Details for: MT1M

Gene ID: 4499

Symbol: MT1M

Ensembl ID: ENSG00000205364

Description: metallothionein 1M

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 117.2613
    Cell Significance Index: 58.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.0724
    Cell Significance Index: -25.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.2340
    Cell Significance Index: -34.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.4029
    Cell Significance Index: -22.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.3670
    Cell Significance Index: -22.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0262
    Cell Significance Index: -24.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.3893
    Cell Significance Index: 148.2500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 7.1893
    Cell Significance Index: 18.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4799
    Cell Significance Index: -25.5700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 4.1696
    Cell Significance Index: 15.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6823
    Cell Significance Index: 105.5600
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.8833
    Cell Significance Index: 20.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.5772
    Cell Significance Index: 154.7200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.8567
    Cell Significance Index: 12.5800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 1.7863
    Cell Significance Index: 24.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7637
    Cell Significance Index: 29.7100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.5916
    Cell Significance Index: 18.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9924
    Cell Significance Index: 127.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8722
    Cell Significance Index: 18.5800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8257
    Cell Significance Index: 8.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7069
    Cell Significance Index: 15.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6884
    Cell Significance Index: 47.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4013
    Cell Significance Index: 65.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3329
    Cell Significance Index: 36.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2755
    Cell Significance Index: 32.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2360
    Cell Significance Index: 44.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2242
    Cell Significance Index: 7.1800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1723
    Cell Significance Index: 0.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1572
    Cell Significance Index: 2.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1564
    Cell Significance Index: 15.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1548
    Cell Significance Index: 2.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1536
    Cell Significance Index: 11.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1255
    Cell Significance Index: 21.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1055
    Cell Significance Index: 95.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1012
    Cell Significance Index: 0.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0987
    Cell Significance Index: 12.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0755
    Cell Significance Index: 3.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0497
    Cell Significance Index: 0.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0142
    Cell Significance Index: 6.2900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0130
    Cell Significance Index: 0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0002
    Cell Significance Index: -0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0088
    Cell Significance Index: -4.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0109
    Cell Significance Index: -20.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0172
    Cell Significance Index: -12.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0183
    Cell Significance Index: -33.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0200
    Cell Significance Index: -2.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0266
    Cell Significance Index: -36.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0280
    Cell Significance Index: -17.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0296
    Cell Significance Index: -8.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0414
    Cell Significance Index: -25.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0419
    Cell Significance Index: -31.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0475
    Cell Significance Index: -21.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0550
    Cell Significance Index: -31.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0593
    Cell Significance Index: -21.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0671
    Cell Significance Index: -3.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0688
    Cell Significance Index: -12.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0859
    Cell Significance Index: -17.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0878
    Cell Significance Index: -12.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1042
    Cell Significance Index: -5.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1193
    Cell Significance Index: -23.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1203
    Cell Significance Index: -13.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1228
    Cell Significance Index: -3.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1301
    Cell Significance Index: -13.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1347
    Cell Significance Index: -16.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1449
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1572
    Cell Significance Index: -33.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1732
    Cell Significance Index: -2.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1851
    Cell Significance Index: -13.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2101
    Cell Significance Index: -12.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2445
    Cell Significance Index: -25.4600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2544
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2553
    Cell Significance Index: -20.2200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2767
    Cell Significance Index: -4.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2807
    Cell Significance Index: -4.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2964
    Cell Significance Index: -18.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3584
    Cell Significance Index: -23.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3803
    Cell Significance Index: -25.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3817
    Cell Significance Index: -23.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3943
    Cell Significance Index: -11.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4023
    Cell Significance Index: -30.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4638
    Cell Significance Index: -8.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4804
    Cell Significance Index: -8.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5007
    Cell Significance Index: -12.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5019
    Cell Significance Index: -26.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5575
    Cell Significance Index: -28.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5598
    Cell Significance Index: -14.3000
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -0.5733
    Cell Significance Index: -2.7300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.5964
    Cell Significance Index: -5.7500
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.6081
    Cell Significance Index: -2.6200
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.6149
    Cell Significance Index: -3.6100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.6184
    Cell Significance Index: -4.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6186
    Cell Significance Index: -34.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6289
    Cell Significance Index: -18.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6411
    Cell Significance Index: -17.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6623
    Cell Significance Index: -30.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6957
    Cell Significance Index: -25.5400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.7015
    Cell Significance Index: -9.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7094
    Cell Significance Index: -24.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MT1M is a cysteine-rich protein that belongs to the metallothionein family, which is characterized by its high affinity for binding metals. MT1M is predominantly expressed in cells that are involved in metal ion homeostasis, such as epithelial cells, endothelial cells, and satellite stem cells. It is also highly expressed in tissues that are exposed to metal ions, such as the exocrine pancreas and the lungs. **Pathways and Functions:** MT1M plays a crucial role in maintaining cellular homeostasis by binding and regulating the levels of essential and toxic metals. Its primary functions include: 1. **Detoxification of copper ion**: MT1M binds copper ions, preventing their accumulation and oxidative damage to cellular components. 2. **Intracellular zinc ion homeostasis**: MT1M regulates the levels of zinc ions, ensuring that they are available for essential biological processes while preventing their toxicity. 3. **Cellular response to metal ions**: MT1M responds to changes in metal ion levels, activating signaling pathways that regulate gene expression and cellular behavior. 4. **Negative regulation of growth**: MT1M can inhibit cell growth and proliferation in response to metal ion stress. **Clinical Significance:** Dysregulation of MT1M has been implicated in various diseases, including: 1. **Copper toxicity**: Elevated levels of MT1M have been observed in patients with copper toxicity, which can lead to neurological and gastrointestinal symptoms. 2. **Zinc deficiency**: Decreased levels of MT1M have been linked to zinc deficiency, which can impair immune function and increase the risk of infections. 3. **Pancreatitis**: MT1M has been shown to play a role in the pathogenesis of pancreatitis, where it can contribute to the development of pancreatic cancer. 4. **Pulmonary disease**: MT1M has been implicated in the pathogenesis of pulmonary diseases, such as chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. In conclusion, MT1M plays a critical role in maintaining cellular homeostasis by regulating metal ion levels and responding to changes in metal ion availability. Its dysregulation has been implicated in various diseases, highlighting the importance of MT1M in maintaining health and preventing disease. Further research is needed to fully understand the mechanisms by which MT1M regulates metal ion homeostasis and its implications in human disease.

Genular Protein ID: 1413703371

Symbol: MT1M_HUMAN

Name: Metallothionein-1M

UniProtKB Accession Codes:

Q8N339 Q8TDN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 28 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 61
  • Mass: 6110
  • Checksum: 754753ED088411CE
  • Sequence:
    • MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC KGTLENCSCC 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.