Details for: CX3CL1

Gene ID: 6376

Symbol: CX3CL1

Ensembl ID: ENSG00000006210

Description: C-X3-C motif chemokine ligand 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.0480
    Cell Significance Index: -20.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.8792
    Cell Significance Index: -19.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1644
    Cell Significance Index: -19.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9901
    Cell Significance Index: 43.1200
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 1.7950
    Cell Significance Index: 6.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4043
    Cell Significance Index: 181.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3662
    Cell Significance Index: 101.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2227
    Cell Significance Index: 232.6900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.0464
    Cell Significance Index: 6.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9354
    Cell Significance Index: 25.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8773
    Cell Significance Index: 86.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8485
    Cell Significance Index: 39.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8382
    Cell Significance Index: 168.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7179
    Cell Significance Index: 648.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5383
    Cell Significance Index: 15.3600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.4893
    Cell Significance Index: 6.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4675
    Cell Significance Index: 31.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4626
    Cell Significance Index: 20.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4471
    Cell Significance Index: 7.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4359
    Cell Significance Index: 70.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3827
    Cell Significance Index: 14.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3703
    Cell Significance Index: 45.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3252
    Cell Significance Index: 64.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3075
    Cell Significance Index: 33.4500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3030
    Cell Significance Index: 3.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2967
    Cell Significance Index: 106.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2964
    Cell Significance Index: 131.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2543
    Cell Significance Index: 13.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2167
    Cell Significance Index: 1.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1972
    Cell Significance Index: 107.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1945
    Cell Significance Index: 35.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1664
    Cell Significance Index: 1.8900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1460
    Cell Significance Index: 1.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1146
    Cell Significance Index: 5.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1071
    Cell Significance Index: 1.5400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0825
    Cell Significance Index: 1.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0612
    Cell Significance Index: 7.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0488
    Cell Significance Index: 1.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0481
    Cell Significance Index: 6.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0413
    Cell Significance Index: 25.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0235
    Cell Significance Index: 1.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0173
    Cell Significance Index: 11.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0102
    Cell Significance Index: 4.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0069
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0006
    Cell Significance Index: -0.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0034
    Cell Significance Index: -0.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0057
    Cell Significance Index: -0.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0062
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0115
    Cell Significance Index: -21.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0146
    Cell Significance Index: -22.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0172
    Cell Significance Index: -23.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0293
    Cell Significance Index: -1.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0497
    Cell Significance Index: -2.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0548
    Cell Significance Index: -7.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0605
    Cell Significance Index: -17.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0617
    Cell Significance Index: -13.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0637
    Cell Significance Index: -0.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0668
    Cell Significance Index: -7.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0800
    Cell Significance Index: -8.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0942
    Cell Significance Index: -12.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1050
    Cell Significance Index: -11.9800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1128
    Cell Significance Index: -0.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1251
    Cell Significance Index: -2.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1578
    Cell Significance Index: -3.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1622
    Cell Significance Index: -9.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1664
    Cell Significance Index: -5.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1860
    Cell Significance Index: -19.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1897
    Cell Significance Index: -11.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2041
    Cell Significance Index: -6.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2226
    Cell Significance Index: -6.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2443
    Cell Significance Index: -19.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2540
    Cell Significance Index: -19.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2624
    Cell Significance Index: -8.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2897
    Cell Significance Index: -6.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3124
    Cell Significance Index: -17.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3127
    Cell Significance Index: -19.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3201
    Cell Significance Index: -6.3300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.3242
    Cell Significance Index: -2.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3411
    Cell Significance Index: -7.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3497
    Cell Significance Index: -7.0200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3525
    Cell Significance Index: -4.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3663
    Cell Significance Index: -10.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3680
    Cell Significance Index: -6.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3744
    Cell Significance Index: -9.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3854
    Cell Significance Index: -13.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3982
    Cell Significance Index: -6.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3999
    Cell Significance Index: -9.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4089
    Cell Significance Index: -11.7200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4273
    Cell Significance Index: -5.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4305
    Cell Significance Index: -15.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4326
    Cell Significance Index: -10.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4350
    Cell Significance Index: -6.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CX3CL1 is a small-inducible cytokine D1 (SICD1) chemokine that belongs to the CXC chemokine family. It is characterized by its unique structure, which features a C-terminal cysteine motif and a N-terminal domain rich in charged amino acids. CX3CL1 is expressed in various cell types, including endothelial cells, immune cells, and epithelial cells, and is involved in several signaling pathways, including the GPCR signaling pathway and the NF-κB pathway. **Pathways and Functions** CX3CL1 is involved in various cellular processes, including: 1. **Angiogenesis**: CX3CL1 promotes angiogenesis by binding to its receptor, CX3CR1, on endothelial cells, which stimulates the migration and proliferation of these cells. 2. **Immune responses**: CX3CL1 acts as a chemoattractant for immune cells, including T cells, B cells, and dendritic cells, which facilitates their migration to sites of inflammation. 3. **Cell-cell signaling**: CX3CL1 interacts with its receptors on adjacent cells to modulate cell-cell adhesion, migration, and signaling. 4. **Inflammatory responses**: CX3CL1 is involved in the regulation of inflammatory responses by modulating the activity of immune cells and endothelial cells. 5. **Cellular homeostasis**: CX3CL1 helps maintain tissue homeostasis by regulating the function of endothelial cells, immune cells, and epithelial cells. **Clinical Significance** CX3CL1 has been implicated in various diseases, including: 1. **Atherosclerosis**: CX3CL1 is involved in the development of atherosclerosis by promoting the migration and proliferation of endothelial cells. 2. **Cancer**: CX3CL1 has been shown to promote tumor growth and metastasis by facilitating the migration and proliferation of cancer cells. 3. **Neurological disorders**: CX3CL1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by regulating the function of immune cells and endothelial cells in the brain. 4. **Infectious diseases**: CX3CL1 has been shown to play a role in the pathogenesis of infectious diseases, such as tuberculosis, by modulating the activity of immune cells. In conclusion, CX3CL1 is a multifunctional chemokine that plays a crucial role in maintaining tissue homeostasis and responding to injury or inflammation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its complex functions and signaling pathways. Further research is needed to elucidate the mechanisms by which CX3CL1 regulates cellular processes and to explore its therapeutic potential in treating diseases associated with its dysregulation.

