Details for: ACKR1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 24.5657
Cell Significance Index: -9.9800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 14.7782
Cell Significance Index: 261.1500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 11.8120
Cell Significance Index: 134.1900 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 7.3880
Cell Significance Index: 53.0600 - Cell Name: vein endothelial cell of respiratory system (CL4033008)
Fold Change: 5.0852
Cell Significance Index: 32.7500 - Cell Name: proerythroblast (CL0000547)
Fold Change: 4.1482
Cell Significance Index: 59.4500 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 3.3527
Cell Significance Index: 28.3700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 3.3206
Cell Significance Index: 25.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0175
Cell Significance Index: 53.0000 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.7730
Cell Significance Index: 4.8400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.7013
Cell Significance Index: 10.8500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1610
Cell Significance Index: 32.3000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1141
Cell Significance Index: 5.9900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1069
Cell Significance Index: 19.2700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0907
Cell Significance Index: 6.7600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0830
Cell Significance Index: 57.4400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0742
Cell Significance Index: 9.5100 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.0503
Cell Significance Index: 0.6100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0497
Cell Significance Index: 17.8200 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.0372
Cell Significance Index: 0.5100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0306
Cell Significance Index: 3.9600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0015
Cell Significance Index: -2.3600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0040
Cell Significance Index: -7.4700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0044
Cell Significance Index: -3.3100 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0046
Cell Significance Index: -0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0057
Cell Significance Index: -10.7000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0058
Cell Significance Index: -0.1000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0098
Cell Significance Index: -0.5500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0121
Cell Significance Index: -16.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0131
Cell Significance Index: -9.5900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0132
Cell Significance Index: -9.8000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0148
Cell Significance Index: -9.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0176
Cell Significance Index: -9.9300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0243
Cell Significance Index: -7.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0258
Cell Significance Index: -11.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0328
Cell Significance Index: -4.0300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0492
Cell Significance Index: -9.7600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0513
Cell Significance Index: -10.8100 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.0562
Cell Significance Index: -0.5000 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: -0.0661
Cell Significance Index: -0.2300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0707
Cell Significance Index: -7.2200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0721
Cell Significance Index: -9.9000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0724
Cell Significance Index: -10.5300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0742
Cell Significance Index: -12.6700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0870
Cell Significance Index: -5.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1014
Cell Significance Index: -11.6200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1016
Cell Significance Index: -11.9800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1035
Cell Significance Index: -10.7800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1395
Cell Significance Index: -7.0500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1460
Cell Significance Index: -2.1000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1471
Cell Significance Index: -11.2900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1518
Cell Significance Index: -9.3300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1555
Cell Significance Index: -6.8800 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.1589
Cell Significance Index: -2.5500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1596
Cell Significance Index: -7.4400 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.1638
Cell Significance Index: -1.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1880
Cell Significance Index: -7.1200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1896
Cell Significance Index: -5.4100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2005
Cell Significance Index: -9.4300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2024
Cell Significance Index: -12.7600 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.2327
Cell Significance Index: -2.8600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2376
Cell Significance Index: -10.3300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2437
Cell Significance Index: -12.6600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2480
Cell Significance Index: -6.9300 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.2534
Cell Significance Index: -3.4800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2592
Cell Significance Index: -9.0800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2629
Cell Significance Index: -9.6500 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.2809
Cell Significance Index: -3.1800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2866
Cell Significance Index: -8.2200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2998
Cell Significance Index: -12.2800 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.3003
Cell Significance Index: -3.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3017
Cell Significance Index: -9.6100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3092
Cell Significance Index: -3.8400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3122
Cell Significance Index: -6.5400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3129
Cell Significance Index: -10.2500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3209
Cell Significance Index: -6.8100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3276
Cell Significance Index: -8.4200 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3417
Cell Significance Index: -3.7400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3545
Cell Significance Index: -7.6600 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3603
Cell Significance Index: -7.5200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3672
Cell Significance Index: -10.0000 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3691
Cell Significance Index: -7.5100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3697
Cell Significance Index: -9.8900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3736
Cell Significance Index: -9.3200 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.3815
Cell Significance Index: -4.3100 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.3877
Cell Significance Index: -3.2000 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.3921
Cell Significance Index: -9.9900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3950
Cell Significance Index: -7.8100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3985
Cell Significance Index: -8.0000 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4004
Cell Significance Index: -10.0000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4021
Cell Significance Index: -8.6000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4134
Cell Significance Index: -10.3100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4152
Cell Significance Index: -14.5900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4207
Cell Significance Index: -8.2100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4214
Cell Significance Index: -11.0800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4336
Cell Significance Index: -10.4000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4367
Cell Significance Index: -11.6600 - Cell Name: gut endothelial cell (CL0000131)
Fold Change: -0.4492
Cell Significance Index: -3.0900 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.4552
Cell Significance Index: -6.4800 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.4817
Cell Significance Index: -9.4800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3550964867
Symbol: ACKR1_HUMAN
Name: Atypical chemokine receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8248172
Title: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.
PubMed ID: 8248172
PubMed ID: 7663520
Title: Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.
PubMed ID: 7663520
DOI: 10.1038/ng0695-224
PubMed ID: 7833467
Title: Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue.
PubMed ID: 7833467
PubMed ID: 9731074
Title: Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.
PubMed ID: 9731074
PubMed ID: 9886340
Title: The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.
PubMed ID: 9886340
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10570183
Title: Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.
PubMed ID: 10570183
PubMed ID: 12956774
Title: Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites.
PubMed ID: 12956774
PubMed ID: 17389925
Title: Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes.
PubMed ID: 17389925
PubMed ID: 20373092
Title: Chemokine decoy receptors: structure-function and biological properties.
PubMed ID: 20373092
DOI: 10.1007/82_2010_19
PubMed ID: 22912641
Title: Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines.
PubMed ID: 22912641
PubMed ID: 22698181
Title: The biochemistry and biology of the atypical chemokine receptors.
PubMed ID: 22698181
PubMed ID: 23356288
Title: Atypical chemokine receptors: from silence to sound.
PubMed ID: 23356288
DOI: 10.1042/bst20120246
PubMed ID: 7705836
Title: Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism.
PubMed ID: 7705836
DOI: 10.1007/bf00208965
PubMed ID: 9746760
Title: A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.
PubMed ID: 9746760
PubMed ID: 18179887
Title: Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies.
PubMed ID: 18179887
Sequence Information:
- Length: 336
- Mass: 35553
- Checksum: C3F2A3E71D972E2D
- Sequence:
MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS
Genular Protein ID: 254102050
Symbol: Q5Y7A1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 22082243
Title: DARC alleles and Duffy phenotypes in African Americans.
PubMed ID: 22082243
Sequence Information:
- Length: 338
- Mass: 35678
- Checksum: 5AC412B001F07F5B
- Sequence:
MASSGYVLQA ELSPSTENSS QLDFEDVWNS SYGVNDSFPD GDYGANLEAA APCHSCNLLD DSALPFFILT SVLGILASST VLFMLFRPLF RWQLCPGWPV LAQLAVGSAL FSIVVPVLAP GLGSTRSSAL CSLGYCVWYG SAFAQALLLG CHASLGHRLG AGQVPGLTLG LTVGIWGVAA LLTLPVTLAS GASGGLCTLI YSTELKALQA THTVACLAIF VLLPLGLFGA KGLKKALGMG PGPWMNILWA WFIFWWPHGV VLGLDFLVRS KLLLLSTCLA QQALDLLLNL AEALAILHCV ATPLLLALFC HQATRTLLPS LPLPEGWSSH LDTLGSKS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.