CCL2 | ENSG00000108691 | NCBI 6347

Details for: CCL2

Gene ID: 6347

Symbol: CCL2

Ensembl ID: ENSG00000108691

Description: C-C motif chemokine ligand 2

Associated with

Atf4 activates genes in response to endoplasmic reticulum stress
(R-HSA-380994)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Nfe2l2 regulating inflammation associated genes
(R-HSA-9818026)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Peptide ligand-binding receptors
(R-HSA-375276)
Perk regulates gene expression
(R-HSA-381042)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Unfolded protein response (upr)
(R-HSA-381119)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Astrocyte cell migration
(GO:0043615)
Ccr2 chemokine receptor binding
(GO:0031727)
Ccr chemokine receptor binding
(GO:0048020)
Cell adhesion
(GO:0007155)
Cell surface receptor signaling pathway
(GO:0007166)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cellular homeostasis
(GO:0019725)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoskeleton organization
(GO:0007010)
Eosinophil chemotaxis
(GO:0048245)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Helper t cell extravasation
(GO:0035684)
Humoral immune response
(GO:0006959)
Inflammatory response
(GO:0006954)
Macrophage chemotaxis
(GO:0048246)
Monocyte chemotaxis
(GO:0002548)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of natural killer cell chemotaxis
(GO:2000502)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of vascular endothelial cell proliferation
(GO:1905563)
Positive regulation of apoptotic cell clearance
(GO:2000427)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of nmda glutamate receptor activity
(GO:1904783)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of t cell activation
(GO:0050870)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Regulation of cell shape
(GO:0008360)
Response to bacterium
(GO:0009617)
Sensory perception of pain
(GO:0019233)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Viral genome replication
(GO:0019079)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 230.2867
Cell Significance Index: -35.8200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 141.3007
Cell Significance Index: -35.8400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 94.9878
Cell Significance Index: -39.1300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 74.5357
Cell Significance Index: -35.1900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 69.7342
Cell Significance Index: -28.3300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 29.8981
Cell Significance Index: -28.5500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 29.0359
Cell Significance Index: -35.8000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 15.2060
Cell Significance Index: 268.7100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.8494
Cell Significance Index: -34.9200
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 6.4240
Cell Significance Index: 19.1100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 6.2378
Cell Significance Index: 178.8100
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 5.3178
Cell Significance Index: 25.3300
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.4019
Cell Significance Index: 14.8600
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.3364
Cell Significance Index: 16.7800
Cell Name: decidual cell (CL2000002)
Fold Change: 2.0943
Cell Significance Index: 33.6000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.8887
Cell Significance Index: 98.3800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.7562
Cell Significance Index: 36.7600
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 1.7447
Cell Significance Index: 6.5000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0278
Cell Significance Index: 48.3100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9126
Cell Significance Index: 116.9900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8609
Cell Significance Index: 13.3200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8506
Cell Significance Index: 109.9000
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.7580
Cell Significance Index: 12.4900
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.6340
Cell Significance Index: 5.1700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4901
Cell Significance Index: 13.3400
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.4808
Cell Significance Index: 2.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.3833
Cell Significance Index: 55.7200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.3807
Cell Significance Index: 2.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3585
Cell Significance Index: 26.7200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3560
Cell Significance Index: 157.4100
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.2557
Cell Significance Index: 2.2700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1866
Cell Significance Index: 2.1200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0792
Cell Significance Index: 10.8800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0021
Cell Significance Index: 1.1300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0012
Cell Significance Index: -0.9300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0030
Cell Significance Index: -0.5200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0058
Cell Significance Index: -4.3200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0123
Cell Significance Index: -6.9400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0131
Cell Significance Index: -0.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0166
Cell Significance Index: -31.1800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0225
Cell Significance Index: -41.5800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0255
Cell Significance Index: -15.9500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0271
Cell Significance Index: -41.6500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0315
Cell Significance Index: -42.8000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0337
Cell Significance Index: -21.3900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0391
Cell Significance Index: -28.6500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0490
Cell Significance Index: -2.4800
Cell Name: peg cell (CL4033014)
Fold Change: -0.0623
Cell Significance Index: -1.4400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0726
Cell Significance Index: -15.2900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0750
Cell Significance Index: -34.0600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0788
Cell Significance Index: -3.2300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0840
Cell Significance Index: -9.6300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0956
Cell Significance Index: -9.7700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0990
Cell Significance Index: -28.4800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1053
