Details for: CAVIN1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 32.41rCSI 47.48%PRS 91.61
-
CSI 28.92rCSI 39.35%PRS 93.71
-
CSI 25.3rCSI 36.11%PRS 89.07
-
CSI 21.59rCSI 18.62%PRS 88.39
-
CSI 20.04rCSI 16.28%PRS 88.1
-
CSI 18.94rCSI 45.45%PRS 89.4
-
CSI 18.73rCSI 19.54%PRS 87.71
-
CSI 18.24rCSI 34.48%PRS 94.38
-
CSI 17.77rCSI 28.38%PRS 91.45
-
CSI 17.59rCSI 32.25%PRS 90.36
-
CSI 16.92rCSI 23.43%PRS 85.41
-
CSI 16.03rCSI 46.41%PRS 87.92
-
CSI 14.13rCSI 11.85%PRS 89.6
-
CSI 14.13rCSI 33.96%PRS 90.09
-
CSI 13.92rCSI 33.19%PRS 83.6
-
CSI 13.89rCSI 21.46%PRS 87.24
-
CSI 13.48rCSI 36.01%PRS 82.7
-
CSI 13.24rCSI 36.12%PRS 92.51
-
CSI 12.67rCSI 24.16%PRS 94.7
-
CSI 12.37rCSI 32.14%PRS 92.36
-
CSI 12.36rCSI 30.6%PRS 89.14
-
CSI 12.33rCSI 11.13%PRS 87.63
-
CSI 12.24rCSI 28.53%PRS 94.97
-
CSI 11.76rCSI 34.03%PRS 91.84
-
CSI 11.71rCSI 57.7%PRS 93.04
-
CSI 11.66rCSI 8.63%PRS 84.61
-
CSI 11.56rCSI 18.25%PRS 89.65
-
CSI 11.24rCSI 10.46%PRS 89.8
-
CSI 11.07rCSI 11.39%PRS 95.22
-
CSI 10.97rCSI 28.94%PRS 92.89
-
CSI 10.87rCSI 40.74%PRS 83.53
-
CSI 10.61rCSI 29.15%PRS 92.33
-
CSI 10.56rCSI 21.91%PRS 86.87
-
CSI 10.52rCSI 34.11%PRS 86.92
-
CSI 9.98rCSI 7.74%PRS 91.61
-
CSI 9.35rCSI 64.21%PRS 92.44
-
CSI 9.22rCSI 18.28%PRS 90.84
-
CSI 8.57rCSI 11.01%PRS 80.11
-
CSI 8.5rCSI 37.41%PRS 77.92
-
CSI 8.43rCSI 10.73%PRS 92.66
-
CSI 8.3rCSI 23.6%PRS 84.95
-
CSI 8.25rCSI 29.27%PRS 90.25
-
CSI 7.97rCSI 8.73%PRS 90.21
-
CSI 7.67rCSI 32.24%PRS 91.14
-
CSI 7.5rCSI 54.86%PRS 93.54
-
CSI 7.47rCSI 6.19%PRS 89.68
-
CSI 7.42rCSI 17.73%PRS 91.14
-
CSI 7.41rCSI 29.89%PRS 89.36
-
CSI 7.2rCSI 18.22%PRS 91.65
-
CSI 6.83rCSI 10.43%PRS 88.15
-
CSI 6.76rCSI 7%PRS 90.71
-
CSI 6.67rCSI 53.24%PRS 93.07
-
CSI 6.46rCSI 11.73%PRS 94.22
-
CSI 6.39rCSI 18.38%PRS 79.95
-
CSI 6.3rCSI 36.64%PRS 90.59
-
CSI 6.26rCSI 5.77%PRS 89.88
-
CSI 6.22rCSI 28.54%PRS 91.07
-
CSI 6.16rCSI 5.93%PRS 87.49
-
CSI 5.96rCSI 10.31%PRS 82.86
-
CSI 5.86rCSI 10.34%PRS 91.74
-
CSI 5.86rCSI 44.92%PRS 88.92
-
CSI 5.69rCSI 15.68%PRS 85.62
-
CSI 5.54rCSI 13.34%PRS 96.26
-
CSI 5.42rCSI 25.95%PRS 84.79
-
CSI 5.38rCSI 15.13%PRS 84.6
-
CSI 5.32rCSI 6.59%PRS 87.3
-
CSI 5.31rCSI 7.1%PRS 86.23
-
CSI 5.28rCSI 16.28%PRS 91.18
-
CSI 5.16rCSI 45.78%PRS 93.06
-
CSI 5.16rCSI 11.35%PRS 91.31
-
CSI 5.04rCSI 8.83%PRS 84.72
-
CSI 5.03rCSI 27.04%PRS 93.18
-
CSI 4.92rCSI 28.25%PRS 92.25
-
CSI 4.89rCSI 6.93%PRS 86.24
-
CSI 4.81rCSI 5.78%PRS 87.54
-
CSI 4.56rCSI 7.25%PRS 83.68
-
CSI 4.55rCSI 28.42%PRS 82.1
-
CSI 4.55rCSI 6.94%PRS 93.42
-
CSI 4.23rCSI 34.39%PRS 85.26
-
CSI 3.92rCSI 6.99%PRS 93.03
-
CSI 3.87rCSI 58.02%PRS 93.5
-
CSI 3.86rCSI 39.96%PRS 83.25
-
CSI 3.74rCSI 7.28%PRS 90.56
-
CSI 3.74rCSI 5.1%PRS 82.03
