Details for: FCN3

Gene ID: 8547

Symbol: FCN3

Ensembl ID: ENSG00000142748

Description: ficolin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.0181
    Cell Significance Index: -7.3200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 16.8582
    Cell Significance Index: 62.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 7.7202
    Cell Significance Index: 402.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.6356
    Cell Significance Index: -7.2900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 4.0185
    Cell Significance Index: 31.7300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 2.2463
    Cell Significance Index: 30.7600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.0176
    Cell Significance Index: 19.1800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.3084
    Cell Significance Index: 18.7500
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.1397
    Cell Significance Index: 3.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5135
    Cell Significance Index: 7.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0619
    Cell Significance Index: 42.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0609
    Cell Significance Index: 38.0600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0446
    Cell Significance Index: 0.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0314
    Cell Significance Index: 0.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0119
    Cell Significance Index: 2.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0047
    Cell Significance Index: -1.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0061
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -10.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0084
    Cell Significance Index: -11.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0085
    Cell Significance Index: -4.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0187
    Cell Significance Index: -8.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0210
    Cell Significance Index: -7.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0262
    Cell Significance Index: -1.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0286
    Cell Significance Index: -5.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0291
    Cell Significance Index: -5.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0311
    Cell Significance Index: -1.5700
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: -0.0331
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0375
    Cell Significance Index: -4.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0381
    Cell Significance Index: -1.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0431
    Cell Significance Index: -4.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0442
    Cell Significance Index: -5.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0495
    Cell Significance Index: -1.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0504
    Cell Significance Index: -7.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0559
    Cell Significance Index: -7.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0568
    Cell Significance Index: -4.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0614
    Cell Significance Index: -7.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0640
    Cell Significance Index: -6.6700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0669
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0714
    Cell Significance Index: -8.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0838
    Cell Significance Index: -9.6000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0907
    Cell Significance Index: -1.0300
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.1034
    Cell Significance Index: -0.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1114
    Cell Significance Index: -8.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1182
    Cell Significance Index: -7.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1217
    Cell Significance Index: -3.2600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1250
    Cell Significance Index: -1.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1263
    Cell Significance Index: -7.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1277
    Cell Significance Index: -8.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1412
    Cell Significance Index: -6.6400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1456
    Cell Significance Index: -1.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1483
    Cell Significance Index: -1.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1483
    Cell Significance Index: -8.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1548
    Cell Significance Index: -3.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1648
    Cell Significance Index: -8.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1720
    Cell Significance Index: -7.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1726
    Cell Significance Index: -6.0500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1807
    Cell Significance Index: -2.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1994
    Cell Significance Index: -7.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2022
    Cell Significance Index: -6.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2055
    Cell Significance Index: -9.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2123
    Cell Significance Index: -6.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2201
    Cell Significance Index: -8.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2248
    Cell Significance Index: -3.9700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2301
    Cell Significance Index: -3.1600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2343
    Cell Significance Index: -2.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2358
    Cell Significance Index: -1.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2389
    Cell Significance Index: -4.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2395
    Cell Significance Index: -3.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2412
    Cell Significance Index: -8.3800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2415
    Cell Significance Index: -3.3900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2427
    Cell Significance Index: -3.3000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2444
    Cell Significance Index: -1.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2527
    Cell Significance Index: -3.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2594
    Cell Significance Index: -6.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2644
    Cell Significance Index: -9.2900
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.2700
    Cell Significance Index: -2.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2777
    Cell Significance Index: -5.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2789
    Cell Significance Index: -7.9600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2801
    Cell Significance Index: -3.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2818
    Cell Significance Index: -6.1700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2828
    Cell Significance Index: -3.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2845
    Cell Significance Index: -8.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2854
    Cell Significance Index: -8.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2885
    Cell Significance Index: -7.3500
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: -0.2888
    Cell Significance Index: -1.8600
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: -0.2928
    Cell Significance Index: -1.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2979
    Cell Significance Index: -7.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3017
    Cell Significance Index: -3.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FCN3 is a member of the ficolin family, which consists of three genes (FCN1, FCN2, and FCN3) that encode proteins with similar structures and functions. The FCN3 protein is a trimeric molecule composed of three subunits, each containing a carbohydrate-binding domain. This domain is responsible for recognizing and binding to repetitive carbohydrate structures on the surface of pathogens, such as bacteria, viruses, and fungi. The binding of FCN3 to these pathogens triggers the activation of the complement cascade, which is a series of enzymatic reactions that ultimately leads to the lysis and clearance of the pathogen. **Pathways and Functions** The FCN3 protein plays a key role in the lectin pathway of complement activation, which is one of the three main pathways of the complement cascade. The lectin pathway is initiated when the FCN3 protein binds to carbohydrate structures on the surface of pathogens, leading to the activation of the C1q protein. This activation triggers a series of enzymatic reactions that ultimately leads to the activation of the C3 protein, which is a central component of the complement cascade. The activation of the complement cascade results in the production of various complement proteins, including C3b, C4b, and C5b, which work together to lyse and clear pathogens from the body. In addition to its role in the complement cascade, FCN3 also plays a role in other immune-related processes, including: * Apoptosis recognition: FCN3 recognizes and binds to apoptotic cells, which are cells that have undergone programmed cell death. * Viral entry regulation: FCN3 regulates the entry of viruses into host cells by binding to viral proteins and preventing their interaction with host cell receptors. * Opsonization: FCN3 promotes the opsonization of pathogens, which is the process of marking pathogens for destruction by the immune system. **Clinical Significance** Dysregulation of the FCN3 gene has been implicated in various diseases, including: * Infectious diseases: Mutations in the FCN3 gene have been associated with increased susceptibility to infections, such as sepsis and pneumonia. * Autoimmune diseases: FCN3 has been implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). * Cancer: FCN3 has been shown to regulate the entry of cancer cells into host tissues and promote tumor growth. Overall, FCN3 is an important gene that plays a critical role in the innate immune system and has significant implications for our understanding of various diseases. Further research is needed to fully elucidate the functions of FCN3 and its role in human health and disease.