Cell Significance Index: -37.7800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1238
Cell Significance Index: -14.4300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1468
Cell Significance Index: -26.4700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1521
Cell Significance Index: -18.7000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1587
Cell Significance Index: -31.4900
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.1729
Cell Significance Index: -1.9100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1789
Cell Significance Index: -35.8800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1845
Cell Significance Index: -13.0500
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.1873
Cell Significance Index: -1.9900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2161
Cell Significance Index: -6.0400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2172
Cell Significance Index: -24.7900
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.2353
Cell Significance Index: -2.7100
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2655
Cell Significance Index: -2.2300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2822
Cell Significance Index: -4.8400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2916
Cell Significance Index: -34.3900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3187
Cell Significance Index: -24.4600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3929
Cell Significance Index: -31.1200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4142
Cell Significance Index: -11.0600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5170
Cell Significance Index: -13.2900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5266
Cell Significance Index: -32.3700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5689
Cell Significance Index: -38.2500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5723
Cell Significance Index: -35.0900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5754
Cell Significance Index: -36.2700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6201
Cell Significance Index: -32.5600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.6222
Cell Significance Index: -11.5000
Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.6812
Cell Significance Index: -2.8400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7128
Cell Significance Index: -40.0000
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.7252
Cell Significance Index: -4.5400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7333
Cell Significance Index: -34.1900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7431
Cell Significance Index: -27.2800
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7578
Cell Significance Index: -14.7900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7780
Cell Significance Index: -20.8100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7796
Cell Significance Index: -40.5000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8344
Cell Significance Index: -29.0000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.8463
Cell Significance Index: -9.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8644
Cell Significance Index: -22.7300
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.9235
Cell Significance Index: -10.0800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.9512
Cell Significance Index: -13.8100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.9627
Cell Significance Index: -23.3200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.9957
Cell Significance Index: -24.8700
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.9987
Cell Significance Index: -13.6800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9999
Cell Significance Index: -29.4500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.0351
Cell Significance Index: -36.2600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0609
Cell Significance Index: -33.9800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.1417
Cell Significance Index: -33.5300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.1550
Cell Significance Index: -36.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Chemotactic properties:** CCL2 is a potent chemotactic agent that attracts monocytes, macrophages, and T cells to sites of inflammation. 2. **Inducible expression:** CCL2 expression is induced in response to inflammatory stimuli, such as lipopolysaccharide, interferons, and tumor necrosis factor-alpha. 3. **Cell-type specificity:** CCL2 is expressed in various cell types, including fibroblasts, epithelial cells, and endothelial cells. 4. **Signal transduction:** CCL2 binds to its receptor, CCR2, and triggers a signaling cascade that leads to the activation of various cellular responses. **Pathways and Functions:** 1. **Immune response:** CCL2 plays a crucial role in the recruitment of immune cells to sites of inflammation and injury, facilitating the clearance of pathogens and the resolution of inflammation. 2. **Inflammation:** CCL2 is involved in the regulation of inflammatory responses, including the recruitment of immune cells, the production of pro-inflammatory cytokines, and the clearance of apoptotic cells. 3. **Cell migration:** CCL2 promotes the migration of immune cells, including monocytes, macrophages, and T cells, to sites of inflammation and injury. 4. **Angiogenesis:** CCL2 has been shown to promote angiogenesis, the formation of new blood vessels, in various tissues, including the tumor microenvironment. 5. **Neuroinflammation:** CCL2 has been implicated in neuroinflammation, including the recruitment of microglia and the promotion of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Clinical Significance:** 1. **Inflammatory disorders:** CCL2 has been implicated in various inflammatory disorders, including rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease. 2. **Cancer:** CCL2 has been shown to promote tumor growth, angiogenesis, and metastasis in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders:** CCL2 has been implicated in neuroinflammatory disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cardiovascular disease:** CCL2 has been shown to contribute to the development of cardiovascular disease, including atherosclerosis and cardiac fibrosis. 5. **Immunotherapy:** CCL2 has been explored as a potential target for immunotherapy, including the development of monoclonal antibodies and small molecule inhibitors that target CCL2 and its receptor, CCR2. In conclusion, CCL2 is a key player in the immune response and beyond, with a wide range of functions in inflammation, cell migration, angiogenesis, and neuroinflammation. Its clinical significance extends to various diseases, including inflammatory disorders, cancer, neurological disorders, cardiovascular disease, and immunotherapy. Further research is needed to fully elucidate the mechanisms of CCL2 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-C motif chemokine 2

