Details for: TIMP4

Gene ID: 7079

Symbol: TIMP4

Ensembl ID: ENSG00000157150

Description: TIMP metallopeptidase inhibitor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.77
    Marker Score: 933
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.57
    Marker Score: 1080.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169404
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.34
    Marker Score: 1676.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.28
    Marker Score: 2607
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.13
    Marker Score: 548
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.69
    Marker Score: 170
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4064
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1255
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.66
    Marker Score: 10298
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.63
    Marker Score: 789.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 298
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 345
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 364.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.56
    Marker Score: 1926
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.54
    Marker Score: 124
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.51
    Marker Score: 729
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 219
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.47
    Marker Score: 594.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3861
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 185
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.41
    Marker Score: 236
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 248.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.41
    Marker Score: 256
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.38
    Marker Score: 610
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.37
    Marker Score: 201
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.35
    Marker Score: 86
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.35
    Marker Score: 604
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.34
    Marker Score: 1065
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.33
    Marker Score: 129
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.32
    Marker Score: 660
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.32
    Marker Score: 2684
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 303
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.3
    Marker Score: 121
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.28
    Marker Score: 434
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 276
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.27
    Marker Score: 456
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.23
    Marker Score: 290
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 208
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.22
    Marker Score: 246
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.21
    Marker Score: 406.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.21
    Marker Score: 190
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.21
    Marker Score: 76
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.2
    Marker Score: 227
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 42
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 218
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.18
    Marker Score: 75
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 119
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.18
    Marker Score: 60
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.16
    Marker Score: 111
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.16
    Marker Score: 969
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.15
    Marker Score: 398
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.15
    Marker Score: 32
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 339
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.14
    Marker Score: 4714
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.14
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.13
    Marker Score: 50

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Other Information

**Key Characteristics** TIMP4 exhibits several key characteristics that distinguish it from other metalloproteinases. Firstly, its metalloendopeptidase inhibitory activity allows it to regulate the activity of various proteases, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAM) family members. This regulatory function is essential for maintaining tissue homeostasis and preventing excessive proteolysis. Secondly, TIMP4 has been shown to play a role in negative regulation of endopeptidase activity, which is critical for controlling the levels of bioactive peptides and hormones. This function is particularly important in the context of immune cell development and function, where tight regulation of signaling pathways is essential for proper immune response. **Pathways and Functions** TIMP4 is involved in several key pathways, including: 1. **Notch signaling pathway**: TIMP4 has been shown to regulate Notch signaling, a crucial pathway involved in cell fate determination, differentiation, and proliferation. 2. **Extracellular matrix regulation**: TIMP4 plays a role in regulating the activity of MMPs and ADAMs, which are essential for maintaining the integrity of the extracellular matrix. 3. **Protease binding**: TIMP4 binds to various proteases, including MMPs and ADAMs, to regulate their activity and prevent excessive proteolysis. 4. **Response to cytokine and hormone signaling**: TIMP4 has been shown to regulate the activity of cytokines and hormones, which are critical for immune cell development and function. **Clinical Significance** The clinical significance of TIMP4 is multifaceted. Dysregulation of TIMP4 has been implicated in various diseases, including: 1. **Cancer**: TIMP4 has been shown to play a role in cancer progression, where its dysregulation can lead to increased proteolysis and tumor growth. 2. **Immunological disorders**: TIMP4 has been implicated in various immunological disorders, including autoimmune diseases and immune deficiency disorders. 3. **Neurological disorders**: TIMP4 has been shown to play a role in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TIMP4 is a multifaceted gene with diverse roles in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its role in human health and disease. Further research is necessary to fully elucidate the functions of TIMP4 and its clinical significance.

Genular Protein ID: 353232348

Symbol: TIMP4_HUMAN

Name: Metalloproteinase inhibitor 4

UniProtKB Accession Codes:

Q99727 B2R7K6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8939999

Title: Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.

PubMed ID: 8939999

DOI: 10.1074/jbc.271.48.30375

PubMed ID: 9693046

Title: Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.

PubMed ID: 9693046

DOI: 10.1006/geno.1998.5362

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 224
  • Mass: 25503
  • Checksum: 39C7187D78D99442
  • Sequence:
    • MPGSPRPAPS WVLLLRLLAL LRPPGLGEAC SCAPAHPQQH ICHSALVIRA KISSEKVVPA 
SADPADTEKM LRYEIKQIKM FKGFEKVKDV QYIYTPFDSS LCGVKLEANS QKQYLLTGQV 
LSDGKVFIHL CNYIEPWEDL SLVQRESLNH HYHLNCGCQI TTCYTVPCTI SAPNECLWTD 
WLLERKLYGY QAQHYVCMKH VDGTCSWYRG HLPLRKEFVD IVQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.