-
CSI 3.64rCSI 4.97%PRS 92.06
-
CSI 3.53rCSI 3.41%PRS 84.29
-
CSI 3.35rCSI 19.33%PRS 85.68
-
CSI 3.26rCSI 63.04%PRS 93.52
-
CSI 3.23rCSI 17.99%PRS 90.05
-
CSI 3.19rCSI 5.22%PRS 80.98
-
CSI 3.19rCSI 8.09%PRS 83.5
-
CSI 3.17rCSI 8.19%PRS 85.48
-
CSI 2.95rCSI 16.12%PRS 85.53
-
CSI 2.86rCSI 8.23%PRS 90.82
-
CSI 2.82rCSI 18.17%PRS 92.49
-
CSI 2.7rCSI 3.47%PRS 90.77
-
CSI 2.65rCSI 8.52%PRS 85.45
-
CSI 2.27rCSI 13.35%PRS 91.5
-
CSI 2.04rCSI 6.01%PRS 88.09
-
CSI 1.86rCSI 2.66%PRS 80.56
-
CSI 0.3rCSI 6.8%PRS 92.0%
-
CSI 0.4rCSI 6.0%PRS 89.8%
-
CSI 0.8rCSI 13.8%PRS 90.6%
-
CSI 1.0rCSI 16.5%PRS 92.9%
-
CSI 1.0rCSI 10.4%PRS 91.1%
-
CSI 1.1rCSI 5.0%PRS 94.8%
-
CSI 1.1rCSI 7.9%PRS 82.3%
-
CSI 1.3rCSI 8.4%PRS 91.6%
-
CSI 1.4rCSI 2.8%PRS 92.5%
-
CSI 1.4rCSI 4.8%PRS 93.0%
-
CSI 1.5rCSI 33.9%PRS 97.1%
-
CSI 1.5rCSI 8.5%PRS 94.6%
-
CSI 1.6rCSI 37.0%PRS 92.7%
-
CSI 1.7rCSI 8.9%PRS 89.2%
-
CSI 1.7rCSI 7.9%PRS 93.2%
-
CSI 1.9rCSI 2.7%PRS 80.6%
-
CSI 2.0rCSI 6.0%PRS 88.1%
-
CSI 2.3rCSI 13.4%PRS 91.5%
-
CSI 2.7rCSI 8.5%PRS 85.5%
-
CSI 2.7rCSI 3.5%PRS 90.8%
-
CSI 2.8rCSI 18.2%PRS 92.5%
-
CSI 2.9rCSI 8.2%PRS 90.8%
-
CSI 3.0rCSI 16.1%PRS 85.5%
-
CSI 3.2rCSI 8.2%PRS 85.5%
-
CSI 3.2rCSI 8.1%PRS 83.5%
-
CSI 3.2rCSI 5.2%PRS 81.0%
-
CSI 3.2rCSI 18.0%PRS 90.1%
-
CSI 3.3rCSI 63.0%PRS 93.5%
-
CSI 3.4rCSI 19.3%PRS 85.7%
-
CSI 3.5rCSI 3.4%PRS 84.3%
-
CSI 3.6rCSI 5.0%PRS 92.1%
-
CSI 3.7rCSI 5.1%PRS 82.0%
-
CSI 3.7rCSI 7.3%PRS 90.6%
-
CSI 3.9rCSI 40.0%PRS 83.3%
-
CSI 3.9rCSI 58.0%PRS 93.5%
-
CSI 3.9rCSI 7.0%PRS 93.0%
-
CSI 4.2rCSI 34.4%PRS 85.3%
-
CSI 4.6rCSI 6.9%PRS 93.4%
-
CSI 4.6rCSI 28.4%PRS 82.1%
-
CSI 4.6rCSI 7.3%PRS 83.7%
-
CSI 4.8rCSI 5.8%PRS 87.5%
-
CSI 4.9rCSI 6.9%PRS 86.2%
-
CSI 4.9rCSI 28.3%PRS 92.3%
-
CSI 5.0rCSI 27.0%PRS 93.2%
-
CSI 5.0rCSI 8.8%PRS 84.7%
-
CSI 5.2rCSI 11.4%PRS 91.3%
-
CSI 5.2rCSI 45.8%PRS 93.1%
-
CSI 5.3rCSI 16.3%PRS 91.2%
-
CSI 5.3rCSI 7.1%PRS 86.2%
-
CSI 5.3rCSI 6.6%PRS 87.3%
-
CSI 5.4rCSI 15.1%PRS 84.6%
-
CSI 5.4rCSI 26.0%PRS 84.8%
-
CSI 5.5rCSI 13.3%PRS 96.3%
-
CSI 5.7rCSI 15.7%PRS 85.6%
-
CSI 5.9rCSI 44.9%PRS 88.9%
-
CSI 5.9rCSI 10.3%PRS 91.7%
-
CSI 6.0rCSI 10.3%PRS 82.9%
-
CSI 6.2rCSI 5.9%PRS 87.5%
-
CSI 6.2rCSI 28.5%PRS 91.1%
-
CSI 6.3rCSI 5.8%PRS 89.9%
-
CSI 6.3rCSI 36.6%PRS 90.6%
-
CSI 6.4rCSI 18.4%PRS 80.0%
-
CSI 6.5rCSI 11.7%PRS 94.2%
-
CSI 6.7rCSI 53.2%PRS 93.1%
-
CSI 6.8rCSI 7.0%PRS 90.7%
-
CSI 6.8rCSI 10.4%PRS 88.2%
-
CSI 7.2rCSI 18.2%PRS 91.7%
-
CSI 7.4rCSI 29.9%PRS 89.4%
-
CSI 7.4rCSI 17.7%PRS 91.1%
-
CSI 7.5rCSI 6.2%PRS 89.7%
-
CSI 7.5rCSI 54.9%PRS 93.5%
-
CSI 7.7rCSI 32.2%PRS 91.1%
-
CSI 8.0rCSI 8.7%PRS 90.2%
-
CSI 8.3rCSI 29.3%PRS 90.3%
-
CSI 8.3rCSI 23.6%PRS 85.0%
-
CSI 8.4rCSI 10.7%PRS 92.7%
-
