Details for: FLT1

Gene ID: 2321

Symbol: FLT1

Ensembl ID: ENSG00000102755

Description: fms related receptor tyrosine kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.32
    Marker Score: 3546
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 3.24
    Marker Score: 1935
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.03
    Marker Score: 4406
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.95
    Marker Score: 1669
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.77
    Marker Score: 645
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.39
    Marker Score: 2247
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.36
    Marker Score: 2523.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.32
    Marker Score: 20400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.16
    Marker Score: 678
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.08
    Marker Score: 4150
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.05
    Marker Score: 2962
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.02
    Marker Score: 491
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2
    Marker Score: 1724
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.95
    Marker Score: 495
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.91
    Marker Score: 4847
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7358
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.75
    Marker Score: 679
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.64
    Marker Score: 3327.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1160
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.59
    Marker Score: 1428
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.58
    Marker Score: 380
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.57
    Marker Score: 651
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.57
    Marker Score: 1686
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.54
    Marker Score: 1372
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.49
    Marker Score: 1346
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.49
    Marker Score: 409.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169053
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.41
    Marker Score: 299
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.4
    Marker Score: 1935
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.38
    Marker Score: 747
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.37
    Marker Score: 2600
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.37
    Marker Score: 318
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.35
    Marker Score: 2282
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4797
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.12
    Marker Score: 295
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.1
    Marker Score: 240
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.09
    Marker Score: 1093
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 495
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16643
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 341
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 645.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 386
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 544
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5149
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.83
    Marker Score: 269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1826
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.77
    Marker Score: 369
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.75
    Marker Score: 4524
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.72
    Marker Score: 273
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.72
    Marker Score: 2026
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.67
    Marker Score: 188
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.64
    Marker Score: 734
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.61
    Marker Score: 221
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.57
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.53
    Marker Score: 355.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.52
    Marker Score: 498
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.52
    Marker Score: 257
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.51
    Marker Score: 1318
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 132
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.5
    Marker Score: 312
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.48
    Marker Score: 133
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.48
    Marker Score: 18162
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.46
    Marker Score: 210
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.46
    Marker Score: 457
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.45
    Marker Score: 127
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.44
    Marker Score: 243
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.44
    Marker Score: 472
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 632
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 169
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.38
    Marker Score: 453
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.36
    Marker Score: 3714
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.35
    Marker Score: 129
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.34
    Marker Score: 181
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.34
    Marker Score: 231
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.34
    Marker Score: 416
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.32
    Marker Score: 161
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.32
    Marker Score: 1951
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.32
    Marker Score: 205
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.32
    Marker Score: 398
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 561
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.3
    Marker Score: 148

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Other Information

**Key characteristics** * FLT1 is a transmembrane receptor that is expressed in endothelial cells, pericytes, and smooth muscle cells. * It is a member of the VEGF receptor family. * FLT1 is a key regulator of angiogenesis, as it is expressed in high levels in blood vessels and is required for the migration and proliferation of endothelial cells. * It is also involved in the regulation of vascular permeability. **Pathways and functions** * FLT1 signaling is initiated by the binding of VEGF to its receptor, VEGFR1. * This binding triggers a cascade of events that leads to the activation of downstream signaling pathways, including the PI3K/Akt pathway and the MAPK pathway. * These pathways promote the migration and proliferation of endothelial cells, and they also regulate the formation of new blood vessels. * FLT1 signaling is also involved in the regulation of inflammation and fibrosis. **Clinical significance** * Mutations in the FLT1 gene have been linked to a number of human diseases, including cancer, heart disease, and stroke. * In cancer, FLT1 mutations can lead to the growth of tumors by promoting the migration and proliferation of endothelial cells. * Targeting FLT1 signaling has been investigated as a therapeutic strategy for cancer. **Additional information** * The FLT1 gene is located on chromosome 17q25. * It is a large gene, with a length of approximately 23 exons. * The protein encoded by FLT1 is a type I transmembrane receptor. * It is expressed in high levels in endothelial cells, pericytes, and smooth muscle cells.

Genular Protein ID: 391235980

Symbol: VGFR1_HUMAN

Name: Vascular endothelial growth factor receptor 1

UniProtKB Accession Codes:

P17948 A3E342 A3E344 A8KA71 B0LPF1 B2BF46 B2BF47 B2BF48 B3FR89 B5A923 F5H5L6 O60722 P16057 Q12954

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 19 DrugCentral 1 EC 2 EMBL 21 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 12 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 2 RefSeq 4 Rhea 3 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2158038

Title: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

PubMed ID: 2158038

PubMed ID: 8248162

Title: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

PubMed ID: 8248162

DOI: 10.1073/pnas.90.22.10705

PubMed ID: 10471394

Title: Characterization of the VEGF binding site on the Flt-1 receptor.

PubMed ID: 10471394

DOI: 10.1006/bbrc.1999.1282

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 18515749

Title: A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia.

PubMed ID: 18515749

DOI: 10.1161/circresaha.108.171504

PubMed ID: 20512933

Title: A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells.

