Details for: IPO11

Gene ID: 51194

Symbol: IPO11

Ensembl ID: ENSG00000086200

Description: importin 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.1966
    Cell Significance Index: -25.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.7286
    Cell Significance Index: -23.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.1155
    Cell Significance Index: -28.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.0791
    Cell Significance Index: -21.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.1581
    Cell Significance Index: -22.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9473
    Cell Significance Index: -27.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8773
    Cell Significance Index: -26.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0455
    Cell Significance Index: -21.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9208
    Cell Significance Index: -27.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8805
    Cell Significance Index: -12.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7571
    Cell Significance Index: 352.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5418
    Cell Significance Index: 1066.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0158
    Cell Significance Index: 100.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9272
    Cell Significance Index: 19.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8748
    Cell Significance Index: 173.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7978
    Cell Significance Index: 17.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7035
    Cell Significance Index: 635.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6546
    Cell Significance Index: 15.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6505
    Cell Significance Index: 49.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6285
    Cell Significance Index: 35.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6088
    Cell Significance Index: 37.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5809
    Cell Significance Index: 39.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5770
    Cell Significance Index: 21.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5697
    Cell Significance Index: 92.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5685
    Cell Significance Index: 203.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5488
    Cell Significance Index: 15.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5230
    Cell Significance Index: 56.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5227
    Cell Significance Index: 23.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5055
    Cell Significance Index: 13.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3799
    Cell Significance Index: 22.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3652
    Cell Significance Index: 10.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3120
    Cell Significance Index: 8.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2072
    Cell Significance Index: 113.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1950
    Cell Significance Index: 13.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1841
    Cell Significance Index: 21.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1450
    Cell Significance Index: 3.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1402
    Cell Significance Index: 4.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1258
    Cell Significance Index: 0.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1121
    Cell Significance Index: 20.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1091
    Cell Significance Index: 13.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0952
    Cell Significance Index: 4.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0810
    Cell Significance Index: 152.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0660
    Cell Significance Index: 1.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0449
    Cell Significance Index: 8.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0395
    Cell Significance Index: 25.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0394
    Cell Significance Index: 72.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0383
    Cell Significance Index: 1.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0362
    Cell Significance Index: 16.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0337
    Cell Significance Index: 51.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0241
    Cell Significance Index: 10.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0239
    Cell Significance Index: 0.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0174
    Cell Significance Index: 0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0122
    Cell Significance Index: 16.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0198
    Cell Significance Index: -2.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0223
    Cell Significance Index: -3.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0229
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0269
    Cell Significance Index: -19.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0327
    Cell Significance Index: -24.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0478
    Cell Significance Index: -29.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0479
    Cell Significance Index: -27.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0481
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0518
    Cell Significance Index: -8.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0598
    Cell Significance Index: -2.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0746
    Cell Significance Index: -4.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0788
    Cell Significance Index: -22.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0800
    Cell Significance Index: -9.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1030
    Cell Significance Index: -10.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1194
    Cell Significance Index: -15.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1383
    Cell Significance Index: -29.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1450
    Cell Significance Index: -2.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1538
    Cell Significance Index: -19.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1642
    Cell Significance Index: -2.2400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1687
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1776
    Cell Significance Index: -18.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1784
    Cell Significance Index: -2.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1820
    Cell Significance Index: -3.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1874
    Cell Significance Index: -21.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1979
    Cell Significance Index: -9.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2117
    Cell Significance Index: -13.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2346
    Cell Significance Index: -4.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2510
    Cell Significance Index: -17.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2532
    Cell Significance Index: -6.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2676
    Cell Significance Index: -8.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2691
    Cell Significance Index: -20.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2968
    Cell Significance Index: -6.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2998
    Cell Significance Index: -23.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3089
    Cell Significance Index: -4.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3194
    Cell Significance Index: -19.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3221
    Cell Significance Index: -10.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3473
    Cell Significance Index: -11.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4150
    Cell Significance Index: -21.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4263
    Cell Significance Index: -8.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4277
    Cell Significance Index: -4.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4398
    Cell Significance Index: -8.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4719
    Cell Significance Index: -16.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4876
    Cell Significance Index: -17.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5129
    Cell Significance Index: -13.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5179
    Cell Significance Index: -11.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IPO11 is a small GTPase-binding protein that functions as a nuclear import receptor, facilitating the transport of proteins and RNAs into the nucleus. Its structure consists of a conserved importin domain, which interacts with specific nuclear localization signals (NLS) and nuclear export signals (NES) to regulate the nuclear import of target proteins. IPO11 is highly expressed in cells that undergo rapid proliferation and differentiation, such as hematopoietic cells, stem cells, and immune cells. **Pathways and Functions:** IPO11 is involved in various cellular pathways, including: 1. **Nuclear import**: IPO11 mediates the transport of proteins and RNAs into the nucleus, regulating gene expression and cellular processes such as proliferation and differentiation. 2. **Ribosomal protein import into nucleus**: IPO11 is essential for the nuclear import of ribosomal proteins, which are critical for protein synthesis and cell growth. 3. **Protein binding**: IPO11 interacts with various proteins, including transcription factors and signaling molecules, to regulate their activity and localization. 4. **GTPase binding**: IPO11 binds to GTPases, such as Ras and Rab, to regulate their activity and localization. **Clinical Significance:** IPO11 has been implicated in various diseases and disorders, including: 1. **Immunodeficiency**: IPO11 is expressed in immune cells, and its dysfunction has been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: IPO11 is overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurological disorders**: IPO11 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to neuronal dysfunction. In conclusion, IPO11 is a multifunctional protein that plays a crucial role in nuclear import, protein regulation, and cellular processes. Its dysregulation has been linked to various diseases and disorders, highlighting the importance of IPO11 in immunology and cell biology. Further research is necessary to fully elucidate the mechanisms underlying IPO11 function and its role in human health and disease.

