Details for: MYL3

Gene ID: 4634

Symbol: MYL3

Ensembl ID: ENSG00000160808

Description: myosin light chain 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 18.2183
    Cell Significance Index: 52.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.8829
    Cell Significance Index: 374.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.4464
    Cell Significance Index: 108.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.0228
    Cell Significance Index: 15.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7949
    Cell Significance Index: 25.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7274
    Cell Significance Index: 15.7600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6587
    Cell Significance Index: 4.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4220
    Cell Significance Index: 6.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3879
    Cell Significance Index: 8.1200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.3371
    Cell Significance Index: 4.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3160
    Cell Significance Index: 5.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2721
    Cell Significance Index: 16.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2179
    Cell Significance Index: 41.4800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2008
    Cell Significance Index: 2.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1969
    Cell Significance Index: 8.9300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1110
    Cell Significance Index: 1.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1013
    Cell Significance Index: 6.0800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0829
    Cell Significance Index: 1.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0599
    Cell Significance Index: 1.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0582
    Cell Significance Index: 5.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0551
    Cell Significance Index: 5.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0459
    Cell Significance Index: 41.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0451
    Cell Significance Index: 5.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0297
    Cell Significance Index: 4.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0072
    Cell Significance Index: 5.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0033
    Cell Significance Index: 1.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0030
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0063
    Cell Significance Index: -11.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -13.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0106
    Cell Significance Index: -6.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0186
    Cell Significance Index: -6.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0223
    Cell Significance Index: -12.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0267
    Cell Significance Index: -7.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0296
    Cell Significance Index: -5.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0338
    Cell Significance Index: -2.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0392
    Cell Significance Index: -0.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0440
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0453
    Cell Significance Index: -7.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0477
    Cell Significance Index: -0.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0477
    Cell Significance Index: -9.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0481
    Cell Significance Index: -3.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0483
    Cell Significance Index: -7.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0492
    Cell Significance Index: -9.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0497
    Cell Significance Index: -2.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0499
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0543
    Cell Significance Index: -6.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0599
    Cell Significance Index: -7.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0645
    Cell Significance Index: -6.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0695
    Cell Significance Index: -8.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0753
    Cell Significance Index: -1.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0776
    Cell Significance Index: -10.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0919
    Cell Significance Index: -5.9300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0998
    Cell Significance Index: -1.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0999
    Cell Significance Index: -1.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1020
    Cell Significance Index: -2.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1168
    Cell Significance Index: -12.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1181
    Cell Significance Index: -2.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1214
    Cell Significance Index: -3.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1291
    Cell Significance Index: -6.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1375
    Cell Significance Index: -10.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1492
    Cell Significance Index: -9.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1523
    Cell Significance Index: -1.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1564
    Cell Significance Index: -3.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1588
    Cell Significance Index: -8.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1594
    Cell Significance Index: -8.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1621
    Cell Significance Index: -10.9000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1622
    Cell Significance Index: -1.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1729
    Cell Significance Index: -2.9800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1748
    Cell Significance Index: -1.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1815
    Cell Significance Index: -8.5300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1896
    Cell Significance Index: -2.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1990
    Cell Significance Index: -10.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2094
    Cell Significance Index: -3.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2112
    Cell Significance Index: -7.3400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2121
    Cell Significance Index: -1.2500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2128
    Cell Significance Index: -2.1700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2179
    Cell Significance Index: -2.5100
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2314
    Cell Significance Index: -2.2700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2327
    Cell Significance Index: -2.5400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2334
    Cell Significance Index: -3.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2336
    Cell Significance Index: -6.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2429
    Cell Significance Index: -9.9500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2432
    Cell Significance Index: -2.3900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2546
    Cell Significance Index: -3.1000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2547
    Cell Significance Index: -3.5700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2589
    Cell Significance Index: -2.8600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2618
    Cell Significance Index: -3.0300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2677
    Cell Significance Index: -1.6400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2695
    Cell Significance Index: -3.4500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2738
    Cell Significance Index: -1.3100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2799
    Cell Significance Index: -4.5000
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.2852
    Cell Significance Index: -2.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** MYL3 is highly expressed in cardiomyocytes, a type of cardiac muscle cell, as well as in other cell types such as lymphocytes, fibroblasts, and epithelial cells. 2. **Protein Structure:** The MYL3 protein is a light chain of the myosin II complex, consisting of a globular head domain and a long tail domain. 3. **Function:** MYL3 is involved in the regulation of muscle contraction, particularly in cardiac muscle cells, by interacting with the myosin heavy chain and actin filaments. 4. **Regulation:** The expression of MYL3 is regulated by various signaling pathways, including those involved in cardiac development and muscle contraction. **Pathways and Functions:** 1. **Muscle Contraction:** MYL3 plays a critical role in the regulation of muscle contraction by interacting with the myosin heavy chain and actin filaments. 2. **Cardiac Function:** MYL3 is highly expressed in cardiomyocytes and is involved in the regulation of cardiac function, including the generation of force and the maintenance of cardiac structure. 3. **Cell Signaling:** MYL3 is regulated by various signaling pathways, including those involved in cardiac development and muscle contraction. 4. **Muscle Morphogenesis:** MYL3 is involved in the regulation of muscle morphogenesis, particularly in the development of striated muscle tissue. **Clinical Significance:** 1. **Cardiac Disease:** Mutations in the MYL3 gene have been implicated in various cardiac diseases, including hypertrophic cardiomyopathy and dilated cardiomyopathy. 2. **Muscle Disorders:** MYL3 mutations have also been associated with muscle disorders, including muscular dystrophy and myositis. 3. **Cancer:** MYL3 has been implicated in the regulation of cancer cell migration and invasion, particularly in epithelial-to-mesenchymal transition (EMT). 4. **Immunological Disorders:** MYL3 has been shown to play a role in the regulation of immune cell function, particularly in the activation and migration of lymphocytes. In conclusion, the MYL3 gene is a critical component of muscle contraction and cardiac function, with implications for various diseases and disorders. Further research into the mechanisms of MYL3 regulation and its role in disease will provide valuable insights into the development of novel therapeutic strategies for the treatment of cardiac and muscle disorders.

