Details for: NUPR1

Gene ID: 26471

Symbol: NUPR1

Ensembl ID: ENSG00000176046

Description: nuclear protein 1, transcriptional regulator

Associated with

  • Acetyltransferase activator activity
    (GO:0010698)
  • Acute inflammatory response
    (GO:0002526)
  • Chromatin binding
    (GO:0003682)
  • Cytoplasm
    (GO:0005737)
  • Dna binding
    (GO:0003677)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Fibroblast proliferation
    (GO:0048144)
  • Intercellular bridge
    (GO:0045171)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Male gonad development
    (GO:0008584)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of autophagosome assembly
    (GO:1902902)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell cycle
    (GO:0045786)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of epithelial cell apoptotic process
    (GO:1904036)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of glycolytic process
    (GO:0045820)
  • Negative regulation of programmed necrotic cell death
    (GO:0062099)
  • Negative regulation of type b pancreatic cell proliferation
    (GO:1904691)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of neuroinflammatory response
    (GO:0150078)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of oxidative phosphorylation
    (GO:1903862)
  • Positive regulation of proteasomal protein catabolic process
    (GO:1901800)
  • Positive regulation of protein modification process
    (GO:0031401)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of female gonad development
    (GO:2000194)
  • Regulation of response to endoplasmic reticulum stress
    (GO:1905897)
  • Response to toxic substance
    (GO:0009636)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • Transcription coactivator activity
    (GO:0003713)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 403.8697
    Cell Significance Index: -62.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 247.6903
    Cell Significance Index: -62.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.9475
    Cell Significance Index: -65.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 123.8026
    Cell Significance Index: -58.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.9507
    Cell Significance Index: -62.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9127
    Cell Significance Index: -61.3800
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 19.7327
    Cell Significance Index: 9.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8108
    Cell Significance Index: -62.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.8302
    Cell Significance Index: -28.0800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.8280
    Cell Significance Index: 69.4900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 10.5301
    Cell Significance Index: 23.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.8956
    Cell Significance Index: 54.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 7.6114
    Cell Significance Index: 354.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.1052
    Cell Significance Index: 166.1800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.0225
    Cell Significance Index: 34.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.0028
    Cell Significance Index: 549.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6591
    Cell Significance Index: 104.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2517
    Cell Significance Index: 152.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.2044
    Cell Significance Index: 43.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.3250
    Cell Significance Index: 298.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1277
    Cell Significance Index: 37.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0965
    Cell Significance Index: 156.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.9405
    Cell Significance Index: 1468.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.9310
    Cell Significance Index: 41.1300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.9237
    Cell Significance Index: 40.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8112
    Cell Significance Index: 800.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7640
    Cell Significance Index: 301.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.7630
    Cell Significance Index: 18.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6321
    Cell Significance Index: 42.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6234
    Cell Significance Index: 20.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5996
    Cell Significance Index: 1444.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4045
    Cell Significance Index: 181.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3580
    Cell Significance Index: 21.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2739
    Cell Significance Index: 207.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9840
    Cell Significance Index: 69.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7861
    Cell Significance Index: 91.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7781
    Cell Significance Index: 35.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6973
    Cell Significance Index: 41.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6463
    Cell Significance Index: 128.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5006
    Cell Significance Index: 49.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4735
    Cell Significance Index: 136.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4175
    Cell Significance Index: 28.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3086
    Cell Significance Index: 581.0600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.2980
    Cell Significance Index: 2.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2814
    Cell Significance Index: 53.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2660
    Cell Significance Index: 47.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2542
    Cell Significance Index: 29.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2364
    Cell Significance Index: 11.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1944
    Cell Significance Index: 5.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1904
    Cell Significance Index: 23.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0904
    Cell Significance Index: 1.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0710
    Cell Significance Index: 1.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0040
    Cell Significance Index: 1.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0004
    Cell Significance Index: 0.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0025
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0252
    Cell Significance Index: -0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0328
    Cell Significance Index: -60.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0350
    Cell Significance Index: -25.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0417
    Cell Significance Index: -64.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0499
    Cell Significance Index: -67.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0620
    Cell Significance Index: -38.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0630
    Cell Significance Index: -28.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0655
    Cell Significance Index: -0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0685
    Cell Significance Index: -50.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0748
    Cell Significance Index: -42.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1218
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1982
    Cell Significance Index: -41.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2179
    Cell Significance Index: -6.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2267
    Cell Significance Index: -32.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2587
    Cell Significance Index: -4.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2869
    Cell Significance Index: -57.5500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3005
    Cell Significance Index: -2.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3546
    Cell Significance Index: -9.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3558
    Cell Significance Index: -40.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4733
    Cell Significance Index: -29.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4932
    Cell Significance Index: -10.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5174
    Cell Significance Index: -53.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5347
    Cell Significance Index: -63.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5363
    Cell Significance Index: -41.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6493
    Cell Significance Index: -26.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6784
    Cell Significance Index: -16.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7005
    Cell Significance Index: -55.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7230
    Cell Significance Index: -17.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7961
    Cell Significance Index: -41.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8257
    Cell Significance Index: -52.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.8494
    Cell Significance Index: -5.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9165
    Cell Significance Index: -47.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9235
    Cell Significance Index: -62.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9725
    Cell Significance Index: -62.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0014
    Cell Significance Index: -61.5500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.0059
    Cell Significance Index: -16.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0649
    Cell Significance Index: -39.0900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.1136
    Cell Significance Index: -8.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1574
    Cell Significance Index: -24.0100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -1.1620
    Cell Significance Index: -9.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1713
    Cell Significance Index: -65.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2208
    Cell Significance Index: -31.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUPR1 is a nuclear protein that exhibits a wide range of functional properties, including transcriptional regulation, DNA binding, and protein-protein interactions. Its expression is tightly regulated, with significant variations across different cell types and tissues. NUPR1 is characterized by its ability to modulate various signaling pathways, including those involved in inflammation, apoptosis, and autophagy. **Pathways and Functions:** NUPR1 is involved in multiple signaling pathways, including: 1. **Acute Inflammatory Response**: NUPR1 is activated in response to inflammatory stimuli, leading to the induction of pro-inflammatory genes and the suppression of anti-inflammatory genes. 2. **Cell Cycle Regulation**: NUPR1 regulates cell cycle progression by modulating the activity of cell cycle-related transcription factors. 3. **DNA Damage Response**: NUPR1 is involved in the regulation of DNA damage response pathways, including those mediated by p53 and ATM. 4. **Autophagy and Apoptosis**: NUPR1 modulates autophagy and apoptosis by regulating the activity of key proteins involved in these processes. 5. **Oxidative Phosphorylation**: NUPR1 is involved in the regulation of oxidative phosphorylation, a critical process for energy production in cells. **Clinical Significance:** NUPR1 has been implicated in various diseases, including: 1. **Inflammatory Disorders**: NUPR1 is overexpressed in inflammatory conditions, such as rheumatoid arthritis and asthma, where it contributes to the development of inflammation. 2. **Cancer**: NUPR1 has been identified as an oncogene in several types of cancer, including breast, lung, and colon cancer. 3. **Neurological Disorders**: NUPR1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Autoimmune Diseases**: NUPR1 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. In conclusion, NUPR1 is a complex transcriptional regulator that plays a multifaceted role in immune regulation and disease. Further research is needed to fully elucidate the mechanisms by which NUPR1 regulates various signaling pathways and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. Further studies are needed to investigate the role of NUPR1 in various diseases, including inflammatory disorders, cancer, and neurological disorders. 2. The development of NUPR1-targeted therapies may provide new avenues for treating these diseases. 3. Understanding the regulatory mechanisms of NUPR1 may provide insights into the development of novel therapeutic strategies. In summary, NUPR1 is a complex gene that plays a multifaceted role in immune regulation and disease. Further research is needed to fully elucidate its mechanisms and to explore its potential as a therapeutic target.

