Details for: TIMP4

Gene ID: 7079

Symbol: TIMP4

Ensembl ID: ENSG00000157150

Description: TIMP metallopeptidase inhibitor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.1060
    Cell Significance Index: 34.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5755
    Cell Significance Index: 157.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8554
    Cell Significance Index: 162.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6865
    Cell Significance Index: 14.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5888
    Cell Significance Index: 58.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4203
    Cell Significance Index: 379.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3635
    Cell Significance Index: 21.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3626
    Cell Significance Index: 39.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3149
    Cell Significance Index: 51.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2614
    Cell Significance Index: 4.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1828
    Cell Significance Index: 12.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0890
    Cell Significance Index: 61.5700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0351
    Cell Significance Index: 0.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0112
    Cell Significance Index: 1.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0056
    Cell Significance Index: 0.1400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0050
    Cell Significance Index: 0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0031
    Cell Significance Index: 0.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0028
    Cell Significance Index: -0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0049
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0064
    Cell Significance Index: -9.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0097
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0116
    Cell Significance Index: -6.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0118
    Cell Significance Index: -4.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0119
    Cell Significance Index: -0.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0126
    Cell Significance Index: -0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0126
    Cell Significance Index: -6.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0163
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0200
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0201
    Cell Significance Index: -2.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0210
    Cell Significance Index: -6.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0256
    Cell Significance Index: -0.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0262
    Cell Significance Index: -5.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0331
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0406
    Cell Significance Index: -8.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0424
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0464
    Cell Significance Index: -6.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0473
    Cell Significance Index: -4.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0474
    Cell Significance Index: -8.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0495
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0498
    Cell Significance Index: -6.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0572
    Cell Significance Index: -1.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0623
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0636
    Cell Significance Index: -7.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0653
    Cell Significance Index: -3.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0681
    Cell Significance Index: -0.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0768
    Cell Significance Index: -5.8900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0799
    Cell Significance Index: -0.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0863
    Cell Significance Index: -6.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0930
    Cell Significance Index: -6.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0937
    Cell Significance Index: -5.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0937
    Cell Significance Index: -4.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0954
    Cell Significance Index: -11.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0974
    Cell Significance Index: -5.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1025
    Cell Significance Index: -6.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1058
    Cell Significance Index: -5.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1079
    Cell Significance Index: -6.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1350
    Cell Significance Index: -3.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1356
    Cell Significance Index: -7.1200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1386
    Cell Significance Index: -1.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1413
    Cell Significance Index: -3.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1458
    Cell Significance Index: -6.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1462
    Cell Significance Index: -2.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1685
    Cell Significance Index: -4.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1698
    Cell Significance Index: -6.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1756
    Cell Significance Index: -2.5200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1786
    Cell Significance Index: -2.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1797
    Cell Significance Index: -8.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1801
    Cell Significance Index: -2.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1804
    Cell Significance Index: -6.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1810
    Cell Significance Index: -6.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1810
    Cell Significance Index: -4.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1850
    Cell Significance Index: -3.6100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1917
    Cell Significance Index: -4.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1943
    Cell Significance Index: -6.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1959
    Cell Significance Index: -6.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1979
    Cell Significance Index: -5.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2034
    Cell Significance Index: -5.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2037
    Cell Significance Index: -5.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2118
    Cell Significance Index: -3.6300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2133
    Cell Significance Index: -4.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2141
    Cell Significance Index: -3.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2261
    Cell Significance Index: -6.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2299
    Cell Significance Index: -6.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2308
    Cell Significance Index: -4.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2312
    Cell Significance Index: -4.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2389
    Cell Significance Index: -8.7700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2391
    Cell Significance Index: -1.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2448
    Cell Significance Index: -5.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2504
    Cell Significance Index: -6.2500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2531
    Cell Significance Index: -2.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TIMP4 exhibits several key characteristics that distinguish it from other metalloproteinases. Firstly, its metalloendopeptidase inhibitory activity allows it to regulate the activity of various proteases, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAM) family members. This regulatory function is essential for maintaining tissue homeostasis and preventing excessive proteolysis. Secondly, TIMP4 has been shown to play a role in negative regulation of endopeptidase activity, which is critical for controlling the levels of bioactive peptides and hormones. This function is particularly important in the context of immune cell development and function, where tight regulation of signaling pathways is essential for proper immune response. **Pathways and Functions** TIMP4 is involved in several key pathways, including: 1. **Notch signaling pathway**: TIMP4 has been shown to regulate Notch signaling, a crucial pathway involved in cell fate determination, differentiation, and proliferation. 2. **Extracellular matrix regulation**: TIMP4 plays a role in regulating the activity of MMPs and ADAMs, which are essential for maintaining the integrity of the extracellular matrix. 3. **Protease binding**: TIMP4 binds to various proteases, including MMPs and ADAMs, to regulate their activity and prevent excessive proteolysis. 4. **Response to cytokine and hormone signaling**: TIMP4 has been shown to regulate the activity of cytokines and hormones, which are critical for immune cell development and function. **Clinical Significance** The clinical significance of TIMP4 is multifaceted. Dysregulation of TIMP4 has been implicated in various diseases, including: 1. **Cancer**: TIMP4 has been shown to play a role in cancer progression, where its dysregulation can lead to increased proteolysis and tumor growth. 2. **Immunological disorders**: TIMP4 has been implicated in various immunological disorders, including autoimmune diseases and immune deficiency disorders. 3. **Neurological disorders**: TIMP4 has been shown to play a role in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TIMP4 is a multifaceted gene with diverse roles in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and its role in human health and disease. Further research is necessary to fully elucidate the functions of TIMP4 and its clinical significance.

Genular Protein ID: 353232348

Symbol: TIMP4_HUMAN

Name: Metalloproteinase inhibitor 4

UniProtKB Accession Codes:

Q99727 B2R7K6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8939999

Title: Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.

PubMed ID: 8939999

DOI: 10.1074/jbc.271.48.30375

PubMed ID: 9693046

Title: Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.

PubMed ID: 9693046

DOI: 10.1006/geno.1998.5362

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 224
  • Mass: 25503
  • Checksum: 39C7187D78D99442
  • Sequence:
    • MPGSPRPAPS WVLLLRLLAL LRPPGLGEAC SCAPAHPQQH ICHSALVIRA KISSEKVVPA 
SADPADTEKM LRYEIKQIKM FKGFEKVKDV QYIYTPFDSS LCGVKLEANS QKQYLLTGQV 
LSDGKVFIHL CNYIEPWEDL SLVQRESLNH HYHLNCGCQI TTCYTVPCTI SAPNECLWTD 
WLLERKLYGY QAQHYVCMKH VDGTCSWYRG HLPLRKEFVD IVQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.