Details for: AKR1C3

Gene ID: 8644

Symbol: AKR1C3

Ensembl ID: ENSG00000196139

Description: aldo-keto reductase family 1 member C3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.5045
    Cell Significance Index: -10.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.8607
    Cell Significance Index: -19.8500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 34.0575
    Cell Significance Index: 15.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.0242
    Cell Significance Index: -22.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.8014
    Cell Significance Index: -19.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.0533
    Cell Significance Index: -18.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.9746
    Cell Significance Index: -2.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.3580
    Cell Significance Index: -22.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.4769
    Cell Significance Index: 284.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2305
    Cell Significance Index: -20.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.6481
    Cell Significance Index: 837.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.6108
    Cell Significance Index: 566.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.5115
    Cell Significance Index: 41.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.1446
    Cell Significance Index: 483.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.1321
    Cell Significance Index: 89.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.0850
    Cell Significance Index: 61.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.9691
    Cell Significance Index: 85.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.9508
    Cell Significance Index: 52.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6825
    Cell Significance Index: 121.5900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.6001
    Cell Significance Index: 26.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.1618
    Cell Significance Index: 36.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0369
    Cell Significance Index: 23.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0208
    Cell Significance Index: 1824.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8807
    Cell Significance Index: 31.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5646
    Cell Significance Index: 44.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3311
    Cell Significance Index: 264.1700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1901
    Cell Significance Index: 17.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7287
    Cell Significance Index: 15.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.7168
    Cell Significance Index: 17.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6596
    Cell Significance Index: 31.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5910
    Cell Significance Index: 18.9300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5806
    Cell Significance Index: 4.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5694
    Cell Significance Index: 8.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4601
    Cell Significance Index: 50.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3043
    Cell Significance Index: 34.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2678
    Cell Significance Index: 26.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2408
    Cell Significance Index: 41.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2221
    Cell Significance Index: 121.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1566
    Cell Significance Index: 1.2500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1525
    Cell Significance Index: 1.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1221
    Cell Significance Index: 4.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0906
    Cell Significance Index: 4.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0827
    Cell Significance Index: 4.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0784
    Cell Significance Index: 48.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0747
    Cell Significance Index: 14.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0580
    Cell Significance Index: 11.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0482
    Cell Significance Index: 0.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0481
    Cell Significance Index: 30.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0281
    Cell Significance Index: 3.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0264
    Cell Significance Index: 11.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0151
    Cell Significance Index: 1.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0113
    Cell Significance Index: 4.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0129
    Cell Significance Index: -19.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0160
    Cell Significance Index: -0.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0182
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0211
    Cell Significance Index: -28.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0242
    Cell Significance Index: -17.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0347
    Cell Significance Index: -3.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0507
    Cell Significance Index: -23.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0540
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0605
    Cell Significance Index: -12.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0626
    Cell Significance Index: -4.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0735
    Cell Significance Index: -10.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0760
    Cell Significance Index: -21.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0962
    Cell Significance Index: -6.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1006
    Cell Significance Index: -13.8200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1387
    Cell Significance Index: -1.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1449
    Cell Significance Index: -4.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1800
    Cell Significance Index: -14.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1976
    Cell Significance Index: -20.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2061
    Cell Significance Index: -24.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2430
    Cell Significance Index: -14.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2456
    Cell Significance Index: -18.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2537
    Cell Significance Index: -17.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2654
    Cell Significance Index: -19.7800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2718
    Cell Significance Index: -1.5700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2756
    Cell Significance Index: -1.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2827
    Cell Significance Index: -4.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3003
    Cell Significance Index: -15.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3101
    Cell Significance Index: -7.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3293
    Cell Significance Index: -20.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3681
    Cell Significance Index: -23.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3690
    Cell Significance Index: -9.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3924
    Cell Significance Index: -22.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4173
    Cell Significance Index: -6.6200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4562
    Cell Significance Index: -3.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4895
    Cell Significance Index: -21.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4906
    Cell Significance Index: -10.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4997
    Cell Significance Index: -21.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5187
    Cell Significance Index: -19.0400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5187
    Cell Significance Index: -7.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5390
    Cell Significance Index: -18.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5406
    Cell Significance Index: -8.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5519
    Cell Significance Index: -19.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** * AKR1C3 is a NADPH-dependent enzyme, which means it uses NADPH as a cofactor to facilitate various redox reactions. * The enzyme belongs to the AKR superfamily, which is a group of enzymes involved in various metabolic processes, including steroid hormone biosynthesis and prostaglandin synthesis. * AKR1C3 has a wide range of substrate specificity, including steroids, prostaglandins, and bile acids. * The enzyme has been shown to have a high affinity for certain substrates, such as androstenedione and pregnenolone. * AKR1C3 has been implicated in several signaling pathways, including the prostaglandin signaling pathway and the retinoic acid signaling pathway. **Pathways and Functions** * Steroid hormone biosynthesis: AKR1C3 plays a crucial role in the biosynthesis of steroid hormones, including testosterone and estrogen. * Lipid metabolism: The enzyme is involved in the metabolism of lipids, including the breakdown of triglycerides and the synthesis of cholesterol. * Prostaglandin synthesis: AKR1C3 is involved in the synthesis of prostaglandins, including prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). * Bile acid synthesis: The enzyme is involved in the synthesis of bile acids, including cholic acid and chenodeoxycholic acid. * Cell proliferation and differentiation: AKR1C3 has been shown to regulate cell proliferation and differentiation in various cell types, including keratinocytes and macrophages. * Apoptosis: The enzyme has been implicated in the regulation of apoptosis in several cell types, including epithelial cells and macrophages. **Clinical Significance** * AKR1C3 has been implicated in several diseases, including cancer, autoimmune diseases, and metabolic disorders. * The enzyme has been shown to play a role in the development of certain types of cancer, including prostate cancer and breast cancer. * AKR1C3 has also been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. * The enzyme has been shown to have a role in metabolic disorders, including obesity and type 2 diabetes. * AKR1C3 has been identified as a potential therapeutic target for the treatment of various diseases, including cancer and metabolic disorders. In conclusion, AKR1C3 is a multifunctional enzyme that plays a crucial role in various metabolic processes, including steroid hormone biosynthesis, lipid metabolism, and prostaglandin synthesis. The enzyme has been implicated in several diseases and has potential therapeutic applications, making it an important area of research in the field of immunology and biochemistry.

