Details for: TCF15

Gene ID: 6939

Symbol: TCF15

Ensembl ID: ENSG00000125878

Description: transcription factor 15

Associated with

  • Bhlh transcription factor binding
    (GO:0043425)
  • Chromatin
    (GO:0000785)
  • Developmental process
    (GO:0032502)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • E-box binding
    (GO:0070888)
  • Ear development
    (GO:0043583)
  • Establishment of epithelial cell apical/basal polarity
    (GO:0045198)
  • Mesenchymal to epithelial transition
    (GO:0060231)
  • Mesoderm development
    (GO:0007498)
  • Muscle organ morphogenesis
    (GO:0048644)
  • Negative regulation of hematopoietic stem cell differentiation
    (GO:1902037)
  • Neuromuscular process controlling posture
    (GO:0050884)
  • Nucleus
    (GO:0005634)
  • Paraxial mesoderm development
    (GO:0048339)
  • Positive regulation of stem cell differentiation
    (GO:2000738)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-anal tail morphogenesis
    (GO:0036342)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of extracellular matrix organization
    (GO:1903053)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory system process
    (GO:0003016)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Skeletal system morphogenesis
    (GO:0048705)
  • Somitogenesis
    (GO:0001756)
  • Stem cell population maintenance
    (GO:0019827)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.9095
    Cell Significance Index: -5.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.2503
    Cell Significance Index: -5.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4381
    Cell Significance Index: 12.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1440
    Cell Significance Index: 27.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6247
    Cell Significance Index: 8.9900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2066
    Cell Significance Index: 2.9600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1585
    Cell Significance Index: 2.2300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.1337
    Cell Significance Index: 0.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1161
    Cell Significance Index: 80.3000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0585
    Cell Significance Index: 0.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0563
    Cell Significance Index: 20.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0298
    Cell Significance Index: 0.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0059
    Cell Significance Index: 0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0043
    Cell Significance Index: 2.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0024
    Cell Significance Index: 0.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -1.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0088
    Cell Significance Index: -1.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0116
    Cell Significance Index: -1.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0119
    Cell Significance Index: -5.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0130
    Cell Significance Index: -3.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0164
    Cell Significance Index: -1.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0193
    Cell Significance Index: -3.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0201
    Cell Significance Index: -3.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0221
    Cell Significance Index: -4.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0242
    Cell Significance Index: -4.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0269
    Cell Significance Index: -3.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0356
    Cell Significance Index: -5.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0360
    Cell Significance Index: -4.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0380
    Cell Significance Index: -1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0381
    Cell Significance Index: -5.2300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0419
    Cell Significance Index: -0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0423
    Cell Significance Index: -5.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0490
    Cell Significance Index: -5.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0495
    Cell Significance Index: -2.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0510
    Cell Significance Index: -5.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0523
    Cell Significance Index: -6.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0524
    Cell Significance Index: -2.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0599
    Cell Significance Index: -0.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0608
    Cell Significance Index: -3.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0617
    Cell Significance Index: -1.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0669
    Cell Significance Index: -1.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0733
    Cell Significance Index: -5.4600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0826
    Cell Significance Index: -0.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0829
    Cell Significance Index: -4.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0831
    Cell Significance Index: -5.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0846
    Cell Significance Index: -1.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0874
    Cell Significance Index: -3.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0893
    Cell Significance Index: -4.2000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0904
    Cell Significance Index: -1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0925
    Cell Significance Index: -5.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0961
    Cell Significance Index: -5.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1293
    Cell Significance Index: -5.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1295
    Cell Significance Index: -2.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1334
    Cell Significance Index: -1.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1359
    Cell Significance Index: -3.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1362
    Cell Significance Index: -4.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1396
    Cell Significance Index: -3.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1407
    Cell Significance Index: -3.7700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1409
    Cell Significance Index: -1.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1413
    Cell Significance Index: -4.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1481
    Cell Significance Index: -1.6100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1502
    Cell Significance Index: -1.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1503
    Cell Significance Index: -5.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1515
    Cell Significance Index: -4.9600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1517
    Cell Significance Index: -1.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1525
    Cell Significance Index: -5.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1622
    Cell Significance Index: -3.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1632
    Cell Significance Index: -5.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1652
    Cell Significance Index: -5.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1660
    Cell Significance Index: -4.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1664
    Cell Significance Index: -3.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1681
    Cell Significance Index: -1.9100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1682
    Cell Significance Index: -4.2000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1737
    Cell Significance Index: -1.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1744
    Cell Significance Index: -5.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1749
    Cell Significance Index: -4.6700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1763
    Cell Significance Index: -3.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1789
    Cell Significance Index: -2.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1802
    Cell Significance Index: -3.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1809
    Cell Significance Index: -2.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1829
    Cell Significance Index: -4.6600
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1849
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1850
    Cell Significance Index: -2.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1874
    Cell Significance Index: -2.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1875
    Cell Significance Index: -4.9300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1891
    Cell Significance Index: -1.8400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1904
    Cell Significance Index: -2.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1931
    Cell Significance Index: -5.5100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1976
    Cell Significance Index: -1.9100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1979
    Cell Significance Index: -1.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2005
    Cell Significance Index: -4.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2041
    Cell Significance Index: -4.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2106
    Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCF15 is a member of the BHLH (basic helix-loop-helix) transcription factor family, which is known for its role in regulating gene expression during development and differentiation. The TCF15 protein exhibits high specificity for binding to E-box sequences, a type of DNA motif found in the promoter regions of target genes. This binding activity is essential for the regulation of transcription by RNA polymerase II, a key enzyme responsible for the synthesis of messenger RNA from DNA templates. TCF15 also interacts with other transcription factors, such as Notch and Wnt, to modulate the expression of target genes involved in developmental processes. **Pathways and Functions:** TCF15 is involved in several developmental and immunological pathways, including: 1. **Developmental Process:** TCF15 plays a crucial role in the development of various tissues and organs, including the nervous system, muscle, and epithelial tissues. It regulates the expression of genes involved in cell differentiation, proliferation, and survival. 2. **Chromatin Regulation:** TCF15 interacts with chromatin-modifying enzymes to regulate the epigenetic landscape of target genes, influencing their expression and function. 3. **DNA-Binding Transcription Activator Activity:** TCF15 binds to specific DNA sequences, activating the transcription of target genes by interacting with RNA polymerase II. 4. **Negative Regulation of Hematopoietic Stem Cell Differentiation:** TCF15 inhibits the differentiation of hematopoietic stem cells, promoting their maintenance and self-renewal. 5. **Positive Regulation of Stem Cell Differentiation:** TCF15 promotes the differentiation of stem cells into specific cell types, influencing their development and function. **Clinical Significance:** Dysregulation of TCF15 has been implicated in various diseases, including: 1. **Cancer:** TCF15 is overexpressed in several types of cancer, including colorectal, breast, and lung cancer. Its dysregulation contributes to tumor development and progression. 2. **Neurological Disorders:** TCF15 is involved in the regulation of neuronal differentiation and function. Dysregulation of TCF15 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune System Disorders:** TCF15 is involved in the regulation of immune cell development and function. Dysregulation of TCF15 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, TCF15 is a complex transcription factor that plays a crucial role in various developmental and immunological processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the molecular mechanisms underlying its function.

