Details for: NOTCH4

Gene ID: 4855

Symbol: NOTCH4

Ensembl ID: ENSG00000204301

Description: notch receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.1900
    Cell Significance Index: -10.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.4846
    Cell Significance Index: -10.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.1473
    Cell Significance Index: -9.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.3414
    Cell Significance Index: -11.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.9959
    Cell Significance Index: -10.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2809
    Cell Significance Index: -10.2100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 6.1632
    Cell Significance Index: 22.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.8983
    Cell Significance Index: 70.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2294
    Cell Significance Index: -11.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3492
    Cell Significance Index: -7.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5874
    Cell Significance Index: -10.2100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 2.1788
    Cell Significance Index: 7.5800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.8721
    Cell Significance Index: 14.7800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.8399
    Cell Significance Index: 17.4900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.7678
    Cell Significance Index: 18.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7315
    Cell Significance Index: 47.1300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6640
    Cell Significance Index: 27.4200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0390
    Cell Significance Index: 18.3600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7442
    Cell Significance Index: 4.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5719
    Cell Significance Index: 56.5700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.5426
    Cell Significance Index: 7.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4792
    Cell Significance Index: 24.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4501
    Cell Significance Index: 9.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4480
    Cell Significance Index: 5.0900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4275
    Cell Significance Index: 3.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4254
    Cell Significance Index: 384.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2905
    Cell Significance Index: 47.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2766
    Cell Significance Index: 30.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2284
    Cell Significance Index: 1.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2139
    Cell Significance Index: 12.8400
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.1326
    Cell Significance Index: 0.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1262
    Cell Significance Index: 8.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1055
    Cell Significance Index: 13.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0840
    Cell Significance Index: 5.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0743
    Cell Significance Index: 32.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0699
    Cell Significance Index: 3.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0686
    Cell Significance Index: 13.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0627
    Cell Significance Index: 0.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0570
    Cell Significance Index: 35.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0337
    Cell Significance Index: 1.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0281
    Cell Significance Index: 0.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0229
    Cell Significance Index: 12.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0215
    Cell Significance Index: 14.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0177
    Cell Significance Index: 3.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0176
    Cell Significance Index: 2.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0129
    Cell Significance Index: 1.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0104
    Cell Significance Index: 1.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0041
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0108
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0118
    Cell Significance Index: -2.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0184
    Cell Significance Index: -3.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0203
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0206
    Cell Significance Index: -2.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0229
    Cell Significance Index: -10.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0230
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0292
    Cell Significance Index: -4.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0310
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0362
    Cell Significance Index: -10.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0464
    Cell Significance Index: -5.4700
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0477
    Cell Significance Index: -0.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0571
    Cell Significance Index: -7.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0590
    Cell Significance Index: -6.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0595
    Cell Significance Index: -8.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0613
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0629
    Cell Significance Index: -1.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0729
    Cell Significance Index: -4.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0735
    Cell Significance Index: -1.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0740
    Cell Significance Index: -2.3700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0819
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0842
    Cell Significance Index: -6.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0973
    Cell Significance Index: -10.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1100
    Cell Significance Index: -1.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1212
    Cell Significance Index: -7.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1224
    Cell Significance Index: -9.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1257
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1299
    Cell Significance Index: -10.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1339
    Cell Significance Index: -6.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1364
    Cell Significance Index: -4.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1383
    Cell Significance Index: -3.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1428
    Cell Significance Index: -6.6600
  • Cell Name: endothelial cell of arteriole (CL1000412)
    Fold Change: -0.1484
    Cell Significance Index: -1.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1542
    Cell Significance Index: -4.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1773
    Cell Significance Index: -9.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1778
    Cell Significance Index: -2.6800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1955
    Cell Significance Index: -2.0600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2084
    Cell Significance Index: -4.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2166
    Cell Significance Index: -9.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2187
    Cell Significance Index: -9.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NOTCH4 is a transmembrane receptor that belongs to the Notch family of receptors. It is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of NOTCH4 is responsible for binding to ligands, such as DLL4, which triggers the activation of NOTCH4. The intracellular domain of NOTCH4 then translocates to the nucleus, where it regulates gene expression by interacting with transcription factors and other proteins. **Pathways and Functions:** NOTCH4 is involved in several signaling pathways, including: 1. **Notch-HHLH transcription pathway:** NOTCH4 activates the transcription of HHLH (Hairy and Enhancer of Split-related) genes, which are involved in the regulation of cell fate determination. 2. **Calcium ion binding:** NOTCH4 binds to calcium ions, which is necessary for its activation and signaling. 3. **Cell differentiation:** NOTCH4 regulates the differentiation of endothelial cells into various subtypes, such as smooth muscle cells and pericytes. 4. **Cell fate determination:** NOTCH4 determines the fate of endothelial cells by regulating the expression of genes involved in cell differentiation and survival. 5. **Vascular morphogenesis:** NOTCH4 is involved in the development and remodeling of blood vessels, including the formation of branching vessels. **Clinical Significance:** Dysregulation of NOTCH4 has been implicated in several diseases, including: 1. **Vascular disorders:** NOTCH4 mutations have been associated with vascular disorders, such as atherosclerosis and aneurysms. 2. **Cancer:** NOTCH4 is involved in the regulation of cell proliferation and survival in various types of cancer, including lung and breast cancer. 3. **Neurological disorders:** NOTCH4 has been implicated in the regulation of neuronal development and function, and its dysregulation has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, NOTCH4 is a critical regulator of vascular development and cell fate determination. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which NOTCH4 regulates vascular development and cell fate determination, and to explore its therapeutic potential in the treatment of diseases associated with its dysregulation.

