Details for: FAM167B

Gene ID: 84734

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: FAM167B

Ensembl ID: ENSG00000183615

Description: family with sequence similarity 167 member B

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • vasa recta ascending limb cell CL1001131
    CSI 8.84
    rCSI 39.99%
    PRS 93.4
  • retinal blood vessel endothelial cell CL0002585
    CSI 6.54
    rCSI 10.44%
    PRS 91.68
  • endothelial cell of placenta CL0009092
    CSI 5.34
    rCSI 26.33%
    PRS 93.27
  • pulmonary capillary endothelial cell CL4028001
    CSI 4.5
    rCSI 8.57%
    PRS 94.86
  • blood vessel endothelial cell CL0000071
    CSI 3.29
    rCSI 6.82%
    PRS 87.27
  • endothelial cell of uterus CL0009095
    CSI 2.86
    rCSI 20.93%
    PRS 93.89
  • collagen secreting cell CL0000667
    CSI 2.26
    rCSI 12.97%
    PRS 92.67
  • lung endothelial cell CL1001567
    CSI 1.94
    rCSI 4.51%
    PRS 95.2
  • prostate gland microvascular endothelial cell CL2000059
    CSI 1.33
    rCSI 31.7%
    PRS 92.98
  • type EC enteroendocrine cell CL0000577
    CSI 1.13
    rCSI 4%
    PRS 90.55
  • vasa recta descending limb cell CL1001285
    CSI 0.8
    rCSI 6.39%
    PRS 93.39
  • lung microvascular endothelial cell CL2000016
    CSI 0.45
    rCSI 8.7%
    PRS 93.71

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [FAM167B](/details-gene/84734) (Family With Sequence Similarity 167 Member B) is a protein-coding gene located on human chromosome 1p35.2. It was identified and annotated through large-scale genomic and cDNA sequencing efforts [Link](https://doi.org/10.1038/nature04727), [Link](https://doi.org/10.1101/gr.2596504). Based on expression data, [FAM167B](/details-gene/84734) shows a distinct expression pattern, with its highest significance observed in specialized endothelial cells and cells of the kidney's vasa recta. This suggests a primary role in vascular biology and renal physiology, particularly in microenvironments requiring specialized transport or barrier functions. ## Cellular Roles and Expression Landscape The **Overall** expression profile of [FAM167B](/details-gene/84734) strongly indicates a specialized role within the vasculature and renal system. The gene's most significant expression is in the [vasa recta ascending limb cell](/details-cell/CL1001131) (CSI: 8.84), a key component of the kidney's countercurrent exchange system responsible for maintaining the medullary osmotic gradient. Beyond the kidney, [FAM167B](/details-gene/84734) is a prominent marker across various endothelial cell populations. It is highly significant in the [retinal blood vessel endothelial cell](/details-cell/CL0002585), [endothelial cell of placenta](/details-cell/CL0009092), and [pulmonary capillary endothelial cell](/details-cell/CL4028001). This consistent high expression in diverse microvascular beds suggests its involvement in fundamental, yet potentially tissue-specific, endothelial functions rather than being a pan-endothelial marker. Its presence in [collagen secreting cell](/details-cell/CL0000667)s also hints at a possible role in extracellular matrix interactions or tissue structure. The collective data portrays [FAM167B](/details-gene/84734) as a gene associated with specialized vascular and epithelial transport systems. ## Pathways and Molecular Function Based on the provided data, detailed functional annotations for [FAM167B](/details-gene/84734) are not available. Its classification as 'family with sequence similarity 167 member B' indicates its membership in a gene family with a yet-to-be-elucidated molecular function. The strong and specific expression pattern in endothelial and renal cells provides the primary clues to its biological relevance, pointing towards potential roles in cell adhesion, solute transport, or the maintenance of specialized biological barriers. ## Research Directions The specific expression pattern of [FAM167B](/details-gene/84734) makes it a compelling subject for further investigation, particularly concerning its role in renal and vascular physiology. ### Proposed Hypotheses 1. **[FAM167B](/details-gene/84734) is essential for maintaining the renal medullary osmotic gradient.** Given its top expression in the [vasa recta ascending limb cell](/details-cell/CL1001131), it may function as a transporter, channel, or signaling molecule critical for the countercurrent exchange mechanism that concentrates urine. 2. **[FAM167B](/details-gene/84734) contributes to the integrity and function of specialized vascular barriers.** Its high expression in endothelial cells of the retina and lung suggests a role in regulating the selective permeability of the blood-retina barrier or facilitating efficient gas exchange in pulmonary capillaries. ### Key Experiment To test the hypothesis that [FAM167B](/details-gene/84734) is critical for renal function, a conditional knockout mouse model would be highly informative. By crossing a floxed *Fam167b* allele mouse with a mouse line expressing Cre recombinase under an endothelial-specific or vasa recta-specific promoter (e.g., driven by Slc14a1), one could specifically delete the gene in the target cells. The resulting mice could be subjected to metabolic cage analysis to assess urine volume and osmolality under normal hydration and following water deprivation. A failure to properly concentrate urine in the knockout mice would provide strong evidence for the gene's essential role in renal medullary function. ### Therapeutic Potential The highly specific expression of [FAM167B](/details-gene/84734) in distinct vascular beds, such as the kidney and retina, suggests it could be a potential therapeutic target. If the FAM167B protein is located on the cell surface, it could be exploited for targeted drug delivery to these tissues. In diseases characterized by vascular dysfunction, such as diabetic nephropathy or retinopathy, modulating FAM167B activity could be a viable strategy. However, without a clear understanding of its molecular function, it is premature to determine whether inhibition or activation would be the desired therapeutic approach. Further research is required to validate its role in pathology and assess its druggability.

Genular Protein ID: 1307714557

Symbol: F167B_HUMAN

Name: Protein FAM167B

UniProtKB Accession Codes:

Q9BTA0 Q5TDH6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 163
  • Mass: 18414
  • Checksum: 7C1F3BF627C4DB60
  • Sequence:
    • MSLGLLKFQA VGEEDEEDEE GESLDSVKAL TAKLQLQTRR PSYLEWTAQV QSQAWRRAQA 
KPGPGGPGDI CGFDSMDSAL EWLRRELREM QAQDRQLAGQ LLRLRAQLHR LKMDQACHLH 
QELLDEAELE LELEPGAGLA LAPLLRHLGL TRMNISARRF TLC