Details for: ACKR1

Gene ID: 2532

Symbol: ACKR1

Ensembl ID: ENSG00000213088

Description: atypical chemokine receptor 1 (Duffy blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.5657
    Cell Significance Index: -9.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.7782
    Cell Significance Index: 261.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 11.8120
    Cell Significance Index: 134.1900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.3880
    Cell Significance Index: 53.0600
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 5.0852
    Cell Significance Index: 32.7500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 4.1482
    Cell Significance Index: 59.4500
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 3.3527
    Cell Significance Index: 28.3700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.3206
    Cell Significance Index: 25.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0175
    Cell Significance Index: 53.0000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7730
    Cell Significance Index: 4.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7013
    Cell Significance Index: 10.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1610
    Cell Significance Index: 32.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1141
    Cell Significance Index: 5.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1069
    Cell Significance Index: 19.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0907
    Cell Significance Index: 6.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0830
    Cell Significance Index: 57.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0742
    Cell Significance Index: 9.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0503
    Cell Significance Index: 0.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0497
    Cell Significance Index: 17.8200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0372
    Cell Significance Index: 0.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0306
    Cell Significance Index: 3.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0058
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0098
    Cell Significance Index: -0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0121
    Cell Significance Index: -16.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0176
    Cell Significance Index: -9.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0243
    Cell Significance Index: -7.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0258
    Cell Significance Index: -11.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0328
    Cell Significance Index: -4.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0492
    Cell Significance Index: -9.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0513
    Cell Significance Index: -10.8100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0562
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0661
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0707
    Cell Significance Index: -7.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0721
    Cell Significance Index: -9.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0724
    Cell Significance Index: -10.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0742
    Cell Significance Index: -12.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0870
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1014
    Cell Significance Index: -11.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1016
    Cell Significance Index: -11.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1035
    Cell Significance Index: -10.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1395
    Cell Significance Index: -7.0500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1460
    Cell Significance Index: -2.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1471
    Cell Significance Index: -11.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1518
    Cell Significance Index: -9.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1555
    Cell Significance Index: -6.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1589
    Cell Significance Index: -2.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1596
    Cell Significance Index: -7.4400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1638
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1880
    Cell Significance Index: -7.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1896
    Cell Significance Index: -5.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2005
    Cell Significance Index: -9.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2024
    Cell Significance Index: -12.7600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2327
    Cell Significance Index: -2.8600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2376
    Cell Significance Index: -10.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2437
    Cell Significance Index: -12.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2480
    Cell Significance Index: -6.9300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2534
    Cell Significance Index: -3.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2592
    Cell Significance Index: -9.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2629
    Cell Significance Index: -9.6500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2809
    Cell Significance Index: -3.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2866
    Cell Significance Index: -8.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2998
    Cell Significance Index: -12.2800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3003
    Cell Significance Index: -3.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3017
    Cell Significance Index: -9.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3092
    Cell Significance Index: -3.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3122
    Cell Significance Index: -6.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3129
    Cell Significance Index: -10.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3209
    Cell Significance Index: -6.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3276
    Cell Significance Index: -8.4200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3417
    Cell Significance Index: -3.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3545
    Cell Significance Index: -7.6600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3603
    Cell Significance Index: -7.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3672
    Cell Significance Index: -10.0000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3691
    Cell Significance Index: -7.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3697
    Cell Significance Index: -9.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3736
    Cell Significance Index: -9.3200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3815
    Cell Significance Index: -4.3100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3877
    Cell Significance Index: -3.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3921
    Cell Significance Index: -9.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3950
    Cell Significance Index: -7.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3985
    Cell Significance Index: -8.0000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4004
    Cell Significance Index: -10.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4021
    Cell Significance Index: -8.6000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4134
    Cell Significance Index: -10.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4152
    Cell Significance Index: -14.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4207
    Cell Significance Index: -8.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4214
    Cell Significance Index: -11.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4336
    Cell Significance Index: -10.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4367
    Cell Significance Index: -11.6600
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.4492
    Cell Significance Index: -3.0900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4552
    Cell Significance Index: -6.4800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4817
    Cell Significance Index: -9.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Atypical Chemokine Receptor:** ACKR1 is a member of the atypical chemokine receptor family, which is distinct from the conventional G protein-coupled receptors (GPCRs). Its unique structure and signaling mechanism set it apart from other chemokine receptors. 2. **Duffy Blood Group:** ACKR1 is also known as the Duffy blood group, which is a classic example of a genetic variation that affects an individual's susceptibility to certain diseases. 3. **Signaling Mechanism:** ACKR1 uses a unique signaling mechanism that involves the activation of G-proteins and the subsequent modulation of downstream signaling pathways. 4. **Tissue Expression:** ACKR1 is significantly expressed in various tissues, including vascular lymphangioblasts, endothelial cells, and goblet cells, highlighting its diverse roles in maintaining immune homeostasis. **Pathways and Functions:** 1. **Chemokine-Mediated Signaling:** ACKR1 plays a crucial role in modulating chemokine-mediated signaling pathways, which are essential for the regulation of immune responses. 2. **G-Protein-Coupled Receptor Activity:** ACKR1 is a member of the GPCR family, which is characterized by its ability to activate G-proteins and modulate downstream signaling pathways. 3. **Inflammatory Response:** ACKR1 has been implicated in the regulation of inflammatory responses, which are critical in maintaining immune homeostasis. 4. **Regulation of Chemokine Production:** ACKR1 has been shown to regulate chemokine production, which is essential for the modulation of immune responses. **Clinical Significance:** 1. **Disease Association:** ACKR1 has been associated with various diseases, including malaria, tuberculosis, and cancer. 2. **Immune Response:** ACKR1 plays a crucial role in modulating immune responses, which is essential for the prevention and treatment of diseases. 3. **Therapeutic Target:** ACKR1 has emerged as a potential therapeutic target for the treatment of diseases, including cancer and inflammatory disorders. 4. **Genetic Variation:** Genetic variations in ACKR1 have been associated with increased susceptibility to certain diseases, highlighting the importance of genetic factors in disease susceptibility. In conclusion, ACKR1 is a fascinating gene that has far-reaching implications in immune response and disease. Its unique characteristics, signaling mechanism, and tissue expression patterns make it an attractive target for further research and potential therapeutic applications. As an expert immunologist, I believe that ACKR1 is a gene that deserves further attention and exploration, and its study has the potential to reveal new insights into the regulation of immune responses and the prevention and treatment of diseases.

