL4033027
    CSI 1.65
    rCSI 12.42%
    PRS 84.36
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.56
    rCSI 3.74%
    PRS 85.77
  • flat midget bipolar cell CL4033033
    CSI 1.5
    rCSI 10.71%
    PRS 85.9
  • diffuse bipolar 2 cell CL4033028
    CSI 1.48
    rCSI 11.44%
    PRS 87.5
  • endothelial cell of venule CL1000414
    CSI 1.16
    rCSI 10.31%
    PRS 96.88
  • medium spiny neuron CL1001474
    CSI 1.03
    rCSI 8.84%
    PRS 87.77

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PTPRB](/details-gene/5787) (Protein Tyrosine Phosphatase Receptor Type B) is a protein-coding gene located on chromosome 12q15. It encodes a receptor-type protein tyrosine phosphatase that plays a crucial role in regulating cellular signaling through dephosphorylation. Functionally, [PTPRB](/details-gene/5787) is strongly implicated in [angiogenesis](/details-go/GO:0001525) (the formation of new blood vessels) by modulating key signaling pathways in endothelial cells. Consistent with this function, expression data shows that **Overall**, [PTPRB](/details-gene/5787) is a highly significant gene in various endothelial cell populations, including those of the cerebral cortex, pulmonary artery, and hepatic sinusoids. Additionally, it exhibits prominent significance in specific neuronal subtypes, particularly `[lamp5 GABAergic cortical interneurons](/details-cell/CL4023011)`, suggesting a secondary role in the central nervous system. Its clinical association is noted under OMIM entry `[176882](https://omim.org/entry/176882)`. ## Cellular Roles and Expression Landscape The expression profile of [PTPRB](/details-gene/5787) highlights its dual importance in the vascular and nervous systems. **Overall**, the gene demonstrates its most significant expression in endothelial and neuronal cell types. It stands out as a defining marker for `[lamp5 GABAergic cortical interneurons](/details-cell/CL4023011)` (CSI: 31.01) and `[cerebral cortex endothelial cells](/details-cell/CL1001602)` (CSI: 30.88), indicating a highly specialized function in these cells. Its significance is consistently high across a broad range of endothelial cells, including `[pulmonary artery endothelial cells](/details-cell/CL1001568)` (CSI: 23.66), `[endothelial cells of pericentral hepatic sinusoid](/details-cell/CL0019022)` (CSI: 20.74), and `[cardiac endothelial cells](/details-cell/CL0010008)` (CSI: 17.75). This widespread and high-level expression in the endothelium underscores its fundamental role in maintaining vascular integrity and function. In the nervous system, beyond the top-ranked `[lamp5 GABAergic cortical interneuron](/details-cell/CL4023011)`, [PTPRB](/details-gene/5787) is also highly significant in other inhibitory interneurons such as `[pvalb GABAergic cortical interneurons](/details-cell/CL4023018)` and `[sst GABAergic cortical interneurons](/details-cell/CL4023017)`, as well as in `[retinal bipolar neurons](/details-cell/CL0000748)`. This pattern suggests a role in regulating neuronal signaling, migration, or synaptic organization within specific neural circuits. ## Pathways and Molecular Function The molecular functions of [PTPRB](/details-gene/5787) are centered on its `[transmembrane receptor protein tyrosine phosphatase activity](/details-go/GO:0005001)`. As a component of the `[plasma membrane](/details-go/GO:0005886)` and `[receptor complexes](/details-go/GO:0043235)`, it acts to dephosphorylate target proteins, thereby modulating intracellular signaling cascades. Its high expression in endothelial cells is strongly aligned with its