Details for: NOTCH4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 65.1900
Cell Significance Index: -10.1400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 39.4846
Cell Significance Index: -10.0200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 24.1473
Cell Significance Index: -9.8100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 23.3414
Cell Significance Index: -11.0200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 20.9959
Cell Significance Index: -10.8000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.2809
Cell Significance Index: -10.2100 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 6.1632
Cell Significance Index: 22.9700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 4.8983
Cell Significance Index: 70.4500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.2294
Cell Significance Index: -11.3300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.3492
Cell Significance Index: -7.3300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.5874
Cell Significance Index: -10.2100 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 2.1788
Cell Significance Index: 7.5800 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.8721
Cell Significance Index: 14.7800 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.8399
Cell Significance Index: 17.4900 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.7678
Cell Significance Index: 18.3100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.7315
Cell Significance Index: 47.1300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.6640
Cell Significance Index: 27.4200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.0390
Cell Significance Index: 18.3600 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.7442
Cell Significance Index: 4.6600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5719
Cell Significance Index: 56.5700 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.5426
Cell Significance Index: 7.4300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4792
Cell Significance Index: 24.9600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4501
Cell Significance Index: 9.5900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.4480
Cell Significance Index: 5.0900 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.4275
Cell Significance Index: 3.0700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4254
Cell Significance Index: 384.1400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2905
Cell Significance Index: 47.2600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2766
Cell Significance Index: 30.0900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2284
Cell Significance Index: 1.3800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2139
Cell Significance Index: 12.8400 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.1326
Cell Significance Index: 0.5700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1262
Cell Significance Index: 8.7300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1055
Cell Significance Index: 13.5300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0840
Cell Significance Index: 5.9400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0743
Cell Significance Index: 32.8600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0699
Cell Significance Index: 3.1700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0686
Cell Significance Index: 13.0600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0627
Cell Significance Index: 0.9700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0570
Cell Significance Index: 35.6100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0337
Cell Significance Index: 1.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0281
Cell Significance Index: 0.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0229
Cell Significance Index: 12.5100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0215
Cell Significance Index: 14.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0177
Cell Significance Index: 3.1900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0176
Cell Significance Index: 2.4200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0160
Cell Significance Index: 0.4000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0129
Cell Significance Index: 1.5000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0104
Cell Significance Index: 1.2800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0006
Cell Significance Index: 0.0200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0013
Cell Significance Index: -0.4600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0029
Cell Significance Index: -5.3900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0037
Cell Significance Index: -5.7200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0041
Cell Significance Index: -0.4700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0043
Cell Significance Index: -5.8600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0050
Cell Significance Index: -9.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0061
Cell Significance Index: -4.4900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0099
Cell Significance Index: -5.5600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0108
Cell Significance Index: -2.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0118
Cell Significance Index: -2.4800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0133
Cell Significance Index: -9.7500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0133
Cell Significance Index: -10.0900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0152
Cell Significance Index: -9.6900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0184
Cell Significance Index: -3.6500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0203
Cell Significance Index: -0.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0206
Cell Significance Index: -2.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0229
Cell Significance Index: -10.3900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0230
Cell Significance Index: -1.2900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0292
Cell Significance Index: -4.9900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0310
Cell Significance Index: -0.8300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0362
Cell Significance Index: -10.4100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0464
Cell Significance Index: -5.4700 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: -0.0477
Cell Significance Index: -0.3500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0571
Cell Significance Index: -7.3800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0590
Cell Significance Index: -6.7300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0595
Cell Significance Index: -8.6500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0613
Cell Significance Index: -3.7600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0629
Cell Significance Index: -1.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0729
Cell Significance Index: -4.7000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0735
Cell Significance Index: -1.2300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0740
Cell Significance Index: -2.3700 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.0819
Cell Significance Index: -0.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0842
Cell Significance Index: -6.4600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0973
Cell Significance Index: -10.1300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1100
Cell Significance Index: -1.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1212
Cell Significance Index: -7.6400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1224
Cell Significance Index: -9.1300 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1257
Cell Significance Index: -1.5500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1299
Cell Significance Index: -10.2900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1339
Cell Significance Index: -6.3000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1364
Cell Significance Index: -4.7400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1383
Cell Significance Index: -3.4500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1428
Cell Significance Index: -6.6600 - Cell Name: endothelial cell of arteriole (CL1000412)
Fold Change: -0.1484
Cell Significance Index: -1.2700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1542
Cell Significance Index: -4.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1773
Cell Significance Index: -9.2100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1778
Cell Significance Index: -2.6800 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.1955
Cell Significance Index: -2.0600 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2084
Cell Significance Index: -4.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2166
Cell Significance Index: -9.5800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2187
Cell Significance Index: -9.5100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2926989065
Symbol: NOTC4_HUMAN
Name: Notch 4 extracellular truncation
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9168133
Title: Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3.