Genular Protein ID: 3152308519

Symbol: IPO11_HUMAN

Name: Importin-11

UniProtKB Accession Codes:

Q9UI26 A6NGJ5 B4DZ73 D3DW98 Q8N5R2 Q9NSJ6 Q9NVB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11032817

Title: Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2.

PubMed ID: 11032817

DOI: 10.1093/emboj/19.20.5502

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 975
  • Mass: 112535
  • Checksum: 6A9349B2F8F36DF9
  • Sequence:
    • MDLNSASTVV LQVLTQATSQ DTAVLKPAEE QLKQWETQPG FYSVLLNIFT NHTLDINVRW 
LAVLYFKHGI DRYWRRVAPH ALSEEEKTTL RAGLITNFNE PINQIATQIA VLIAKVARLD 
CPRQWPELIP TLIESVKVQD DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYNF 
ACSLWNHHTD TFLQEVSSGN EAAILSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH 
GIFERLKQFL ECSRSIGTDN VCRDRLEKTI ILFTKVLLDF LDQHPFSFTP LIQRSLEFSV 
SYVFTEVGEG VTFERFIVQC MNLIKMIVKN YAYKPSKNFE DSSPETLEAH KIKMAFFTYP 
TLTEICRRLV SHYFLLTEEE LTMWEEDPEG FTVEETGGDS WKYSLRPCTE VLFIDIFHEY 
NQTLTPVLLE MMQTLQGPTN VEDMNALLIK DAVYNAVGLA AYELFDSVDF DQWFKNQLLP 
ELQVIHNRYK PLRRRVIWLI GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK 
LTVDDFEFRT DQFLPYLETM FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNMQIRPYVG 
CLVQYLPLLW KQSEEHNMLR CAILTTLIHL VQGLGADSKN LYPFLLPVIQ LSTDVSQPPH 
VYLLEDGLEL WLVTLENSPC ITPELLRIFQ NMSPLLELSS ENLRTCFKII NGYIFLSSTE 
FLQTYAVGLC QSFCELLKEI TTEGQVQVLK VVENALKVNP ILGPQMFQPI LPYVFKGIIE 
GERYPVVMST YLGVMGRVLL QNTSFFSSLL NEMAHKFNQE MDQLLGNMIE MWVDRMDNIT 
QPERRKLSAL ALLSLLPSDN SVIQDKFCGI INISVEGLHD VMTEDPETGT YKDCMLMSHL 
EEPKVTEDEE PPTEQDKRKK MLALKDPVHT VSLQQFIYEK LKAQQEMLGE QGFQSLMETV 
DTEIVTQLQE FLQGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.