Genular Protein ID: 938967506

Symbol: X3CL1_HUMAN

Name: Small-inducible cytokine D1

UniProtKB Accession Codes:

P78423 O00672

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 79 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9177350

Title: Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.

PubMed ID: 9177350

DOI: 10.1038/42491

PubMed ID: 9024663

Title: A new class of membrane-bound chemokine with a CX3C motif.

PubMed ID: 9024663

DOI: 10.1038/385640a0

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9782118

Title: Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.

PubMed ID: 9782118

DOI: 10.1084/jem.188.8.1413

PubMed ID: 12055230

Title: Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression.

PubMed ID: 12055230

DOI: 10.4049/jimmunol.168.12.6173

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23125415

Title: Integrins alphavbeta3 and alpha4beta1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.

PubMed ID: 23125415

DOI: 10.4049/jimmunol.1200889

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 24789099

Title: The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

PubMed ID: 24789099

DOI: 10.1371/journal.pone.0096372

PubMed ID: 27653778

Title: Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1.

PubMed ID: 27653778

DOI: 10.1038/srep33786

PubMed ID: 9931005

Title: Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.

PubMed ID: 9931005

DOI: 10.1021/bi9820614

PubMed ID: 10770945

Title: The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.

PubMed ID: 10770945

DOI: 10.1074/jbc.m002584200

PubMed ID: 21829356

Title: Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor.

PubMed ID: 21829356

DOI: 10.1371/journal.ppat.1002162

PubMed ID: 25745166

Title: Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.

PubMed ID: 25745166

DOI: 10.1126/science.aaa5026

PubMed ID: 29882741

Title: Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

PubMed ID: 29882741

DOI: 10.7554/elife.35850

Sequence Information:

  • Length: 397
  • Mass: 42203
  • Checksum: BAC71F5080DF9CA6
  • Sequence:
    • MAPISLSWLL RLATFCHLTV LLAGQHHGVT KCNITCSKMT SKIPVALLIH YQQNQASCGK 
RAIILETRQH RLFCADPKEQ WVKDAMQHLD RQAAALTRNG GTFEKQIGEV KPRTTPAAGG 
MDESVVLEPE ATGESSSLEP TPSSQEAQRA LGTSPELPTG VTGSSGTRLP PTPKAQDGGP 
VGTELFRVPP VSTAATWQSS APHQPGPSLW AEAKTSEAPS TQDPSTQAST ASSPAPEENA 
PSEGQRVWGQ GQSPRPENSL EREEMGPVPA HTDAFQDWGP GSMAHVSVVP VSSEGTPSRE 
PVASGSWTPK AEEPIHATMD PQRLGVLITP VPDAQAATRR QAVGLLAFLG LLFCLGVAMF 
TYQSLQGCPR KMAGEMAEGL RYIPRSCGSN SYVLVPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.