TEK | ENSG00000120156 | NCBI 7010

Details for: TEK

Gene ID: 7010

Symbol: TEK

Ensembl ID: ENSG00000120156

Description: TEK receptor tyrosine kinase

Associated with

Cell surface interactions at the vascular wall
(R-HSA-202733)
Hemostasis
(R-HSA-109582)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Raf/map kinase cascade
(R-HSA-5673001)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Actin filament
(GO:0005884)
Angiogenesis
(GO:0001525)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cell-cell junction
(GO:0005911)
Cell-cell signaling
(GO:0007267)
Cell surface
(GO:0009986)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Centriolar satellite
(GO:0034451)
Cytoplasm
(GO:0005737)
Definitive hemopoiesis
(GO:0060216)
Endochondral ossification
(GO:0001958)
Endothelial cell proliferation
(GO:0001935)
Extracellular region
(GO:0005576)
Focal adhesion
(GO:0005925)
Glomerulus vasculature development
(GO:0072012)
Growth factor binding
(GO:0019838)
Heart development
(GO:0007507)
Heart trabecula formation
(GO:0060347)
Identical protein binding
(GO:0042802)
Membrane raft
(GO:0045121)
Microvillus
(GO:0005902)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of inflammatory response
(GO:0050728)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of rac protein signal transduction
(GO:0035022)
Positive regulation of rho protein signal transduction
(GO:0035025)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Receptor complex
(GO:0043235)
Regulation of endothelial cell apoptotic process
(GO:2000351)
Regulation of establishment or maintenance of cell polarity
(GO:0032878)
Regulation of vascular permeability
(GO:0043114)
Response to camp
(GO:0051591)
Response to estrogen
(GO:0043627)
Response to hypoxia
(GO:0001666)
Response to peptide hormone
(GO:0043434)
Signaling receptor activity
(GO:0038023)
Sprouting angiogenesis
(GO:0002040)
Stress fiber
(GO:0001725)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Tie signaling pathway
(GO:0048014)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 75.6693
Cell Significance Index: -11.7700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 46.3643
Cell Significance Index: -11.7600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.5462
Cell Significance Index: -11.7700
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 6.5496
Cell Significance Index: 24.4100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 6.4776
Cell Significance Index: 93.1700
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 5.8272
Cell Significance Index: 60.3600
Cell Name: endocardial cell (CL0002350)
Fold Change: 4.5854
Cell Significance Index: 27.0700
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.8080
Cell Significance Index: 6.2900
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.6657
Cell Significance Index: 10.4300
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.0887
Cell Significance Index: 8.6000
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.0120
Cell Significance Index: 9.6200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9492
Cell Significance Index: 49.4400
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.6736
Cell Significance Index: 4.0700
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.6364
Cell Significance Index: 4.6700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.6237
Cell Significance Index: 7.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3303
Cell Significance Index: 20.3000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1815
Cell Significance Index: 36.4100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1459
Cell Significance Index: 52.3300
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1061
Cell Significance Index: 2.5500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0526
Cell Significance Index: 32.8500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0401
Cell Significance Index: 1.7800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0327
Cell Significance Index: 1.2400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0127
Cell Significance Index: 0.7100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0070
Cell Significance Index: 10.7900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0064
Cell Significance Index: 8.7200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0062
Cell Significance Index: 0.1100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0026
Cell Significance Index: 4.7600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0023
Cell Significance Index: 1.5900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0014
Cell Significance Index: -1.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0014
Cell Significance Index: -2.6500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0025
Cell Significance Index: -0.5200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0068
Cell Significance Index: -3.8600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0157
Cell Significance Index: -9.9500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0159
Cell Significance Index: -12.0700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0165
Cell Significance Index: -2.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0180
Cell Significance Index: -13.1800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0212
Cell Significance Index: -11.5800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0216
Cell Significance Index: -4.2900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0245
Cell Significance Index: -11.1200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0305
Cell Significance Index: -8.7700
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0321
Cell Significance Index: -0.4400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0373
Cell Significance Index: -6.7300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0518
Cell Significance Index: -6.0400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0535
Cell Significance Index: -7.3500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0709
Cell Significance Index: -10.3100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0795
Cell Significance Index: -9.7700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0830
Cell Significance Index: -6.3700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0831
Cell Significance Index: -9.4900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0856
Cell Significance Index: -10.9700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0919
Cell Significance Index: -6.1800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0988
Cell Significance Index: -12.7600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1098
