Details for: CL0002188

Cell ID: CL0002188

Cell Name: glomerular endothelial cell

Marker Score Threshold: 254
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.15
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.14
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.88
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.69
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.54
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.53
    Ensembl ID: ENSG00000145741
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.41
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.35
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.29
    Ensembl ID: ENSG00000019582
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.24
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.21
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.16
    Ensembl ID: ENSG00000077549
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.14
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.06
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.97
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.93
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.91
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.86
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.83
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.82
    Ensembl ID: ENSG00000169020
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.81
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.77
    Ensembl ID: ENSG00000122545
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.77
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.77
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.75
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.73
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.71
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.69
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.69
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.64
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.63
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.62
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.61
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.55
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.5
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.5
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.47
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.47
    Ensembl ID: ENSG00000070961
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.46
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.46
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.45
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.42
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.42
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.41
    Ensembl ID: ENSG00000104763
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.4
    Ensembl ID: ENSG00000175899
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.38
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.37
    Ensembl ID: ENSG00000111348
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 1.36
    Ensembl ID: ENSG00000174059
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.36
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.34
    Ensembl ID: ENSG00000149925
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.34
    Ensembl ID: ENSG00000108561
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.33
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.31
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.31
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.31
    Ensembl ID: ENSG00000168374
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.26
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.26
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 1.25
    Ensembl ID: ENSG00000240583
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.21
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.2
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.19
    Ensembl ID: ENSG00000084234
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.15
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.15
    Ensembl ID: ENSG00000107262
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149131
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CDA (ENSG00000158825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000158825
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.08
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.07
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.05
    Ensembl ID: ENSG00000204217
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.04
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.04
    Ensembl ID: ENSG00000115307
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.04
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.02
    Ensembl ID: ENSG00000174437
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060971
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.02
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: N/A
    Ensembl ID: ENSG00000113328
Hovered Details

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Hovered Details

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**Key Characteristics** The glomerular endothelial cell has several key characteristics that enable it to perform its functions: 1. **Flattened shape**: The cell's flattened shape allows it to increase its surface area for filtration. 2. **High number of fenestrae**: The cell's high number of fenestrae, or small pores, allows it to filter small molecules and ions. 3. **High fenestrated surface area**: The cell's fenestrated surface area is increased by the presence of podocytes, which are specialized cells that cover the glomerular endothelium. 4. **Unique gene expression profile**: The cell's gene expression profile includes genes involved in energy metabolism, protein transport, and regulation of cell signaling pathways. **Clinical Significance** The glomerular endothelial cell plays a crucial role in the kidney's ability to filter waste products from the blood. Dysfunction of this cell can lead to various kidney diseases, including: 1. **Nephrotic syndrome**: A condition characterized by excessive loss of protein in the urine, which can be caused by damage to the glomerular endothelial cell. 2. **Glomerulonephritis**: A condition characterized by inflammation of the glomerulus, which can be caused by damage to the glomerular endothelial cell. 3. **Diabetic nephropathy**: A condition characterized by damage to the kidneys due to high blood sugar levels, which can be caused by damage to the glomerular endothelial cell. Understanding the biology of the glomerular endothelial cell is essential for the development of new treatments for kidney diseases and for improving our understanding of the complex interactions between the kidneys and the rest of the body. **Gene Symbol and Ensembl ID** The gene symbol for the glomerular endothelial cell is SLC25A6, and its Ensembl ID is ENSG00000169100. The gene is involved in various cellular processes, including energy metabolism, protein transport, and regulation of cell signaling pathways. **Pathways and Ontology** The pathways and ontology of the glomerular endothelial cell include: 1. **Apoptotic process**: The cell's involvement in programmed cell death, which is essential for maintaining tissue homeostasis. 2. **ATP:ADP antiporter activity**: The cell's ability to transport ATP and ADP across the plasma membrane, which is essential for energy metabolism. 3. **Disease**: The cell's involvement in various kidney diseases, including nephrotic syndrome and glomerulonephritis. 4. **HIV infection**: The cell's involvement in HIV infection and disease. 5. **Host interactions of HIV factors**: The cell's interaction with HIV factors, which are essential for the virus's replication and survival. Overall, the glomerular endothelial cell is a complex cell that plays a crucial role in the kidney's ability to filter waste products from the blood. Understanding its biology is essential for the development of new treatments for kidney diseases and for improving our understanding of the complex interactions between the kidneys and the rest of the body.