Genular Protein ID: 2515926502

Symbol: FCN3_HUMAN

Name: Ficolin-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9694814

Title: Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family.

PubMed ID: 9694814

DOI: 10.1074/jbc.273.33.20721

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10330454

Title: Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile.

PubMed ID: 10330454

DOI: 10.1177/002215549904700607

PubMed ID: 11907111

Title: Activation of the lectin complement pathway by H-ficolin (Hakata antigen).

PubMed ID: 11907111

DOI: 10.4049/jimmunol.168.7.3502

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19535802

Title: Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency.

PubMed ID: 19535802

DOI: 10.1056/nejmoa0900381

PubMed ID: 17215869

Title: Structural insights into the innate immune recognition specificities of L- and H-ficolins.

PubMed ID: 17215869

DOI: 10.1038/sj.emboj.7601500

Sequence Information:

  • Length: 299
  • Mass: 32903
  • Checksum: 5CB8A7D3668FA364
  • Sequence:
  • MDLLWILPSL WLLLLGGPAC LKTQEHPSCP GPRELEASKV VLLPSCPGAP GSPGEKGAPG 
    PQGPPGPPGK MGPKGEPGDP VNLLRCQEGP RNCRELLSQG ATLSGWYHLC LPEGRALPVF 
    CDMDTEGGGW LVFQRRQDGS VDFFRSWSSY RAGFGNQESE FWLGNENLHQ LTLQGNWELR 
    VELEDFNGNR TFAHYATFRL LGEVDHYQLA LGKFSEGTAG DSLSLHSGRP FTTYDADHDS 
    SNSNCAVIVH GAWWYASCYR SNLNGRYAVS EAAAHKYGID WASGRGVGHP YRRVRMMLR

Genular Protein ID: 4269352366

Symbol: Q6UY50_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

Sequence Information:

  • Length: 218
  • Mass: 24596
  • Checksum: 16DB31AE64EBAEBC
  • Sequence:
  • MGPKGEPGPR NCRELLSQGA TLSGWYHLCL PEGRALPVFC DMDTEGGGWL VFQRRQDGSV 
    DFFRSWSSYR AGFGNQESEF WLGNENLHQL TLQGNWELRV ELEDFNGNRT FAHYATFRLL 
    GEVDHYQLAL GKFSEGTAGD SLSLHSGRPF TTYDADHDSS NSNCAVIVHG AWWYASCYRS 
    NLNGRYAVSE AAAHKYGIDW ASGRGVGHPY RRVRMMLR

Genular Protein ID: 2376895279

Symbol: Q6UXM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

Sequence Information:

  • Length: 288
  • Mass: 31678
  • Checksum: 5027676AFCA39752
  • Sequence:
  • MDLLWILPSL WLLLLGGPAC LKTQEHPSCP GPRELEASKV VLLPSCPGAP GSPGEKGAPG 
    PQGPPGPPGK MGPKGEPGPR NCRELLSQGA TLSGWYHLCL PEGRALPVFC DMDTEGGGWL 
    VFQRRQDGSV DFFRSWSSYR AGFGNQESEF WLGNENLHQL TLQGNWELRV ELEDFNGNRT 
    FAHYATFRLL GEVDHYQLAL GKFSEGTAGD SLSLHSGRPF TTYDADHDSS NSNCAVIVHG 
    AWWYASCYRS NLNGRYAVSE AAAHKYGIDW ASGRGVGHPY RRVRMMLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.