Cell Significance Index: -12.5900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1098
Cell Significance Index: -11.4400
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: -0.1188
Cell Significance Index: -1.0100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1233
Cell Significance Index: -12.6000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1271
Cell Significance Index: -1.8200
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1367
Cell Significance Index: -1.6800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1658
Cell Significance Index: -13.1300
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1675
Cell Significance Index: -2.3000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1713
Cell Significance Index: -7.4500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1715
Cell Significance Index: -12.7800
Cell Name: decidual cell (CL2000002)
Fold Change: -0.2132
Cell Significance Index: -3.4200
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.2136
Cell Significance Index: -2.3200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2147
Cell Significance Index: -3.6800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2181
Cell Significance Index: -6.2300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2197
Cell Significance Index: -4.4100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2489
Cell Significance Index: -12.9300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2547
Cell Significance Index: -11.9700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2560
Cell Significance Index: -6.8600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2755
Cell Significance Index: -9.6500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2973
Cell Significance Index: -9.4700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2983
Cell Significance Index: -13.9100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2989
Cell Significance Index: -7.9800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3009
Cell Significance Index: -9.8500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3095
Cell Significance Index: -8.2800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3221
Cell Significance Index: -5.3900
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3295
Cell Significance Index: -6.4300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3539
Cell Significance Index: -12.9900
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3580
Cell Significance Index: -7.2900
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3608
Cell Significance Index: -9.0000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3658
Cell Significance Index: -18.4900
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3772
Cell Significance Index: -11.9300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.3787
Cell Significance Index: -2.7200
Cell Name: gut endothelial cell (CL0000131)
Fold Change: -0.3800
Cell Significance Index: -2.6100
Cell Name: endothelial stalk cell (CL0002671)
Fold Change: -0.3802
Cell Significance Index: -4.2600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3819
Cell Significance Index: -8.2500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3822
Cell Significance Index: -13.2800
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.3977
Cell Significance Index: -5.1900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3980
Cell Significance Index: -13.9900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4124
Cell Significance Index: -9.9900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4297
Cell Significance Index: -9.1200
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4317
Cell Significance Index: -9.0100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4331
Cell Significance Index: -10.8000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4368
Cell Significance Index: -12.5200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4482
Cell Significance Index: -13.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4537
Cell Significance Index: -11.9300
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: -0.4585
Cell Significance Index: -3.3300
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4683
Cell Significance Index: -10.2600
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.4687
Cell Significance Index: -4.9400
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4719
Cell Significance Index: -9.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TEK is a member of the TIE family of receptor tyrosine kinases, which are characterized by their high degree of sequence homology and similar ligand-binding properties. TEK is specifically expressed in endothelial cells, including those of the vascular tree, sinusoids, and blood-brain barrier. TEK is also expressed in other cell types, including retinal bipolar neurons and OFF-bipolar cells. **Pathways and Functions** TEK signaling is involved in various cellular processes, including: 1. **Angiogenesis**: TEK activation by Ang-1 leads to the regulation of endothelial cell migration, proliferation, and survival, promoting the formation of new blood vessels. 2. **Endothelial cell function**: TEK signaling regulates endothelial cell barrier function, vascular permeability, and the establishment of cell polarity. 3. **Apoptosis regulation**: TEK phosphorylates and activates anti-apoptotic proteins, leading to the inhibition of endothelial cell apoptosis. 4. **Cell-cell signaling**: TEK signaling regulates the interaction between endothelial cells and other cell types, including pericytes and smooth muscle cells. **Clinical Significance** TEK dysregulation has been implicated in various diseases, including: 1. **Angiogenesis-related disorders**: TEK mutations have been associated with hereditary hemorrhagic telangiectasia (HHT), a disorder characterized by the formation of abnormal blood vessels. 2. **Cancer**: TEK overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor angiogenesis and metastasis. 3. **Neurological disorders**: TEK signaling has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates endothelial cell function and vascular permeability. In conclusion, TEK receptor tyrosine kinase plays a crucial role in regulating endothelial cell function and angiogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of TEK in maintaining vascular health and function. Further research is needed to fully elucidate the mechanisms of TEK signaling and its role in disease pathogenesis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Angiopoietin-1 receptor
Q59HG2_HUMAN

