Details for: ACKR1

Gene ID: 2532

Symbol: ACKR1

Ensembl ID: ENSG00000213088

Description: atypical chemokine receptor 1 (Duffy blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.09
    Marker Score: 5223
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.34
    Marker Score: 4677
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.12
    Marker Score: 451
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.81
    Marker Score: 705
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.57
    Marker Score: 378
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.53
    Marker Score: 2226
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.5
    Marker Score: 1505
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.34
    Marker Score: 1214
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.06
    Marker Score: 1741
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1
    Marker Score: 6639
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5317
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.86
    Marker Score: 739
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.77
    Marker Score: 1112
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.76
    Marker Score: 1944
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.73
    Marker Score: 361.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.72
    Marker Score: 244
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.65
    Marker Score: 1230
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1261
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.58
    Marker Score: 5050
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.52
    Marker Score: 217
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.48
    Marker Score: 910
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.46
    Marker Score: 197
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.44
    Marker Score: 390
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.42
    Marker Score: 1696
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.41
    Marker Score: 235
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.39
    Marker Score: 484
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.39
    Marker Score: 258
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.37
    Marker Score: 281
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.37
    Marker Score: 5804
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.36
    Marker Score: 247
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.36
    Marker Score: 79
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.33
    Marker Score: 401
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 133
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.31
    Marker Score: 334
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.31
    Marker Score: 259
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.31
    Marker Score: 195
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3
    Marker Score: 3135
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3
    Marker Score: 181
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.3
    Marker Score: 76
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.3
    Marker Score: 107
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.29
    Marker Score: 77
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 160
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.27
    Marker Score: 100
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.27
    Marker Score: 281.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 160
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.26
    Marker Score: 1017
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.26
    Marker Score: 531
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.26
    Marker Score: 162
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.25
    Marker Score: 369
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.25
    Marker Score: 69
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 64
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.24
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.23
    Marker Score: 14372
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 111
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.23
    Marker Score: 115
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.23
    Marker Score: 299
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 349
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.22
    Marker Score: 210
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.21
    Marker Score: 134
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2
    Marker Score: 245
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.18
    Marker Score: 760
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.18
    Marker Score: 1669
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.17
    Marker Score: 73
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.17
    Marker Score: 6345
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.17
    Marker Score: 161
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.16
    Marker Score: 1565
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.16
    Marker Score: 262
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.16
    Marker Score: 618
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.16
    Marker Score: 5872
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.16
    Marker Score: 135
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.15
    Marker Score: 1177
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.15
    Marker Score: 184
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.15
    Marker Score: 276
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 260
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.15
    Marker Score: 151
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.14
    Marker Score: 161
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.14
    Marker Score: 2845

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Other Information

**Key characteristics:** * The ACKR1 gene is located on chromosome 1 and is approximately 280 kb in length. * The protein is a type I transmembrane receptor that is expressed on the surface of endothelial cells. * ACKR1 is a member of the C-c chemokine receptor family, which is a large family of receptors that are involved in the regulation of inflammation. * The ACKR1 receptor is expressed in high levels in endothelial cells of blood vessels, which are the cells that line blood vessels. * ACKR1 is also expressed in low levels in stromal cells, such as vascular lymphangioblast and endothelial cells of the uterus. **Pathways and functions:** * ACKR1 is a receptor for the chemokine CXCL1, which is a protein that is produced by endothelial cells and is involved in the regulation of inflammation. * ACKR1 signaling is activated by CXCL1, which leads to the activation of the G protein-coupled receptor (GPCR) pathway. * The GPCR pathway is a signaling pathway that is involved in a variety of cellular processes, including inflammation and immune responses. * Activation of the GPCR pathway by CXCL1 leads to the activation of the mitogen-activated protein kinase (MAPK) pathway, which is a second messenger pathway that is involved in cell signaling. * The MAPK pathway leads to the phosphorylation of a variety of target proteins, which can lead to changes in cell behavior, including the activation of inflammatory responses. **Clinical significance:** * Mutations in the ACKR1 gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. * ACKR1 is a potential therapeutic target for these diseases, as blocking ACKR1 signaling can inhibit inflammation. **Additional notes:** * ACKR1 is a highly conserved protein, with a similar sequence in mice and humans. * The ACKR1 receptor is expressed in a variety of cell types, including endothelial cells, immune cells, and cancer cells. * ACKR1 signaling is a critical for the regulation of inflammation and immune responses.