PubMed ID: 20512933

DOI: 10.1002/jcb.22584

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3040650

Title: A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.

PubMed ID: 3040650

PubMed ID: 9722576

Title: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.

PubMed ID: 9722576

DOI: 10.1074/jbc.273.36.23410

PubMed ID: 7824266

Title: A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

PubMed ID: 7824266

PubMed ID: 8605350

Title: Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1.

PubMed ID: 8605350

PubMed ID: 9299537

Title: The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.

PubMed ID: 9299537

DOI: 10.1006/bbrc.1997.7327

PubMed ID: 9600074

Title: Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

PubMed ID: 9600074

DOI: 10.1006/bbrc.1998.8578

PubMed ID: 11141500

Title: Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells.

PubMed ID: 11141500

DOI: 10.1016/s0002-9440(10)63965-x

PubMed ID: 11513746

Title: Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding.

PubMed ID: 11513746

DOI: 10.1042/0264-6021:3580465

PubMed ID: 11811792

Title: Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor.

PubMed ID: 11811792

DOI: 10.3109/08977190109001086

PubMed ID: 11312102

Title: Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers.

PubMed ID: 11312102

DOI: 10.1016/s1357-2725(01)00019-x

PubMed ID: 14633857

Title: Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.

PubMed ID: 14633857

DOI: 10.2337/diabetes.52.12.2959

PubMed ID: 12796773

Title: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.

PubMed ID: 12796773

DOI: 10.1038/nm884

PubMed ID: 15001553

Title: The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).

PubMed ID: 15001553

DOI: 10.1096/fj.03-0767fje

PubMed ID: 15735759

Title: Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells.

PubMed ID: 15735759

DOI: 10.1038/sj.onc.1208246

PubMed ID: 16685275

Title: Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases.

PubMed ID: 16685275

DOI: 10.1038/sj.bjc.6603143

PubMed ID: 16286478

Title: A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1.

PubMed ID: 16286478

DOI: 10.1074/jbc.m506454200

PubMed ID: 18079407

Title: The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes.

PubMed ID: 18079407

DOI: 10.1161/atvbaha.107.158022

PubMed ID: 18583712

Title: Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.

PubMed ID: 18583712

DOI: 10.1161/circresaha.108.174128

PubMed ID: 20551949

Title: Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement.

PubMed ID: 20551949

DOI: 10.1038/sj.bjc.6605746

PubMed ID: 21212275

Title: RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway.

PubMed ID: 21212275

DOI: 10.1074/jbc.m110.165605

PubMed ID: 22016384

Title: gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.

PubMed ID: 22016384

DOI: 10.1074/jbc.m111.296590

PubMed ID: 21752276

Title: Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis.

PubMed ID: 21752276

DOI: 10.1186/2045-824x-3-15

PubMed ID: 17002866

Title: Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.

PubMed ID: 17002866

DOI: 10.5483/bmbrep.2006.39.5.469

PubMed ID: 18680722

Title: VEGF receptor protein-tyrosine kinases: structure and regulation.

PubMed ID: 18680722

DOI: 10.1016/j.bbrc.2008.07.121

PubMed ID: 19230644

Title: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.

PubMed ID: 19230644

DOI: 10.1016/j.ceb.2008.12.012

PubMed ID: 19761875

Title: Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

PubMed ID: 19761875

DOI: 10.1016/j.bbapap.2009.09.002

PubMed ID: 20127948

Title: Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1).

PubMed ID: 20127948

DOI: 10.1002/cncr.24789

PubMed ID: 21711246

Title: Signal transduction by vascular endothelial growth factor receptors.

PubMed ID: 21711246

DOI: 10.1042/bj20110301

PubMed ID: 21558755

Title: Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia.

PubMed ID: 21558755

DOI: 10.2183/pjab.87.167

PubMed ID: 9393862

Title: Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.

PubMed ID: 9393862

DOI: 10.1016/s0092-8674(00)80456-0

PubMed ID: 10543948

Title: Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.

PubMed ID: 10543948

DOI: 10.1006/jmbi.1999.3134

PubMed ID: 14684734

Title: The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.

PubMed ID: 14684734

DOI: 10.1074/jbc.m313237200

PubMed ID: 20501651

Title: Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity.

PubMed ID: 20501651

DOI: 10.1074/jbc.m110.130658

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1338
  • Mass: 150769
  • Checksum: FF3381EEFAF0787C
  • Sequence:
    • MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK 
WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET 
ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD 
GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV 
KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK 
MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK 
AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA 
TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC 
DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK 
VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM 
HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRDQEA 
PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK IQQEPGIILG PGSSTLFIER 
VTEEDEGVYH CKATNQKGSV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI 
RKMKRSSSEI KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK 
VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK 
QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE QGKKPRLDSV 
TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI SYSFQVARGM EFLSSRKCIH 
RDLAARNILL SENNVVKICD FGLARDIYKN PDYVRKGDTR LPLKWMAPES IFDKIYSTKS 
DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD 
PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA 
PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL ASPMLKRFTW 
TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV SEGKRRFTYD HAELERKIAC 
CSPPPDYNSV VLYSTPPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.