well-documented role in `[angiogenesis](/details-go/GO:0001525)`. Research has shown that [PTPRB](/details-gene/5787), also known as VE-PTP (Vascular Endothelial-PTP), directly regulates the activity of key receptor tyrosine kinases involved in blood vessel development, such as VEGFR2 and Tie-2. By dephosphorylating these receptors, it fine-tunes signaling to control endothelial cell morphogenesis and vessel stability [Link](https://doi.org/10.1096/fj.08-123810), [Link](https://doi.org/10.1083/jcb.200811159). This is further supported by its annotation for `[cadherin binding](/details-go/GO:0045296)`, suggesting it may regulate cell-cell adhesion at endothelial junctions. While Reactome analysis also links [PTPRB](/details-gene/5787) to the `[Innate immune system](/details-reactome/R-HSA-168249)` and specifically `[neutrophil degranulation](/details-reactome/R-HSA-6798695)`, the current expression data does not show high significance in immune cell populations, indicating this role may be context-specific or less prominent than its vascular functions. ## Research Directions The dual-specificity of [PTPRB](/details-gene/5787) expression in both the vasculature and specific neuronal subtypes presents several compelling avenues for future investigation. ### Testable Hypotheses 1. **Hypothesis 1:** Given its high expression in multiple cortical interneuron subtypes (`lamp5`, `pvalb`, `sst`), [PTPRB](/details-gene/5787) may function as a critical regulator of inhibitory synapse formation or maintenance by dephosphorylating key synaptic adhesion molecules or scaffolding proteins, thereby shaping the excitatory/inhibitory balance in the cerebral cortex. 2. **Hypothesis 2:** Based on its function in regulating endothelial cell junctions via `[cadherin binding](/details-go/GO:0045296)` and its exceptionally high significance in `[cerebral cortex endothelial cells](/details-cell/CL1001602)`, [PTPRB](/details-gene/5787) is essential for the establishment and maintenance of the blood-brain barrier (BBB) integrity. ### Proposed Experimental Approach To test Hypothesis 2, a conditional knockout mouse model could be generated using a Cre-loxP system to specifically delete `PtpRB` in brain endothelial cells (e.g., using a *Slco1c1-CreERT2* driver). Following deletion, the integrity of the BBB could be quantitatively assessed by measuring the extravasation of systemically injected fluorescent tracers of different molecular weights (e.g., sodium fluorescein, Evans blue-albumin) into the brain parenchyma. Furthermore, transmission electron microscopy of brain capillaries could be employed to examine the ultrastructure of tight junctions and adherens junctions between endothelial cells, providing a direct assessment of junctional integrity. ### Therapeutic Potential The critical role of [PTPRB](/details-gene/5787) in angiogenesis makes it an attractive therapeutic target, particularly in oncology. As tumor growth is dependent on the formation of new blood vessels, inhibition of [PTPRB](/details-gene/5787) could serve as an anti-angiogenic strategy to restrict tumor progression. The development of potent, non-peptidic small molecule inhibitors has already been explored [Link](https://doi.org/10.1016/j.bmcl.2006.05.074). Because it is a transmembrane receptor, it is also amenable to targeting with therapeutic antibodies or antibody-drug conjugates. The primary therapeutic strategy would involve **inhibition** to disrupt pathologic vascularization in tumors or other diseases characterized by excessive angiogenesis, such as diabetic retinopathy.