Genular Protein ID: 2926989065

Symbol: NOTC4_HUMAN

Name: Notch 4 extracellular truncation

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9168133

Title: Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3.

PubMed ID: 9168133

DOI: 10.1016/s0378-1119(96)00857-8

PubMed ID: 9693032

Title: Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene.

PubMed ID: 9693032

DOI: 10.1006/geno.1998.5330

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 10079256

Title: Human ligands of the Notch receptor.

PubMed ID: 10079256

DOI: 10.1016/s0002-9440(10)65325-4

PubMed ID: 11101851

Title: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.

PubMed ID: 11101851

DOI: 10.1038/82644

PubMed ID: 11119607

Title: An Epstein-Barr virus protein interacts with Notch.

PubMed ID: 11119607

DOI: 10.1128/jvi.75.1.384-395.2001

PubMed ID: 12370315

Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

PubMed ID: 12370315

DOI: 10.1128/mcb.22.21.7688-7700.2002

Sequence Information:

  • Length: 2003
  • Mass: 209622
  • Checksum: BED10283A43A0C14
  • Sequence:
  • MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT CQCAPGFLGE 
    TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS FLCTCLPGFT GERCQAKLED 
    PCPPSFCSKR GRCHIQASGR PQCSCMPGWT GEQCQLRDFC SANPCVNGGV CLATYPQIQC 
    HCPPGFEGHA CERDVNECFQ DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP 
    RGCSNGGTCQ LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC 
    LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT SCEENLDDCI 
    AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP CHGDAQCSTN PLTGSTLCLC 
    QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG SCLNTPGSFN CLCPPGYTGS RCEADHNECL 
    SQPCHPGSTC LDLLATFHCL CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL 
    PGFSGTRCEE DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV 
    GASCLDLPGA FFCLCPSGFT GQLCEVPLCA PNLCQPKQIC KDQKDKANCL CPDGSPGCAP 
    PEDNCTCHHG HCQRSSCVCD VGWTGPECEA ELGGCISAPC AHGGTCYPQP SGYNCTCPTG 
    YTGPTCSEEM TACHSGPCLN GGSCNPSPGG YYCTCPPSHT GPQCQTSTDY CVSAPCFNGG 
    TCVNRPGTFS CLCAMGFQGP RCEGKLRPSC ADSPCRNRAT CQDSPQGPRC LCPTGYTGGS 
    CQTLMDLCAQ KPCPRNSHCL QTGPSFHCLC LQGWTGPLCN LPLSSCQKAA LSQGIDVSSL 
    CHNGGLCVDS GPSYFCHCPP GFQGSLCQDH VNPCESRPCQ NGATCMAQPS GYLCQCAPGY 
    DGQNCSKELD ACQSQPCHNH GTCTPKPGGF HCACPPGFVG LRCEGDVDEC LDQPCHPTGT 
    AACHSLANAF YCQCLPGHTG QWCEVEIDPC HSQPCFHGGT CEATAGSPLG FICHCPKGFE 
    GPTCSHRAPS CGFHHCHHGG LCLPSPKPGF PPRCACLSGY GGPDCLTPPA PKGCGPPSPC 
    LYNGSCSETT GLGGPGFRCS CPHSSPGPRC QKPGAKGCEG RSGDGACDAG CSGPGGNWDG 
    GDCSLGVPDP WKGCPSHSRC WLLFRDGQCH PQCDSEECLF DGYDCETPPA CTPAYDQYCH 
    DHFHNGHCEK GCNTAECGWD GGDCRPEDGD PEWGPSLALL VVLSPPALDQ QLFALARVLS 
    LTLRVGLWVR KDRDGRDMVY PYPGARAEEK LGGTRDPTYQ ERAAPQTQPL GKETDSLSAG 
    FVVVMGVDLS RCGPDHPASR CPWDPGLLLR FLAAMAAVGA LEPLLPGPLL AVHPHAGTAP 
    PANQLPWPVL CSPVAGVILL ALGALLVLQL IRRRRREHGA LWLPPGFTRR PRTQSAPHRR 
    RPPLGEDSIG LKALKPKAEV DEDGVVMCSG PEEGEEVGQA EETGPPSTCQ LWSLSGGCGA 
    LPQAAMLTPP QESEMEAPDL DTRGPDGVTP LMSAVCCGEV QSGTFQGAWL GCPEPWEPLL 
    DGGACPQAHT VGTGETPLHL AARFSRPTAA RRLLEAGANP NQPDRAGRTP LHAAVAADAR 
    EVCQLLLRSR QTAVDARTED GTTPLMLAAR LAVEDLVEEL IAAQADVGAR DKWGKTALHW 
    AAAVNNARAA RSLLQAGADK DAQDNREQTP LFLAAREGAV EVAQLLLGLG AARELRDQAG 
    LAPADVAHQR NHWDLLTLLE GAGPPEARHK ATPGREAGPF PRARTVSVSV PPHGGGALPR 
    CRTLSAGAGP RGGGACLQAR TWSVDLAARG GGAYSHCRSL SGVGAGGGPT PRGRRFSAGM 
    RGPRPNPAIM RGRYGVAAGR GGRVSTDDWP CDWVALGACG SASNIPIPPP CLTPSPERGS 
    PQLDCGPPAL QEMPINQGGE GKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.