Details for: FABP4

Gene ID: 2167

Symbol: FABP4

Ensembl ID: ENSG00000170323

Description: fatty acid binding protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.9023
    Cell Significance Index: -17.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.7292
    Cell Significance Index: -17.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5342
    Cell Significance Index: -17.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.3204
    Cell Significance Index: 253.0600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 11.4238
    Cell Significance Index: 49.7300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 7.7977
    Cell Significance Index: 98.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.0991
    Cell Significance Index: 99.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5007
    Cell Significance Index: -17.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.8098
    Cell Significance Index: 197.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7533
    Cell Significance Index: 25.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5887
    Cell Significance Index: 286.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3932
    Cell Significance Index: 171.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7718
    Cell Significance Index: 22.1300
  • Cell Name: endothelial cell of arteriole (CL1000412)
    Fold Change: 0.7254
    Cell Significance Index: 6.2100
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.6944
    Cell Significance Index: 5.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6155
    Cell Significance Index: 5.1700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.5965
    Cell Significance Index: 2.5700
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 0.2360
    Cell Significance Index: 1.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1281
    Cell Significance Index: 1.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0682
    Cell Significance Index: 5.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0664
    Cell Significance Index: 3.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0461
    Cell Significance Index: 28.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0301
    Cell Significance Index: 3.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0019
    Cell Significance Index: 1.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0010
    Cell Significance Index: 0.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0019
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0022
    Cell Significance Index: -2.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0099
    Cell Significance Index: -18.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0103
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0103
    Cell Significance Index: -19.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0141
    Cell Significance Index: -7.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0202
    Cell Significance Index: -14.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0210
    Cell Significance Index: -4.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0310
    Cell Significance Index: -14.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0428
    Cell Significance Index: -5.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0480
    Cell Significance Index: -4.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0531
    Cell Significance Index: -15.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0539
    Cell Significance Index: -9.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0556
    Cell Significance Index: -11.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0693
    Cell Significance Index: -9.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0778
    Cell Significance Index: -11.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0922
    Cell Significance Index: -10.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0922
    Cell Significance Index: -18.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1190
    Cell Significance Index: -13.5800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1615
    Cell Significance Index: -1.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1780
    Cell Significance Index: -18.5300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1815
    Cell Significance Index: -2.2100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1952
    Cell Significance Index: -1.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2000
    Cell Significance Index: -5.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2362
    Cell Significance Index: -4.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2384
    Cell Significance Index: -6.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2410
    Cell Significance Index: -15.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2523
    Cell Significance Index: -7.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2655
    Cell Significance Index: -17.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2737
    Cell Significance Index: -16.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2755
    Cell Significance Index: -14.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3007
    Cell Significance Index: -15.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3195
    Cell Significance Index: -17.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3411
    Cell Significance Index: -15.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3521
    Cell Significance Index: -15.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4221
    Cell Significance Index: -18.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4267
    Cell Significance Index: -18.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4308
    Cell Significance Index: -14.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4483
    Cell Significance Index: -14.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4634
    Cell Significance Index: -17.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4925
    Cell Significance Index: -14.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4930
    Cell Significance Index: -18.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4949
    Cell Significance Index: -5.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5002
    Cell Significance Index: -16.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5020
    Cell Significance Index: -17.5900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.5029
    Cell Significance Index: -4.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5306
    Cell Significance Index: -8.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5443
    Cell Significance Index: -17.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5538
    Cell Significance Index: -14.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5633
    Cell Significance Index: -15.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5875
    Cell Significance Index: -18.7100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.6048
    Cell Significance Index: -5.9200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.6167
    Cell Significance Index: -6.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6276
    Cell Significance Index: -15.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6287
    Cell Significance Index: -17.9400
  • Cell Name: endothelial cell of respiratory system lymphatic vessel (CL0009086)
    Fold Change: -0.6345
    Cell Significance Index: -3.9800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.6467
    Cell Significance Index: -8.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6647
    Cell Significance Index: -5.4200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6736
    Cell Significance Index: -8.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6786
    Cell Significance Index: -17.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6857
    Cell Significance Index: -18.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6931
    Cell Significance Index: -12.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7120
    Cell Significance Index: -17.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7126
    Cell Significance Index: -17.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7146
    Cell Significance Index: -17.3100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.7214
    Cell Significance Index: -8.4300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.7314
    Cell Significance Index: -4.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7446
    Cell Significance Index: -10.8100
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.7664
    Cell Significance Index: -9.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7741
    Cell Significance Index: -19.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7805
    Cell Significance Index: -17.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7840
    Cell Significance Index: -19.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FABP4 is a small, cytoplasmic protein that binds to long-chain fatty acids, facilitating their transport into cells. It is primarily expressed in adipocytes, macrophages, and endothelial cells. FABP4 is also known for its ability to regulate the expression of genes involved in lipid metabolism, inflammation, and cell differentiation. The protein's expression is induced by various stimuli, including obesity, insulin resistance, and inflammatory signals. **Pathways and Functions:** FABP4 is involved in several key pathways, including: 1. **Fatty Acid Transport:** FABP4 binds to long-chain fatty acids, facilitating their transport into cells, where they can be stored, metabolized, or utilized as energy sources. 2. **Cholesterol Homeostasis:** FABP4 regulates the expression of genes involved in cholesterol metabolism, influencing the balance of cholesterol levels in the body. 3. **Inflammation:** FABP4 is induced by inflammatory signals, promoting the production of pro-inflammatory cytokines and mediators, which contribute to metabolic disorders. 4. **Cell Differentiation:** FABP4 regulates the expression of genes involved in white adipocyte differentiation, influencing the development and function of adipose tissue. 5. **Metabolism:** FABP4 is involved in the regulation of lipid metabolism, influencing the breakdown and synthesis of triglycerides and cholesterol. **Clinical Significance:** Dysregulation of FABP4 has been implicated in various metabolic disorders, including: 1. **Obesity:** FABP4 expression is increased in obese individuals, contributing to insulin resistance and metabolic syndrome. 2. **Type 2 Diabetes:** FABP4 is associated with insulin resistance and impaired glucose metabolism in type 2 diabetes patients. 3. **Atherosclerosis:** FABP4 promotes the development of atherosclerosis by regulating the expression of genes involved in lipid metabolism and inflammation. 4. **Metastatic Cancer:** FABP4 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and metastasis. In conclusion, FABP4 plays a critical role in regulating fatty acid metabolism, inflammation, and cell differentiation. Its dysregulation contributes to various metabolic disorders, including obesity, type 2 diabetes, and atherosclerosis. Understanding the functions and pathways of FABP4 holds promise for the development of novel therapeutic strategies to prevent and treat metabolic diseases.

Genular Protein ID: 2594913031

Symbol: FABP4_HUMAN

Name: Fatty acid-binding protein, adipocyte

UniProtKB Accession Codes:

P15090 Q6IBA1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2481498

Title: Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA.

PubMed ID: 2481498

DOI: 10.1021/bi00448a003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 15357969

Title: Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target.

PubMed ID: 15357969

DOI: 10.1016/j.bmcl.2004.06.057

PubMed ID: 17077479

Title: Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2).

PubMed ID: 17077479

DOI: 10.1107/s1744309106038656

Sequence Information:

  • Length: 132
  • Mass: 14719
  • Checksum: 819D788FF4BF7235
  • Sequence:
    • MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN 
TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM 
KGVTSTRVYE RA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.