Genular Protein ID: 2277047232

Symbol: PTPRB_HUMAN

Name: Receptor-type tyrosine-protein phosphatase beta

UniProtKB Accession Codes:

P23467 B7ZKS8 B7ZKT0 C9JX87 F5H3G6 Q14D85 Q3MIV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2170109

Title: Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

PubMed ID: 2170109

DOI: 10.1002/j.1460-2075.1990.tb07523.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 19116766

Title: Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.

PubMed ID: 19116766

DOI: 10.1007/s10456-008-9126-0

PubMed ID: 19136612

Title: Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.

PubMed ID: 19136612

DOI: 10.1096/fj.08-123810

PubMed ID: 19451274

Title: VE-PTP controls blood vessel development by balancing Tie-2 activity.

PubMed ID: 19451274

DOI: 10.1083/jcb.200811159

PubMed ID: 17139078

Title: Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.

PubMed ID: 17139078

DOI: 10.1107/s0907444906037784

PubMed ID: 16759857

Title: Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.

PubMed ID: 16759857

DOI: 10.1016/j.bmcl.2006.05.074

PubMed ID: 19167335

Title: Large-scale structural analysis of the classical human protein tyrosine phosphatome.

PubMed ID: 19167335

DOI: 10.1016/j.cell.2008.11.038

Sequence Information:

  • Length: 1997
  • Mass: 224301
  • Checksum: 76E67B4A6109AA0F
  • Sequence:
    • MLSHGAGLAL WITLSLLQTG LAEPERCNFT LAESKASSHS VSIQWRILGS PCNFSLIYSS 
DTLGAALCPT FRIDNTTYGC NLQDLQAGTI YNFRIISLDE ERTVVLQTDP LPPARFGVSK 
EKTTSTSLHV WWTPSSGKVT SYEVQLFDEN NQKIQGVQIQ ESTSWNEYTF FNLTAGSKYN 
IAITAVSGGK RSFSVYTNGS TVPSPVKDIG ISTKANSLLI SWSHGSGNVE RYRLMLMDKG 
ILVHGGVVDK HATSYAFHGL TPGYLYNLTV MTEAAGLQNY RWKLVRTAPM EVSNLKVTND 
GSLTSLKVKW QRPPGNVDSY NITLSHKGTI KESRVLAPWI TETHFKELVP GRLYQVTVSC 
VSGELSAQKM AVGRTFPDKV ANLEANNNGR MRSLVVSWSP PAGDWEQYRI LLFNDSVVLL 
NITVGKEETQ YVMDDTGLVP GRQYEVEVIV ESGNLKNSER CQGRTVPLAV LQLRVKHANE 
TSLSIMWQTP VAEWEKYIIS LADRDLLLIH KSLSKDAKEF TFTDLVPGRK YMATVTSISG 
DLKNSSSVKG RTVPAQVTDL HVANQGMTSS LFTNWTQAQG DVEFYQVLLI HENVVIKNES 
ISSETSRYSF HSLKSGSLYS VVVTTVSGGI SSRQVVVEGR TVPSSVSGVT VNNSGRNDYL 
SVSWLLAPGD VDNYEVTLSH DGKVVQSLVI AKSVRECSFS SLTPGRLYTV TITTRSGKYE 
NHSFSQERTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN NFIQTKSIPK 
SENECVFVQL VPGRLYSVTV TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR STEDLHVTWS 
GANGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT ISGDVQQSAF 
IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD SQTIPKHVFE 
HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG VIADNAYSSY SLIVSWQKAA 
GVAERYDILL LTENGILLRN TSEPATTKQH KFEDLTPGKK YKIQILTVSG GLFSKEAQTE 
GRTVPAAVTD LRITENSTRH LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPLVQSFS 
FQNLLQGRMY KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL WFNWSPASGD 
FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS NKVTAESRTA 
PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR DALTVFNPYN NRKSEGRIVY 
GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS VRTKPDKIQN LHCRPQNSTA IACSWIPPDS 
DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS 
TITMIDRPPP PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE 
LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA EMESLGGKCD 
PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT TESEPLFGAI 
EGVSAGLFLI GMLVAVVALL ICRQKVSHGR ERPSARLSIR RDRPLSVHLN LGQKGNRKTS 
CPIKINQFEG HFMKLQADSN YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD 
ATRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM 
VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG EEQLDAHRLI 
RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT VVHCSAGVGR TGTFIALDRI 
LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR SEQENPLFPI 
YENVNPEYHR DPVYSRH

