Details for: FLT1

Gene ID: 2321

Symbol: FLT1

Ensembl ID: ENSG00000102755

Description: fms related receptor tyrosine kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 133.7232
    Cell Significance Index: -20.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.1232
    Cell Significance Index: -20.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.0484
    Cell Significance Index: -19.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4924
    Cell Significance Index: -19.5700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 17.9369
    Cell Significance Index: 111.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 14.0400
    Cell Significance Index: 374.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 12.3695
    Cell Significance Index: 177.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.7336
    Cell Significance Index: -25.6800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 11.6878
    Cell Significance Index: 43.5600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 8.5084
    Cell Significance Index: 88.1300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 7.7216
    Cell Significance Index: 60.9600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 5.4391
    Cell Significance Index: 18.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2812
    Cell Significance Index: -20.8400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.1437
    Cell Significance Index: 29.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.8239
    Cell Significance Index: 199.1800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 3.0980
    Cell Significance Index: 29.4500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.4802
    Cell Significance Index: 15.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3785
    Cell Significance Index: 76.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1818
    Cell Significance Index: 38.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0231
    Cell Significance Index: 31.3000
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.8377
    Cell Significance Index: 10.8500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.5426
    Cell Significance Index: 9.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9137
    Cell Significance Index: 10.3800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8653
    Cell Significance Index: 6.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4866
    Cell Significance Index: 92.6100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.3888
    Cell Significance Index: 1.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3538
    Cell Significance Index: 5.8300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.2980
    Cell Significance Index: 4.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1536
    Cell Significance Index: 30.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1312
    Cell Significance Index: 1.0700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1306
    Cell Significance Index: 1.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1071
    Cell Significance Index: 6.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1011
    Cell Significance Index: 91.2600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0916
    Cell Significance Index: 0.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0685
    Cell Significance Index: 7.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0551
    Cell Significance Index: 34.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0323
    Cell Significance Index: 5.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0251
    Cell Significance Index: 17.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0248
    Cell Significance Index: 4.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0240
    Cell Significance Index: 0.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0215
    Cell Significance Index: 1.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0038
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0095
    Cell Significance Index: -14.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0140
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0152
    Cell Significance Index: -20.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0169
    Cell Significance Index: -10.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0192
    Cell Significance Index: -4.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0234
    Cell Significance Index: -4.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0243
    Cell Significance Index: -13.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0293
    Cell Significance Index: -10.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0315
    Cell Significance Index: -14.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0317
    Cell Significance Index: -2.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0330
    Cell Significance Index: -0.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0425
    Cell Significance Index: -6.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0438
    Cell Significance Index: -19.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0482
    Cell Significance Index: -3.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0562
    Cell Significance Index: -16.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0628
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0654
    Cell Significance Index: -11.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0706
    Cell Significance Index: -8.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0998
    Cell Significance Index: -4.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1221
    Cell Significance Index: -15.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1373
    Cell Significance Index: -18.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1409
    Cell Significance Index: -14.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1475
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1524
    Cell Significance Index: -17.4000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1578
    Cell Significance Index: -1.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1593
    Cell Significance Index: -18.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1599
    Cell Significance Index: -2.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1615
    Cell Significance Index: -20.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1646
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1766
    Cell Significance Index: -20.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1782
    Cell Significance Index: -18.5600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1820
    Cell Significance Index: -2.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1944
    Cell Significance Index: -22.9300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2264
    Cell Significance Index: -2.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2423
    Cell Significance Index: -19.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2653
    Cell Significance Index: -3.8000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2725
    Cell Significance Index: -3.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2729
    Cell Significance Index: -18.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2925
    Cell Significance Index: -21.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3295
    Cell Significance Index: -20.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3379
    Cell Significance Index: -17.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3386
    Cell Significance Index: -21.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3425
    Cell Significance Index: -21.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3830
    Cell Significance Index: -18.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3836
    Cell Significance Index: -8.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4105
    Cell Significance Index: -19.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4139
    Cell Significance Index: -21.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4232
    Cell Significance Index: -11.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4305
    Cell Significance Index: -19.0400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4613
    Cell Significance Index: -2.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5113
    Cell Significance Index: -19.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5409
    Cell Significance Index: -10.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FLT1 is a single-pass transmembrane receptor tyrosine kinase that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains immunoglobulin-like domains and a fibronectin-type III domain, which are involved in ligand binding and dimerization. The transmembrane domain spans the cell membrane, while the intracellular domain contains tyrosine kinase domains that are involved in signal transduction. FLT1 is a high-affinity receptor for VEGF, which is a potent angiogenic factor that promotes endothelial cell proliferation, migration, and survival. **Pathways and Functions** FLT1 is a key component of the VEGF signaling pathway, which is involved in angiogenesis, wound healing, and embryonic development. The pathway involves the binding of VEGF to FLT1, leading to receptor dimerization and the activation of downstream signaling cascades, including: 1. Phosphorylation of tyrosine residues: FLT1 phosphorylates tyrosine residues on itself and downstream targets, including phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK). 2. Activation of MAPK cascade: The phosphorylation of MAPK kinase (MAP2K) activates the MAPK cascade, which regulates cell proliferation, migration, and survival. 3. Activation of PI3K/protein kinase B (Akt) signaling pathway: FLT1 phosphorylates PI3K, which activates the PI3K/Akt signaling pathway, which regulates cell survival and metabolism. 4. Regulation of vascular endothelial cell proliferation and migration: FLT1 regulates the proliferation and migration of vascular endothelial cells, which are critical for angiogenesis. FLT1 also interacts with other signaling pathways, including the Notch and Wnt/β-catenin pathways, which regulate cell fate determination and tissue development. **Clinical Significance** Dysregulation of FLT1 has been implicated in several pathological conditions, including: 1. Cancer: FLT1 is overexpressed in various types of cancer, including glioblastoma, breast cancer, and ovarian cancer, and is associated with tumor growth, angiogenesis, and metastasis. 2. Cardiovascular disease: FLT1 is involved in the development of atherosclerosis and cardiovascular disease, and its dysregulation is associated with hypertension and cardiac remodeling. 3. Retinopathy: FLT1 is involved in the pathogenesis of diabetic retinopathy and age-related macular degeneration. 4. Neurological disorders: FLT1 is implicated in the pathogenesis of neurological disorders, including glioblastoma, multiple sclerosis, and Alzheimer's disease. In conclusion, FLT1 is a critical component of the VEGF signaling pathway, which regulates angiogenesis, cell proliferation, migration, and survival. Its dysregulation has been implicated in several pathological conditions, highlighting the importance of FLT1 as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 391235980

