Details for: LRRC32

Gene ID: 2615

Symbol: LRRC32

Ensembl ID: ENSG00000137507

Description: leucine rich repeat containing 32

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.4211
    Cell Significance Index: -11.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.7515
    Cell Significance Index: -12.6300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 18.8220
    Cell Significance Index: -12.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.8025
    Cell Significance Index: 31.9400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.4423
    Cell Significance Index: 17.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4081
    Cell Significance Index: 42.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.3213
    Cell Significance Index: 58.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0967
    Cell Significance Index: -6.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9804
    Cell Significance Index: 51.0700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.7299
    Cell Significance Index: 3.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5994
    Cell Significance Index: 114.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4804
    Cell Significance Index: 6.9100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.4396
    Cell Significance Index: 3.7200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.4148
    Cell Significance Index: 5.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3706
    Cell Significance Index: 4.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3552
    Cell Significance Index: 35.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2648
    Cell Significance Index: 239.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2639
    Cell Significance Index: 1.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2216
    Cell Significance Index: 4.7200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.2058
    Cell Significance Index: 1.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1804
    Cell Significance Index: 1.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1678
    Cell Significance Index: 18.2600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.1613
    Cell Significance Index: 1.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1609
    Cell Significance Index: 9.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1583
    Cell Significance Index: 25.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1500
    Cell Significance Index: 4.3000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0711
    Cell Significance Index: 0.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0638
    Cell Significance Index: 4.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0528
    Cell Significance Index: 32.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0210
    Cell Significance Index: 1.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0033
    Cell Significance Index: 1.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0011
    Cell Significance Index: -0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0067
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0121
    Cell Significance Index: -2.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0158
    Cell Significance Index: -5.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0178
    Cell Significance Index: -11.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0193
    Cell Significance Index: -2.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0313
    Cell Significance Index: -0.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0319
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0391
    Cell Significance Index: -0.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0396
    Cell Significance Index: -11.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0446
    Cell Significance Index: -1.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0463
    Cell Significance Index: -9.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0489
    Cell Significance Index: -1.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0662
    Cell Significance Index: -13.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0739
    Cell Significance Index: -2.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0767
    Cell Significance Index: -9.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0805
    Cell Significance Index: -11.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0969
    Cell Significance Index: -11.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0986
    Cell Significance Index: -10.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1005
    Cell Significance Index: -12.9800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1062
    Cell Significance Index: -1.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1104
    Cell Significance Index: -2.2900
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.1130
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1174
    Cell Significance Index: -13.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1236
    Cell Significance Index: -12.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1237
    Cell Significance Index: -2.5900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.1480
    Cell Significance Index: -0.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1540
    Cell Significance Index: -12.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1596
    Cell Significance Index: -12.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1713
    Cell Significance Index: -12.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1736
    Cell Significance Index: -7.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1755
    Cell Significance Index: -11.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1784
    Cell Significance Index: -11.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1979
    Cell Significance Index: -13.3100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.2012
    Cell Significance Index: -0.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2039
    Cell Significance Index: -9.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2297
    Cell Significance Index: -14.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2363
    Cell Significance Index: -6.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2433
    Cell Significance Index: -11.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2462
    Cell Significance Index: -6.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2563
    Cell Significance Index: -6.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2563
    Cell Significance Index: -14.3800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2702
    Cell Significance Index: -3.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2710
    Cell Significance Index: -14.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2766
    Cell Significance Index: -3.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2836
    Cell Significance Index: -7.5900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2858
    Cell Significance Index: -12.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2903
    Cell Significance Index: -15.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2937
    Cell Significance Index: -7.5500
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.3131
    Cell Significance Index: -2.1500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3222
    Cell Significance Index: -3.5000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3236
    Cell Significance Index: -3.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3253
    Cell Significance Index: -14.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3393
    Cell Significance Index: -11.7900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3615
    Cell Significance Index: -4.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3635
    Cell Significance Index: -13.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** LRRC32 is widely expressed in various cell types, including alveolar capillary type 1 endothelial cells, pulmonary artery endothelial cells, cerebral cortex endothelial cells, and immature innate lymphoid cells. This suggests a broad range of cellular functions and potential interactions. 2. **Leucine-Rich Repeat Domain:** The presence of a leucine-rich repeat (LRR) domain is a hallmark of LRRC32, which is involved in protein-protein interactions, cell adhesion, and signaling. 3. **Protein Binding:** LRRC32 has been shown to interact with various proteins, including transforming growth factor-beta receptors, cytokines, and other immune-related molecules, underscoring its role in immune regulation and signaling pathways. **Pathways and Functions:** 1. **Immune Regulation:** LRRC32 has been implicated in the negative regulation of activated T cell proliferation and cytokine production, suggesting a role in modulating the immune response. 2. **Vascular Development:** The expression of LRRC32 in endothelial cells, including those of the vascular tree, peritubular capillaries, and lung microvascular endothelial cells, highlights its involvement in vascular development and maintenance. 3. **Transforming Growth Factor-Beta Signaling:** LRRC32 interacts with transforming growth factor-beta receptors, influencing the activation of this signaling pathway, which plays a crucial role in cell growth, differentiation, and immune responses. 4. **Regulation of Gene Expression:** LRRC32 has been shown to positively regulate gene expression, suggesting a role in transcriptional control and cellular differentiation. **Clinical Significance:** 1. **Immunological Disorders:** Alterations in LRRC32 expression or function may contribute to immunological disorders, such as autoimmune diseases or immune-related cancers. 2. **Vascular Diseases:** Dysregulation of LRRC32 in vascular endothelial cells may lead to vascular diseases, including atherosclerosis, hypertension, or pulmonary hypertension. 3. **Cancer:** LRRC32 has been implicated in cancer progression, with its expression altered in various types of cancer, including lung, breast, and colon cancers. 4. **Neurological Disorders:** The expression of LRRC32 in cerebral cortex endothelial cells suggests its potential involvement in neurological disorders, such as Alzheimer's disease or multiple sclerosis. In conclusion, LRRC32 is a multifunctional gene with diverse cellular expression patterns and roles in immune regulation, vascular development, and gene expression. Further research is necessary to fully elucidate the complexities of LRRC32 and its clinical significance in various diseases. As an expert immunologist, I emphasize the importance of continued investigation into the functions and dysregulation of LRRC32, with the ultimate goal of developing targeted therapies for immunological and vascular disorders.