Genular Protein ID: 1832551780

Symbol: NUPR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60356 B2R5C4 O60357 Q6FGG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 42 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10092851

Title: Cloning and expression of the human p8, a nuclear protein with mitogenic activity.

PubMed ID: 10092851

DOI: 10.1046/j.1432-1327.1999.00092.x

PubMed ID: 10493524

Title: Expression of a novel factor in human breast cancer cells with metastatic potential.

PubMed ID: 10493524

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16341674

Title: Transcriptome analysis of human gastric cancer.

PubMed ID: 16341674

DOI: 10.1007/s00335-005-0075-2

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11056169

Title: Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation.

PubMed ID: 11056169

DOI: 10.1074/jbc.m008594200

PubMed ID: 11940591

Title: The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.

PubMed ID: 11940591

DOI: 10.1074/jbc.m201657200

PubMed ID: 16300740

Title: Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.

PubMed ID: 16300740

DOI: 10.1016/j.bbrc.2005.11.018

PubMed ID: 16478804

Title: Regulation of apoptosis by the p8/prothymosin alpha complex.

PubMed ID: 16478804

DOI: 10.1073/pnas.0508955103

PubMed ID: 18690848

Title: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.

PubMed ID: 18690848

DOI: 10.2174/156800908785133196

PubMed ID: 19650074

Title: p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.

PubMed ID: 19650074

DOI: 10.1002/jcp.21889

PubMed ID: 19723804

Title: The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter.

PubMed ID: 19723804

DOI: 10.1242/jcs.048678

PubMed ID: 20181828

Title: Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

PubMed ID: 20181828

DOI: 10.1091/mbc.e09-09-0818

PubMed ID: 22858377

Title: Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance.

PubMed ID: 22858377

DOI: 10.1016/j.febslet.2012.07.063

PubMed ID: 22565310

Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

PubMed ID: 22565310

DOI: 10.1172/jci60144

PubMed ID: 28720707

Title: Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

PubMed ID: 28720707

DOI: 10.1073/pnas.1619932114

PubMed ID: 30451898

Title: Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

PubMed ID: 30451898

DOI: 10.1038/s41598-018-35020-3

Sequence Information:

  • Length: 82
  • Mass: 8873
  • Checksum: 596E342D10F87AF3
  • Sequence:
    • MATFPPATSA PQQPPGPEDE DSSLDESDLY SLAHSYLGGG GRKGRTKREA AANTNRPSPG 
GHERKLVTKL QNSERKKRGA RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.