Symbol: VGFR1_HUMAN

Name: Vascular endothelial growth factor receptor 1

UniProtKB Accession Codes:

P17948 A3E342 A3E344 A8KA71 B0LPF1 B2BF46 B2BF47 B2BF48 B3FR89 B5A923 F5H5L6 O60722 P16057 Q12954

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 2 EMBL 21 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 2 RefSeq 4 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2158038

Title: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

PubMed ID: 2158038

PubMed ID: 8248162

Title: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

PubMed ID: 8248162

DOI: 10.1073/pnas.90.22.10705

PubMed ID: 10471394

Title: Characterization of the VEGF binding site on the Flt-1 receptor.

PubMed ID: 10471394

DOI: 10.1006/bbrc.1999.1282

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 18515749

Title: A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia.

PubMed ID: 18515749

DOI: 10.1161/circresaha.108.171504

PubMed ID: 20512933

Title: A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells.

PubMed ID: 20512933

DOI: 10.1002/jcb.22584

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3040650

Title: A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.

PubMed ID: 3040650

PubMed ID: 9722576

Title: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.

PubMed ID: 9722576

DOI: 10.1074/jbc.273.36.23410

PubMed ID: 7824266

Title: A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

PubMed ID: 7824266

PubMed ID: 8605350

Title: Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1.

PubMed ID: 8605350

PubMed ID: 9299537

Title: The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.

PubMed ID: 9299537

DOI: 10.1006/bbrc.1997.7327

PubMed ID: 9600074

Title: Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

PubMed ID: 9600074

DOI: 10.1006/bbrc.1998.8578

PubMed ID: 11141500

Title: Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells.

PubMed ID: 11141500

DOI: 10.1016/s0002-9440(10)63965-x

PubMed ID: 11513746

Title: Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding.