Genular Protein ID: 3550964867

Symbol: ACKR1_HUMAN

Name: Atypical chemokine receptor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8248172

Title: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.

PubMed ID: 8248172

DOI: 10.1073/pnas.90.22.10793

PubMed ID: 7663520

Title: Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.

PubMed ID: 7663520

DOI: 10.1038/ng0695-224

PubMed ID: 7833467

Title: Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue.

PubMed ID: 7833467

PubMed ID: 9731074

Title: Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.

PubMed ID: 9731074

PubMed ID: 9886340

Title: The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.

PubMed ID: 9886340

DOI: 10.1046/j.1365-2141.1998.01083.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10570183

Title: Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.

PubMed ID: 10570183

DOI: 10.1073/pnas.96.24.13973

PubMed ID: 12956774

Title: Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites.

PubMed ID: 12956774

DOI: 10.1046/j.1365-2141.2003.04533.x

PubMed ID: 17389925

Title: Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes.

PubMed ID: 17389925

DOI: 10.1371/journal.pone.0000336

PubMed ID: 20373092

Title: Chemokine decoy receptors: structure-function and biological properties.

PubMed ID: 20373092

DOI: 10.1007/82_2010_19

PubMed ID: 22912641

Title: Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines.

PubMed ID: 22912641

DOI: 10.3389/fimmu.2012.00266

PubMed ID: 22698181

Title: The biochemistry and biology of the atypical chemokine receptors.

PubMed ID: 22698181

DOI: 10.1016/j.imlet.2012.04.004

PubMed ID: 23356288

Title: Atypical chemokine receptors: from silence to sound.

PubMed ID: 23356288

DOI: 10.1042/bst20120246

PubMed ID: 7705836

Title: Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism.

PubMed ID: 7705836

DOI: 10.1007/bf00208965

PubMed ID: 9746760

Title: A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.

PubMed ID: 9746760

PubMed ID: 18179887

Title: Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies.

PubMed ID: 18179887

DOI: 10.1016/j.ajhg.2007.09.003

Sequence Information:

  • Length: 336
  • Mass: 35553
  • Checksum: C3F2A3E71D972E2D
  • Sequence:
  • MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS 
    ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL 
    GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL 
    TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG 
    PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT 
    PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS

Genular Protein ID: 254102050

Symbol: Q5Y7A1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 22082243

Title: DARC alleles and Duffy phenotypes in African Americans.

PubMed ID: 22082243

DOI: 10.1111/j.1537-2995.2011.03431.x

Sequence Information:

  • Length: 338
  • Mass: 35678
  • Checksum: 5AC412B001F07F5B
  • Sequence:
  • MASSGYVLQA ELSPSTENSS QLDFEDVWNS SYGVNDSFPD GDYGANLEAA APCHSCNLLD 
    DSALPFFILT SVLGILASST VLFMLFRPLF RWQLCPGWPV LAQLAVGSAL FSIVVPVLAP 
    GLGSTRSSAL CSLGYCVWYG SAFAQALLLG CHASLGHRLG AGQVPGLTLG LTVGIWGVAA 
    LLTLPVTLAS GASGGLCTLI YSTELKALQA THTVACLAIF VLLPLGLFGA KGLKKALGMG 
    PGPWMNILWA WFIFWWPHGV VLGLDFLVRS KLLLLSTCLA QQALDLLLNL AEALAILHCV 
    ATPLLLALFC HQATRTLLPS LPLPEGWSSH LDTLGSKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.