Genular Protein ID: 3550964867

Symbol: ACKR1_HUMAN

Name: Atypical chemokine receptor 1

UniProtKB Accession Codes:

Q16570 A8YPG5 O75898 Q16300 Q8WWE3 Q9UJP0 Q9UKZ5 Q9UKZ6 Q9UQE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8248172

Title: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.

PubMed ID: 8248172

DOI: 10.1073/pnas.90.22.10793

PubMed ID: 7663520

Title: Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals.

PubMed ID: 7663520

DOI: 10.1038/ng0695-224

PubMed ID: 7833467

Title: Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue.

PubMed ID: 7833467

PubMed ID: 9731074

Title: Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals.

PubMed ID: 9731074

PubMed ID: 9886340

Title: The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein.

PubMed ID: 9886340

DOI: 10.1046/j.1365-2141.1998.01083.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10570183

Title: Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea.

PubMed ID: 10570183

DOI: 10.1073/pnas.96.24.13973

PubMed ID: 12956774

Title: Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites.

PubMed ID: 12956774

DOI: 10.1046/j.1365-2141.2003.04533.x

PubMed ID: 17389925

Title: Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes.

PubMed ID: 17389925

DOI: 10.1371/journal.pone.0000336

PubMed ID: 20373092

Title: Chemokine decoy receptors: structure-function and biological properties.

PubMed ID: 20373092

DOI: 10.1007/82_2010_19

PubMed ID: 22912641

Title: Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines.

PubMed ID: 22912641

DOI: 10.3389/fimmu.2012.00266

PubMed ID: 22698181

Title: The biochemistry and biology of the atypical chemokine receptors.

PubMed ID: 22698181

DOI: 10.1016/j.imlet.2012.04.004

PubMed ID: 23356288

Title: Atypical chemokine receptors: from silence to sound.

PubMed ID: 23356288

DOI: 10.1042/bst20120246

PubMed ID: 7705836

Title: Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism.

PubMed ID: 7705836

DOI: 10.1007/bf00208965

PubMed ID: 9746760

Title: A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.

PubMed ID: 9746760

PubMed ID: 18179887

Title: Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies.

PubMed ID: 18179887

DOI: 10.1016/j.ajhg.2007.09.003

Sequence Information:

  • Length: 336
  • Mass: 35553
  • Checksum: C3F2A3E71D972E2D
  • Sequence:
    • MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS 
ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL 
GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL 
TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG 
PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT 
PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS

Genular Protein ID: 254102050

Symbol: Q5Y7A1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5Y7A1

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 24 ExpressionAtlas 1 GO 7 Gene3D 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 22082243

Title: DARC alleles and Duffy phenotypes in African Americans.

PubMed ID: 22082243

DOI: 10.1111/j.1537-2995.2011.03431.x

Sequence Information:

  • Length: 338
  • Mass: 35678
  • Checksum: 5AC412B001F07F5B
  • Sequence:
    • MASSGYVLQA ELSPSTENSS QLDFEDVWNS SYGVNDSFPD GDYGANLEAA APCHSCNLLD 
DSALPFFILT SVLGILASST VLFMLFRPLF RWQLCPGWPV LAQLAVGSAL FSIVVPVLAP 
GLGSTRSSAL CSLGYCVWYG SAFAQALLLG CHASLGHRLG AGQVPGLTLG LTVGIWGVAA 
LLTLPVTLAS GASGGLCTLI YSTELKALQA THTVACLAIF VLLPLGLFGA KGLKKALGMG 
PGPWMNILWA WFIFWWPHGV VLGLDFLVRS KLLLLSTCLA QQALDLLLNL AEALAILHCV 
ATPLLLALFC HQATRTLLPS LPLPEGWSSH LDTLGSKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.