PubMed ID: 11513746

DOI: 10.1042/0264-6021:3580465

PubMed ID: 11811792

Title: Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor.

PubMed ID: 11811792

DOI: 10.3109/08977190109001086

PubMed ID: 11312102

Title: Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers.

PubMed ID: 11312102

DOI: 10.1016/s1357-2725(01)00019-x

PubMed ID: 14633857

Title: Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.

PubMed ID: 14633857

DOI: 10.2337/diabetes.52.12.2959

PubMed ID: 12796773

Title: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.

PubMed ID: 12796773

DOI: 10.1038/nm884

PubMed ID: 15001553

Title: The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).

PubMed ID: 15001553

DOI: 10.1096/fj.03-0767fje

PubMed ID: 15735759

Title: Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells.

PubMed ID: 15735759

DOI: 10.1038/sj.onc.1208246

PubMed ID: 16685275

Title: Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases.

PubMed ID: 16685275

DOI: 10.1038/sj.bjc.6603143

PubMed ID: 16286478

Title: A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1.

PubMed ID: 16286478

DOI: 10.1074/jbc.m506454200

PubMed ID: 18079407

Title: The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes.

PubMed ID: 18079407

DOI: 10.1161/atvbaha.107.158022

PubMed ID: 18583712

Title: Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.

PubMed ID: 18583712

DOI: 10.1161/circresaha.108.174128

PubMed ID: 20551949

Title: Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement.

PubMed ID: 20551949

DOI: 10.1038/sj.bjc.6605746

PubMed ID: 21212275

Title: RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway.

PubMed ID: 21212275

DOI: 10.1074/jbc.m110.165605

PubMed ID: 22016384

Title: gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.

PubMed ID: 22016384

DOI: 10.1074/jbc.m111.296590

PubMed ID: 21752276

Title: Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis.

PubMed ID: 21752276

DOI: 10.1186/2045-824x-3-15

PubMed ID: 17002866

Title: Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.

PubMed ID: 17002866

DOI: 10.5483/bmbrep.2006.39.5.469

PubMed ID: 18680722

Title: VEGF receptor protein-tyrosine kinases: structure and regulation.

PubMed ID: 18680722

DOI: 10.1016/j.bbrc.2008.07.121

PubMed ID: 19230644

Title: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.

PubMed ID: 19230644

DOI: 10.1016/j.ceb.2008.12.012

PubMed ID: 19761875

Title: Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

PubMed ID: 19761875

DOI: 10.1016/j.bbapap.2009.09.002

PubMed ID: 20127948

Title: Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1).

PubMed ID: 20127948

DOI: 10.1002/cncr.24789

PubMed ID: 21711246

Title: Signal transduction by vascular endothelial growth factor receptors.

PubMed ID: 21711246

DOI: 10.1042/bj20110301

PubMed ID: 21558755

Title: Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia.

PubMed ID: 21558755

DOI: 10.2183/pjab.87.167

PubMed ID: 9393862

Title: Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.

PubMed ID: 9393862

DOI: 10.1016/s0092-8674(00)80456-0

PubMed ID: 10543948

Title: Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.

PubMed ID: 10543948

DOI: 10.1006/jmbi.1999.3134

PubMed ID: 14684734

Title: The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.

PubMed ID: 14684734

DOI: 10.1074/jbc.m313237200

PubMed ID: 20501651

Title: Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity.

PubMed ID: 20501651

DOI: 10.1074/jbc.m110.130658

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1338
  • Mass: 150769
  • Checksum: FF3381EEFAF0787C
  • Sequence:
    • MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK 
WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET 
ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD 
GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV 
KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK 
MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK 
AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA 
TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC 
DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK 
VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM 
HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRDQEA 
PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK IQQEPGIILG PGSSTLFIER 
VTEEDEGVYH CKATNQKGSV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI 
RKMKRSSSEI KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK 
VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK 
QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE QGKKPRLDSV 
TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI SYSFQVARGM EFLSSRKCIH 
RDLAARNILL SENNVVKICD FGLARDIYKN PDYVRKGDTR LPLKWMAPES IFDKIYSTKS 
DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD 
PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA 
PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL ASPMLKRFTW 
TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV SEGKRRFTYD HAELERKIAC 
CSPPPDYNSV VLYSTPPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.