CSI 8.5rCSI 37.4%PRS 77.9%
-
CSI 8.6rCSI 11.0%PRS 80.1%
-
CSI 9.2rCSI 18.3%PRS 90.8%
-
CSI 9.4rCSI 64.2%PRS 92.4%
-
CSI 10.0rCSI 7.7%PRS 91.6%
-
CSI 10.5rCSI 34.1%PRS 86.9%
-
CSI 10.6rCSI 21.9%PRS 86.9%
-
CSI 10.6rCSI 29.2%PRS 92.3%
-
CSI 10.9rCSI 40.7%PRS 83.5%
-
CSI 11.0rCSI 28.9%PRS 92.9%
-
CSI 11.1rCSI 11.4%PRS 95.2%
-
CSI 11.2rCSI 10.5%PRS 89.8%
-
CSI 11.6rCSI 18.3%PRS 89.7%
-
CSI 11.7rCSI 8.6%PRS 84.6%
-
CSI 11.7rCSI 57.7%PRS 93.0%
-
CSI 11.8rCSI 34.0%PRS 91.8%
-
CSI 12.2rCSI 28.5%PRS 95.0%
-
CSI 12.3rCSI 11.1%PRS 87.6%
-
CSI 12.4rCSI 30.6%PRS 89.1%
-
CSI 12.4rCSI 32.1%PRS 92.4%
-
CSI 12.7rCSI 24.2%PRS 94.7%
-
CSI 13.2rCSI 36.1%PRS 92.5%
-
CSI 13.5rCSI 36.0%PRS 82.7%
-
CSI 13.9rCSI 21.5%PRS 87.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1985051520
Symbol: CAVN1_HUMAN
Name: Cavin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9582279
Title: Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.
PubMed ID: 9582279
PubMed ID: 15242332
Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
PubMed ID: 15242332
DOI: 10.1042/bj20040647
PubMed ID: 17026959
Title: Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.
PubMed ID: 17026959
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18191225
Title: PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function.
PubMed ID: 18191225
PubMed ID: 18056712
Title: A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization.
PubMed ID: 18056712
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19726876
Title: Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy.
PubMed ID: 19726876
DOI: 10.1172/jci38660
PubMed ID: 19525939
Title: SDPR induces membrane curvature and functions in the formation of caveolae.
PubMed ID: 19525939
DOI: 10.1038/ncb1887
PubMed ID: 20684003
Title: Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations.
PubMed ID: 20684003
DOI: 10.1002/ajmg.a.33578
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 24567387
Title: MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.
PubMed ID: 24567387
PubMed ID: 26614875
Title: Cavin family: new players in the biology of caveolae.
PubMed ID: 26614875
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 390
- Mass: 43476
- Checksum: E37945A9C9E819D4
- Sequence:
MEDPTLYIVE RPLPGYPDAE APEPSSAGAQ AAEEPSGAGS EELIKSDQVN GVLVLSLLDK IIGAVDQIQL TQAQLEERQA EMEGAVQSIQ GELSKLGKAH ATTSNTVSKL LEKVRKVSVN VKTVRGSLER QAGQIKKLEV NEAELLRRRN FKVMIYQDEV KLPAKLSISK SLKESEALPE KEGEELGEGE RPEEDAAALE LSSDEAVEVE EVIEESRAER IKRSGLRRVD DFKKAFSKEK MEKTKVRTRE NLEKTRLKTK ENLEKTRHTL EKRMNKLGTR LVPAERREKL KTSRDKLRKS FTPDHVVYAR SKTAVYKVPP FTFHVKKIRE GQVEVLKATE MVEVGADDDE GGAERGEAGD LRRGSSPDVH ALLEITEESD AVLVDKSDSD