Genular Protein ID: 675929239

Symbol: LRC32_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14392 Q86V06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 5 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8180135

Title: The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins.

PubMed ID: 8180135

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18628982

Title: Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.

PubMed ID: 18628982

DOI: 10.1371/journal.pone.0002705

PubMed ID: 19750484

Title: Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg.

PubMed ID: 19750484

DOI: 10.1002/eji.200939684

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19651619

Title: GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.

PubMed ID: 19651619

DOI: 10.1073/pnas.0901944106

PubMed ID: 21615933

Title: Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).

PubMed ID: 21615933

DOI: 10.1186/1471-2091-12-27

PubMed ID: 22278742

Title: GARP regulates the bioavailability and activation of TGFbeta.

PubMed ID: 22278742

DOI: 10.1091/mbc.e11-12-1018

PubMed ID: 26126825

Title: Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor beta1 (TGF-beta1) Production in Human Regulatory T Cells.

PubMed ID: 26126825

DOI: 10.1074/jbc.m115.655340

PubMed ID: 30976112

Title: Homozygous stop-gain variant in LRRC32, encoding a TGFbeta receptor, associated with cleft palate, proliferative retinopathy, and developmental delay.

PubMed ID: 30976112

DOI: 10.1038/s41431-019-0380-y

Sequence Information:

  • Length: 662
  • Mass: 71979
  • Checksum: 700B93ADCDF25960
  • Sequence:
    • MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD TETLDLSGNQ 
LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE HLSLAHNRLA MATALSAGGL 
GPLPRVTSLD LSGNSLYSGL LERLLGEAPS LHTLSLAENS LTRLTRHTFR DMPALEQLDL 
HSNVLMDIED GAFEGLPRLT HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ 
AEFQLTWLDL RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL 
PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC LRTFEARRLG 
SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD LPPYTFANLA SLQRLNLQGN 
RVSPCGGPDE PGPSGCVAFS GITSLRSLSL VDNEIELLRA GAFLHTPLTE LDLSSNPGLE 
VATGALGGLE ASLEVLALQG NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV 
LDLRNNSFSL LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC 
RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC VRRQKFNQQY 
KA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.