Details for: FABP4

Gene ID: 2167

Symbol: FABP4

Ensembl ID: ENSG00000170323

Description: fatty acid binding protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.73
    Marker Score: 1365
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.17
    Marker Score: 1771
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.86
    Marker Score: 73152
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.16
    Marker Score: 525
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.12
    Marker Score: 3124
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.09
    Marker Score: 3540
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.57
    Marker Score: 1693
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168043
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.38
    Marker Score: 352
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2432
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.24
    Marker Score: 289
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.2
    Marker Score: 255
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.13
    Marker Score: 1067
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.12
    Marker Score: 397
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.07
    Marker Score: 508
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.04
    Marker Score: 6329
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.04
    Marker Score: 304
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.97
    Marker Score: 1410
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.96
    Marker Score: 252
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.89
    Marker Score: 1157
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.89
    Marker Score: 286
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5046
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.87
    Marker Score: 1659
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.84
    Marker Score: 221
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.84
    Marker Score: 407
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.83
    Marker Score: 5412
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.82
    Marker Score: 741
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.8
    Marker Score: 2035.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.77
    Marker Score: 418
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.76
    Marker Score: 1963.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.75
    Marker Score: 381
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.75
    Marker Score: 25580
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1185
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.73
    Marker Score: 831
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.68
    Marker Score: 814
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.66
    Marker Score: 414
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 433
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 397
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.64
    Marker Score: 1139
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 337
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.58
    Marker Score: 839
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.57
    Marker Score: 991
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.57
    Marker Score: 578
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.57
    Marker Score: 491
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.57
    Marker Score: 180
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.57
    Marker Score: 360
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 451
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.56
    Marker Score: 3362
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.56
    Marker Score: 501
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.54
    Marker Score: 516
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.54
    Marker Score: 520
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1086
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.53
    Marker Score: 572
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.52
    Marker Score: 841
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.52
    Marker Score: 371
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 213
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.51
    Marker Score: 950
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.49
    Marker Score: 1175
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.46
    Marker Score: 130
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.46
    Marker Score: 190
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.45
    Marker Score: 1187
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.45
    Marker Score: 114
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.44
    Marker Score: 543
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.44
    Marker Score: 210
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.43
    Marker Score: 6970
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.43
    Marker Score: 530
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.42
    Marker Score: 175
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.42
    Marker Score: 246
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.42
    Marker Score: 91
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.41
    Marker Score: 228
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.41
    Marker Score: 147
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.4
    Marker Score: 1158
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 184
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.38
    Marker Score: 428
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.38
    Marker Score: 362
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.38
    Marker Score: 438
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.37
    Marker Score: 150
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.35
    Marker Score: 1864
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 154
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.35
    Marker Score: 161
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.34
    Marker Score: 336
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.34
    Marker Score: 297
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.34
    Marker Score: 231
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.33
    Marker Score: 479.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FABP4 is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of brown fat cell differentiation. * It is also involved in the regulation of cellular response to tumor necrosis factor, cholesterol homeostasis, and white fat cell differentiation. **Pathways and functions:** * FABP4 is a key regulator of brown fat cell differentiation. It is expressed in the developing brown fat cells and is required for the proper differentiation of these cells. * It also plays a role in the regulation of cellular response to tumor necrosis factor. FABP4 binds to tumor necrosis factor-alpha (TNF-alpha) and inhibits its interaction with its receptor, leading to the inhibition of inflammation. * FABP4 also plays a role in cholesterol homeostasis. It is expressed in the liver and is required for the production of very low-density lipoprotein (VLDL), a lipid that is responsible for carrying cholesterol from the liver to the cells. * FABP4 is also involved in white fat cell differentiation. It is expressed in the skin and is required for the development of white fat tissue. **Clinical significance:** FABP4 is a potential therapeutic target for a variety of diseases. For example, it is a target for the treatment of obesity, as it is expressed in the fat cells of obese individuals. FABP4 inhibitors are being investigated as a treatment for obesity and other metabolic disorders.

Genular Protein ID: 2594913031

Symbol: FABP4_HUMAN

Name: Fatty acid-binding protein, adipocyte

UniProtKB Accession Codes:

P15090 Q6IBA1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2481498

Title: Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA.

PubMed ID: 2481498

DOI: 10.1021/bi00448a003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 15357969

Title: Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.

PubMed ID: 15357969

DOI: 10.1016/j.bmcl.2004.06.057

PubMed ID: 17077479

Title: Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2).

PubMed ID: 17077479

DOI: 10.1107/s1744309106038656

Sequence Information:

  • Length: 132
  • Mass: 14719
  • Checksum: 819D788FF4BF7235
  • Sequence:
    • MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN 
TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM 
KGVTSTRVYE RA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.