Genular Protein ID: 3681544798

Symbol: TIE2_HUMAN

Name: Angiopoietin-1 receptor

UniProtKB Accession Codes:

Q02763 A8K6W0 B4DH20 B4DHD3 D3DRK5 E7EWI2 Q5TCU2 Q8IV34

Database IDs:

Citations:

PubMed ID: 8382358

Title: Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.

PubMed ID: 8382358

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9204896

Title: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

PubMed ID: 9204896

DOI: 10.1126/science.277.5322.55

PubMed ID: 11806244

Title: Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood.

PubMed ID: 11806244

DOI: 10.1023/a:1012226627813

PubMed ID: 11513602

Title: Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2.

PubMed ID: 11513602

DOI: 10.1021/bi010959e

PubMed ID: 12816861

Title: Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1.

PubMed ID: 12816861

DOI: 10.1182/blood-2003-03-0670

PubMed ID: 12609966

Title: The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

PubMed ID: 12609966

DOI: 10.1161/01.res.0000063422.38690.dc

PubMed ID: 15284220

Title: Biological characterization of angiopoietin-3 and angiopoietin-4.

PubMed ID: 15284220

DOI: 10.1096/fj.03-1466com

PubMed ID: 14665640

Title: Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.

PubMed ID: 14665640

DOI: 10.1074/jbc.m307456200

PubMed ID: 15851516

Title: Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2.

PubMed ID: 15851516

DOI: 10.1083/jcb.200411105

PubMed ID: 18425120

Title: Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1.

PubMed ID: 18425120

DOI: 10.1038/ncb1714

PubMed ID: 18425119

Title: Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.

PubMed ID: 18425119

DOI: 10.1038/ncb1715

PubMed ID: 19116766

Title: Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.

PubMed ID: 19116766

DOI: 10.1007/s10456-008-9126-0

PubMed ID: 19689429

Title: Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.

PubMed ID: 19689429

DOI: 10.1042/bj20091010

PubMed ID: 19451274

Title: VE-PTP controls blood vessel development by balancing Tie-2 activity.

PubMed ID: 19451274

DOI: 10.1083/jcb.200811159

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19223473

Title: Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.

PubMed ID: 19223473

DOI: 10.1128/mcb.01472-08

PubMed ID: 18366015

Title: Tie2: a journey from normal angiogenesis to cancer and beyond.

PubMed ID: 18366015

DOI: 10.14670/hh-23.773

PubMed ID: 19293632

Title: Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1.

PubMed ID: 19293632

DOI: 10.3858/emm.2009.41.3.016

PubMed ID: 19234476

Title: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.

PubMed ID: 19234476

DOI: 10.1038/nrm2639

PubMed ID: 20054809

Title: Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis.

PubMed ID: 20054809

DOI: 10.14670/hh-25.387

PubMed ID: 20651738

Title: Targeting the ANGPT-TIE2 pathway in malignancy.

PubMed ID: 20651738

DOI: 10.1038/nrc2894

PubMed ID: 32908006

Title: Characterization of ANGPT2 mutations associated with primary lymphedema.

PubMed ID: 32908006

DOI: 10.1126/scitranslmed.aax8013

PubMed ID: 11080633

Title: Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.

PubMed ID: 11080633

DOI: 10.1016/s0969-2126(00)00516-5

PubMed ID: 16732286

Title: Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.

PubMed ID: 16732286

DOI: 10.1038/nsmb1101

PubMed ID: 17350837

Title: Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.

PubMed ID: 17350837

DOI: 10.1016/j.bmcl.2007.02.067

PubMed ID: 17253678

Title: Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

PubMed ID: 17253678

DOI: 10.1021/jm061107l

PubMed ID: 19854647

Title: Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.