Genular Protein ID: 3453633946

Symbol: F8VU56_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VU56

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 12 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 2127
  • Mass: 239565
  • Checksum: 54FDF7C61DBE92B0
  • Sequence:
    • MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTEDEKL 
LHVKSALCLA ISNSSRGPSR SAILDRCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV 
KKARKYLHSW MKIDVNKEGK LVNESLCLQK AGLGAEVSVR STRNTAPPQI LTTFNAVPDG 
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SSTTEETGLA 
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPTFR IDNTTYGCNL 
QDLQAGTIYN FRIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY 
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS FSVYTNGSTV 
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP 
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI 
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN 
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI TVGKEETQYV MDDTGLVPGR 
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQTPVA EWEKYIISLA 
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT VPAQVTDLHV 
ANQGMTSSLF TNWTQAQGDV EFYQVLLIHE NVVIKNESIS SETSRYSFHS LKSGSLYSVV 
VTTVSGGISS RQVVVEGRTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN 
NFIQTKSIPK SENECVFVQL VPGRLYSVTV TTKSGQYEAN EQGNGRTIPE PVKDLTLRNR 
STEDLHVTWS GANGDVDQYE IQLLFNDMKV FPPFHLVNTA TEYRFTSLTP GRQYKILVLT 
ISGDVQQSAF IEGFTVPSAV KNIHISPNGA TDSLTVNWTP GGGDVDSYTV SAFRHSQKVD 
SQTIPKHVFE HTFHRLEAGE QYQIMIASVS GSLKNQINVV GRTVPASVQG VIADNAYSSY 
SLIVSWQKAA GVAERYDILL LTENGILLRN TSEPATTKQH KFEDLTPGKK YKIQILTVSG 
GLFSKEAQTE GRTVPAAVTD LRITENSTRH LSFRWTASEG ELSWYNIFLY NPDGNLQERA 
QVDPLVQSFS FQNLLQGRMY KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNTTDSL 
WFNWSPASGD FDFYELILYN PNGTKKENWK DKDLTEWRFQ GLVPGRKYVL WVVTHSGDLS 
NKVTAESRTA PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR DALTVFNPYN 
NRKSEGRIVY GLRPGRSYQF NVKTVSGDSW KTYSKPIFGS VRTKPDKIQN LHCRPQNSTA 
IACSWIPPDS DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA 
GMTSEVVEDS TITMIDRPPP PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV 
VVREADGSDE LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA 
EMESLGGKCD PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT 
TESEPLFGAI EGVSAGLFLI GMLVAVVALL ICRQKVSHGR ERPSARLSIR RDRPLSVHLN 
LGQKGNRKTS CPIKINQFEG HFMKLQADSN YLLSKEYEEL KDVGRNQSCD IALLPENRGK 
NRYNNILPYD ATRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV 
WEQNVHNIVM VTQCVEKGRV KCDHYWPADQ DSLYYGDLIL QMLSESVLPE WTIREFKICG 
EEQLDAHRLI RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT VVHCSAGVGR 
TGTFIALDRI LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR 
SEQENPLFPI YENVNPEYHR DPVYSRH

Genular Protein ID: 251245051

Symbol: Q68D73_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D73

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 919
  • Mass: 102459
  • Checksum: 7723EFDBC03CEED0
  • Sequence:
    • MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTENEKL 
LHVKSALCLA ISNSSRGPSR SAILDRCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV 
KKARKYLHSW MKIDVNKEGK LVNESLCLQK AGLGAEVSVR STRNTAPPQI LTTFNAVPDG 
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SSTTEETGLA 
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPTFR IDNTTYGCNL 
QDLQAGTIYN FKIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY 
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS FSVYTNGSTV 
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP 
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI 
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN 
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI TVGKEETQYV MDDTGLVPGR 
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQTPVA EWEKYIISLA 
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT VPAQVTDLHV 
ANQGMTSSLF TNWTQAQGDV EFYQVLLIHE NVVIKNESIS SETSRYSFHS LKSGSLYSVV 
VTTVSGGISS RQVVVEGRTV PDKVQGVSVS NSARSDYLRV SWVHATGDFD HYEVTIKNKN 
NFIQTKAFPS QKTNVYLFS

Genular Protein ID: 831200787

Symbol: Q86VA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VA4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 771
  • Mass: 86056
  • Checksum: B6E388D6E3F573BF
  • Sequence:
    • MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTEDEKL 
LHVKSALCLA ISNSSRGPSR SAILDRCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV 
KKARKYLHSW MKIDVNKEGK LVNESLCLQK AGLGAEVSVR STRNTAPPQI LTTFNAVPDG 
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SSTTEETGLA 
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPTFR IDNTTYGCNL 
QDLQAGTIYN FKIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY 
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS FSVYTNGSTV 
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP 
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI 
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN 
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI TVGKEETQYV MDDTGLVPGR 
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQTPVA EWEKYIISLA 
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT V