Details for: HIF3A

Gene ID: 64344

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HIF3A

Ensembl ID: ENSG00000124440

Description: hypoxia inducible factor 3 subunit alpha

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac muscle cell CL0000746
    CSI 23.85
    rCSI 34.23%
    PRS 77.51
  • astrocyte of the cerebral cortex CL0002605
    CSI 22.04
    rCSI 49.41%
    PRS 71.7
  • erythroblast CL0000765
    CSI 13.8
    rCSI 36.61%
    PRS 89.38
  • Bergmann glial cell CL0000644
    CSI 12.36
    rCSI 16.91%
    PRS 78.16
  • glioblast CL0000030
    CSI 12.17
    rCSI 19.41%
    PRS 78.43
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 11.06
    rCSI 20.1%
    PRS 78.85
  • myofibroblast cell CL0000186
    CSI 7.48
    rCSI 10.36%
    PRS 82.71
  • interstitial cell of Cajal CL0002088
    CSI 7.32
    rCSI 9.32%
    PRS 90.37
  • peripheral nervous system neuron CL2000032
    CSI 6.51
    rCSI 8.87%
    PRS 79.01
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6.39
    rCSI 7%
    PRS 87.91
  • hepatic stellate cell CL0000632
    CSI 6.37
    rCSI 23.86%
    PRS 80.41
  • chondrocyte CL0000138
    CSI 6.34
    rCSI 10.08%
    PRS 80.63
  • cerebral cortex endothelial cell CL1001602
    CSI 6.33
    rCSI 10.95%
    PRS 79.63
  • sncg GABAergic cortical interneuron CL4023015
    CSI 4.93
    rCSI 7.93%
    PRS 72.27
  • mature astrocyte CL0002627
    CSI 4.81
    rCSI 20.43%
    PRS 79.78
  • alveolar adventitial fibroblast CL4028006
    CSI 4.67
    rCSI 7.37%
    PRS 87.3
  • retinal blood vessel endothelial cell CL0002585
    CSI 4.49
    rCSI 7.17%
    PRS 89.47
  • macroglial cell CL0000126
    CSI 4.46
    rCSI 11.46%
    PRS 82.57
  • fibroblast of lung CL0002553
    CSI 4.34
    rCSI 4.04%
    PRS 87.22
  • keratocyte CL0002363
    CSI 3.88
    rCSI 9.33%
    PRS 88.03
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.87
    rCSI 7.37%
    PRS 93.25
  • epithelial cell of lung CL0000082
    CSI 3.82
    rCSI 3.17%
    PRS 87.35
  • adipocyte CL0000136
    CSI 3.78
    rCSI 4.85%
    PRS 77.24
  • bronchus fibroblast of lung CL2000093
    CSI 3.61
    rCSI 2.93%
    PRS 85.73
  • erythrocyte CL0000232
    CSI 3.6
    rCSI 8.17%
    PRS 85.58
  • cardiac endothelial cell CL0010008
    CSI 3.59
    rCSI 14.49%
    PRS 86.77
  • oligodendrocyte precursor cell CL0002453
    CSI 3.45
    rCSI 7.6%
    PRS 69.2
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 3.45
    rCSI 6.09%
    PRS 70.39
  • myeloid leukocyte CL0000766
    CSI 3.41
    rCSI 3.14%
    PRS 87.33
  • intestinal epithelial cell CL0002563
    CSI 3.32
    rCSI 3.47%
    PRS 83.88
  • blood vessel endothelial cell CL0000071
    CSI 3.27
    rCSI 6.79%
    PRS 83.86
  • capillary endothelial cell CL0002144
    CSI 3.13
    rCSI 5.74%
    PRS 88.62
  • lung endothelial cell CL1001567
    CSI 3.08
    rCSI 7.19%
    PRS 93.53
  • Mueller cell CL0000636
    CSI 3.05
    rCSI 6.97%
    PRS 78.97
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.84
    rCSI 3.39%
    PRS 71.03
  • enteric smooth muscle cell CL0002504
    CSI 2.72
    rCSI 3.89%
    PRS 86.78
  • lung neuroendocrine cell CL1000223
    CSI 2.69
    rCSI 3.99%
    PRS 88.81
  • goblet cell CL0000160
    CSI 2.62
    rCSI 2.47%
    PRS 84.4
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 2.62
    rCSI 12.01%
    PRS 88.78
  • smooth muscle cell CL0000192
    CSI 2.61
    rCSI 6.21%
    PRS 81.29
  • mesodermal cell CL0000222
    CSI 2.52
    rCSI 3.02%
    PRS 84.6
  • endothelial cell of vascular tree CL0002139
    CSI 2.49
    rCSI 13.62%
    PRS 82.66
  • Schwann cell CL0002573
    CSI 2.43
    rCSI 6.9%
    PRS 82.09
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.4
    rCSI 2.31%
    PRS 85.49
  • pulmonary artery endothelial cell CL1001568
    CSI 2.39
    rCSI 3.25%
    PRS 92.16
  • BEST4+ enteroycte CL4030026
    CSI 2.31
    rCSI 2.87%
    PRS 86.53
  • vascular leptomeningeal cell CL4023051
    CSI 2.23
    rCSI 3.91%
    PRS 81.64
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.23
    rCSI 3.16%
    PRS 83.61
  • endocardial cell CL0002350
    CSI 2.21
    rCSI 10.6%
    PRS 82.43
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.2
    rCSI 3.41%
    PRS 88.42
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.14
    rCSI 5.77%
    PRS 89.31
  • adventitial cell CL0002503
    CSI 2.09
    rCSI 5%
    PRS 89.08
  • intrahepatic cholangiocyte CL0002538
    CSI 2.09
    rCSI 5.02%
    PRS 88.19
  • regular atrial cardiac myocyte CL0002129
    CSI 2.08
    rCSI 6.68%
    PRS 83.2
  • cardiac blood vessel endothelial cell CL0010006
    CSI 2
    rCSI 14.13%
    PRS 79.83
  • lung secretory cell CL1000272
    CSI 1.96
    rCSI 4.86%
    PRS 86.85
  • cardiac neuron CL0010022
    CSI 1.84
    rCSI 5.87%
    PRS 84.38
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 1.8
    rCSI 5.55%
    PRS 89.13
  • epicardial adipocyte CL1000309
    CSI 1.79
    rCSI 5.83%
    PRS 83.62
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 1.78
    rCSI 9.9%
    PRS 87.68
  • contractile cell CL0000183
    CSI 1.68
    rCSI 4.97%
    PRS 85.47
  • mesenchymal cell CL0008019
    CSI 1.68
    rCSI 4.26%
    PRS 80.22
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.66
    rCSI 2.92%
    PRS 89.89
  • lung pericyte CL0009089
    CSI 1.55
    rCSI 4.1%
    PRS 91.12
  • stem cell CL0000034
    CSI 1.55
    rCSI 1.49%
    PRS 81.25
  • type L enteroendocrine cell CL0002279
    CSI 1.45
    rCSI 2.72%
    PRS 89.9
  • renal interstitial pericyte CL1001318
    CSI 1.31
    rCSI 3.6%
    PRS 82.59
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.26
    rCSI 3.66%
    PRS 85.5
  • stromal cell CL0000499
    CSI 1.21
    rCSI 3.4%
    PRS 81.61
  • endothelial cell of arteriole CL1000412
    CSI 1.11
    rCSI 6.18%
    PRS 92.63
  • vasa recta ascending limb cell CL1001131
    CSI 1.07
    rCSI 4.85%
    PRS 90.98
  • endothelial cell of placenta CL0009092
    CSI 1.03
    rCSI 5.05%
    PRS 91.6
  • fibroblast of cardiac tissue CL0002548
    CSI 1.02
    rCSI 4.9%
    PRS 86.75
  • glial cell CL0000125
    CSI 0.96
    rCSI 3.66%
    PRS 78.64
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 0.91
    rCSI 6.96%
    PRS 86.71
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.81
    rCSI 5.06%
    PRS 79.35
  • type EC enteroendocrine cell CL0000577
    CSI 0.79
    rCSI 2.8%
    PRS 88.29
  • enteroglial cell CL4040002
    CSI 0.74
    rCSI 3.89%
    PRS 86.98
  • collagen secreting cell CL0000667
    CSI 0.71
    rCSI 4.05%
    PRS 89.77
  • pulmonary alveolar type 1 cell CL0002062
    CSI 0.7
    rCSI 4.04%
    PRS 82.96
  • brain vascular cell CL4023072
    CSI 0.63
    rCSI 6.56%
    PRS 80.2
  • vasa recta descending limb cell CL1001285
    CSI 0.53
    rCSI 4.19%
    PRS 91.75
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.44
    rCSI 3%
    PRS 90.47
  • lung microvascular endothelial cell CL2000016
    CSI 0.32
    rCSI 6.09%
    PRS 91.57
  • central nervous system neuron CL2000029
    CSI 0.3
    rCSI 2.18%
    PRS 75.82
  • mesenchymal stem cell CL0000134
    CSI 0.25
    rCSI 2.7%
    PRS 89.31

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [HIF3A](/details-gene/64344), or Hypoxia Inducible Factor 3 Subunit Alpha, is a protein-coding gene located on chromosome 19q13.32. It encodes a member of the basic-helix-loop-helix-PAS family of transcription factors that are central to the cellular response to hypoxia. Functionally, [HIF3A](/details-gene/64344) is involved in processes such as [Angiogenesis](/details-gene/GO:0001525) ([GO:0001525](https://www.ebi.ac.uk/QuickGO/term/GO:0001525)) and the [Cellular response to hypoxia](/details-gene/GO:0071456) ([GO:0071456](https://www.ebi.ac.uk/QuickGO/term/GO:0071456)). Unlike other HIF-alpha subunits which are generally activators, various splice isoforms of [HIF3A](/details-gene/64344) can function as dominant-negative regulators, suppressing the transcriptional activity of other HIF complexes ([Link](https://doi.org/10.1006/bbrc.2001.5659), [Link](https://doi.org/10.1096/fj.05-3788com)). **Overall**, expression data indicate its highest significance in [cardiac muscle cells](/details-cell/CL0000746), various glial cells of the central nervous system such as [astrocytes of the cerebral cortex](/details-cell/CL0002605), and hematopoietic progenitors like [erythroblasts](/details-cell/CL0000765), suggesting a key modulatory role in tissues with high metabolic demand or those intrinsically sensitive to oxygen levels. ## Cellular Roles and Expression Landscape The expression profile of [HIF3A](/details-gene/64344) highlights its importance in several distinct biological systems. **Overall**, its most significant expression is observed in [cardiac muscle cells](/details-cell/CL0000746) (CSI: 23.85), pointing towards a critical function in the heart's adaptation to ischemic conditions. A second major site of [HIF3A](/details-gene/64344) activity is the central nervous system. It is a highly significant gene in multiple glial populations, including [astrocytes of the cerebral cortex](/details-cell/CL0002605) (CSI: 22.04), [Bergmann glial cells](/details-cell/CL0000644) (CSI: 12.36), and [differentiation-committed oligodendrocyte precursors](/details-cell/CL4023059) (CSI: 11.06). Its high significance in malignant [glioblasts](/details-cell/CL0000030) (CSI: 12.17) further suggests a potential role in the biology of brain tumors, which are often characterized by severe hypoxia. Consistent with the fundamental role of hypoxia in hematopoiesis, [HIF3A](/details-gene/64344) is also significantly expressed in [erythroblasts](/details-cell/CL0000765) (CSI: 13.80). This suggests its involvement in regulating the differentiation of red blood cell precursors. Furthermore, the gene shows notable significance in various mesenchymal and stromal cell types, including [myofibroblast cells](/details-cell/CL0000186), [hepatic stellate cells](/details-cell/CL0000632), and [chondrocytes](/details-cell/CL0000138), indicating a broader role in tissue remodeling and structural cell responses to low oxygen. ## Pathways and Molecular Function As a transcription factor, the primary molecular function of [HIF3A](/details-gene/64344) is [Dna-binding transcription factor activity, rna polymerase ii-specific](/details-gene/GO:0000981) ([GO:0000981](https://www.ebi.ac.uk/QuickGO/term/GO:0000981)). It is a core component of the [Cellular response to hypoxia](/details-gene/R-HSA-1234174) pathway ([R-HSA-1234174](https://reactome.org/content/detail/R-HSA-1234174)) and is involved in the overarching [Regulation of gene expression by hypoxia-inducible factor](/details-gene/R-HSA-1234158) ([R-HSA-1234158](https://reactome.org/content/detail/R-HSA-1234158)). The functional complexity of [HIF3A](/details-gene/64344) arises from extensive alternative splicing, which generates multiple protein isoforms. Several of these isoforms lack the transactivation domain and can act as dominant-negative regulators by dimerizing with HIF-1-beta (ARNT), thereby sequestering it and inhibiting the transcriptional activity of canonical HIF-1-alpha and HIF-2-alpha complexes ([Link](https://doi.org/10.1096/fj.05-3788com), [Link](https://doi.org/10.1016/j.biocel.2010.04.008)). The expression of [HIF3A](/details-gene/64344) itself is induced by hypoxia and is a direct target of HIF-1, establishing a negative feedback loop that may serve to fine-tune the duration and intensity of the hypoxic response ([Link](https://doi.org/10.1042/bj20090120)). This regulatory circuit is critical for processes like [Angiogenesis](/details-gene/GO:0001525) ([GO:0001525](https://www.ebi.ac.uk/QuickGO/term/GO:0001525)), where precise control of vascular growth is essential. ## Research Directions The unique regulatory role of [HIF3A](/details-gene/64344) as a potential inhibitor of the canonical HIF pathway, combined with its specific expression patterns, suggests several avenues for future research. ### Testable Hypotheses: 1. Given its exceptionally high significance in [cardiac muscle cells](/details-cell/CL0000746), [HIF3A](/details-gene/64344) may act as a crucial negative feedback regulator to prevent excessive or prolonged hypoxic signaling during ischemic events, thereby protecting cardiomyocytes from maladaptive remodeling or apoptosis. 2. The high significance of [HIF3A](/details-gene/64344) in both normal glial cells ([astrocytes](/details-cell/CL0002605)) and malignant [glioblasts](/details-cell/CL0000030) suggests that the balance of its dominant-negative versus transcriptionally active isoforms is dysregulated in glioblastoma, contributing to tumor progression or resistance to hypoxia-targeted therapies, mirroring its described role in renal cell carcinoma ([Link](https://doi.org/10.4161/cc.6.22.4947)). ### Key Experiment: To test the first hypothesis regarding the protective role of [HIF3A](/details-gene/64344) in cardiac muscle, a key experiment would be to generate a cardiomyocyte-specific knockout of `Hif3a` in a murine model (e.g., using a Cre-Lox system driven by the alpha-MHC promoter). These conditional knockout mice and their wild-type littermates would be subjected to a model of myocardial infarction via left anterior descending artery ligation. The primary outcomes would be a comparative analysis of infarct size, cardiac function (assessed by echocardiography), levels of cardiac fibrosis, and cardiomyocyte apoptosis. Concurrently, the expression of canonical HIF-1 target genes (e.g., *Vegfa*, *Pgk1*) in the ischemic border zone would be quantified via qPCR or RNA-seq to determine if the loss of [HIF3A](/details-gene/64344) leads to hyper-activation of the hypoxic response. ### Therapeutic Potential: The potential of [HIF3A](/details-gene/64344) as a therapeutic target is nuanced. Given that some of its isoforms function as dominant-negative regulators and its expression is lost in certain cancers like renal cell carcinoma ([Link](https://doi.org/10.1096/fj.05-3788com)), the therapeutic strategy would likely involve **activation** or **restoration** rather than inhibition. For cancers driven by an overactive HIF-1/HIF-2 pathway, developing strategies to specifically upregulate the expression of inhibitory [HIF3A](/details-gene/64344) splice variants could represent a novel approach to suppress tumor growth and angiogenesis. This might be achieved through targeted gene delivery or small molecules that selectively stabilize these repressive isoforms.

Genular Protein ID: 2974439232

Symbol: HIF3A_HUMAN

Name: Basic-helix-loop-helix-PAS protein MOP7

UniProtKB Accession Codes:

Q9Y2N7 B0M185 B4DNA2 I6L988 Q58A43 Q66K72 Q8WXA1 Q96K34 Q9H7Z9 Q9HAI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11573933

Title: Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha.

PubMed ID: 11573933

DOI: 10.1006/bbrc.2001.5659

PubMed ID: 16126907

Title: Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.

PubMed ID: 16126907

DOI: 10.1096/fj.05-3788com

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12538644

Title: Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.

PubMed ID: 12538644

DOI: 10.1074/jbc.m208681200

PubMed ID: 16775626

Title: Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.

PubMed ID: 16775626

DOI: 10.1038/sj.cr.7310072

PubMed ID: 17998805

Title: Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression.

PubMed ID: 17998805

DOI: 10.4161/cc.6.22.4947

PubMed ID: 19694616

Title: The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.

PubMed ID: 19694616

DOI: 10.1042/bj20090120

PubMed ID: 20416395

Title: Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.

PubMed ID: 20416395

DOI: 10.1016/j.biocel.2010.04.008

PubMed ID: 21069422

Title: Cell-specific and hypoxia-dependent regulation of human HIF-3alpha: inhibition of the expression of HIF target genes in vascular cells.

PubMed ID: 21069422

DOI: 10.1007/s00018-010-0575-4

Sequence Information:

  • Length: 669
  • Mass: 72433
  • Checksum: 81C4C84517000DE2
  • Sequence:
    • MALGLQRARS TTELRKEKSR DAARSRRSQE TEVLYQLAHT LPFARGVSAH LDKASIMRLT 
ISYLRMHRLC AAGEWNQVGA GGEPLDACYL KALEGFVMVL TAEGDMAYLS ENVSKHLGLS 
QLELIGHSIF DFIHPCDQEE LQDALTPQQT LSRRKVEAPT ERCFSLRMKS TLTSRGRTLN 
LKAATWKVLN CSGHMRAYKP PAQTSPAGSP DSEPPLQCLV LICEAIPHPG SLEPPLGRGA 
FLSRHSLDMK FTYCDDRIAE VAGYSPDDLI GCSAYEYIHA LDSDAVSKSI HTLLSKGQAV 
TGQYRFLARS GGYLWTQTQA TVVSGGRGPQ SESIVCVHFL ISQVEETGVV LSLEQTEQHS 
RRPIQRGAPS QKDTPNPGDS LDTPGPRILA FLHPPSLSEA ALAADPRRFC SPDLRRLLGP 
ILDGASVAAT PSTPLATRHP QSPLSADLPD ELPVGTENVH RLFTSGKDTE AVETDLDIAQ 
DADALDLEML APYISMDDDF QLNASEQLPR AYHRPLGAVP RPRARSFHGL SPPALEPSLL 
PRWGSDPRLS CSSPSRGDPS ASSPMAGARK RTLAQSSEDE DEGVELLGVR PPKRSPSPEH 
ENFLLFPLSL SFLLTGGPAP GSLQDPSTPL LNLNEPLGLG PSLLSPYSDE DTTQPGGPFQ 
PRAGSAQAD

Genular Protein ID: 2221852890

Symbol: H0YDZ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YDZ5

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 450
  • Mass: 48574
  • Checksum: 75E1791B14449283
  • Sequence:
    • MRPAAGAARR PRCCTSWLTR CPSPAASAPT WTRPLSCASP SATCACTASA PQLELIGHSI 
FDFIHPCDQE ELQDALTPQQ TLSRRKVEAP TERCFSLRMK STLTSRGRTL NLKAATWKVL 
NCSGHMRAYK PPAQTSPAGS PDSEPPLQCL VLICEAIPHP GSLEPPLGRG AFLSRHSLDM 
KFTYCDDRIA EVAGYSPDDL IGCSAYEYIH ALDSDAVSKS IHTLLSKGQA VTGQYRFLAR 
SGGYLWTQTQ ATVVSGGRGP QSESIVCVHF LISQVEETGV VLSLEQTEQH SRRPIQRGAP 
SQKDTPNPGD SLDTPGPRIL AFLHPPSLSE AALAADPRRF CSPDLRRLLG PILDGASVAA 
TPSTPLATRH PQSPLSADLP DELPVGTENV HRLFTSGKDT EAVETDLDIA QDPSTPLLNL 
NEPLGFHFVT QSGVQWHKHS SPQPRPPGLK

Genular Protein ID: 1963473332

Symbol: B2RBI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RBI6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 7 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 667
  • Mass: 72328
  • Checksum: 4C6E76238238DF85
  • Sequence:
    • MDWQDHRSTT ELRKEKSRDA ARSRRSQETE VLYQLAHTLP LARGVSAHLD KASIMRLTIS 
YLRMHRLCAA GEWNQVGAGG EPLDACYLKA LEGFVMVLTA EGDMAYLSEN VSKHLGLSQL 
ELIGHSIFDF IHPCDQEELQ DALTPQQTLS RRKVEAPTER CFSLRMKSTL TSRGRTLNLK 
AATWKVLNCS GHMRAYKPPA QTSPAGSPDS EPPLQCLVLI CEAIPHPGSL EPPLGRGAFL 
SRHSLDMKFT YCDDRIAEVA GYSPDDLIGC SAYEYIHALD SDAVSKSIHT LLSKGQAVTG 
QYRFLARSGG YLWTQTQATV VSGGRGPQSE SIVCVHFLIS QVEETGVVLS LEQTEQHSRR 
PIQRGAPSQK DTPNPGDSLD TPGPRILAFL HPPSLSEAAL AADPRRFCGP DLRRLLGPIL 
DGASVAATPS TPLATRHPQS PLSADLPDEL PVGTENVHRL FTSGKDTEAV ETDLDTAQDA 
DALDLEMLAP YISMDDDFQL NASEQLPRAY HRPLGAVPRP RARSFHGLSP PALEPSLLPR 
WGSDPRLSCS SPSRGDPSAS SPMAGARKRT LAQSSEDEDE GVELLGVRPP KRSPSPEHEN 
FLLFPLSLSF LLTGGPAPGS LQDPSTPLLN LNEPLGLGPS LLSPYSDEDT TQPGGPFQPR 
AGSAQAD

Genular Protein ID: 3477765206

Symbol: M0R104_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0R104

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 594
  • Mass: 64082
  • Checksum: 00A4DAE1AFCB39B8
  • Sequence:
    • MRPAAGAARR PRCCTSWLTR CPSPAASAPT WTRPLSCASP SATCACTASA PQLELIGHSI 
FDFIHPCDQE ELQDALTPQQ TLSRRKVEAP TERCFSLRMK STLTSRGRTL NLKAATWKVL 
NCSGHMRAYK PPAQTSPAGS PDSEPPLQCL VLICEAIPHP GSLEPPLGRG AFLSRHSLDM 
KFTYCDDRIA EVAGYSPDDL IGCSAYEYIH ALDSDAVSKS IHTLLSKGQA VTGQYRFLAR 
SGGYLWTQTQ ATVVSGGRGP QSESIVCVHF LISQVEETGV VLSLEQTEQH SRRPIQRGAP 
SQKDTPNPGD SLDTPGPRIL AFLHPPSLSE AALAADPRRF CSPDLRRLLG PILDGASVAA 
TPSTPLATRH PQSPLSADLP DELPVGTENV HRLFTSGKDT EAVETDLDIA QDADALDLEM 
LAPYISMDDD FQLNASEQLP RAYHRPLGAV PRPRARSFHG LSPPALEPSL LPRWGSDPRL 
SCSSPSRGDP SASSPMAGAR KRTLAQSSED EDEGVELLGV RPPKRSPSPE HENFLLFPLS 
LSFLLTGGPA PGSLQDPSTP LLNLNEPLGF HFVTQSGVQW HKHSSPQPRP PGLK