PubMed ID: 19854647

DOI: 10.1016/j.bmcl.2009.10.001

PubMed ID: 8980225

Title: Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.

PubMed ID: 8980225

DOI: 10.1016/s0092-8674(00)81814-0

PubMed ID: 10369874

Title: Allelic and locus heterogeneity in inherited venous malformations.

PubMed ID: 10369874

DOI: 10.1093/hmg/8.7.1279

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19079259

Title: Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations.

PubMed ID: 19079259

DOI: 10.1038/ng.272

PubMed ID: 19888299

Title: Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects.

PubMed ID: 19888299

DOI: 10.1038/ejhg.2009.193

PubMed ID: 27270174

Title: Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.

PubMed ID: 27270174

DOI: 10.1172/jci85830

Sequence Information:

Length: 1124
Mass: 125830
Checksum: E739DEC3E4FEB124
Sequence:

MDSLASLVLC GVSLLLSGTV EGAMDLILIN SLPLVSDAET SLTCIASGWR PHEPITIGRD 
FEALMNQHQD PLEVTQDVTR EWAKKVVWKR EKASKINGAY FCEGRVRGEA IRIRTMKMRQ 
QASFLPATLT MTVDKGDNVN ISFKKVLIKE EDAVIYKNGS FIHSVPRHEV PDILEVHLPH 
AQPQDAGVYS ARYIGGNLFT SAFTRLIVRR CEAQKWGPEC NHLCTACMNN GVCHEDTGEC 
ICPPGFMGRT CEKACELHTF GRTCKERCSG QEGCKSYVFC LPDPYGCSCA TGWKGLQCNE 
ACHPGFYGPD CKLRCSCNNG EMCDRFQGCL CSPGWQGLQC EREGIQRMTP KIVDLPDHIE 
VNSGKFNPIC KASGWPLPTN EEMTLVKPDG TVLHPKDFNH TDHFSVAIFT IHRILPPDSG 
VWVCSVNTVA GMVEKPFNIS VKVLPKPLNA PNVIDTGHNF AVINISSEPY FGDGPIKSKK 
LLYKPVNHYE AWQHIQVTNE IVTLNYLEPR TEYELCVQLV RRGEGGEGHP GPVRRFTTAS 
IGLPPPRGLN LLPKSQTTLN LTWQPIFPSS EDDFYVEVER RSVQKSDQQN IKVPGNLTSV 
LLNNLHPREQ YVVRARVNTK AQGEWSEDLT AWTLSDILPP QPENIKISNI THSSAVISWT 
ILDGYSISSI TIRYKVQGKN EDQHVDVKIK NATITQYQLK GLEPETAYQV DIFAENNIGS 
SNPAFSHELV TLPESQAPAD LGGGKMLLIA ILGSAGMTCL TVLLAFLIIL QLKRANVQRR 
MAQAFQNVRE EPAVQFNSGT LALNRKVKNN PDPTIYPVLD WNDIKFQDVI GEGNFGQVLK 
ARIKKDGLRM DAAIKRMKEY ASKDDHRDFA GELEVLCKLG HHPNIINLLG ACEHRGYLYL 
AIEYAPHGNL LDFLRKSRVL ETDPAFAIAN STASTLSSQQ LLHFAADVAR GMDYLSQKQF 
IHRDLAARNI LVGENYVAKI ADFGLSRGQE VYVKKTMGRL PVRWMAIESL NYSVYTTNSD 
VWSYGVLLWE IVSLGGTPYC GMTCAELYEK LPQGYRLEKP LNCDDEVYDL MRQCWREKPY 
ERPSFAQILV SLNRMLEERK TYVNTTLYEK FTYAGIDCSA EEAA

Genular Protein ID: 2284991154

Symbol: Q59HG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HG2

Database IDs:

Sequence Information:

Length: 1157
Mass: 129275
Checksum: 872EFE11E6CDCF56
Sequence:

DDANGKSQTA GFLKGSLGPH AHLWKLDGEI WGSMDSLASL VLCGVSLLLS GTVEGAMDLI 
LINSLPLVSD AETSLTCIAS GWRPHEPITI GRDFEALMNQ HQDPLEVTQD VTREWAKKVV 
WKREKASKIN GAYFCEGRVR GEAIRIRTMK MRQQASFLPA TLTMTVDKGD NVNISFKKVL 
IKEEDAVIYK NGSFIHSVPR HEVPDILEVH LPHAQPQDAG VYSARYIGGN LFTSAFTRLI 
VRRCEAQKWG PECNHLCTAC MNNGVCHEDT GECICPPGFM GRTCEKACEL HTFGRTCKER 
CSGQEGCKSY VFCLPDPYGC SCATGWKGLQ CNEACHPGFY GPDCKLRCSC NNGEMCDRFQ 
GCLCSPGWQG LQCEREGIPR MTPKIVDLPD HIEVNSGKFN PICKASGWPL PTNEEMTLVK 
PDGTVLHPKD FNHTDHFSVA IFTIHRILPP DSGVWVCSVN TVAGMVEKPF NISVKVLPKP 
LNAPNVIDTG HNFAVINISS EPYFGDGPIK SKKLLYKPVN HYEAWQHIQV TNEIVTLNYL 
EPRTEYELCV QLVRRGEGGE GHPGPVRRFT TASIGLPPPR GLNLLPKSQT TLNLTWQPIF 
PSSEDDFYVE VERRSVQKSD QQNIKVPGNL TSVLLNNLHP REQYVVRARV NTKAQGEWSE 
DLTAWTLSDI LPPQPENIKI SNITHSSAVI SWTILDGYSI SSITIRYKVQ GKNEDQHVDV 
KIKNATITQY QLKGLEPETA YQVDIFAENN IGSSNPAFSH ELVTLPESQA PADLGGGKML 
LIAILGSAGM TCLTVLLAFL IILQLKRANV QRRMAQAFQN VREEPAVQFN SGTLALNRKV 
KNNPDPTIYP VLDWNDIKFQ DVIGEGNFGQ VLKARIKKDG LRMDAAIKRM KEYASKDDHR 
DFAGELEVLC KLGHHPNIIN LLGACEHRGY LYLAIEYAPH GNLLDFLRKS RVLETDPAFA 
IANSTASTLS SQQLLHFAAD VARGMDYLSQ KQFIHRDLAA RNILVGENYV AKIADFGLSR 
GQEVYVKKTM GRLPVRWMAI ESLNYSVYTT NSDVWSYGVL LWEIVSLGGT PYCGMTCAEL 
YEKLPQGYRL EKPLNCDDEV YDLMRQCWRE KPYERPSFAQ ILVSLNRMLE ERKTYVNTTL 
YEKFTYAGID CSAEEAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TEK

Associated with

Cells (max top 100)

Other Information

Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. PubMed ID: 8382358

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. PubMed ID: 9204896

Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood. PubMed ID: 11806244

Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2. PubMed ID: 11513602

Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. PubMed ID: 12816861

The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. PubMed ID: 12609966

Biological characterization of angiopoietin-3 and angiopoietin-4. PubMed ID: 15284220

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells. PubMed ID: 14665640

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. PubMed ID: 15851516

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. PubMed ID: 18425120

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. PubMed ID: 18425119

Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. PubMed ID: 19116766

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. PubMed ID: 19689429

VE-PTP controls blood vessel development by balancing Tie-2 activity. PubMed ID: 19451274

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. PubMed ID: 19223473

Tie2: a journey from normal angiogenesis to cancer and beyond. PubMed ID: 18366015

Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1. PubMed ID: 19293632

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. PubMed ID: 19234476

Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis. PubMed ID: 20054809

Targeting the ANGPT-TIE2 pathway in malignancy. PubMed ID: 20651738

Characterization of ANGPT2 mutations associated with primary lymphedema. PubMed ID: 32908006

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. PubMed ID: 11080633

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. PubMed ID: 16732286

Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors. PubMed ID: 17350837

Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. PubMed ID: 17253678

Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo. PubMed ID: 19854647

Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. PubMed ID: 8980225

Allelic and locus heterogeneity in inherited venous malformations. PubMed ID: 10369874

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations. PubMed ID: 19079259

Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects. PubMed ID: 19888299

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. PubMed ID: 27270174