Details for: TIE1

Gene ID: 7075

Symbol: TIE1

Ensembl ID: ENSG00000066056

Description: tyrosine kinase with immunoglobulin like and EGF like domains 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.97
    Marker Score: 26072
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.74
    Marker Score: 1549
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.48
    Marker Score: 2337
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.18
    Marker Score: 1301
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.16
    Marker Score: 5492
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.04
    Marker Score: 2947
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.8
    Marker Score: 3592
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.74
    Marker Score: 423
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.74
    Marker Score: 1500
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.61
    Marker Score: 374
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.55
    Marker Score: 2247
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169548
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.35
    Marker Score: 315
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.21
    Marker Score: 1096
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.12
    Marker Score: 1130
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.08
    Marker Score: 260
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.08
    Marker Score: 419.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.04
    Marker Score: 934
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251808
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.96
    Marker Score: 1030
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.96
    Marker Score: 1620.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 383
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.88
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1467
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.77
    Marker Score: 168
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 237
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.74
    Marker Score: 158
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.73
    Marker Score: 458
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.71
    Marker Score: 179
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.64
    Marker Score: 169
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.59
    Marker Score: 816
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.58
    Marker Score: 626
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8875
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 362.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.56
    Marker Score: 153
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.5
    Marker Score: 163
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 198
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.44
    Marker Score: 217
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.38
    Marker Score: 105
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.36
    Marker Score: 432
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 94
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.34
    Marker Score: 96
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 220
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 713
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 604
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.29
    Marker Score: 100
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.28
    Marker Score: 138
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.27
    Marker Score: 1802
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.26
    Marker Score: 164
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.26
    Marker Score: 171
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.23
    Marker Score: 229
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.23
    Marker Score: 205
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 129
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.22
    Marker Score: 94
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.21
    Marker Score: 144
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.21
    Marker Score: 170
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.19
    Marker Score: 117
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.19
    Marker Score: 229
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.18
    Marker Score: 141
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.18
    Marker Score: 90
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.18
    Marker Score: 2901
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.18
    Marker Score: 129
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.18
    Marker Score: 132
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 177
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 72

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Other Information

**Key Characteristics:** TIE1 is a type I transmembrane receptor tyrosine kinase, characterized by the presence of immunoglobulin-like and EGF-like domains. Its unique structure allows it to interact with various ligands, including vascular endothelial growth factor (VEGF), which is a key player in angiogenesis. TIE1 is expressed in a wide range of cell types, including endothelial cells, mesenchymal cells, and immune cells, highlighting its broad functional scope. **Pathways and Functions:** TIE1 is integral to several signaling pathways that regulate endothelial cell behavior, including: 1. **Angiogenesis:** TIE1, in conjunction with its ligand VEGF, promotes angiogenesis by regulating endothelial cell migration, proliferation, and tube formation. 2. **Endothelial Cell Differentiation:** TIE1 is essential for the differentiation of endothelial progenitor cells into mature endothelial cells, a process critical for vascular development and maintenance. 3. **Tissue Remodeling:** TIE1 is involved in the regulation of extracellular matrix assembly and degradation, allowing for tissue remodeling in response to injury or disease. 4. **Immune Response:** TIE1 has been implicated in the regulation of immune cell function, including the activation of T cells and the production of cytokines. **Clinical Significance:** Dysregulation of TIE1 has been linked to various diseases, including: 1. **Cancer:** TIE1 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, where it promotes angiogenesis and tumor growth. 2. **Cardiovascular Disease:** TIE1 is involved in the regulation of vascular remodeling and atherosclerosis, highlighting its potential as a therapeutic target for cardiovascular disease. 3. **Autoimmune Disorders:** TIE1 has been implicated in the regulation of immune cell function, making it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, TIE1 is a complex gene that plays a multifaceted role in the regulation of angiogenesis, endothelial cell differentiation, and tissue remodeling. Its dysregulation has significant implications for human disease, highlighting the need for further research into the molecular mechanisms underlying TIE1 function and its role in disease.

Genular Protein ID: 754637412

Symbol: TIE1_HUMAN

Name: Tyrosine-protein kinase receptor Tie-1

UniProtKB Accession Codes:

P35590 B5A949 B5A950

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 6 Ensembl 2 GO 22 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 1 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1312667

Title: A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

PubMed ID: 1312667

DOI: 10.1128/mcb.12.4.1698-1707.1992

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 15851516

Title: Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2.

PubMed ID: 15851516

DOI: 10.1083/jcb.200411105

PubMed ID: 20227369

Title: Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.

PubMed ID: 20227369

DOI: 10.1016/j.molcel.2010.02.007

PubMed ID: 37097004

Title: Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner.

PubMed ID: 37097004

DOI: 10.7554/elife.82969

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 32947856

Title: TIE1 as a Candidate Gene for Lymphatic Malformations with or without Lymphedema.

PubMed ID: 32947856

DOI: 10.3390/ijms21186780

Sequence Information:

  • Length: 1138
  • Mass: 125090
  • Checksum: 3B42BE33678C58A1
  • Sequence:
    • MVWRVPPFLL PILFLASHVG AAVDLTLLAN LRLTDPQRFF LTCVSGEAGA GRGSDAWGPP 
LLLEKDDRIV RTPPGPPLRL ARNGSHQVTL RGFSKPSDLV GVFSCVGGAG ARRTRVIYVH 
NSPGAHLLPD KVTHTVNKGD TAVLSARVHK EKQTDVIWKS NGSYFYTLDW HEAQDGRFLL 
QLPNVQPPSS GIYSATYLEA SPLGSAFFRL IVRGCGAGRW GPGCTKECPG CLHGGVCHDH 
DGECVCPPGF TGTRCEQACR EGRFGQSCQE QCPGISGCRG LTFCLPDPYG CSCGSGWRGS 
QCQEACAPGH FGADCRLQCQ CQNGGTCDRF SGCVCPSGWH GVHCEKSDRI PQILNMASEL 
EFNLETMPRI NCAAAGNPFP VRGSIELRKP DGTVLLSTKA IVEPEKTTAE FEVPRLVLAD 
SGFWECRVST SGGQDSRRFK VNVKVPPVPL AAPRLLTKQS RQLVVSPLVS FSGDGPISTV 
RLHYRPQDST MDWSTIVVDP SENVTLMNLR PKTGYSVRVQ LSRPGEGGEG AWGPPTLMTT 
DCPEPLLQPW LEGWHVEGTD RLRVSWSLPL VPGPLVGDGF LLRLWDGTRG QERRENVSSP 
QARTALLTGL TPGTHYQLDV QLYHCTLLGP ASPPAHVLLP PSGPPAPRHL HAQALSDSEI 
QLTWKHPEAL PGPISKYVVE VQVAGGAGDP LWIDVDRPEE TSTIIRGLNA STRYLFRMRA 
SIQGLGDWSN TVEESTLGNG LQAEGPVQES RAAEEGLDQQ LILAVVGSVS ATCLTILAAL 
LTLVCIRRSC LHRRRTFTYQ SGSGEETILQ FSSGTLTLTR RPKLQPEPLS YPVLEWEDIT 
FEDLIGEGNF GQVIRAMIKK DGLKMNAAIK MLKEYASEND HRDFAGELEV LCKLGHHPNI 
INLLGACKNR GYLYIAIEYA PYGNLLDFLR KSRVLETDPA FAREHGTAST LSSRQLLRFA 
SDAANGMQYL SEKQFIHRDL AARNVLVGEN LASKIADFGL SRGEEVYVKK TMGRLPVRWM 
AIESLNYSVY TTKSDVWSFG VLLWEIVSLG GTPYCGMTCA ELYEKLPQGY RMEQPRNCDD 
EVYELMRQCW RDRPYERPPF AQIALQLGRM LEARKAYVNM SLFENFTYAG IDATAEEA

Genular Protein ID: 724238906

Symbol: B4DTW8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DTW8

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 13 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 3 SAM 1 SMART 4 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1093
  • Mass: 120186
  • Checksum: 73614F6A97FD3E2B
  • Sequence:
    • MWAGAGRGSD AWGPPLLLEK DDRIVRTPPG PPLRLARNGS HQVTLRGFSK PSDLVGVFSC 
VGGAGARRTR VIYVHNSPGA HLLPDKVTHT VNKGDTAVLS ARVHKEKQTD VIWKSNGSYF 
YTLDWHEAQD GRFLLQLPNV QPPSSGIYSA TYLEASPLGS AFFRLIVRGC GAGRWGPGCT 
KECPGCLHGG VCHDHDGECV CPPGFTGTRC EQACREGRFG QSCQEQCPGI SGCRGLTFCL 
PDPYGCSCGS GWRGSQCQEA CAPGHFGADC RLQCQCQNGG TCDRFSGCVC PSGWHGVHCE 
KSDRIPQILN MASELEFNLE TMPRINCAAA GNPFPVRGSI ELRKPDGTVL LSTKAIVEPE 
KTTAEFEVPR LVLADSGFWE CRVSTSGGQD SRRFKVNVKV PPVPLAAPRL LTKQSRQLVV 
SPLVSFSGDG PISTVRLHYR PQDSTMDWST IVVDPSENVT LMNLRPKTGY SVRVQLSRPG 
EGGEGAWGPP TLMTTDCPEP LLQPWLEGWH VEGTDRLRVS WSLPLVPGPL VGDGFLLRLW 
DGTRGQERRE NVSSPQARTA LLTGLTPGTH YQLDVQLYHC TLLGPASPPA HVLLPPSGPP 
APRHLHAQAL SDSEIQLTWK HPEALPGPIS KYVVEVQVAG GAGDPLWIDV DRPEETSTII 
RGLNASTRYL FRMRASIQGL GDWSNTVEES TLGNGLQAEG PVQESRAAEE GLDQQLILAV 
VGSVSATCLT ILAALLTLVC IRRSCLHRRR TFTYQSGSGE ETILQFSSGT LTLTRRPKLQ 
PEPLSYPVLE WEDITFEDLI GEGNFGQVIR AMIKKDGLKM NAAIKMLKEY ASENDHRDFA 
GELEVLCKLG HHPNIINLLG ACKNRGYLYI AIEYAPYGNL LDFLRKSRVL ETDPAFAREH 
GTASTLSSRQ LLRFASDAAN GMQYLSEKQF IHRDLAARNV LVGENLASKI ADFGLSRGEE 
VYVKKTMGRL PVRWMAIESL NYSVYTTKSD VWSFGVLLWE IVSLGGTPYC GMTCAELYEK 
LPQGYRMEQP RNCDDEVYEL MRQCWRDRPY ERPPFAQIAL QLGRMLEARK AYVNMSLFEN 
FTYAGIDATA EEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.