Genular Protein ID: 3947691133

Symbol: AK1C3_HUMAN

Name: Aldo-keto reductase family 1 member C3

UniProtKB Accession Codes:

P42330 A8K2V0 B4DL37 Q5T2L1 Q96DJ1 Q96KI8 Q99530 Q9UCX1 Q9UII3 Q9UKL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 9 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 97 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EC 9 EMBL 22 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 59 PDBsum 59 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 41 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8274401

Title: Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

PubMed ID: 8274401

DOI: 10.1016/0960-0760(93)90308-j

PubMed ID: 7650035

Title: Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

PubMed ID: 7650035

DOI: 10.1074/jbc.270.34.20162

PubMed ID: 7626489

Title: Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

PubMed ID: 7626489

DOI: 10.1016/0960-0760(95)00019-v

PubMed ID: 9415401

Title: Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.

PubMed ID: 9415401

DOI: 10.1210/mend.11.13.0026

PubMed ID: 10622721

Title: cDNA cloning, expression and characterization of human prostaglandin F synthase.

PubMed ID: 10622721

DOI: 10.1016/s0014-5793(99)01551-3

PubMed ID: 10557352

Title: Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.

PubMed ID: 10557352

DOI: 10.1073/pnas.96.23.13512

PubMed ID: 10672042

Title: Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

PubMed ID: 10672042

DOI: 10.1046/j.1365-2443.2000.00310.x

PubMed ID: 11165022

Title: Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).

PubMed ID: 11165022

DOI: 10.1016/s0303-7207(00)00426-3

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9927279

Title: Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase.

PubMed ID: 9927279

DOI: 10.1210/endo.140.2.6531

PubMed ID: 10998348

Title: Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

PubMed ID: 10998348

DOI: 10.1042/0264-6021:3510067

PubMed ID: 15047184

Title: Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS.

PubMed ID: 15047184

DOI: 10.1016/j.abb.2004.02.009

PubMed ID: 14672942

Title: Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

PubMed ID: 14672942

DOI: 10.1074/jbc.m313308200

PubMed ID: 19010934

Title: Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.

PubMed ID: 19010934

DOI: 10.1093/jb/mvn152

PubMed ID: 20036328

Title: Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

PubMed ID: 20036328

DOI: 10.1016/j.jsbmb.2009.12.009

PubMed ID: 21851338

Title: Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

PubMed ID: 21851338

DOI: 10.1042/bj20111286

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 14979715

Title: Crystal structure of human prostaglandin F synthase (AKR1C3).

PubMed ID: 14979715

DOI: 10.1021/bi036046x

PubMed ID: 14996743

Title: Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin.

PubMed ID: 14996743

DOI: 10.1158/0008-5472.can-03-2847

PubMed ID: 15087468

Title: Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.

PubMed ID: 15087468

DOI: 10.1210/me.2004-0032

Sequence Information:

  • Length: 323
  • Mass: 36853
  • Checksum: 86A7690D9498C6FD
  • Sequence:
    • MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 
SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP 
GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD 
RNLHYFNSDS FASHPNYPYS DEY

Genular Protein ID: 1595956335

Symbol: B4DKT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKT3

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 2 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 138
  • Mass: 15651
  • Checksum: 26C0DC81406E2165
  • Sequence:
    • MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 
SLKVCSLYEH KIALLLSL

Genular Protein ID: 3877129939

Symbol: A0A0A0MSS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSS8

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 30 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 4 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 14 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 323
  • Mass: 36867
  • Checksum: 97D56010726AC006
  • Sequence:
    • MDSKHQCLKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM 
SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP 
GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD 
RNLHYFNSDS FASHPNYPYS DEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.