Genular Protein ID: 3822104082

Symbol: MYL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P08590 B2R534 Q9NRS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 2 Ensembl 6 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3417683

Title: Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones.

PubMed ID: 3417683

DOI: 10.1016/s0021-9258(18)68333-4

PubMed ID: 3357795

Title: Molecular cloning and complete nucleotide sequence of a human ventricular myosin light chain 1.

PubMed ID: 3357795

DOI: 10.1093/nar/16.5.2353

PubMed ID: 2789520

Title: Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location.

PubMed ID: 2789520

DOI: 10.1016/s0021-9258(18)94153-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 3979397

Title: The widespread distribution of alpha-N-trimethylalanine as the N-terminal amino acid of light chains from vertebrate striated muscle myosins.

PubMed ID: 3979397

DOI: 10.1111/j.1432-1033.1985.tb08809.x

PubMed ID: 8673105

Title: Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle.

PubMed ID: 8673105

DOI: 10.1038/ng0596-63

PubMed ID: 12021217

Title: Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology.

PubMed ID: 12021217

DOI: 10.1161/01.cir.0000018444.47798.94

PubMed ID: 12707239

Title: Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy.

PubMed ID: 12707239

DOI: 10.1161/01.cir.0000066323.15244.54

PubMed ID: 23594557

Title: Infantile hypertrophic cardiomyopathy associated with a novel MYL3 mutation.

PubMed ID: 23594557

DOI: 10.1159/000347138

Sequence Information:

  • Length: 195
  • Mass: 21932
  • Checksum: 306CF328841729DD
  • Sequence:
    • MAPKKPEPKK DDAKAAPKAA PAPAPPPEPE RPKEVEFDAS KIKIEFTPEQ IEEFKEAFML 
FDRTPKCEMK ITYGQCGDVL RALGQNPTQA EVLRVLGKPR QEELNTKMMD FETFLPMLQH 
ISKNKDTGTY EDFVEGLRVF DKEGNGTVMG AELRHVLATL GERLTEDEVE KLMAGQEDSN 
GCINYEAFVK HIMSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.