Details for: LRRC32

Gene ID: 2615

Symbol: LRRC32

Ensembl ID: ENSG00000137507

Description: leucine rich repeat containing 32

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.69
    Marker Score: 6839
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.48
    Marker Score: 2136
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.76
    Marker Score: 1048
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.57
    Marker Score: 3190
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.52
    Marker Score: 323
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.51
    Marker Score: 1421
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.48
    Marker Score: 2151
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.45
    Marker Score: 337
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.32
    Marker Score: 413
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.27
    Marker Score: 1212
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.26
    Marker Score: 302
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19563
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.24
    Marker Score: 300
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.22
    Marker Score: 870
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.2
    Marker Score: 1081
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.19
    Marker Score: 1275
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4801
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.13
    Marker Score: 1390
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.08
    Marker Score: 1836
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.08
    Marker Score: 612
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.02
    Marker Score: 396
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.01
    Marker Score: 480
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.98
    Marker Score: 1418
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.96
    Marker Score: 254
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1803
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 393
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.93
    Marker Score: 940
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5296
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.91
    Marker Score: 1826
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 539
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 401
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.87
    Marker Score: 361
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.84
    Marker Score: 756
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.81
    Marker Score: 513.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.81
    Marker Score: 238
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.81
    Marker Score: 296
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.79
    Marker Score: 183.5
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.78
    Marker Score: 6829.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 448
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.74
    Marker Score: 1012
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.71
    Marker Score: 201
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.67
    Marker Score: 184
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.65
    Marker Score: 1230
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 375
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.58
    Marker Score: 128
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.56
    Marker Score: 154
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.53
    Marker Score: 609
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.53
    Marker Score: 134
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.49
    Marker Score: 935
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.48
    Marker Score: 318.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.47
    Marker Score: 15857
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.45
    Marker Score: 4510
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.45
    Marker Score: 780
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.44
    Marker Score: 188
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.41
    Marker Score: 105
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.41
    Marker Score: 398
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 179
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 221
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.38
    Marker Score: 465
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.37
    Marker Score: 201
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.36
    Marker Score: 166
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.35
    Marker Score: 202
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.34
    Marker Score: 104
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.34
    Marker Score: 210
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.32
    Marker Score: 91
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.32
    Marker Score: 120
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.31
    Marker Score: 375
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.31
    Marker Score: 76
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.3
    Marker Score: 220
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.3
    Marker Score: 458
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.28
    Marker Score: 201.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.27
    Marker Score: 184
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.27
    Marker Score: 116
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.25
    Marker Score: 270
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.25
    Marker Score: 72
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.24
    Marker Score: 66
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.23
    Marker Score: 614

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Other Information

**Key characteristics:** - LRRC32 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a variety of cell types, including endothelial cells, immune cells, and cancer cells. - It is known to interact with a number of signaling molecules, including TGF-beta, BMP-1, and VEGFR. - It is involved in the regulation of cell surface signaling pathways, including the TGF-beta signaling pathway. - It is also involved in the regulation of tissue development, including the development of the secondary palate. **Pathways and functions:** - LRRC32 is involved in the regulation of cell surface signaling pathways. - It is a key regulator of the TGF-beta signaling pathway, which is important for the development and maintenance of endothelial cells. - It also regulates the production of cytokines, which are proteins that are secreted by cells to communicate with other cells. - LRRC32 is involved in the regulation of tissue development, including the development of the secondary palate. **Clinical significance:** - Mutations in LRRC32 have been linked to a number of human diseases, including cancer and cardiovascular disease. - In cancer, LRRC32 mutations can lead to the growth of tumors and the development of resistance to therapy. - Targeting LRRC32 has been shown to be a promising strategy for treating cancer.

Genular Protein ID: 675929239

Symbol: LRC32_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14392 Q86V06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8180135

Title: The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins.

PubMed ID: 8180135

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18628982

Title: Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.

PubMed ID: 18628982

DOI: 10.1371/journal.pone.0002705

PubMed ID: 19750484

Title: Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.

PubMed ID: 19750484

DOI: 10.1002/eji.200939684

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19651619

Title: GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

PubMed ID: 19651619

DOI: 10.1073/pnas.0901944106

PubMed ID: 21615933

Title: Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).

PubMed ID: 21615933

DOI: 10.1186/1471-2091-12-27

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 26126825

Title: Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor beta1 (TGF-beta1) Production in Human Regulatory T Cells.

PubMed ID: 26126825

DOI: 10.1074/jbc.m115.655340

PubMed ID: 30976112

Title: Homozygous stop-gain variant in LRRC32, encoding a TGFbeta receptor, associated with cleft palate, proliferative retinopathy, and developmental delay.

PubMed ID: 30976112

DOI: 10.1038/s41431-019-0380-y

Sequence Information:

  • Length: 662
  • Mass: 71979
  • Checksum: 700B93ADCDF25960
  • Sequence:
    • MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD TETLDLSGNQ 
LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE HLSLAHNRLA MATALSAGGL 
GPLPRVTSLD LSGNSLYSGL LERLLGEAPS LHTLSLAENS LTRLTRHTFR DMPALEQLDL 
HSNVLMDIED GAFEGLPRLT HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ 
AEFQLTWLDL RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL 
PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC LRTFEARRLG 
SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD LPPYTFANLA SLQRLNLQGN 
RVSPCGGPDE PGPSGCVAFS GITSLRSLSL VDNEIELLRA GAFLHTPLTE LDLSSNPGLE 
VATGALGGLE ASLEVLALQG NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV 
LDLRNNSFSL LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC 
RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC VRRQKFNQQY 
KA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.