Genular Protein ID: 2769669944

Symbol: TCF15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12870 Q9NQQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8041747

Title: Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites.

PubMed ID: 8041747

DOI: 10.1073/pnas.91.15.7066

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

Sequence Information:

  • Length: 199
  • Mass: 20816
  • Checksum: A3BF546A24ACF68A
  • Sequence:
    • MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG PGPGGGRRAG 
GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP TEPVDRKLSK IETVRLASSY 
IAHLANVLLL GDSADDGQPC FRAAGSAKGA VPAAADGGRQ PRSICTFCLS NQRKGGGRRD 
LGGSCLKVRG VAPLRGPRR

Genular Protein ID: 1485109546

Symbol: A4LBB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4LBB6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 199
  • Mass: 20831
  • Checksum: E2054FD024BC3C30
  • Sequence:
    • MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGPEAARRG PGPGGGRRAG 
GGGGAGPVVV VRQRQAANAR ERDRTQSVNT AFTALRTLIP TEPVDRKLSK IETLRLASSY 
IAHLANVLLL GDSADDGQPC FRAAGSAKGA VPAAADGGRQ PRSICTFCLS NQRKGGGRRD 
LGGSCLKVRG VAPLRGPRR

Genular Protein ID: 1502674977

Symbol: Q6NVX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVX3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 223
  • Mass: 23427
  • Checksum: DDB9E62177EF724D
  • Sequence:
    • SARERTAGRG RRWDAAHGGT RPAPRAFALL RPVGAHVLYP DVRLLSEDEE NRSESDASDQ 
SFGCCEGPEA ARRGPGPGGG RRAGGGGGAG PVVVVRQRQA ANARERDRTQ SVNTAFTALR 
TLIPTEPVDR KLSKIETLRL ASSYIAHLAN VLLLGDSADD GQPCFRAAGS AKGAVPAAAD 
GGRQPRSICT FCLSNQRKGG GRRDLGGSCL KVRGVAPLRG PRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.