Genular Protein ID: 2896858537

Symbol: CCL2_HUMAN

Name: C-C motif chemokine 2

UniProtKB Accession Codes:

P13500 B2R4V3 Q9UDF3

Database IDs:

Citations:

PubMed ID: 2923622

Title: Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF).

PubMed ID: 2923622

DOI: 10.1016/0006-291x(89)92430-3

PubMed ID: 2513477

Title: The human homolog of the JE gene encodes a monocyte secretory protein.

PubMed ID: 2513477

DOI: 10.1128/mcb.9.11.4687-4695.1989

PubMed ID: 2465924

Title: Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE.

PubMed ID: 2465924

DOI: 10.1016/0014-5793(89)80590-3

PubMed ID: 2518726

Title: Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family.

PubMed ID: 2518726

DOI: 10.1093/intimm/1.4.388

PubMed ID: 2357211

Title: Structure of human monocyte chemotactic protein gene and its regulation by TPA.

PubMed ID: 2357211

DOI: 10.1016/0006-291x(90)90338-n

PubMed ID: 1661560

Title: Human monocyte chemoattractant protein-1 (MCP-1).

PubMed ID: 1661560

DOI: 10.1007/978-1-4684-6009-4_6

PubMed ID: 8107690

Title: The expression of monocyte chemotactic protein (MCP-1) in human vascular endothelium in vitro and in vivo.

PubMed ID: 8107690

DOI: 10.1007/bf01772208

PubMed ID: 10918580

Title: Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.

PubMed ID: 10918580

DOI: 10.1038/sj.onc.1203643

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2648385

Title: Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions.

PubMed ID: 2648385

DOI: 10.1073/pnas.86.6.1850

PubMed ID: 2322286

Title: Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form.

PubMed ID: 2322286

DOI: 10.1016/0006-291x(90)90609-q

PubMed ID: 2071154

Title: Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus.

PubMed ID: 2071154

DOI: 10.1016/0888-7543(91)90338-f

PubMed ID: 8195247

Title: Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis.

PubMed ID: 8195247

DOI: 10.1016/s0021-9258(17)40768-x

PubMed ID: 8627182

Title: Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant.

PubMed ID: 8627182

DOI: 10.1084/jem.183.2.681

PubMed ID: 8898111

Title: Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.

PubMed ID: 8898111

DOI: 10.1016/0014-5793(96)01024-1

PubMed ID: 9792674

Title: Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding.

PubMed ID: 9792674

DOI: 10.1074/jbc.273.45.29641

PubMed ID: 9837883

Title: Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B.

PubMed ID: 9837883

DOI: 10.1074/jbc.273.50.33157

PubMed ID: 10587439

Title: Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2.

PubMed ID: 10587439

DOI: 10.1021/bi9912239

PubMed ID: 10529171

Title: Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2.

PubMed ID: 10529171

DOI: 10.1021/bi991029m

PubMed ID: 15033992

Title: Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo.

PubMed ID: 15033992

DOI: 10.1074/jbc.m311224200

PubMed ID: 23233732

Title: Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.

PubMed ID: 23233732

DOI: 10.1194/jlr.m033365

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 30568593

Title: TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1.

PubMed ID: 30568593

DOI: 10.3389/fphar.2018.01431

PubMed ID: 34831181

Title: Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.

PubMed ID: 34831181

DOI: 10.3390/cells10112958

PubMed ID: 1857712

Title: Modeling the three-dimensional structure of the monocyte chemo-attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8.

PubMed ID: 1857712

DOI: 10.1093/protein/4.3.263

PubMed ID: 8639605

Title: Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer.

PubMed ID: 8639605

DOI: 10.1021/bi9602270

PubMed ID: 8989326

Title: The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions.

PubMed ID: 8989326

DOI: 10.1038/nsb0197-64

PubMed ID: 16352737

Title: A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.

PubMed ID: 16352737

DOI: 10.1084/jem.20050126

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

Sequence Information:

Length: 99
Mass: 11025
Checksum: 45EC72361435302F
Sequence:

MKVSAALLCL LLIAATFIPQ GLAQPDAINA PVTCCYNFTN RKISVQRLAS YRRITSSKCP 
KEAVIFKTIV AKEICADPKQ KWVQDSMDHL DKQTQTPKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCL2

Associated with

Cells (max top 100)

Other Information

Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). PubMed ID: 2923622

The human homolog of the JE gene encodes a monocyte secretory protein. PubMed ID: 2513477

Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. PubMed ID: 2465924

Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. PubMed ID: 2518726

Structure of human monocyte chemotactic protein gene and its regulation by TPA. PubMed ID: 2357211

Human monocyte chemoattractant protein-1 (MCP-1). PubMed ID: 1661560

The expression of monocyte chemotactic protein (MCP-1) in human vascular endothelium in vitro and in vivo. PubMed ID: 8107690

Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. PubMed ID: 10918580

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions. PubMed ID: 2648385

Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form. PubMed ID: 2322286

Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus. PubMed ID: 2071154

Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocyte chemotaxis. PubMed ID: 8195247

Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant. PubMed ID: 8627182

Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. PubMed ID: 8898111

Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. PubMed ID: 9792674

Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. PubMed ID: 9837883

Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2. PubMed ID: 10587439

Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2. PubMed ID: 10529171

Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. PubMed ID: 15033992

Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. PubMed ID: 23233732

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. PubMed ID: 23765988

TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1. PubMed ID: 30568593

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1. PubMed ID: 34831181

Modeling the three-dimensional structure of the monocyte chemo-attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8. PubMed ID: 1857712

Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer. PubMed ID: 8639605

The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. PubMed ID: 8989326

A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. PubMed ID: 16352737

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions. PubMed ID: 27044744