Details for: SNCG

Gene ID: 6623

Symbol: SNCG

Ensembl ID: ENSG00000173267

Description: synuclein gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.1462
    Cell Significance Index: -26.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 12.8974
    Cell Significance Index: 669.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 12.8467
    Cell Significance Index: 107.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 12.2797
    Cell Significance Index: 113.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.7142
    Cell Significance Index: 457.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 7.6752
    Cell Significance Index: 205.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.3050
    Cell Significance Index: 652.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.2501
    Cell Significance Index: 946.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.0542
    Cell Significance Index: 89.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7939
    Cell Significance Index: 31.7400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.9614
    Cell Significance Index: 22.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6303
    Cell Significance Index: 8.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4463
    Cell Significance Index: 10.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3543
    Cell Significance Index: 9.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3431
    Cell Significance Index: 44.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2785
    Cell Significance Index: 55.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1802
    Cell Significance Index: 124.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0944
    Cell Significance Index: 6.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0884
    Cell Significance Index: 0.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0665
    Cell Significance Index: 23.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0520
    Cell Significance Index: 23.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0051
    Cell Significance Index: 2.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0042
    Cell Significance Index: 6.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0017
    Cell Significance Index: 1.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0143
    Cell Significance Index: -26.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0215
    Cell Significance Index: -2.5000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0249
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0249
    Cell Significance Index: -33.9000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0259
    Cell Significance Index: -0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0282
    Cell Significance Index: -3.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0353
    Cell Significance Index: -22.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0356
    Cell Significance Index: -26.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0454
    Cell Significance Index: -33.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0490
    Cell Significance Index: -30.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0591
    Cell Significance Index: -33.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0600
    Cell Significance Index: -27.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0774
    Cell Significance Index: -22.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0858
    Cell Significance Index: -12.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1331
    Cell Significance Index: -26.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1363
    Cell Significance Index: -10.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1370
    Cell Significance Index: -6.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1515
    Cell Significance Index: -15.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1534
    Cell Significance Index: -3.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1546
    Cell Significance Index: -21.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1757
    Cell Significance Index: -37.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1824
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1932
    Cell Significance Index: -32.9900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2086
    Cell Significance Index: -2.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2295
    Cell Significance Index: -27.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2411
    Cell Significance Index: -3.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2412
    Cell Significance Index: -13.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2628
    Cell Significance Index: -20.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2750
    Cell Significance Index: -31.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2889
    Cell Significance Index: -18.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2914
    Cell Significance Index: -17.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2934
    Cell Significance Index: -13.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3064
    Cell Significance Index: -31.9000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3383
    Cell Significance Index: -4.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3616
    Cell Significance Index: -4.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3743
    Cell Significance Index: -10.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3780
    Cell Significance Index: -19.6900
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3912
    Cell Significance Index: -3.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3925
    Cell Significance Index: -26.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4291
    Cell Significance Index: -26.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4398
    Cell Significance Index: -33.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5020
    Cell Significance Index: -13.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5139
    Cell Significance Index: -25.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5150
    Cell Significance Index: -18.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5293
    Cell Significance Index: -15.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5476
    Cell Significance Index: -22.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5619
    Cell Significance Index: -12.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5847
    Cell Significance Index: -15.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5853
    Cell Significance Index: -26.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5969
    Cell Significance Index: -15.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6137
    Cell Significance Index: -12.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6776
    Cell Significance Index: -21.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6853
    Cell Significance Index: -29.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6875
    Cell Significance Index: -17.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6995
    Cell Significance Index: -30.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7021
    Cell Significance Index: -25.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7167
    Cell Significance Index: -8.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7171
    Cell Significance Index: -24.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7291
    Cell Significance Index: -17.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7371
    Cell Significance Index: -21.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7389
    Cell Significance Index: -24.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7636
    Cell Significance Index: -12.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7707
    Cell Significance Index: -11.7100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7930
    Cell Significance Index: -16.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7984
    Cell Significance Index: -21.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8168
    Cell Significance Index: -30.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8371
    Cell Significance Index: -13.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8430
    Cell Significance Index: -22.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8991
    Cell Significance Index: -22.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9047
    Cell Significance Index: -26.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9297
    Cell Significance Index: -23.1900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.9377
    Cell Significance Index: -10.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9377
    Cell Significance Index: -32.9500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.9474
    Cell Significance Index: -11.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SNCG is primarily expressed in the nervous system, with significant levels detected in respiratory basal cells, glycinergic neurons, and kidney interstitial cells. 2. **Protein Structure:** SNCG is a small, cytoplasmic protein consisting of 96 amino acids, with a predicted molecular weight of approximately 11 kDa. 3. **Cellular Localization:** SNCG is predominantly localized to the cytoplasm and perinuclear region, where it interacts with various cellular components, including proteins, lipids, and nucleic acids. **Pathways and Functions:** 1. **Regulation of Dopamine Secretion:** SNCG has been shown to regulate dopamine secretion in neurons, suggesting a potential role in the pathophysiology of neurological disorders, such as Parkinson's disease. 2. **Axon Terminus Formation:** SNCG is involved in the formation and maintenance of axon terminals, a process critical for neuronal development and function. 3. **Synaptic Organization:** SNCG interacts with other synaptic proteins to regulate synaptic organization and plasticity, which are essential for learning and memory. 4. **Cytoplasmic Protein Interactions:** SNCG interacts with various cytoplasmic proteins, including actin-binding proteins, tubulin, and microtubule-associated proteins, to regulate cytoskeletal dynamics and cellular motility. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of SNCG has been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). 2. **Respiratory Diseases:** SNCG expression has been linked to respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, where it may play a role in airway inflammation and remodeling. 3. **Cancer:** SNCG has been detected in various types of cancer, including kidney cancer, bladder cancer, and lung cancer, where it may contribute to tumorigenesis and metastasis. 4. **Immunological Implications:** SNCG has been shown to interact with immune cells, including T cells and macrophages, suggesting a potential role in immune regulation and modulation. In conclusion, SNCG is a multifunctional protein with a wide range of cellular and clinical implications. Further research is needed to fully elucidate the mechanisms by which SNCG regulates various cellular processes and its role in disease pathogenesis. As an expert immunologist, I believe that SNCG is an exciting area of study, with significant potential for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 13687403

Symbol: SYUG_HUMAN

Name: Gamma-synuclein

UniProtKB Accession Codes:

O76070 O15104 Q96P61

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 5 CPTC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9044857

Title: Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.

PubMed ID: 9044857

PubMed ID: 9700196

Title: Organization, expression and polymorphism of the human persyn gene.

PubMed ID: 9700196

DOI: 10.1093/hmg/7.9.1417

PubMed ID: 9737786

Title: Identification, localization and characterization of the human gamma-synuclein gene.

PubMed ID: 9737786

DOI: 10.1007/s004390050792

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10852916

Title: Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

PubMed ID: 10852916

DOI: 10.1074/jbc.m003542200

PubMed ID: 11746666

Title: Gamma synuclein: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction.

PubMed ID: 11746666

DOI: 10.1002/cm.1035

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 127
  • Mass: 13331
  • Checksum: F183DEF302DBE688
  • Sequence:
    • MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK 
EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGE ASKEKEEVAE 
EAQSGGD

Genular Protein ID: 2765255275

Symbol: F8W754_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W754

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 126
  • Mass: 13125
  • Checksum: 023E55773AF1696B
  • Sequence:
    • MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSGLPWGW 
GWGGGQPVSS HSGREDQGAG QRRERGCGEQ RQHCGHQDRG GGGEHRGHLR GGAQGGLEAI 
CPPTGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.