PubMed ID: 9168133
PubMed ID: 9693032
Title: Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene.
PubMed ID: 9693032
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 10079256
PubMed ID: 11101851
Title: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
PubMed ID: 11101851
DOI: 10.1038/82644
PubMed ID: 11119607
Title: An Epstein-Barr virus protein interacts with Notch.
PubMed ID: 11119607
PubMed ID: 12370315
Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
PubMed ID: 12370315
Sequence Information:
- Length: 2003
- Mass: 209622
- Checksum: BED10283A43A0C14
- Sequence:
MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT CQCAPGFLGE TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS FLCTCLPGFT GERCQAKLED PCPPSFCSKR GRCHIQASGR PQCSCMPGWT GEQCQLRDFC SANPCVNGGV CLATYPQIQC HCPPGFEGHA CERDVNECFQ DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP RGCSNGGTCQ LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT SCEENLDDCI AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP CHGDAQCSTN PLTGSTLCLC QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG SCLNTPGSFN CLCPPGYTGS RCEADHNECL SQPCHPGSTC LDLLATFHCL CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL PGFSGTRCEE DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV GASCLDLPGA FFCLCPSGFT GQLCEVPLCA PNLCQPKQIC KDQKDKANCL CPDGSPGCAP PEDNCTCHHG HCQRSSCVCD VGWTGPECEA ELGGCISAPC AHGGTCYPQP SGYNCTCPTG YTGPTCSEEM TACHSGPCLN GGSCNPSPGG YYCTCPPSHT GPQCQTSTDY CVSAPCFNGG TCVNRPGTFS CLCAMGFQGP RCEGKLRPSC ADSPCRNRAT CQDSPQGPRC LCPTGYTGGS CQTLMDLCAQ KPCPRNSHCL QTGPSFHCLC LQGWTGPLCN LPLSSCQKAA LSQGIDVSSL CHNGGLCVDS GPSYFCHCPP GFQGSLCQDH VNPCESRPCQ NGATCMAQPS GYLCQCAPGY DGQNCSKELD ACQSQPCHNH GTCTPKPGGF HCACPPGFVG LRCEGDVDEC LDQPCHPTGT AACHSLANAF YCQCLPGHTG QWCEVEIDPC HSQPCFHGGT CEATAGSPLG FICHCPKGFE GPTCSHRAPS CGFHHCHHGG LCLPSPKPGF PPRCACLSGY GGPDCLTPPA PKGCGPPSPC LYNGSCSETT GLGGPGFRCS CPHSSPGPRC QKPGAKGCEG RSGDGACDAG CSGPGGNWDG GDCSLGVPDP WKGCPSHSRC WLLFRDGQCH PQCDSEECLF DGYDCETPPA CTPAYDQYCH DHFHNGHCEK GCNTAECGWD GGDCRPEDGD PEWGPSLALL VVLSPPALDQ QLFALARVLS LTLRVGLWVR KDRDGRDMVY PYPGARAEEK LGGTRDPTYQ ERAAPQTQPL GKETDSLSAG FVVVMGVDLS RCGPDHPASR CPWDPGLLLR FLAAMAAVGA LEPLLPGPLL AVHPHAGTAP PANQLPWPVL CSPVAGVILL ALGALLVLQL IRRRRREHGA LWLPPGFTRR PRTQSAPHRR RPPLGEDSIG LKALKPKAEV DEDGVVMCSG PEEGEEVGQA EETGPPSTCQ LWSLSGGCGA LPQAAMLTPP QESEMEAPDL DTRGPDGVTP LMSAVCCGEV QSGTFQGAWL GCPEPWEPLL DGGACPQAHT VGTGETPLHL AARFSRPTAA RRLLEAGANP NQPDRAGRTP LHAAVAADAR EVCQLLLRSR QTAVDARTED GTTPLMLAAR LAVEDLVEEL IAAQADVGAR DKWGKTALHW AAAVNNARAA RSLLQAGADK DAQDNREQTP LFLAAREGAV EVAQLLLGLG AARELRDQAG LAPADVAHQR NHWDLLTLLE GAGPPEARHK ATPGREAGPF PRARTVSVSV PPHGGGALPR CRTLSAGAGP RGGGACLQAR TWSVDLAARG GGAYSHCRSL SGVGAGGGPT PRGRRFSAGM RGPRPNPAIM RGRYGVAAGR GGRVSTDDWP CDWVALGACG SASNIPIPPP CLTPSPERGS PQLDCGPPAL QEMPINQGGE GKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.